Click here to switch to the map view.

The map label for this gene is ytnA [H]

Identifier: 213157605

GI number: 213157605

Start: 2384791

End: 2386197

Strand: Reverse

Name: ytnA [H]

Synonym: AB57_2298

Alternate gene names: 213157605

Gene position: 2386197-2384791 (Counterclockwise)

Preceding gene: 213157606

Following gene: 213157604

Centisome position: 58.91

GC content: 38.24

Gene sequence:

>1407_bases
ATGAGTAGTTTTGATGAAATACAAAATAGAGAAGCTGGGCTGCATAAAAAGTTATCTGCAAAACAGATGGGGATGATTGC
GATTGGTGGAGCAATTGGAACCGGATTGTTTATGGGAAGCAAATTTGCAATTAGTTTTGCAGGTCCAGCAGTCATCGTCA
GCTATGCGATTGGTGGTTTAATTGCTTTTGCACTTATGGCTTGTTTGGCTGAAATGACAGTTCAGCATCCTACTTCAGGT
TCATTTGGTGCATATGCAGAACATTATATAAATCCACTTGCTGGCTTCTTAGTTCGCTACTGTTATTGGGCTTGTATTGT
ACTGGCGGTAGGTACAGAGATTACCGCCGTTGCTGATTATATGAAGCTCTGGTTCCCGAATGTAGGCTCTTGGGTCTGGA
TTGGATTTTTTTCACTGACCTTACTTGTTGTAAATGCCTATAGTGTTAAAGCTTTTGGACTAGTGGAATACTGGTTTTCC
ACAATTAAAGTTTTTGCCATTATTGTGTTTATTCTTTTGTCTATTGGTATCTTGACGCAAAGCAATCAGGGAATGACGCA
AGTTGTAACTCATTTATCAGGACATGGGGGCTTTTTTCCAAATGGCTTTAGTGGGGTCTGGATTGGAGTAATCATTTCAA
TATTTAGTTATTTAAGTATAGAAATGATTGCTGTCGCGGCTGGCGAAGCTAAAGACCCGGAAAAGGCAGTTAAAAAAGCA
TTCAAAAGCACAGCACTTCGACTCATTTTGTTTTATTTATTGTCCTTATTCCTAATCGTTACTTTGGTGCCGTGGACTGT
TTTGATTGGAGCAGATGCAACAAGCCCTTTTGTTATGGTCATGAAGATTGTCGGTATCCCGTATGCGGATAGCATTTTAA
ACTTTATTGTAATTGTAGCTGCCTTATCAGCTATGAATAGCATGCTTTATATTTCAACTCGTATGCTGTTTAGCTTGTCA
CGTGCAGGTGATGCCCCAAAAGTCTTTGGTCGAATTAGTAGTAATGGGGTACCGATAAATGCGCTGTTGTTATCTGCGGT
AGGGATTGGTATTGCTAGTATTGTTTATACGATTAATCCAGCTTCCGCATTTCCAATTATGATTGCACTATCCATGTTTG
GTGCGTTGTTCACGTGGGGAAGTATATTTGTGACTCATATGTTTTTTAGAAGACATATGGTTCAGCAAAATATACAACTA
AAATTTAAAATTCCTGCTAGTCGATTTATCTCTTTGTTTGGGTTTATTGCGATTTTAAGCATTACAGTGACTACCTGGTT
TACCAGTGAATTTAAGTCTACTTTACAATTTGGCGTACCTTTAGTTCTGGTTCTTATATTTTTCTATTATTTGAAGCGTT
CTACCGTAAAGTTAAATCTCAACTCTAGTGAAGAAACATTGAAGTGA

Upstream 100 bases:

>100_bases
ACCATGCTGAATAGTGAATGGAAAAACAAAGAGTATTTAGTTCGCGGTGAAGTGACCTGATTTTAAGGAATCAAAATAAA
ACAAATGGCTAGGAGGGCCT

Downstream 100 bases:

>100_bases
TTGGTATATGAGAAGGTATGACAATGCTACAACGGTAGAGAATGAAGGTGAAATACTAGCAGGCTTCCAATACAGAAGCT
TGCTGAGTTATCGGGCCTAT

Product: proline-specific permease ProY

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSSFDEIQNREAGLHKKLSAKQMGMIAIGGAIGTGLFMGSKFAISFAGPAVIVSYAIGGLIAFALMACLAEMTVQHPTSG
SFGAYAEHYINPLAGFLVRYCYWACIVLAVGTEITAVADYMKLWFPNVGSWVWIGFFSLTLLVVNAYSVKAFGLVEYWFS
TIKVFAIIVFILLSIGILTQSNQGMTQVVTHLSGHGGFFPNGFSGVWIGVIISIFSYLSIEMIAVAAGEAKDPEKAVKKA
FKSTALRLILFYLLSLFLIVTLVPWTVLIGADATSPFVMVMKIVGIPYADSILNFIVIVAALSAMNSMLYISTRMLFSLS
RAGDAPKVFGRISSNGVPINALLLSAVGIGIASIVYTINPASAFPIMIALSMFGALFTWGSIFVTHMFFRRHMVQQNIQL
KFKIPASRFISLFGFIAILSITVTTWFTSEFKSTLQFGVPLVLVLIFFYYLKRSTVKLNLNSSEETLK

Sequences:

