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The map label for this gene is blh [H]

Identifier: 213157249

GI number: 213157249

Start: 2023876

End: 2024523

Strand: Direct

Name: blh [H]

Synonym: AB57_1936

Alternate gene names: 213157249

Gene position: 2023876-2024523 (Clockwise)

Preceding gene: 213157246

Following gene: 213157250

Centisome position: 49.97

GC content: 38.89

Gene sequence:

>648_bases
ATGCTTGGGTGTGAAGAAACACGAGGGGCTGTTTTAATTGACCCAGTTGCATCAGATATAGAGATTTATGCAAAAGAATT
AGAGCAGCATCAATTTACACTCATCTATACCTTAGATACTCATGTTCATGCAGACCATATTACCGCTGCAGATTTACTTC
GTGAACGTTTTCATTGCAAATCGGTTTTACACCGAAACTCAGAAGTAAGTTGCGGAGATATTTTAATTACTGATGGTTGC
ATGCTTAAAGTTGGCAACCTCAGTATTGAAGCGCGTTACACACCAGGTCATACCAATGCTTGTACGAGTTACCTAGTTGG
AAACATGATTTTCACTGGTGATGCATTATTAATTGACGGCTGCGGTCGAACTGACTTCCAGCAAGGTAATGCAGGCACAC
TTTATGACAGTATTCATAAACAACTTTTTAGCCTGCCTGACAACACTATTGTATATCCGGGACACGATTATAAAGGTCGT
CTGTCTTCAACAATTGGTTATGAACGCTTAAATAATTCACGTCTAGGTCAGAATCGCTCGCGTGAAGATTTTATTGAATT
AATGAATAACTTAAATCTGCCATATCCAAAACAAATCGATAAAGCACTTCCTGCTAATCAGGCTTGCGGCTCAATTTCAC
AATTATAA

Upstream 100 bases:

>100_bases
TGGCACCTTATTTGCAAAATATAGCAAAGAAATAAATTATTAGGGTATAAATCATGTTCTTTAAGCAGTTTTTGAAAAAG
AAAGTTCGACTTATACATAT

Downstream 100 bases:

>100_bases
GGTGGCAATATGGAACTTAAACGAGTTAATCAAGATTTTTATGTTGCTGGCCAGATTACTGCCAACGATATTGTAAAAAT
TGCAGACCAAGGAATAAAAA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MLGCEETRGAVLIDPVASDIEIYAKELEQHQFTLIYTLDTHVHADHITAADLLRERFHCKSVLHRNSEVSCGDILITDGC
MLKVGNLSIEARYTPGHTNACTSYLVGNMIFTGDALLIDGCGRTDFQQGNAGTLYDSIHKQLFSLPDNTIVYPGHDYKGR
LSSTIGYERLNNSRLGQNRSREDFIELMNNLNLPYPKQIDKALPANQACGSISQL

Sequences:

>Translated_215_residues
MLGCEETRGAVLIDPVASDIEIYAKELEQHQFTLIYTLDTHVHADHITAADLLRERFHCKSVLHRNSEVSCGDILITDGC
MLKVGNLSIEARYTPGHTNACTSYLVGNMIFTGDALLIDGCGRTDFQQGNAGTLYDSIHKQLFSLPDNTIVYPGHDYKGR
LSSTIGYERLNNSRLGQNRSREDFIELMNNLNLPYPKQIDKALPANQACGSISQL
>Mature_215_residues
MLGCEETRGAVLIDPVASDIEIYAKELEQHQFTLIYTLDTHVHADHITAADLLRERFHCKSVLHRNSEVSCGDILITDGC
MLKVGNLSIEARYTPGHTNACTSYLVGNMIFTGDALLIDGCGRTDFQQGNAGTLYDSIHKQLFSLPDNTIVYPGHDYKGR
LSSTIGYERLNNSRLGQNRSREDFIELMNNLNLPYPKQIDKALPANQACGSISQL

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=213, Percent_Identity=47.887323943662, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI21703352, Length=156, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI116642887, Length=156, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI94538322, Length=160, Percent_Identity=30.625, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI94538320, Length=160, Percent_Identity=30.625, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1787158, Length=197, Percent_Identity=29.9492385786802, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538952, Length=214, Percent_Identity=46.7289719626168, Blast_Score=195, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17536925, Length=161, Percent_Identity=31.055900621118, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221330176, Length=203, Percent_Identity=44.8275862068966, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24667703, Length=160, Percent_Identity=29.375, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356335, Length=160, Percent_Identity=29.375, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667711, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 23890; Mature: 23890

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGCEETRGAVLIDPVASDIEIYAKELEQHQFTLIYTLDTHVHADHITAADLLRERFHCK
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
SVLHRNSEVSCGDILITDGCMLKVGNLSIEARYTPGHTNACTSYLVGNMIFTGDALLIDG
HHHHCCCCCCCCCEEEECCCEEEECCEEEEEEECCCCCHHHHHHHHCCEEEECCEEEEEC
CGRTDFQQGNAGTLYDSIHKQLFSLPDNTIVYPGHDYKGRLSSTIGYERLNNSRLGQNRS
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
REDFIELMNNLNLPYPKQIDKALPANQACGSISQL
HHHHHHHHHCCCCCCHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure
MLGCEETRGAVLIDPVASDIEIYAKELEQHQFTLIYTLDTHVHADHITAADLLRERFHCK
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
SVLHRNSEVSCGDILITDGCMLKVGNLSIEARYTPGHTNACTSYLVGNMIFTGDALLIDG
HHHHCCCCCCCCCEEEECCCEEEECCEEEEEEECCCCCHHHHHHHHCCEEEECCEEEEEC
CGRTDFQQGNAGTLYDSIHKQLFSLPDNTIVYPGHDYKGRLSSTIGYERLNNSRLGQNRS
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
REDFIELMNNLNLPYPKQIDKALPANQACGSISQL
HHHHHHHHHCCCCCCHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]