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The map label for this gene is cyaA [H]

Identifier: 213157167

GI number: 213157167

Start: 1937987

End: 1939456

Strand: Direct

Name: cyaA [H]

Synonym: AB57_1850

Alternate gene names: 213157167

Gene position: 1937987-1939456 (Clockwise)

Preceding gene: 213157166

Following gene: 213157176

Centisome position: 47.85

GC content: 35.92

Gene sequence:

>1470_bases
GTGCAATTAGAGAGGTTTATAGATCGGGAACCTAAGCAGTTTGCATATTTTCATCGTTTGATGGGATATTCAATTCTGTC
ATTAATTTTAGTGATCTATGCCTTTACCTCACCGAATACTAATTATCAAATCTATATTCCTCCTTTTTTTCTTTTTTTAC
TTTTTGTCAGTTCTAAACTAGAACACTGGTTGCAGTACCAGTTTGATAAGAAAACTCAAAAAAGTGTTTTTTTCGCAATA
GATGCGATTGTAGTGGCTGTTACTCTGGCAGGAGTGCACCTTAATCTCGTTCCAACATTTATTGCGCTTTTTGCATTGTT
TTACTCAGCAATTAATAGTCGTATTTCCTTTGCCGTTATTTGTTTAACGAGTTTGCTTGGTGCGATTATTTTTTATTTGA
GTACATTTTTCCTATTTGGTTTTCATCCATATTTCGAAGCCACAAGCCAAGAATTAACAGTAATTACCTTACTTGGTTTG
GTAATGTTTATCACTATCGGAAATTATTACCAACACCGCTGGGTTAAAAAAATTAGTCAGCAACGTCAGCATTATTATGA
CCAGATGACACGTTATATTGCTTTTGCTAATCAGTTAAGCCGCTATGCTCCATTACAATTATGGCAGTCGATTATGCGTG
GGGAAGCTGAAGCAAAAATCGAATATAAACGTAAAAAAATGACCGTATTCTTTTCTGATATTCAGGGGTTCACCGAACTA
TCAGAAACTTTAATTCCTGATGACTTAGCTTTCTTGCTTAACGATTATTTAAGTCATATGACTGAAATTGCAAAGCAATA
TGAAGCGACGGTCGACAAATTTATGGGAGATGCGATTCTCATATTTTTTGGAGATCCGAATTCACAAGGGGTTGAGCAAG
ATGCCAAATCCTGTGTAGAAATGGCAATTGCTATGCGTCAGCAAATGAAGTTGTTGCGCGAACGATGGAAGAAAATGGGA
TATTCAGCCTTACATATCCGTATGGGTATTAGTACAGGTTATTGCCACGTAGGGAATTATGGTGCAACCCATCGTATGGC
TTATACGATTGTAGGTCGCGATGTAAATTTAGCGGCACGTTTACAGTATGCTGCTGAAATTGATGAAATACTCATTTCTG
ATGATACTTATCAATTGATCAAAAGTGATTTTCTATGTGCGCCTAAGACCCCAATTTATTTAAAGGGTATTCAAGGGGCA
GTAAAAACATGGCAAGTCATGGAAAAATACACAGGAAATAAATCAGACCATCAACAATGGTTTGATTATGAATATAAAGG
TTTCCATTTAGTTTTAAATTTAGAAGAAGTACAAAACTACGAATACCCTGAGTTGGTTGAGGTGCTTGAAAAAATGATTC
AGCGCATTAAAGTTCAACAAACTTTGGTTAATACTCAAGGTGTTGCTCAGCTTAGACTTGAGGATGAAGTTAAGCCTATA
AATATCGATGAAGAACAAGATCAGGTATAA

Upstream 100 bases:

>100_bases
GCTCTACGTGGCCAAGGTGATATGCCTTTTGATTGGCGCATGGATTAAATCAATGTAATGCCACATATCAATGTGGCAAC
ATTGAAATGTGGAGGATAGG

Downstream 100 bases:

