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The map label for this gene is kynU [H]

Identifier: 213157606

GI number: 213157606

Start: 2386238

End: 2387488

Strand: Reverse

Name: kynU [H]

Synonym: AB57_2299

Alternate gene names: 213157606

Gene position: 2387488-2386238 (Counterclockwise)

Preceding gene: 213157609

Following gene: 213157605

Centisome position: 58.94

GC content: 38.45

Gene sequence:

>1251_bases
ATGATTACTCGTGAACAGTGTTTGTATTGGGATCAGGAAGATGAACTCAAAAAATTTAAAGATGAATTTGCATTGCCAGA
AGGCGTCATTTATTTAGATGGTAACTCTTTAGGTGCTAGACCAAAGAAATCTTTGGCTGTCGCTCAGCATATTATTTCCC
AAGAATGGGGAGAAGATCTGATCAATAGCTGGAATAAGGCAGACTGGTGGGGGCTACCAACACGGCTGGGTGACAAAGTC
GCTAAACTGATTGGTGCGGAAAAAGGTGAAGTTGTTATTTCAGATTCAACTACACTGAACTTATTTAAAGTTTTATCTGC
AGCGGTAAAAATTCAGGCTGATAAATTCCCTGAACACAAAATTATTGTGGCAGAAAAAGATGCTTTTCCAACAGATATTT
ACATTATTGAAGGTTTCATTGACTTAATTCAAAAGGGCTATCAGGTTGAATTAATTGATGGCGTAGAAGACTTATCTCGT
GCTTTAGAGAAAGATGTTGCTGTAGTGGTACTTTCCCATGTGAATTACCGCACTGGTTATTTTTATGATATGGCATCTAT
TAATGAACAAATTCATTCTAAAGATGCTTTGGTGATTTGGGATTTATGTCACTCAGTCGGTGCTGTTCCTATGCACCTTA
ATCAAACTGATAGTGATTTTGCGATTGGTTGTACCTATAAATATTTAAATGGTGGCCCTGGTTCTCCTGCATTGCTCTGG
GTCAATGAAAAGCACCGTGATCAGTTCTGGCAGCCTTTATCAGGTTGGTGGAGTCATAAAAAACCATTTGGTATGGCACA
GCATTATGAGCCAGCGAATAGTATCCGCCGATATTTATGTGGAACTCAGCCGGTTATTTCTATGAGTCTGATTGAATGCG
GAGTGGATATTTTCCTGCATGCTGATATGCAAAAAATCCGTGAGAAATCTTTGAAATTAACTGATTTATTTATTCAATTG
GTACATCAAGAATGTTCTGAATTTGGATTTGAGTTAATTACGCCTTTAGGTCATAAGCATCGTGGTAGTCATGTTAGTTA
TCGTCATGAATTCGGCTATGAAATTATTCAGGCGCTTATCGCACGTGGTGTGATTGGTGATTATCGGGAACCTGCAGTCT
TGAGATTTGGTATTACACCTTTGTATCTGGGCTTTGAAGATATTTGGAATGCAGTACAGCACTTAAAAGAAACCATGCTG
AATAGTGAATGGAAAAACAAAGAGTATTTAGTTCGCGGTGAAGTGACCTGA

Upstream 100 bases:

>100_bases
GAAAATAGCTATTTTTGATCAAATATTATCGAATAAATCGTACAAATTGACGTGATAAAATTCAAATACAAAGGAAATGT
AGAAATAGGTGCAATATCAA

Downstream 100 bases:

>100_bases
TTTTAAGGAATCAAAATAAAACAAATGGCTAGGAGGGCCTATGAGTAGTTTTGATGAAATACAAAATAGAGAAGCTGGGC
TGCATAAAAAGTTATCTGCA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MITREQCLYWDQEDELKKFKDEFALPEGVIYLDGNSLGARPKKSLAVAQHIISQEWGEDLINSWNKADWWGLPTRLGDKV
AKLIGAEKGEVVISDSTTLNLFKVLSAAVKIQADKFPEHKIIVAEKDAFPTDIYIIEGFIDLIQKGYQVELIDGVEDLSR
ALEKDVAVVVLSHVNYRTGYFYDMASINEQIHSKDALVIWDLCHSVGAVPMHLNQTDSDFAIGCTYKYLNGGPGSPALLW
VNEKHRDQFWQPLSGWWSHKKPFGMAQHYEPANSIRRYLCGTQPVISMSLIECGVDIFLHADMQKIREKSLKLTDLFIQL
VHQECSEFGFELITPLGHKHRGSHVSYRHEFGYEIIQALIARGVIGDYREPAVLRFGITPLYLGFEDIWNAVQHLKETML
NSEWKNKEYLVRGEVT

Sequences:

>Translated_416_residues
MITREQCLYWDQEDELKKFKDEFALPEGVIYLDGNSLGARPKKSLAVAQHIISQEWGEDLINSWNKADWWGLPTRLGDKV
AKLIGAEKGEVVISDSTTLNLFKVLSAAVKIQADKFPEHKIIVAEKDAFPTDIYIIEGFIDLIQKGYQVELIDGVEDLSR
ALEKDVAVVVLSHVNYRTGYFYDMASINEQIHSKDALVIWDLCHSVGAVPMHLNQTDSDFAIGCTYKYLNGGPGSPALLW
VNEKHRDQFWQPLSGWWSHKKPFGMAQHYEPANSIRRYLCGTQPVISMSLIECGVDIFLHADMQKIREKSLKLTDLFIQL
VHQECSEFGFELITPLGHKHRGSHVSYRHEFGYEIIQALIARGVIGDYREPAVLRFGITPLYLGFEDIWNAVQHLKETML
NSEWKNKEYLVRGEVT
>Mature_416_residues
MITREQCLYWDQEDELKKFKDEFALPEGVIYLDGNSLGARPKKSLAVAQHIISQEWGEDLINSWNKADWWGLPTRLGDKV
AKLIGAEKGEVVISDSTTLNLFKVLSAAVKIQADKFPEHKIIVAEKDAFPTDIYIIEGFIDLIQKGYQVELIDGVEDLSR
ALEKDVAVVVLSHVNYRTGYFYDMASINEQIHSKDALVIWDLCHSVGAVPMHLNQTDSDFAIGCTYKYLNGGPGSPALLW
VNEKHRDQFWQPLSGWWSHKKPFGMAQHYEPANSIRRYLCGTQPVISMSLIECGVDIFLHADMQKIREKSLKLTDLFIQL
VHQECSEFGFELITPLGHKHRGSHVSYRHEFGYEIIQALIARGVIGDYREPAVLRFGITPLYLGFEDIWNAVQHLKETML
NSEWKNKEYLVRGEVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=448, Percent_Identity=26.7857142857143, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI74101437, Length=278, Percent_Identity=28.7769784172662, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17550466, Length=439, Percent_Identity=29.1571753986333, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323261, Length=448, Percent_Identity=29.6875, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 47485; Mature: 47485

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITREQCLYWDQEDELKKFKDEFALPEGVIYLDGNSLGARPKKSLAVAQHIISQEWGEDL
CCCHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
INSWNKADWWGLPTRLGDKVAKLIGAEKGEVVISDSTTLNLFKVLSAAVKIQADKFPEHK
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHEECCCCCCCE
IIVAEKDAFPTDIYIIEGFIDLIQKGYQVELIDGVEDLSRALEKDVAVVVLSHVNYRTGY
EEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHEEEEECCCCCCCE
FYDMASINEQIHSKDALVIWDLCHSVGAVPMHLNQTDSDFAIGCTYKYLNGGPGSPALLW
EEEHHHHHHHHHCCCCEEHHHHHHHHCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEE
VNEKHRDQFWQPLSGWWSHKKPFGMAQHYEPANSIRRYLCGTQPVISMSLIECGVDIFLH
ECCHHHHHHHCHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHCHHHEEE
ADMQKIREKSLKLTDLFIQLVHQECSEFGFELITPLGHKHRGSHVSYRHEFGYEIIQALI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ARGVIGDYREPAVLRFGITPLYLGFEDIWNAVQHLKETMLNSEWKNKEYLVRGEVT
HHCCCCCCCCCCEEEECCCHHEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
>Mature Secondary Structure
MITREQCLYWDQEDELKKFKDEFALPEGVIYLDGNSLGARPKKSLAVAQHIISQEWGEDL
CCCHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
INSWNKADWWGLPTRLGDKVAKLIGAEKGEVVISDSTTLNLFKVLSAAVKIQADKFPEHK
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHEECCCCCCCE
IIVAEKDAFPTDIYIIEGFIDLIQKGYQVELIDGVEDLSRALEKDVAVVVLSHVNYRTGY
EEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHEEEEECCCCCCCE
FYDMASINEQIHSKDALVIWDLCHSVGAVPMHLNQTDSDFAIGCTYKYLNGGPGSPALLW
EEEHHHHHHHHHCCCCEEHHHHHHHHCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEE
VNEKHRDQFWQPLSGWWSHKKPFGMAQHYEPANSIRRYLCGTQPVISMSLIECGVDIFLH
ECCHHHHHHHCHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHCHHHEEE
ADMQKIREKSLKLTDLFIQLVHQECSEFGFELITPLGHKHRGSHVSYRHEFGYEIIQALI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ARGVIGDYREPAVLRFGITPLYLGFEDIWNAVQHLKETMLNSEWKNKEYLVRGEVT
HHCCCCCCCCCCEEEECCCHHEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA