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The map label for this gene is lrp [H]

Identifier: 213157607

GI number: 213157607

Start: 2387635

End: 2388084

Strand: Direct

Name: lrp [H]

Synonym: AB57_2300

Alternate gene names: 213157607

Gene position: 2387635-2388084 (Clockwise)

Preceding gene: 213157602

Following gene: 213157608

Centisome position: 58.95

GC content: 30.89

Gene sequence:

>450_bases
ATGAATTTAGATGCGATCGATCTAAAAATTTTGAAGTATTTACAAGACAATGCCCGTTTAAGTAACCAAGAACTTGCTGA
TCTTGTTAATCTTTCAGCATCTGCTTGTCACAGACGCGTCAAAATTTTAGAAACCAACGGAATCATTGAAAAATATCAAG
CAAAAGTTAATTATGAAAAATTAGGTATAAAAATTGAGGCGATAGTTGAAATAAAACTTGCTCAACTCACCGAAAATGAC
CACAACTTTTTTTTAAGCCAAATCAAGAATTTTGATGAAGTCATCAATGCCTATATCATTACAGGTGAATCTAATTATGT
ACTGCACGTTGCCACTAAAGATCTAAACTCTTTTTCTCATTTTGTTATTAATACACTCAATAAAATTAAAGGTGTGGTAA
GCATTAACTCAAAAATTATCTTACAGAAAATTATACAAAAGCCGCTGTAG

Upstream 100 bases:

>100_bases
CACGTCAATTTGTACGATTTATTCGATAATATTTGATCAAAAATAGCTATTTTCATATAAAATTCTAATTAAAATTAAAA
AATATGGATGAAATTCGAAA

Downstream 100 bases:

>100_bases
AATATTTAGCTAAAATTAAAAAACTCTCGTTAAAGAATTTTTACTATGATCGAAACTGAACGTTTAATCTTAAGACAATG
GAAAGAGTCTGATTCAGAGC

Product: transcriptional regulator, AsnC family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MNLDAIDLKILKYLQDNARLSNQELADLVNLSASACHRRVKILETNGIIEKYQAKVNYEKLGIKIEAIVEIKLAQLTEND
HNFFLSQIKNFDEVINAYIITGESNYVLHVATKDLNSFSHFVINTLNKIKGVVSINSKIILQKIIQKPL

Sequences:

>Translated_149_residues
MNLDAIDLKILKYLQDNARLSNQELADLVNLSASACHRRVKILETNGIIEKYQAKVNYEKLGIKIEAIVEIKLAQLTEND
HNFFLSQIKNFDEVINAYIITGESNYVLHVATKDLNSFSHFVINTLNKIKGVVSINSKIILQKIIQKPL
>Mature_149_residues
MNLDAIDLKILKYLQDNARLSNQELADLVNLSASACHRRVKILETNGIIEKYQAKVNYEKLGIKIEAIVEIKLAQLTEND
HNFFLSQIKNFDEVINAYIITGESNYVLHVATKDLNSFSHFVINTLNKIKGVVSINSKIILQKIIQKPL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081742, Length=142, Percent_Identity=30.9859154929577, Blast_Score=86, Evalue=9e-19,
Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=28.9655172413793, Blast_Score=80, Evalue=6e-17,
Organism=Escherichia coli, GI1790182, Length=145, Percent_Identity=28.9655172413793, Blast_Score=68, Evalue=3e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16937; Mature: 16937

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDAIDLKILKYLQDNARLSNQELADLVNLSASACHRRVKILETNGIIEKYQAKVNYEK
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHEEEECCCHHHHHHHHCCHHH
LGIKIEAIVEIKLAQLTENDHNFFLSQIKNFDEVINAYIITGESNYVLHVATKDLNSFSH
HCEEEEHHEEEHEHHHCCCCHHHHHHHHCCHHHHHEEEEEECCCCEEEEEECCCCCHHHH
FVINTLNKIKGVVSINSKIILQKIIQKPL
HHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNLDAIDLKILKYLQDNARLSNQELADLVNLSASACHRRVKILETNGIIEKYQAKVNYEK
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHEEEECCCHHHHHHHHCCHHH
LGIKIEAIVEIKLAQLTENDHNFFLSQIKNFDEVINAYIITGESNYVLHVATKDLNSFSH
HCEEEEHHEEEHEHHHCCCCHHHHHHHHCCHHHHHEEEEEECCCCEEEEEECCCCCHHHH
FVINTLNKIKGVVSINSKIILQKIIQKPL
HHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]