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The map label for this gene is emrA [H]

Identifier: 213157438

GI number: 213157438

Start: 2210238

End: 2211323

Strand: Direct

Name: emrA [H]

Synonym: AB57_2127

Alternate gene names: 213157438

Gene position: 2210238-2211323 (Clockwise)

Preceding gene: 213157437

Following gene: 213157441

Centisome position: 54.57

GC content: 40.33

Gene sequence:

>1086_bases
ATGAGTACTCTCGAAGCCCAAGATCACTCCATGACCGAGTCACCCAAGTTAACAAAGATGCAATATCTTAAGAAACACTG
GGTTATGGTTATTGCATTTATTATCGTTCTAGTTTCCATTTTATGGATTTTAAAAGTTATATTTTTACCTTCTTCCATTG
TTAAAACTGACGATGCGCGGGTAGACGTCGAGTACTCAACCATTGCTCCAAAAGTGTCAGGTAATATTGAAGAAATTTAT
ATTAAAGATCACCAGACCGTAAAAAAAGGCCAGCTTTTGGCACGAATTGATGCACGTGATTATCAGGCGGCTTTAGCTGA
AGCTGAATCTAATTATGCCAAAGCACAAGCTGACTTAAATGAAGCAATGCTGGCAGTAGAAAGACAACCAACTGTTATTC
GAGAAACAGAGGCCCAGCTTAGAAAAGTAGAAGCCGGCATTAAACTCACTAAAGATAATACCGCACGCTATGAGCAATTA
CAGGCACTTGGCGCTGAATCTAGATTGATTACACAACAGTCAAAAACCACACTAACCGAGCAATATGCCGACTTGGACAG
CAGTAAAGAAAAAGTCATTGATGCACAGTATCAGCTCAACCAATATAAGATTCAGGTTCAAGCTAAACAAGCGGCTTTGA
AACAAGCCCAAGCTGCGCTTGATAAAGCAAAACTGAATCTGAGCTATACAGAAATTCGAGCGCCTATTGATGGTATGATT
GGGCAGAAGTCTGCAAATGTGGGCAACTTTGTTGGCGCAGGTAATCCACTCATGGTAGTTGTGCCTTTAGATCAAGTGTA
TGTAGAAGCAAACTTCCGTGAAATTGAGCTAAAACAAATTAAAATCGGCCAGCCTGTCACTGTTTATGTCGATGCTTATA
ACGTTGAGTTAAAAGGTGTGGTAGATAGTTTTTCACCATCGACTGGTGCATTCTTCTCGCCAATTTCAGCAACAAATGCG
ACGGGTAACTTTACTAAAATTGTTCAGCGTTTACCTTTACGCATCAAACTCCTTGAGAACCAACCTGATATTAAATTGTT
GCGTCCTGGTCTATCTGTTGTGGTTTCTGTGGATACGACCAAATAA

Upstream 100 bases:

>100_bases
CAATTTTATTTATCGTTATGCTGATTTTGCCAGTTAGAACTTATCCACCACGCATTGCTCTCATTAAGTTAATGAATAGT
CATAACTCAGGAAAATCTTT

Downstream 100 bases:

>100_bases
ACGTAATCAACTGAGCACTTCAAACTTTAAATGAGCCTCATTGTTAGTCTTACTCCTAATGAGGCCTCATCAAATTCAAT
ATTAAATTAAGCCCGTATTT

Product: multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSTLEAQDHSMTESPKLTKMQYLKKHWVMVIAFIIVLVSILWILKVIFLPSSIVKTDDARVDVEYSTIAPKVSGNIEEIY
IKDHQTVKKGQLLARIDARDYQAALAEAESNYAKAQADLNEAMLAVERQPTVIRETEAQLRKVEAGIKLTKDNTARYEQL
QALGAESRLITQQSKTTLTEQYADLDSSKEKVIDAQYQLNQYKIQVQAKQAALKQAQAALDKAKLNLSYTEIRAPIDGMI
GQKSANVGNFVGAGNPLMVVVPLDQVYVEANFREIELKQIKIGQPVTVYVDAYNVELKGVVDSFSPSTGAFFSPISATNA
TGNFTKIVQRLPLRIKLLENQPDIKLLRPGLSVVVSVDTTK

Sequences:

