Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 213157210

GI number: 213157210

Start: 1986920

End: 1988095

Strand: Direct

Name: lpxB [H]

Synonym: AB57_1894

Alternate gene names: 213157210

Gene position: 1986920-1988095 (Clockwise)

Preceding gene: 213157205

Following gene: 213157212

Centisome position: 49.05

GC content: 37.76

Gene sequence:

>1176_bases
TTGGCAAACCGAAAACTTAAAATAGGCATTGTAGTTGGAGAAGTTTCTGGAGATACGCTCGGCGTAAAACTCATGCGTAG
TTTTCGTGAGCAGGGAATCGATGCTGAATTTGAGGGAATCGGTGGCCCTCAAATGATTGCGGAAGGTTTTAACAGTTATT
ACCCAATGGAAACTCTGTCTGTGATGGGCATTGTTGAGGTATTAAAAGACTTAAAAAAACTATTCGCCGTACGTGATGGC
TTAATTAATCAATGGACTCAGCATCCAGTTGATATTTTTATTGGTATTGATGCACCAGACTTTAACCTCAGACTTTCGAA
AAGTATCAAAGAAAAGAATCTTCCAATAAAAACAGTTCAATATGTGAGTCCATCAGTTTGGGCATGGCGCCAAGGGCGAG
TACATGGCATCAAACAAAGTATAGATTTAGTACTTTGCTTATTTCCTTTTGAAAAAGTTTTTTATGAACAATATGAAGTT
CCAGCGGCATTTGTAGGCCATCCATTAGCTAAACAATTACCGCTTGAGAACCCTATTCAAATTGCTAAACAAGAATTGGG
TGTTGATGAAACTCAAAAACATATTGCTTTGTTGCCTGGTAGCCGCAAAGGTGAAGTAGAAAGACTTCTTCCTATGCTAT
TGGGGGCAGCCAATATTTTGCATACAAAATATCCAGATATTCAATTTTTAATACCGGCAATTAATGATGCACGCAAACAG
CAGATTGAGCAGGGGGTTGAACAATTAGCACCGCAGTTAAAAGCAAAAATTCATATTTTAGAAAATACGGATAGCGAATC
GAAAATTGGTCGTATGGTCATGAACGCGAGTGACATTATTGCTTTAGCGTCTGGAACGGCGACATTAGAAGCAATGCTCA
TGCATAGACCAATGGTCACTTTCTATAAACTGCATTGGCTAACTTATTTAATTGCTAAATTCTTGGTGAAAATACCTTAT
TACTCCTTGCCAAATATCATCGCGGGTAAAAAAGTAATTGAAGAGCTGATTCAGGCAGATGCAACACCTGAAAATTTAGC
GGCTGAAATAGAAAAACTAATGAATGTTGAAACCGCTCAAATTCAAGTAATGCAACATTTAACTATGCATAAACAGCTTA
TTTCTGGAAATACAGAAGATCCGGTTCAAGCCATCCTAAATGTGCTTGAAAAATAA

Upstream 100 bases:

>100_bases
ATGTGCTAGGGCTAGGTTTAGCTGGGATTGATTAGGCAAGTTCAAGATTAATAAGCCTCTATGCTAGAATGCATTATTTC
AAATTCTTGGGTAAATCGCC

Downstream 100 bases:

>100_bases
AAAAAGGCATTCTTATGAATGCCTTTTCTAGTTATGCACGTACAATCAGCTCGTAACCTGTATATTTACGGATATTAATA
ACACCAATATCAAAAATTAA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLSVMGIVEVLKDLKKLFAVRDG
LINQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQYVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEV
PAAFVGHPLAKQLPLENPIQIAKQELGVDETQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQ
QIEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVTFYKLHWLTYLIAKFLVKIPY
YSLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQIQVMQHLTMHKQLISGNTEDPVQAILNVLEK

Sequences:

>Translated_391_residues
MANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLSVMGIVEVLKDLKKLFAVRDG
LINQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQYVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEV
PAAFVGHPLAKQLPLENPIQIAKQELGVDETQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQ
QIEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVTFYKLHWLTYLIAKFLVKIPY
YSLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQIQVMQHLTMHKQLISGNTEDPVQAILNVLEK
>Mature_390_residues
ANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLSVMGIVEVLKDLKKLFAVRDGL
INQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQYVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEVP
AAFVGHPLAKQLPLENPIQIAKQELGVDETQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQQ
IEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVTFYKLHWLTYLIAKFLVKIPYY
SLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQIQVMQHLTMHKQLISGNTEDPVQAILNVLEK

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=386, Percent_Identity=42.7461139896373, Blast_Score=310, Evalue=9e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43861; Mature: 43730

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLS
CCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
VMGIVEVLKDLKKLFAVRDGLINQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHCCCCEEEHH
YVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEVPAAFVGHPLAKQLPLENPIQ
HCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCHHH
IAKQELGVDETQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQ
HHHHHCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
QIEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVT
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCHHHHEEEECCHHHHHHHHHHCCHHH
FYKLHWLTYLIAKFLVKIPYYSLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
IQVMQHLTMHKQLISGNTEDPVQAILNVLEK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLS
CCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
VMGIVEVLKDLKKLFAVRDGLINQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHCCCCEEEHH
YVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEVPAAFVGHPLAKQLPLENPIQ
HCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCHHH
IAKQELGVDETQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQ
HHHHHCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
QIEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVT
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCHHHHEEEECCHHHHHHHHHHCCHHH
FYKLHWLTYLIAKFLVKIPYYSLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
IQVMQHLTMHKQLISGNTEDPVQAILNVLEK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA