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The map label for this gene is aldH [H]

Identifier: 213157435

GI number: 213157435

Start: 2206221

End: 2207798

Strand: Direct

Name: aldH [H]

Synonym: AB57_2124

Alternate gene names: 213157435

Gene position: 2206221-2207798 (Clockwise)

Preceding gene: 213157434

Following gene: 213157437

Centisome position: 54.47

GC content: 46.89

Gene sequence:

>1578_bases
ATGACCATTATCGGACACAACTTTATTGGCGGTTCACGCAGCGCACAAGGTACAACCTTATTAAAAAGCATTCATGCTAC
GACTGGTGAAACTTTGCCTTATGAGTTTCACCATGCAACCGAGCAAGAAGTGAATCAGGCCTGTGAAGCAGCCAGTCAAG
CGTTTAAGACTTACCGCCATACATCTCCTGAACAGCGTGCTGTTTTTTTAGAAAATATTGCAGATGAACTCGATGCTTTA
GGTACAGATTTTCTTGAAATTGTCTCACAGGAAACCGCTTTGCCACTTGCACGCTTACAAGGTGAACGTGCCCGGACCAG
TGGGCAAATGCGTTTATTTGCCAAAGTGCTGCGCCGTGGCGACTTTTTAGGTGCCCGTATTGATACCGCTTTGCCTGAGC
GTCAGCCTTTACCTCGCCCAGACCTGCGCCAGATTAAAATCGGTGTTGGCCCTGTTGCAGTCTTTGGGGCAAGTAACTTT
CCTTTAGCATTCTCAACTGCGGGTGGTGACACTGCTTCGGCACTGGCGGCTGGATGTTCGGTGGTAGTAAAAGCCCATAG
TGGGCATATGGCGACAGCAGACTTTGTAGCGCAGGCAATTGAACGTGCCGTAGAAAAATCAAATATGCCTAAAGGTGTGT
TTAACATGATCTACGGTAATGGCGTAGGTGAACCTTTAGTGAAACATCCTTTAATCCAGGCTGTGGGTTTTACAGGTTCA
TTGCGTGGCGGACGAGCTTTATGTGACATGGCCGCAGCCCGACCACAACCGATTCCGGTGTTTGCTGAAATGAGCAGTAT
TAACCCGATGCTGATGTTGCCAGAAGCCTTAAAAAACCGTGGTGAAAAAATTGCACAGGACTTGGCTGATTCAGTGGTTT
TAGGCTGTGGTCAGTTCTGTACCAATCCGGGTTTAATTTTAGGTATTAAATCAGCTGAATTTAGTCAGCTCATTAACAAC
CTGACCAACATTATGGGGGCTAAGCCTGCACAAACCATGCTCAATGCTGGCACCTTAAAAAGCTATACCGCTGGTCTTGA
GCACTTAACCGAGCATCAAGGTATTAAGCATTTGGCAGGTCAAACTCAACAAGGCAATCAGGCGCAGCCACAACTGTTTA
AAGCTGATGTTGAGCTTTTACTGGCGGGTGACCAGCTTTTACAAGAAGAAATCTTTGGGCCAACCACAGTCGTCATTGAA
GTTGAAGATAAAGCCCAACTCATTCAGGCACTACAAAGCATGAATGGACAACTGACTGCGACTTTAATTGCCGATGAAGC
TGACTTAACCGAGTTTGCAGATGTAGTTCCTGTGCTAGAGGAAAAAGCCGGTCGATTACTTATAAATGGCTACCCAACAG
GTGTTGAGGTGTGTGATGCCATGGTACACGGCGGGCCATACCCAGCCACTTCAGATGCACGAGGTACTTCAGTCGGAACC
TTAGCCATTGACCGTTACTTGCGCCCTGTGTGTTACCAGAACTATCCACAGAGTTTATTGCCGGAAGCCTTAAAAGACAG
CAATCCGTTGCAGATTTTAAGACTGGTCAATGGTGAGATGACCAAAGAAGCGATCTAA

Upstream 100 bases:

