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The map label for this gene is bdhA [H]

Identifier: 213157246

GI number: 213157246

Start: 2020278

End: 2021336

Strand: Direct

Name: bdhA [H]

Synonym: AB57_1933

Alternate gene names: 213157246

Gene position: 2020278-2021336 (Clockwise)

Preceding gene: 213157245

Following gene: 213157249

Centisome position: 49.88

GC content: 41.45

Gene sequence:

>1059_bases
ATGAAAGCAGCGCGTTTTTATGACAGAGGTGATATTCGTATTGAAGATATTCCTGAACCAGAAGTCACTCCTGGCACTGT
AGGCATTAAGGTAGCTTGGTGTGGAATCTGTGGTACAGATTTGCACGAATTTATGGAAGGACCAATTTTTATTCCACCTT
GTGGACATCCGCATCCTATTTCAGGTGAATCTGCACCGATTACCATGGGACATGAATTTTCAGGTGTGGTTTATGCCGTA
GGTGAAGGTGTTGATGATATTGAAATTGGTCAGCATGTCGTCGTAGAGCCTTATATTGTGGCGGATGATGTACCGACTGG
ACCGGGCGATAATTATCATCTTTCCAAAAATATGAACTTTATTGGTTTAGGTGGTCGTGGTGGTGGTTTATCGGAAAAAA
TCGCGGTTAAACGCCGTTGGGTGCATCCAATTTCCAATAAAATTCCACTGGATCAGGCAGCCTTAATTGAACCTTTATCG
GTTGGTCATCATGCTTTCGTACGTAGTGGTGCAAAGGCTGGTGATATTGCACTGGTTGGCGGTGCGGGGCCAATTGGTTT
ATTGCTTTCGGCAATTTTAAAAGCGAAAGGTCTTAAGGTCATCATTACCGAACTAAGTGCCAAACGTAAAGAAAAAGCCA
AAGAGTCGGGAGTTGCAGATTATATTTTAGACCCGTCAGAAGTTGATGTTGTTTCTGAGGTCATGAAAATTACTAATGGA
GAGGGTGTCGATGTCGCGTTTGAATGTAGTAGCGTTAACAAGGTATTAGATACTTTGGTTGCGGCAGTGAAACCAACAGG
CGTCATAGTTATCGTTTCGATTTGGAGCCATCCAGCATCAATTAATGTGCATAGTGTGGTAATGAAAGAGCTCGATGTAA
GAGGCACAATTGCCTACGTAAATGACCATCAAGAAACCATTAAACTGGTCGAAGAAGGTAAAATAAATCTGGAACCTTTT
ATTACCCAGCGCATTCAACTTGATGATTTGATTTCACAAGGTTTTGAAACCTTAATTCATAACAATGAATCAGCCGTTAA
GATTATTGTACATCCATAA

Upstream 100 bases:

>100_bases
TGGCAAGTGAAGATTCGAACTATATAACGGGTCAATCCATTTTAACGGACGGCGGAATTGTCTATCGCTAAAACAATATC
CTGATTTGAGGGAGATAATA

Downstream 100 bases:

>100_bases
ACAGACACTTAAGCCTATAAAAAAGAGCGATGATTCGCTCTTTTTTATTAAAGTAAATTGTTGTCTTGGGCTTCAATAAT
GGGTGGTAATGGCTGCCCTA

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAV
GEGVDDIEIGQHVVVEPYIVADDVPTGPGDNYHLSKNMNFIGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLS
VGHHAFVRSGAKAGDIALVGGAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNG
EGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYVNDHQETIKLVEEGKINLEPF
ITQRIQLDDLISQGFETLIHNNESAVKIIVHP

Sequences:

>Translated_352_residues
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAV
GEGVDDIEIGQHVVVEPYIVADDVPTGPGDNYHLSKNMNFIGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLS
VGHHAFVRSGAKAGDIALVGGAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNG
EGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYVNDHQETIKLVEEGKINLEPF
ITQRIQLDDLISQGFETLIHNNESAVKIIVHP
>Mature_352_residues
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAV
GEGVDDIEIGQHVVVEPYIVADDVPTGPGDNYHLSKNMNFIGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLS
VGHHAFVRSGAKAGDIALVGGAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNG
EGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYVNDHQETIKLVEEGKINLEPF
ITQRIQLDDLISQGFETLIHNNESAVKIIVHP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=30.8383233532934, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=25.8160237388724, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=328, Percent_Identity=27.7439024390244, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788407, Length=327, Percent_Identity=29.6636085626911, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=29.3768545994065, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=27.3712737127371, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=27.6729559748428, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790718, Length=309, Percent_Identity=25.2427184466019, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=31.5151515151515, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=27.9661016949153, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=379, Percent_Identity=35.3562005277045, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319257, Length=380, Percent_Identity=33.1578947368421, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323099, Length=350, Percent_Identity=30, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=29.1316526610644, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=357, Percent_Identity=29.1316526610644, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319520, Length=261, Percent_Identity=29.1187739463602, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=28.5302593659942, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=27.3775216138329, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37705; Mature: 37705

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPI
CCCCCEECCCCEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCEEECCCCCCCCC
SGESAPITMGHEFSGVVYAVGEGVDDIEIGQHVVVEPYIVADDVPTGPGDNYHLSKNMNF
CCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEECCEEEECCCCCCCCCCEEEECCCCE
IGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLSVGHHAFVRSGAKAGDIALVG
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEE
GAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNG
CCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCC
EGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYV
CCCEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEE
NDHQETIKLVEEGKINLEPFITQRIQLDDLISQGFETLIHNNESAVKIIVHP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPI
CCCCCEECCCCEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCEEECCCCCCCCC
SGESAPITMGHEFSGVVYAVGEGVDDIEIGQHVVVEPYIVADDVPTGPGDNYHLSKNMNF
CCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEECCEEEECCCCCCCCCCEEEECCCCE
IGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLSVGHHAFVRSGAKAGDIALVG
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEE
GAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNG
CCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCC
EGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYV
CCCEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEE
NDHQETIKLVEEGKINLEPFITQRIQLDDLISQGFETLIHNNESAVKIIVHP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]