>100_bases
ATTTATATAAATAAAAAAAAGCTGCCTAAGCAGCTTTTTTTTTAATTTATTAGTGATTTTCCGAAGCATGGTTAATTGTG
TATTTCGGAATCTCAATTTC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MQLERFIDREPKQFAYFHRLMGYSILSLILVIYAFTSPNTNYQIYIPPFFLFLLFVSSKLEHWLQYQFDKKTQKSVFFAI
DAIVVAVTLAGVHLNLVPTFIALFALFYSAINSRISFAVICLTSLLGAIIFYLSTFFLFGFHPYFEATSQELTVITLLGL
VMFITIGNYYQHRWVKKISQQRQHYYDQMTRYIAFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKMTVFFSDIQGFTEL
SETLIPDDLAFLLNDYLSHMTEIAKQYEATVDKFMGDAILIFFGDPNSQGVEQDAKSCVEMAIAMRQQMKLLRERWKKMG
YSALHIRMGISTGYCHVGNYGATHRMAYTIVGRDVNLAARLQYAAEIDEILISDDTYQLIKSDFLCAPKTPIYLKGIQGA
VKTWQVMEKYTGNKSDHQQWFDYEYKGFHLVLNLEEVQNYEYPELVEVLEKMIQRIKVQQTLVNTQGVAQLRLEDEVKPI
NIDEEQDQV

Sequences:

>Translated_489_residues
MQLERFIDREPKQFAYFHRLMGYSILSLILVIYAFTSPNTNYQIYIPPFFLFLLFVSSKLEHWLQYQFDKKTQKSVFFAI
DAIVVAVTLAGVHLNLVPTFIALFALFYSAINSRISFAVICLTSLLGAIIFYLSTFFLFGFHPYFEATSQELTVITLLGL
VMFITIGNYYQHRWVKKISQQRQHYYDQMTRYIAFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKMTVFFSDIQGFTEL
SETLIPDDLAFLLNDYLSHMTEIAKQYEATVDKFMGDAILIFFGDPNSQGVEQDAKSCVEMAIAMRQQMKLLRERWKKMG
YSALHIRMGISTGYCHVGNYGATHRMAYTIVGRDVNLAARLQYAAEIDEILISDDTYQLIKSDFLCAPKTPIYLKGIQGA
VKTWQVMEKYTGNKSDHQQWFDYEYKGFHLVLNLEEVQNYEYPELVEVLEKMIQRIKVQQTLVNTQGVAQLRLEDEVKPI
NIDEEQDQV
>Mature_489_residues
MQLERFIDREPKQFAYFHRLMGYSILSLILVIYAFTSPNTNYQIYIPPFFLFLLFVSSKLEHWLQYQFDKKTQKSVFFAI
DAIVVAVTLAGVHLNLVPTFIALFALFYSAINSRISFAVICLTSLLGAIIFYLSTFFLFGFHPYFEATSQELTVITLLGL
VMFITIGNYYQHRWVKKISQQRQHYYDQMTRYIAFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKMTVFFSDIQGFTEL
SETLIPDDLAFLLNDYLSHMTEIAKQYEATVDKFMGDAILIFFGDPNSQGVEQDAKSCVEMAIAMRQQMKLLRERWKKMG
YSALHIRMGISTGYCHVGNYGATHRMAYTIVGRDVNLAARLQYAAEIDEILISDDTYQLIKSDFLCAPKTPIYLKGIQGA
VKTWQVMEKYTGNKSDHQQWFDYEYKGFHLVLNLEEVQNYEYPELVEVLEKMIQRIKVQQTLVNTQGVAQLRLEDEVKPI
NIDEEQDQV

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI148536830, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4580422, Length=245, Percent_Identity=24.4897959183673, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI167830411, Length=241, Percent_Identity=25.3112033195021, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI193208534, Length=196, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=218, Percent_Identity=26.1467889908257, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=209, Percent_Identity=25.8373205741627, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076872, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574512, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585694, Length=189, Percent_Identity=24.8677248677249, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221330468, Length=226, Percent_Identity=27.4336283185841, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 56958; Mature: 56958

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCC
>Mature Secondary Structure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CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]