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The map label for this gene is blh [H]

Identifier: 213157250

GI number: 213157250

Start: 2024533

End: 2026188

Strand: Direct

Name: blh [H]

Synonym: AB57_1937

Alternate gene names: 213157250

Gene position: 2024533-2026188 (Clockwise)

Preceding gene: 213157249

Following gene: 213157251

Centisome position: 49.98

GC content: 43.36

Gene sequence:

>1656_bases
ATGGAACTTAAACGAGTTAATCAAGATTTTTATGTTGCTGGCCAGATTACTGCCAACGATATTGTAAAAATTGCAGACCA
AGGAATAAAAACTCTGATATGTAACCGTCCAGATGGAGAAGGTGCAGATCAACCCAATGTGATTGAAATTGAAGAAGCAG
CTCAACAATATGGCCTAAACGTAATCTATCAGCCTGTTATCAGTGGTAAAATTACCGACCAACAAGTTACCGAGTTTAAG
CAGCTTTATCAGAATGCTCAGAAGCCCGTTTTAGCATATTGTCGCTCTGGTATGCGTGCAATCAGTTTGTGGGCTTTGGC
TGAAGTTGCTCCACAAGATGCAGCACTGTTAGTTGAGTCGGGTAATAAGCTTGGGTTTAACTTAAAAGGCTTGGTGCCAC
GTATTTTAAAACGTGATCATGAACCAGCCACAATTCCTTGTTATAGCGTTGTGATTGTTGGCGCTGGGGCAGCAGGAATT
TCTGTAGCGTCGAGTCTTTTATGTCGTGAACCTCATTTAGATATTGTCATTATTGATCCCGCAGATACACATTATTATCA
ACCGGGCTGGACCATGGTTGGTGGCGGTATTTTCAAACCACAAGTAACCGCACGCTCAATGGTAAGTGTGATTCCTTTAA
AAGTGAAATGGATGAAAGCTGCGGTTGCCGGATTCGACCCTGAGCATAATCAGGTTATTTTGGAAGGATGCCAACCCATT
CAATATAAAGCTTTGGTCGTGTGTCCCGGTTTAAAACTGAATTGGCATGGAATTGAAGGTTTAGTCGAAACCTTAGGAAA
AAATGGGGTGACGTCTAACTATCGTTATGATCTAGCGCCGTATACATGGGAACTGGTGCAACAGTTAAATAGTGGAACGG
CAATCTTTACCCAGCCGCCTATGCCGATTAAATGTGCCGGTGCTCCTCAAAAAGCGATGTACCTTTCAGCCGACTACTGG
TTAAAGCAAGGCAAACTTAAAGATATCTCTATCCATTTTTATAACACTGGTGCTGTTTTATTTGGTGTGAAGGAATATGT
ACCTGCACTAATGCAATACGTTGAAAAATATGGCACTGAACTTCATTTTAACCATCAACTTGTCAAAGTAGACGGGCCTG
CAAAGAAAGCATGGTTCAAAGTGGTGAATGATGAAAATGCAGCATTGATCGAAACAGATTTCGATATGTTGCATGTTGTT
CCACCGCAACAAGCCCCAGACTTTATTCGTGCAAGTACTCTTACTGATGAAGCCGGCTGGGTGAGTGTGAATCCTCAAAC
CCTACAACACACACAGCACGCCAATATTTTTGCTTTAGGTGATGTGATGAATGCGCCTAATGCCAAAACTGCTGCTGCGG
CACGGGCACAAGCTCCGATCGTTGCGGTTAATGTTATAGCCCAGCTCAAAGGTGAGCAAAACTTCTGTGAATACAATGGC
TATGGCTCATGTCCACTTACGGTAGAACGAGGAAAAATCGTTCTGGCTGAGTTTGGCTACGGCGGCAAATTACTTCCAAG
TTTTCCAAAATGGGTGATTGATGGACAAAAACCATCTCGTTTGGCATGGCTACTTAAAGAGCAAATTTTACCGCCGATTT
ACTGGCAAGGCATGCTCAAGGGCCGCGAGTGGATGGTCAAACCTGAGCGAGGATAA

Upstream 100 bases:

>100_bases
ATTAATGAATAACTTAAATCTGCCATATCCAAAACAAATCGATAAAGCACTTCCTGCTAATCAGGCTTGCGGCTCAATTT
CACAATTATAAGGTGGCAAT

Downstream 100 bases:

>100_bases
GTAAAGCAACGCTTTACCCTGAGAAGCGACTAAAGCTTCGCTAGAAGACGAGAGCTGTGCTCGAGTCGAAGAGGATAAAT
AAAGCATCCTTTGTCCTGAG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MELKRVNQDFYVAGQITANDIVKIADQGIKTLICNRPDGEGADQPNVIEIEEAAQQYGLNVIYQPVISGKITDQQVTEFK
QLYQNAQKPVLAYCRSGMRAISLWALAEVAPQDAALLVESGNKLGFNLKGLVPRILKRDHEPATIPCYSVVIVGAGAAGI
SVASSLLCREPHLDIVIIDPADTHYYQPGWTMVGGGIFKPQVTARSMVSVIPLKVKWMKAAVAGFDPEHNQVILEGCQPI
QYKALVVCPGLKLNWHGIEGLVETLGKNGVTSNYRYDLAPYTWELVQQLNSGTAIFTQPPMPIKCAGAPQKAMYLSADYW
LKQGKLKDISIHFYNTGAVLFGVKEYVPALMQYVEKYGTELHFNHQLVKVDGPAKKAWFKVVNDENAALIETDFDMLHVV
PPQQAPDFIRASTLTDEAGWVSVNPQTLQHTQHANIFALGDVMNAPNAKTAAAARAQAPIVAVNVIAQLKGEQNFCEYNG
YGSCPLTVERGKIVLAEFGYGGKLLPSFPKWVIDGQKPSRLAWLLKEQILPPIYWQGMLKGREWMVKPERG

Sequences:

>Translated_551_residues
MELKRVNQDFYVAGQITANDIVKIADQGIKTLICNRPDGEGADQPNVIEIEEAAQQYGLNVIYQPVISGKITDQQVTEFK
QLYQNAQKPVLAYCRSGMRAISLWALAEVAPQDAALLVESGNKLGFNLKGLVPRILKRDHEPATIPCYSVVIVGAGAAGI
SVASSLLCREPHLDIVIIDPADTHYYQPGWTMVGGGIFKPQVTARSMVSVIPLKVKWMKAAVAGFDPEHNQVILEGCQPI
QYKALVVCPGLKLNWHGIEGLVETLGKNGVTSNYRYDLAPYTWELVQQLNSGTAIFTQPPMPIKCAGAPQKAMYLSADYW
LKQGKLKDISIHFYNTGAVLFGVKEYVPALMQYVEKYGTELHFNHQLVKVDGPAKKAWFKVVNDENAALIETDFDMLHVV
PPQQAPDFIRASTLTDEAGWVSVNPQTLQHTQHANIFALGDVMNAPNAKTAAAARAQAPIVAVNVIAQLKGEQNFCEYNG
YGSCPLTVERGKIVLAEFGYGGKLLPSFPKWVIDGQKPSRLAWLLKEQILPPIYWQGMLKGREWMVKPERG
>Mature_551_residues
MELKRVNQDFYVAGQITANDIVKIADQGIKTLICNRPDGEGADQPNVIEIEEAAQQYGLNVIYQPVISGKITDQQVTEFK
QLYQNAQKPVLAYCRSGMRAISLWALAEVAPQDAALLVESGNKLGFNLKGLVPRILKRDHEPATIPCYSVVIVGAGAAGI
SVASSLLCREPHLDIVIIDPADTHYYQPGWTMVGGGIFKPQVTARSMVSVIPLKVKWMKAAVAGFDPEHNQVILEGCQPI
QYKALVVCPGLKLNWHGIEGLVETLGKNGVTSNYRYDLAPYTWELVQQLNSGTAIFTQPPMPIKCAGAPQKAMYLSADYW
LKQGKLKDISIHFYNTGAVLFGVKEYVPALMQYVEKYGTELHFNHQLVKVDGPAKKAWFKVVNDENAALIETDFDMLHVV
PPQQAPDFIRASTLTDEAGWVSVNPQTLQHTQHANIFALGDVMNAPNAKTAAAARAQAPIVAVNVIAQLKGEQNFCEYNG
YGSCPLTVERGKIVLAEFGYGGKLLPSFPKWVIDGQKPSRLAWLLKEQILPPIYWQGMLKGREWMVKPERG

Specific function: Unknown

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI10864011, Length=394, Percent_Identity=35.5329949238579, Blast_Score=276, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI115534373, Length=342, Percent_Identity=37.4269005847953, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17539680, Length=424, Percent_Identity=30.188679245283, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24657386, Length=384, Percent_Identity=37.5, Blast_Score=265, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24657391, Length=384, Percent_Identity=37.5, Blast_Score=265, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 60767; Mature: 60767

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKRVNQDFYVAGQITANDIVKIADQGIKTLICNRPDGEGADQPNVIEIEEAAQQYGLN
CCCCCCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHCCCE
VIYQPVISGKITDQQVTEFKQLYQNAQKPVLAYCRSGMRAISLWALAEVAPQDAALLVES
EEEEHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEC
GNKLGFNLKGLVPRILKRDHEPATIPCYSVVIVGAGAAGISVASSLLCREPHLDIVIIDP
CCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECC
ADTHYYQPGWTMVGGGIFKPQVTARSMVSVIPLKVKWMKAAVAGFDPEHNQVILEGCQPI
CCCCEECCCCEEECCCCCCCCHHHHHHHHHHCEEEEEHHHHHHCCCCCCCEEEEECCCCC
QYKALVVCPGLKLNWHGIEGLVETLGKNGVTSNYRYDLAPYTWELVQQLNSGTAIFTQPP
EEEEEEEECCCEEECCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCEEEECCC
MPIKCAGAPQKAMYLSADYWLKQGKLKDISIHFYNTGAVLFGVKEYVPALMQYVEKYGTE
CCEEECCCCCCEEEEEHHHHHCCCCEEEEEEEEEECCEEEEEHHHHHHHHHHHHHHHCCE
LHFNHQLVKVDGPAKKAWFKVVNDENAALIETDFDMLHVVPPQQAPDFIRASTLTDEAGW
EEECEEEEEECCCCCCEEEEEECCCCCEEEEECCCEEEECCCCCCCCHHHHHCCCCCCCE
VSVNPQTLQHTQHANIFALGDVMNAPNAKTAAAARAQAPIVAVNVIAQLKGEQNFCEYNG
EEECHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCC
YGSCPLTVERGKIVLAEFGYGGKLLPSFPKWVIDGQKPSRLAWLLKEQILPPIYWQGMLK
CCCCCEEEECCEEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHC
GREWMVKPERG
CCEEEECCCCC
>Mature Secondary Structure
MELKRVNQDFYVAGQITANDIVKIADQGIKTLICNRPDGEGADQPNVIEIEEAAQQYGLN
CCCCCCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHCCCE
VIYQPVISGKITDQQVTEFKQLYQNAQKPVLAYCRSGMRAISLWALAEVAPQDAALLVES
EEEEHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEC
GNKLGFNLKGLVPRILKRDHEPATIPCYSVVIVGAGAAGISVASSLLCREPHLDIVIIDP
CCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECC
ADTHYYQPGWTMVGGGIFKPQVTARSMVSVIPLKVKWMKAAVAGFDPEHNQVILEGCQPI
CCCCEECCCCEEECCCCCCCCHHHHHHHHHHCEEEEEHHHHHHCCCCCCCEEEEECCCCC
QYKALVVCPGLKLNWHGIEGLVETLGKNGVTSNYRYDLAPYTWELVQQLNSGTAIFTQPP
EEEEEEEECCCEEECCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCEEEECCC
MPIKCAGAPQKAMYLSADYWLKQGKLKDISIHFYNTGAVLFGVKEYVPALMQYVEKYGTE
CCEEECCCCCCEEEEEHHHHHCCCCEEEEEEEEEECCEEEEEHHHHHHHHHHHHHHHCCE
LHFNHQLVKVDGPAKKAWFKVVNDENAALIETDFDMLHVVPPQQAPDFIRASTLTDEAGW
EEECEEEEEECCCCCCEEEEEECCCCCEEEEECCCEEEECCCCCCCCHHHHHCCCCCCCE
VSVNPQTLQHTQHANIFALGDVMNAPNAKTAAAARAQAPIVAVNVIAQLKGEQNFCEYNG
EEECHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCC
YGSCPLTVERGKIVLAEFGYGGKLLPSFPKWVIDGQKPSRLAWLLKEQILPPIYWQGMLK
CCCCCEEEECCEEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHC
GREWMVKPERG
CCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]