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The map label for this gene is ilvD [H]

Identifier: 213157434

GI number: 213157434

Start: 2204417

End: 2206204

Strand: Direct

Name: ilvD [H]

Synonym: AB57_2123

Alternate gene names: 213157434

Gene position: 2204417-2206204 (Clockwise)

Preceding gene: 213157433

Following gene: 213157435

Centisome position: 54.42

GC content: 44.52

Gene sequence:

>1788_bases
ATGAATGATCAAAATAAACGGATTTTTTTACGTAGCCAAGAATGGTTTGATGATCCTGAACATGCCGACATGACAGCACT
TTATGTTGAGCGTTATGTGAATTATGGCCTGACCCGTGCCGAGCTACAATCCGGCCGCCCGATTATTGGAATTGCACAAA
CCGGTAGTGATTTGACCCCATGTAACCGTCATCACAAAGAACTTGCTGAACGTGTTAAAGCGGGTATTCGAGATGCGGGT
GGTATTCCAATGGAATTCCCCGTCCACCCGATTGCAGAACAAACCCGTCGTCCAACTGCTGCACTTGACCGCAACTTGGC
CTATTTAGGTTTGGTTGAAATCTTGCATGGTTATCCGCTTGATGGTGTAGTGCTGACTACTGGCTGTGACAAAACTACCC
CTGCATGTTTAATGGCAGCAGCCACAACAGATTTACCTGCAATTGTGTTGTCTGGTGGGCCAATGCTAGATGGTCATTTT
AAAGGTGAGTTAATTGGTTCCGGCACTGTGCTTTGGCATGCAAGAAACTTACTTGCCACTGGTGAAATTGATTATGAAGG
GTTCATGGAAATGACCACTTCTGCTTCACCTTCGGTCGGGCATTGCAACACCATGGGCACTGCACTTTCCATGAATGCTT
TGGCAGAAGCGTTGGGTATGTCTTTACCAACATGTGCAAGTATTCCGGCACCATATCGCGAACGTGGGCAAATGGCCTAT
ATGACCGGCAAAAGAATATGTGAAATGGTTTTAGAAGATTTACGTCCTTCTAAAATTATGACCAAACAATCTTTTGAAAA
TGCAATCGCAGTAGCCTCAGCTTTAGGTGCATCAAGTAACTGTCCTCCTCACCTCATTGCAATTGCCCGTCATATGGGTA
TTGAGCTGAGTTTAGAAGACTGGCAACGTGTGGGTGAAAACATTCCGCTTATTGTGAACTGTATGCCGGCGGGTAAATAT
TTGGGTGAAGGTTTTCACCGTGCGGGTGGTGTTCCTGCCGTTCTACACGAATTACAAAAAGCTGGTGTATTACACGAAGA
TTGTGCATCGGTTAGCGGTAAAACAATTGGGGAAATTGCCAAAAATGCAAAAACCTCAAATGCAGATGTCATTTTCCCTT
ATGAACAACCTCTTAAACATGGTGCCGGTTTCATTGTGCTCAGTGGCAACTTCTTTGACAGCGCCATTATGAAAATGTCT
GTAGTGGGCGAAGCATTTAAAAAAACCTATTTATCAGATCCAAACAATGAAAATAGTTTCGAAGCACGTGCAATCGTTTT
TGAAGGTCCCGAAGACTATCACGCACGTATCAATGACCCTGCCTTAAACATTGATGAACATTGTATTTTAGTCATTCGTG
GCGCAGGTACGGTGGGTTATCCGGGTAGTGCTGAAGTCGTCAATATGGCTCCTCCAGCGGAGTTAATTAAAAAAGGGATT
GATTCACTGCCTTGCTTAGGAGATGGCCGCCAAAGTGGAACTTCTGCCAGCCCATCTATTCTCAATATGTCACCCGAAGC
GGCTGTAGGCGGTGGAATTGCCTTACTTAAAACCAATGACCGTTTACGTATTGATTTAAATAAACGTTCTGTCAACGTGC
TCATTTCTGACGAAGAGTTAGAACAACGCCGCCGTGAATGGAAACCGACGGTATCTCCATCTCAAACACCTTGGCAAGAA
ATGTATCGCAACATGGTAGGTCAATTATCTACTGGTGGTTGTTTGGAACCCGCAACTTTATATATGCGAGTCGTAAACCA
AGACAACCTTCCAAGACACTCTCATTAA

Upstream 100 bases:

>100_bases
GAATTACTATAATTTTCACGTATTATCGATCGGTTGAATTGCAAGATTCATCTCGTAAATAAACTAAATTTCAAAAAGTA
TGAGTGAAAGGGATCAAAAA

Downstream 100 bases:

>100_bases
TTTCAGGATATTTGTTATGACCATTATCGGACACAACTTTATTGGCGGTTCACGCAGCGCACAAGGTACAACCTTATTAA
AAAGCATTCATGCTACGACT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MNDQNKRIFLRSQEWFDDPEHADMTALYVERYVNYGLTRAELQSGRPIIGIAQTGSDLTPCNRHHKELAERVKAGIRDAG
GIPMEFPVHPIAEQTRRPTAALDRNLAYLGLVEILHGYPLDGVVLTTGCDKTTPACLMAAATTDLPAIVLSGGPMLDGHF
KGELIGSGTVLWHARNLLATGEIDYEGFMEMTTSASPSVGHCNTMGTALSMNALAEALGMSLPTCASIPAPYRERGQMAY
MTGKRICEMVLEDLRPSKIMTKQSFENAIAVASALGASSNCPPHLIAIARHMGIELSLEDWQRVGENIPLIVNCMPAGKY
LGEGFHRAGGVPAVLHELQKAGVLHEDCASVSGKTIGEIAKNAKTSNADVIFPYEQPLKHGAGFIVLSGNFFDSAIMKMS
VVGEAFKKTYLSDPNNENSFEARAIVFEGPEDYHARINDPALNIDEHCILVIRGAGTVGYPGSAEVVNMAPPAELIKKGI
DSLPCLGDGRQSGTSASPSILNMSPEAAVGGGIALLKTNDRLRIDLNKRSVNVLISDEELEQRRREWKPTVSPSQTPWQE
MYRNMVGQLSTGGCLEPATLYMRVVNQDNLPRHSH

Sequences:

>Translated_595_residues
MNDQNKRIFLRSQEWFDDPEHADMTALYVERYVNYGLTRAELQSGRPIIGIAQTGSDLTPCNRHHKELAERVKAGIRDAG
GIPMEFPVHPIAEQTRRPTAALDRNLAYLGLVEILHGYPLDGVVLTTGCDKTTPACLMAAATTDLPAIVLSGGPMLDGHF
KGELIGSGTVLWHARNLLATGEIDYEGFMEMTTSASPSVGHCNTMGTALSMNALAEALGMSLPTCASIPAPYRERGQMAY
MTGKRICEMVLEDLRPSKIMTKQSFENAIAVASALGASSNCPPHLIAIARHMGIELSLEDWQRVGENIPLIVNCMPAGKY
LGEGFHRAGGVPAVLHELQKAGVLHEDCASVSGKTIGEIAKNAKTSNADVIFPYEQPLKHGAGFIVLSGNFFDSAIMKMS
VVGEAFKKTYLSDPNNENSFEARAIVFEGPEDYHARINDPALNIDEHCILVIRGAGTVGYPGSAEVVNMAPPAELIKKGI
DSLPCLGDGRQSGTSASPSILNMSPEAAVGGGIALLKTNDRLRIDLNKRSVNVLISDEELEQRRREWKPTVSPSQTPWQE
MYRNMVGQLSTGGCLEPATLYMRVVNQDNLPRHSH
>Mature_595_residues
MNDQNKRIFLRSQEWFDDPEHADMTALYVERYVNYGLTRAELQSGRPIIGIAQTGSDLTPCNRHHKELAERVKAGIRDAG
GIPMEFPVHPIAEQTRRPTAALDRNLAYLGLVEILHGYPLDGVVLTTGCDKTTPACLMAAATTDLPAIVLSGGPMLDGHF
KGELIGSGTVLWHARNLLATGEIDYEGFMEMTTSASPSVGHCNTMGTALSMNALAEALGMSLPTCASIPAPYRERGQMAY
MTGKRICEMVLEDLRPSKIMTKQSFENAIAVASALGASSNCPPHLIAIARHMGIELSLEDWQRVGENIPLIVNCMPAGKY
LGEGFHRAGGVPAVLHELQKAGVLHEDCASVSGKTIGEIAKNAKTSNADVIFPYEQPLKHGAGFIVLSGNFFDSAIMKMS
VVGEAFKKTYLSDPNNENSFEARAIVFEGPEDYHARINDPALNIDEHCILVIRGAGTVGYPGSAEVVNMAPPAELIKKGI
DSLPCLGDGRQSGTSASPSILNMSPEAAVGGGIALLKTNDRLRIDLNKRSVNVLISDEELEQRRREWKPTVSPSQTPWQE
MYRNMVGQLSTGGCLEPATLYMRVVNQDNLPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=587, Percent_Identity=28.6201022146508, Blast_Score=195, Evalue=9e-51,
Organism=Escherichia coli, GI1788157, Length=446, Percent_Identity=29.372197309417, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1786464, Length=534, Percent_Identity=26.9662921348315, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI2367371, Length=531, Percent_Identity=27.1186440677966, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=519, Percent_Identity=29.2870905587669, Blast_Score=206, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64482; Mature: 64482