>Translated_468_residues
MSSFDEIQNREAGLHKKLSAKQMGMIAIGGAIGTGLFMGSKFAISFAGPAVIVSYAIGGLIAFALMACLAEMTVQHPTSG
SFGAYAEHYINPLAGFLVRYCYWACIVLAVGTEITAVADYMKLWFPNVGSWVWIGFFSLTLLVVNAYSVKAFGLVEYWFS
TIKVFAIIVFILLSIGILTQSNQGMTQVVTHLSGHGGFFPNGFSGVWIGVIISIFSYLSIEMIAVAAGEAKDPEKAVKKA
FKSTALRLILFYLLSLFLIVTLVPWTVLIGADATSPFVMVMKIVGIPYADSILNFIVIVAALSAMNSMLYISTRMLFSLS
RAGDAPKVFGRISSNGVPINALLLSAVGIGIASIVYTINPASAFPIMIALSMFGALFTWGSIFVTHMFFRRHMVQQNIQL
KFKIPASRFISLFGFIAILSITVTTWFTSEFKSTLQFGVPLVLVLIFFYYLKRSTVKLNLNSSEETLK
>Mature_467_residues
SSFDEIQNREAGLHKKLSAKQMGMIAIGGAIGTGLFMGSKFAISFAGPAVIVSYAIGGLIAFALMACLAEMTVQHPTSGS
FGAYAEHYINPLAGFLVRYCYWACIVLAVGTEITAVADYMKLWFPNVGSWVWIGFFSLTLLVVNAYSVKAFGLVEYWFST
IKVFAIIVFILLSIGILTQSNQGMTQVVTHLSGHGGFFPNGFSGVWIGVIISIFSYLSIEMIAVAAGEAKDPEKAVKKAF
KSTALRLILFYLLSLFLIVTLVPWTVLIGADATSPFVMVMKIVGIPYADSILNFIVIVAALSAMNSMLYISTRMLFSLSR
AGDAPKVFGRISSNGVPINALLLSAVGIGIASIVYTINPASAFPIMIALSMFGALFTWGSIFVTHMFFRRHMVQQNIQLK
FKIPASRFISLFGFIAILSITVTTWFTSEFKSTLQFGVPLVLVLIFFYYLKRSTVKLNLNSSEETLK

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Phenylalanine. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=338, Percent_Identity=25.7396449704142, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI258645169, Length=388, Percent_Identity=21.1340206185567, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786789, Length=404, Percent_Identity=40.8415841584158, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1786302, Length=423, Percent_Identity=37.3522458628842, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1786602, Length=451, Percent_Identity=36.1419068736142, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1790653, Length=412, Percent_Identity=33.9805825242718, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87081708, Length=468, Percent_Identity=33.3333333333333, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788480, Length=472, Percent_Identity=33.6864406779661, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=32.3725055432373, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87081915, Length=414, Percent_Identity=35.5072463768116, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1789017, Length=398, Percent_Identity=34.4221105527638, Blast_Score=232, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324990, Length=450, Percent_Identity=33.3333333333333, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324061, Length=456, Percent_Identity=28.7280701754386, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320772, Length=419, Percent_Identity=28.8782816229117, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=447, Percent_Identity=30.2013422818792, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=404, Percent_Identity=31.1881188118812, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=479, Percent_Identity=28.1837160751566, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=30.1052631578947, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=416, Percent_Identity=28.3653846153846, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=448, Percent_Identity=28.5714285714286, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=28.3251231527094, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321053, Length=400, Percent_Identity=26.5, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=28.1173594132029, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=436, Percent_Identity=27.7522935779816, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=26.1194029850746, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=26.1421319796954, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=495, Percent_Identity=26.2626262626263, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=24.7165532879819, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=491, Percent_Identity=22.6069246435845, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221512776, Length=373, Percent_Identity=23.3243967828418, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666159, Length=373, Percent_Identity=23.3243967828418, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51068; Mature: 50937

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFDEIQNREAGLHKKLSAKQMGMIAIGGAIGTGLFMGSKFAISFAGPAVIVSYAIGGL
CCCHHHHHHHHCCHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
IAFALMACLAEMTVQHPTSGSFGAYAEHYINPLAGFLVRYCYWACIVLAVGTEITAVADY
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MKLWFPNVGSWVWIGFFSLTLLVVNAYSVKAFGLVEYWFSTIKVFAIIVFILLSIGILTQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SNQGMTQVVTHLSGHGGFFPNGFSGVWIGVIISIFSYLSIEMIAVAAGEAKDPEKAVKKA
CCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHH
FKSTALRLILFYLLSLFLIVTLVPWTVLIGADATSPFVMVMKIVGIPYADSILNFIVIVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ALSAMNSMLYISTRMLFSLSRAGDAPKVFGRISSNGVPINALLLSAVGIGIASIVYTINP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCC
ASAFPIMIALSMFGALFTWGSIFVTHMFFRRHMVQQNIQLKFKIPASRFISLFGFIAILS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHH
ITVTTWFTSEFKSTLQFGVPLVLVLIFFYYLKRSTVKLNLNSSEETLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCC
>Mature Secondary Structure 
SSFDEIQNREAGLHKKLSAKQMGMIAIGGAIGTGLFMGSKFAISFAGPAVIVSYAIGGL
CCHHHHHHHHCCHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]