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The map label for this gene is emrY [H]

Identifier: 213157437

GI number: 213157437

Start: 2208664

End: 2210241

Strand: Direct

Name: emrY [H]

Synonym: AB57_2126

Alternate gene names: 213157437

Gene position: 2208664-2210241 (Clockwise)

Preceding gene: 213157435

Following gene: 213157438

Centisome position: 54.53

GC content: 40.43

Gene sequence:

>1578_bases
ATGAATATACGACCACTCATCGGTTTGGCAGGTGCAATTTTTGCAGCCATGACTGTCGAATTAAATAACCGAATTAGCAG
CATTACCTTGGTCGATATTCGCGGTGAGATGGGTATTAGTGTCGACTCTGGTTATTGGGTCAGCAGTATTTATGCCAGTG
CCATGATTATTGGGATGATCCTGTCCACCAGTTGGGCGGTTATTTTTTCTATGCGTCGGGTTCTTCTTTTTGCGATAGGA
CTTTGCCTCTTCTCTAGCGTTTTAATTCCTTTTAGCCCAAATATCGAAATATTTTATTTATTACGGGGCTTACAAGGACT
CGCCAATGGCTTAACTATTCCTTTATTAATGGCATGTGCACTTAGATTCCTAGGGCCTGAAATTCGTCTATGGGGCTTGG
CCTGCTATGCATTGACAGCAACTTTTTTCCCAAACTTAAGCGCTGCGCTTGCTGCCTTTTATTTAGATGTGATTGGTTGG
AAGATGATATTTTTCCAAACCATTCCTTTTTGTGCTTTAAGTGCTGCGTTAGTTTACTTCGGTATTCCGCAAGATCCGTT
AAATTACTCAAGAATAAAAACTTACGATTGGACTGGCGCGATTCTAGCCATTATTGGTTTGGCAAGCCTTAGTACCATGC
TTTTGCATGGCAATCATTTGGACTGGTTCCATTCAAAATTGATTTGTGTTTTGGCTTTAATGAGTGCCATTACCCTACCT
TTATTTTTAATACATGAATGGCGCTATCCAACACCATTAATTAAACCGCAAATGCTCGAAATACGAAATTTTGGTTATGC
TGTTATTGCATTGTTCTGCTTTGTGGTTATTGGTATGTCAACCAGTACATTACCTCTTAATTACTTAAGCGCTGTGCATG
GTTATAAGCCTACTCAAACCATGTGGATTGGCTTACAAATTGCCGCATTACAATTTATCTATATCCCGATTGTTATTAAA
GTTTTGAACCAAGCTTGGGTTGATAGCCGATATGTACATGGGTTTGGTTTGCTTTTGGTTATGGTTGGCTGCTTAGGTGC
AAGTCAACTTGATACGACTTGGAACCAAGACCAATTCTATTTTTGGCATGCAATCTCATGTTTAGGACAAACCTGTGTAG
TGCTTTCGCTCCTCATGATGGGTACAAATAGTGTCCACCCAACTATGGCAATCTATGCTTCGCCTATGATTAACACCCCG
CGTGCTATTAGTGGCGTACTTGGTGTGTGCCTTTTGGACTGGGTCAATCGAGTACGTGGTGAATACCATTCAACACGGCT
GATTGAAAATACCGCACAACATGTTTTTCAAAATATTCAAGGTCCTGTTATTAATCCTCTTACCCCGCCTGTGCTGAGTG
CAGATGGTACCGAACGTGTTTCCGGTGGTTTATCTGCCTTAAATTCTGCGATTCAGGCACAGCAATCAGTTTTAGTCATT
AGTGATCAATATCTGATTTTAGCGGGACTTACTGCAATTTTATTTATCGTTATGCTGATTTTGCCAGTTAGAACTTATCC
ACCACGCATTGCTCTCATTAAGTTAATGAATAGTCATAACTCAGGAAAATCTTTATGA

Upstream 100 bases:

>100_bases
AATTGACGTAAATTTAATAAGATAGTAGAGTACCGATCGGTACAGTTGAGCTTAATCACCGCTATAAGCATTAAGCTCAT
TTTAAAATTTAAGGTAAAAG

Downstream 100 bases:

>100_bases
GTACTCTCGAAGCCCAAGATCACTCCATGACCGAGTCACCCAAGTTAACAAAGATGCAATATCTTAAGAAACACTGGGTT
ATGGTTATTGCATTTATTAT

Product: transporter, major facilitator family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNIRPLIGLAGAIFAAMTVELNNRISSITLVDIRGEMGISVDSGYWVSSIYASAMIIGMILSTSWAVIFSMRRVLLFAIG
LCLFSSVLIPFSPNIEIFYLLRGLQGLANGLTIPLLMACALRFLGPEIRLWGLACYALTATFFPNLSAALAAFYLDVIGW
KMIFFQTIPFCALSAALVYFGIPQDPLNYSRIKTYDWTGAILAIIGLASLSTMLLHGNHLDWFHSKLICVLALMSAITLP
LFLIHEWRYPTPLIKPQMLEIRNFGYAVIALFCFVVIGMSTSTLPLNYLSAVHGYKPTQTMWIGLQIAALQFIYIPIVIK
VLNQAWVDSRYVHGFGLLLVMVGCLGASQLDTTWNQDQFYFWHAISCLGQTCVVLSLLMMGTNSVHPTMAIYASPMINTP
RAISGVLGVCLLDWVNRVRGEYHSTRLIENTAQHVFQNIQGPVINPLTPPVLSADGTERVSGGLSALNSAIQAQQSVLVI
SDQYLILAGLTAILFIVMLILPVRTYPPRIALIKLMNSHNSGKSL

Sequences:

>Translated_525_residues
MNIRPLIGLAGAIFAAMTVELNNRISSITLVDIRGEMGISVDSGYWVSSIYASAMIIGMILSTSWAVIFSMRRVLLFAIG
LCLFSSVLIPFSPNIEIFYLLRGLQGLANGLTIPLLMACALRFLGPEIRLWGLACYALTATFFPNLSAALAAFYLDVIGW
KMIFFQTIPFCALSAALVYFGIPQDPLNYSRIKTYDWTGAILAIIGLASLSTMLLHGNHLDWFHSKLICVLALMSAITLP
LFLIHEWRYPTPLIKPQMLEIRNFGYAVIALFCFVVIGMSTSTLPLNYLSAVHGYKPTQTMWIGLQIAALQFIYIPIVIK
VLNQAWVDSRYVHGFGLLLVMVGCLGASQLDTTWNQDQFYFWHAISCLGQTCVVLSLLMMGTNSVHPTMAIYASPMINTP
RAISGVLGVCLLDWVNRVRGEYHSTRLIENTAQHVFQNIQGPVINPLTPPVLSADGTERVSGGLSALNSAIQAQQSVLVI
SDQYLILAGLTAILFIVMLILPVRTYPPRIALIKLMNSHNSGKSL
>Mature_525_residues
MNIRPLIGLAGAIFAAMTVELNNRISSITLVDIRGEMGISVDSGYWVSSIYASAMIIGMILSTSWAVIFSMRRVLLFAIG
LCLFSSVLIPFSPNIEIFYLLRGLQGLANGLTIPLLMACALRFLGPEIRLWGLACYALTATFFPNLSAALAAFYLDVIGW
KMIFFQTIPFCALSAALVYFGIPQDPLNYSRIKTYDWTGAILAIIGLASLSTMLLHGNHLDWFHSKLICVLALMSAITLP
LFLIHEWRYPTPLIKPQMLEIRNFGYAVIALFCFVVIGMSTSTLPLNYLSAVHGYKPTQTMWIGLQIAALQFIYIPIVIK
VLNQAWVDSRYVHGFGLLLVMVGCLGASQLDTTWNQDQFYFWHAISCLGQTCVVLSLLMMGTNSVHPTMAIYASPMINTP
RAISGVLGVCLLDWVNRVRGEYHSTRLIENTAQHVFQNIQGPVINPLTPPVLSADGTERVSGGLSALNSAIQAQQSVLVI
SDQYLILAGLTAILFIVMLILPVRTYPPRIALIKLMNSHNSGKSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=515, Percent_Identity=25.631067961165, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789042, Length=500, Percent_Identity=22.8, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57836; Mature: 57836

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRPLIGLAGAIFAAMTVELNNRISSITLVDIRGEMGISVDSGYWVSSIYASAMIIGMI
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
LSTSWAVIFSMRRVLLFAIGLCLFSSVLIPFSPNIEIFYLLRGLQGLANGLTIPLLMACA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LRFLGPEIRLWGLACYALTATFFPNLSAALAAFYLDVIGWKMIFFQTIPFCALSAALVYF
HHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIPQDPLNYSRIKTYDWTGAILAIIGLASLSTMLLHGNHLDWFHSKLICVLALMSAITLP
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LFLIHEWRYPTPLIKPQMLEIRNFGYAVIALFCFVVIGMSTSTLPLNYLSAVHGYKPTQT
HHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCE
MWIGLQIAALQFIYIPIVIKVLNQAWVDSRYVHGFGLLLVMVGCLGASQLDTTWNQDQFY
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
FWHAISCLGQTCVVLSLLMMGTNSVHPTMAIYASPMINTPRAISGVLGVCLLDWVNRVRG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
EYHSTRLIENTAQHVFQNIQGPVINPLTPPVLSADGTERVSGGLSALNSAIQAQQSVLVI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
SDQYLILAGLTAILFIVMLILPVRTYPPRIALIKLMNSHNSGKSL
ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNIRPLIGLAGAIFAAMTVELNNRISSITLVDIRGEMGISVDSGYWVSSIYASAMIIGMI
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
LSTSWAVIFSMRRVLLFAIGLCLFSSVLIPFSPNIEIFYLLRGLQGLANGLTIPLLMACA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LRFLGPEIRLWGLACYALTATFFPNLSAALAAFYLDVIGWKMIFFQTIPFCALSAALVYF
HHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIPQDPLNYSRIKTYDWTGAILAIIGLASLSTMLLHGNHLDWFHSKLICVLALMSAITLP
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LFLIHEWRYPTPLIKPQMLEIRNFGYAVIALFCFVVIGMSTSTLPLNYLSAVHGYKPTQT
HHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCE
MWIGLQIAALQFIYIPIVIKVLNQAWVDSRYVHGFGLLLVMVGCLGASQLDTTWNQDQFY
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
FWHAISCLGQTCVVLSLLMMGTNSVHPTMAIYASPMINTPRAISGVLGVCLLDWVNRVRG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
EYHSTRLIENTAQHVFQNIQGPVINPLTPPVLSADGTERVSGGLSALNSAIQAQQSVLVI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
SDQYLILAGLTAILFIVMLILPVRTYPPRIALIKLMNSHNSGKSL
ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]