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQNKRIFLRSQEWFDDPEHADMTALYVERYVNYGLTRAELQSGRPIIGIAQTGSDLTP
CCCCCCEEEEECHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCC
CNRHHKELAERVKAGIRDAGGIPMEFPVHPIAEQTRRPTAALDRNLAYLGLVEILHGYPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCC
DGVVLTTGCDKTTPACLMAAATTDLPAIVLSGGPMLDGHFKGELIGSGTVLWHARNLLAT
CCEEEECCCCCCCCHHHEEHHCCCCCEEEECCCCEECCCCCCEEEECCEEEEEECCEEEE
GEIDYEGFMEMTTSASPSVGHCNTMGTALSMNALAEALGMSLPTCASIPAPYRERGQMAY
CCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEE
MTGKRICEMVLEDLRPSKIMTKQSFENAIAVASALGASSNCPPHLIAIARHMGIELSLED
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEHHH
WQRVGENIPLIVNCMPAGKYLGEGFHRAGGVPAVLHELQKAGVLHEDCASVSGKTIGEIA
HHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHH
KNAKTSNADVIFPYEQPLKHGAGFIVLSGNFFDSAIMKMSVVGEAFKKTYLSDPNNENSF
HCCCCCCCCEEECCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EARAIVFEGPEDYHARINDPALNIDEHCILVIRGAGTVGYPGSAEVVNMAPPAELIKKGI
EEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHHCC
DSLPCLGDGRQSGTSASPSILNMSPEAAVGGGIALLKTNDRLRIDLNKRSVNVLISDEEL
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEEECCCEEEEEECCHHH
EQRRREWKPTVSPSQTPWQEMYRNMVGQLSTGGCLEPATLYMRVVNQDNLPRHSH
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNDQNKRIFLRSQEWFDDPEHADMTALYVERYVNYGLTRAELQSGRPIIGIAQTGSDLTP
CCCCCCEEEEECHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCC
CNRHHKELAERVKAGIRDAGGIPMEFPVHPIAEQTRRPTAALDRNLAYLGLVEILHGYPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCC
DGVVLTTGCDKTTPACLMAAATTDLPAIVLSGGPMLDGHFKGELIGSGTVLWHARNLLAT
CCEEEECCCCCCCCHHHEEHHCCCCCEEEECCCCEECCCCCCEEEECCEEEEEECCEEEE
GEIDYEGFMEMTTSASPSVGHCNTMGTALSMNALAEALGMSLPTCASIPAPYRERGQMAY
CCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEE
MTGKRICEMVLEDLRPSKIMTKQSFENAIAVASALGASSNCPPHLIAIARHMGIELSLED
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEHHH
WQRVGENIPLIVNCMPAGKYLGEGFHRAGGVPAVLHELQKAGVLHEDCASVSGKTIGEIA
HHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHH
KNAKTSNADVIFPYEQPLKHGAGFIVLSGNFFDSAIMKMSVVGEAFKKTYLSDPNNENSF
HCCCCCCCCEEECCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EARAIVFEGPEDYHARINDPALNIDEHCILVIRGAGTVGYPGSAEVVNMAPPAELIKKGI
EEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHHCC
DSLPCLGDGRQSGTSASPSILNMSPEAAVGGGIALLKTNDRLRIDLNKRSVNVLISDEEL
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEEECCCEEEEEECCHHH
EQRRREWKPTVSPSQTPWQEMYRNMVGQLSTGGCLEPATLYMRVVNQDNLPRHSH
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]