>100_bases
TTATCTACTGGTGGTTGTTTGGAACCCGCAACTTTATATATGCGAGTCGTAAACCAAGACAACCTTCCAAGACACTCTCA
TTAATTTCAGGATATTTGTT

Downstream 100 bases:

>100_bases
AAATAAAAAGAGACCACGAGTTGGTCTCTTTTTTACTTCTACATTTAGGTTTTTTAAGGAGGTATAAGTTCCTTAATATC
AATCTAGTTTGTAATTAATA

Product: NADP-dependent fatty aldehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTIIGHNFIGGSRSAQGTTLLKSIHATTGETLPYEFHHATEQEVNQACEAASQAFKTYRHTSPEQRAVFLENIADELDAL
GTDFLEIVSQETALPLARLQGERARTSGQMRLFAKVLRRGDFLGARIDTALPERQPLPRPDLRQIKIGVGPVAVFGASNF
PLAFSTAGGDTASALAAGCSVVVKAHSGHMATADFVAQAIERAVEKSNMPKGVFNMIYGNGVGEPLVKHPLIQAVGFTGS
LRGGRALCDMAAARPQPIPVFAEMSSINPMLMLPEALKNRGEKIAQDLADSVVLGCGQFCTNPGLILGIKSAEFSQLINN
LTNIMGAKPAQTMLNAGTLKSYTAGLEHLTEHQGIKHLAGQTQQGNQAQPQLFKADVELLLAGDQLLQEEIFGPTTVVIE
VEDKAQLIQALQSMNGQLTATLIADEADLTEFADVVPVLEEKAGRLLINGYPTGVEVCDAMVHGGPYPATSDARGTSVGT
LAIDRYLRPVCYQNYPQSLLPEALKDSNPLQILRLVNGEMTKEAI

Sequences:

>Translated_525_residues
MTIIGHNFIGGSRSAQGTTLLKSIHATTGETLPYEFHHATEQEVNQACEAASQAFKTYRHTSPEQRAVFLENIADELDAL
GTDFLEIVSQETALPLARLQGERARTSGQMRLFAKVLRRGDFLGARIDTALPERQPLPRPDLRQIKIGVGPVAVFGASNF
PLAFSTAGGDTASALAAGCSVVVKAHSGHMATADFVAQAIERAVEKSNMPKGVFNMIYGNGVGEPLVKHPLIQAVGFTGS
LRGGRALCDMAAARPQPIPVFAEMSSINPMLMLPEALKNRGEKIAQDLADSVVLGCGQFCTNPGLILGIKSAEFSQLINN
LTNIMGAKPAQTMLNAGTLKSYTAGLEHLTEHQGIKHLAGQTQQGNQAQPQLFKADVELLLAGDQLLQEEIFGPTTVVIE
VEDKAQLIQALQSMNGQLTATLIADEADLTEFADVVPVLEEKAGRLLINGYPTGVEVCDAMVHGGPYPATSDARGTSVGT
LAIDRYLRPVCYQNYPQSLLPEALKDSNPLQILRLVNGEMTKEAI
>Mature_524_residues
TIIGHNFIGGSRSAQGTTLLKSIHATTGETLPYEFHHATEQEVNQACEAASQAFKTYRHTSPEQRAVFLENIADELDALG
TDFLEIVSQETALPLARLQGERARTSGQMRLFAKVLRRGDFLGARIDTALPERQPLPRPDLRQIKIGVGPVAVFGASNFP
LAFSTAGGDTASALAAGCSVVVKAHSGHMATADFVAQAIERAVEKSNMPKGVFNMIYGNGVGEPLVKHPLIQAVGFTGSL
RGGRALCDMAAARPQPIPVFAEMSSINPMLMLPEALKNRGEKIAQDLADSVVLGCGQFCTNPGLILGIKSAEFSQLINNL
TNIMGAKPAQTMLNAGTLKSYTAGLEHLTEHQGIKHLAGQTQQGNQAQPQLFKADVELLLAGDQLLQEEIFGPTTVVIEV
EDKAQLIQALQSMNGQLTATLIADEADLTEFADVVPVLEEKAGRLLINGYPTGVEVCDAMVHGGPYPATSDARGTSVGTL
AIDRYLRPVCYQNYPQSLLPEALKDSNPLQILRLVNGEMTKEAI