>Translated_361_residues
MSTLEAQDHSMTESPKLTKMQYLKKHWVMVIAFIIVLVSILWILKVIFLPSSIVKTDDARVDVEYSTIAPKVSGNIEEIY
IKDHQTVKKGQLLARIDARDYQAALAEAESNYAKAQADLNEAMLAVERQPTVIRETEAQLRKVEAGIKLTKDNTARYEQL
QALGAESRLITQQSKTTLTEQYADLDSSKEKVIDAQYQLNQYKIQVQAKQAALKQAQAALDKAKLNLSYTEIRAPIDGMI
GQKSANVGNFVGAGNPLMVVVPLDQVYVEANFREIELKQIKIGQPVTVYVDAYNVELKGVVDSFSPSTGAFFSPISATNA
TGNFTKIVQRLPLRIKLLENQPDIKLLRPGLSVVVSVDTTK
>Mature_360_residues
STLEAQDHSMTESPKLTKMQYLKKHWVMVIAFIIVLVSILWILKVIFLPSSIVKTDDARVDVEYSTIAPKVSGNIEEIYI
KDHQTVKKGQLLARIDARDYQAALAEAESNYAKAQADLNEAMLAVERQPTVIRETEAQLRKVEAGIKLTKDNTARYEQLQ
ALGAESRLITQQSKTTLTEQYADLDSSKEKVIDAQYQLNQYKIQVQAKQAALKQAQAALDKAKLNLSYTEIRAPIDGMIG
QKSANVGNFVGAGNPLMVVVPLDQVYVEANFREIELKQIKIGQPVTVYVDAYNVELKGVVDSFSPSTGAFFSPISATNAT
GNFTKIVQRLPLRIKLLENQPDIKLLRPGLSVVVSVDTTK

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=338, Percent_Identity=31.6568047337278, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788711, Length=311, Percent_Identity=31.5112540192926, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790519, Length=320, Percent_Identity=30, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081951, Length=333, Percent_Identity=26.7267267267267, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789637, Length=339, Percent_Identity=26.8436578171091, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082036, Length=229, Percent_Identity=26.6375545851528, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789900, Length=298, Percent_Identity=22.1476510067114, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790024, Length=228, Percent_Identity=26.7543859649123, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40098; Mature: 39966

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLEAQDHSMTESPKLTKMQYLKKHWVMVIAFIIVLVSILWILKVIFLPSSIVKTDDAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCE
VDVEYSTIAPKVSGNIEEIYIKDHQTVKKGQLLARIDARDYQAALAEAESNYAKAQADLN
EEEEEHHCCCCCCCCEEEEEECCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EAMLAVERQPTVIRETEAQLRKVEAGIKLTKDNTARYEQLQALGAESRLITQQSKTTLTE
HHHHHHCCCCCEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCHHEEHHHHHHHHHH
QYADLDSSKEKVIDAQYQLNQYKIQVQAKQAALKQAQAALDKAKLNLSYTEIRAPIDGMI
HHHCCCCCHHHHHHHHEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHC
GQKSANVGNFVGAGNPLMVVVPLDQVYVEANFREIELKQIKIGQPVTVYVDAYNVELKGV
CCCCCCCCCCCCCCCCEEEEEECCEEEEECCCEEEEEEEEECCCCEEEEEEEEEEEEEEE
VDSFSPSTGAFFSPISATNATGNFTKIVQRLPLRIKLLENQPDIKLLRPGLSVVVSVDTT
ECCCCCCCCCEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEECCCCEEEEEEECC
K
C
>Mature Secondary Structure 
STLEAQDHSMTESPKLTKMQYLKKHWVMVIAFIIVLVSILWILKVIFLPSSIVKTDDAR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCE
VDVEYSTIAPKVSGNIEEIYIKDHQTVKKGQLLARIDARDYQAALAEAESNYAKAQADLN
EEEEEHHCCCCCCCCEEEEEECCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EAMLAVERQPTVIRETEAQLRKVEAGIKLTKDNTARYEQLQALGAESRLITQQSKTTLTE
HHHHHHCCCCCEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCHHEEHHHHHHHHHH
QYADLDSSKEKVIDAQYQLNQYKIQVQAKQAALKQAQAALDKAKLNLSYTEIRAPIDGMI
HHHCCCCCHHHHHHHHEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHC
GQKSANVGNFVGAGNPLMVVVPLDQVYVEANFREIELKQIKIGQPVTVYVDAYNVELKGV
CCCCCCCCCCCCCCCCEEEEEECCEEEEECCCEEEEEEEEECCCCEEEEEEEEEEEEEEE
VDSFSPSTGAFFSPISATNATGNFTKIVQRLPLRIKLLENQPDIKLLRPGLSVVVSVDTT
ECCCCCCCCCEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEECCCCEEEEEEECC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]