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507229, Length=252, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI25777721, Length=261, Percent_Identity=26.4367816091954, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789015, Length=415, Percent_Identity=25.3012048192771, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081896, Length=433, Percent_Identity=24.4803695150115, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787715, Length=404, Percent_Identity=26.7326732673267, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787250, Length=400, Percent_Identity=25.5, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788042, Length=456, Percent_Identity=23.9035087719298, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786504, Length=470, Percent_Identity=23.6170212765957, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787684, Length=398, Percent_Identity=22.8643216080402, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17551164, Length=462, Percent_Identity=24.6753246753247, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25143874, Length=434, Percent_Identity=24.4239631336406, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25143876, Length=434, Percent_Identity=24.4239631336406, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319478, Length=215, Percent_Identity=30.6976744186047, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323821, Length=503, Percent_Identity=24.8508946322068, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323822, Length=466, Percent_Identity=26.3948497854077, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281362580, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472918, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472926, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472936, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356737, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 56185; Mature: 56054

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIGHNFIGGSRSAQGTTLLKSIHATTGETLPYEFHHATEQEVNQACEAASQAFKTYRH
CEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
TSPEQRAVFLENIADELDALGTDFLEIVSQETALPLARLQGERARTSGQMRLFAKVLRRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCHHHHHHHHHHHCC
DFLGARIDTALPERQPLPRPDLRQIKIGVGPVAVFGASNFPLAFSTAGGDTASALAAGCS
CCCCCHHHHCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCEEEECCCCCHHHHHHHCCE
VVVKAHSGHMATADFVAQAIERAVEKSNMPKGVFNMIYGNGVGEPLVKHPLIQAVGFTGS
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
LRGGRALCDMAAARPQPIPVFAEMSSINPMLMLPEALKNRGEKIAQDLADSVVLGCGQFC
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNPGLILGIKSAEFSQLINNLTNIMGAKPAQTMLNAGTLKSYTAGLEHLTEHQGIKHLAG
CCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCC
QTQQGNQAQPQLFKADVELLLAGDQLLQEEIFGPTTVVIEVEDKAQLIQALQSMNGQLTA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEE
TLIADEADLTEFADVVPVLEEKAGRLLINGYPTGVEVCDAMVHGGPYPATSDARGTSVGT
EEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHH
LAIDRYLRPVCYQNYPQSLLPEALKDSNPLQILRLVNGEMTKEAI
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TIIGHNFIGGSRSAQGTTLLKSIHATTGETLPYEFHHATEQEVNQACEAASQAFKTYRH
EEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
TSPEQRAVFLENIADELDALGTDFLEIVSQETALPLARLQGERARTSGQMRLFAKVLRRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCHHHHHHHHHHHCC
DFLGARIDTALPERQPLPRPDLRQIKIGVGPVAVFGASNFPLAFSTAGGDTASALAAGCS
CCCCCHHHHCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCEEEECCCCCHHHHHHHCCE
VVVKAHSGHMATADFVAQAIERAVEKSNMPKGVFNMIYGNGVGEPLVKHPLIQAVGFTGS
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
LRGGRALCDMAAARPQPIPVFAEMSSINPMLMLPEALKNRGEKIAQDLADSVVLGCGQFC
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNPGLILGIKSAEFSQLINNLTNIMGAKPAQTMLNAGTLKSYTAGLEHLTEHQGIKHLAG
CCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCC
QTQQGNQAQPQLFKADVELLLAGDQLLQEEIFGPTTVVIEVEDKAQLIQALQSMNGQLTA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEE
TLIADEADLTEFADVVPVLEEKAGRLLINGYPTGVEVCDAMVHGGPYPATSDARGTSVGT
EEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHH
LAIDRYLRPVCYQNYPQSLLPEALKDSNPLQILRLVNGEMTKEAI
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]