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The map label for this gene is lpxK [H]

Identifier: 213157117

GI number: 213157117

Start: 1888111

End: 1889121

Strand: Direct

Name: lpxK [H]

Synonym: AB57_1800

Alternate gene names: 213157117

Gene position: 1888111-1889121 (Clockwise)

Preceding gene: 213157116

Following gene: 213157118

Centisome position: 46.61

GC content: 38.58

Gene sequence:

>1011_bases
ATGTCATTAGCCCGGCTGATCCAAAATGCATGGAATAAGCAATCAAGTTGGTTGATAGTTTTACGTCCTTTGTCTTGCTT
GTATCGTGCTGGGTTTTTACTAAATCGTGGTTTTCATAGTTCAGGCTTTAAAAAAGTTTATACCGCACCTGTGCCGGTCA
TGGTAATTGGCAATATTACGGTGGGGGGAAGTGGAAAAACTCCATTATTAATAGAGCTGGTCAATTATCTAAAGCAGCAT
AATGTAAAGGTAGGGGTAATTAGTAGAGGCTATGGTGGAGCTGGCCCTTTTCCTATGTTGGTAACATCGGCCAGTCAAGC
AGCTGAAGCAGGAGATGAACCTGCTTTGATTGTACAGTCAACTGGCGTACCTATGGCAGTAGGACCCAATAGACAAGTAG
CAATCGAGTTATTATTAGCATCGACTAAACTAGATTTAATTATTAGTGATGATGGGTTGCAACATTGGGCATTAGGTCGC
CAAATAGAATGGATCGTACTTGATCAAAATCGTGGCCTTGGAAATAGAAAGTTATTACCAGAGGGATATTTACGTGAACC
TGTGGAACGTTTAAAAACTAGTACGGTAATTGAGCATACTTTCACACCAACAACTACATTGCATATGCATCTTGATGCAG
GGCAGCCTTACTTATTGAATCCTTCTTCGGCAACTGAATTATCATTCAATATTCAAAATAATTACCATGCAGTAGTCGGT
ATTGGTTTTCCTCAGCGCTTTTACCAAACACTTAAAGGTTTAGGGGTGAAACAATTTCAAGAGCATGCTTTTCGTGATCA
TCATGATTACAGTATTGATGACCTTCTATTTAATGATGACCAACCTATCATTACAACTGAAAAAGATGCAGTTAAGTTGT
TACCATTACTTGAAAAGCATCCAGAATTTAAACGACCTATTTGGGTTGTGCCAGTTAAAGCTGTTTTGTCTACAGAGTGC
TATCAGGTTTTAAATCAACAATTGCAAAAGCTTGATATTCAAATATCTTAG

Upstream 100 bases:

>100_bases
ATCGCGGACAAATTGTTGAACAAGGTACCCATCAAGAATTACTTGCTAAGCACGGTGCTTATTATCAATTACATCAGCGT
AATTTTGAGGACCATTAAGT

Downstream 100 bases:

>100_bases
GAAGAAAAAATGAAACATATCGTCATTCCAGCACGCTTCTCAAGTTCGCGTTTGCCAGGTAAGCCATTGTTACTTATTCA
TGATCGTCCTATGATTTTAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSLARLIQNAWNKQSSWLIVLRPLSCLYRAGFLLNRGFHSSGFKKVYTAPVPVMVIGNITVGGSGKTPLLIELVNYLKQH
NVKVGVISRGYGGAGPFPMLVTSASQAAEAGDEPALIVQSTGVPMAVGPNRQVAIELLLASTKLDLIISDDGLQHWALGR
QIEWIVLDQNRGLGNRKLLPEGYLREPVERLKTSTVIEHTFTPTTTLHMHLDAGQPYLLNPSSATELSFNIQNNYHAVVG
IGFPQRFYQTLKGLGVKQFQEHAFRDHHDYSIDDLLFNDDQPIITTEKDAVKLLPLLEKHPEFKRPIWVVPVKAVLSTEC
YQVLNQQLQKLDIQIS

Sequences:

>Translated_336_residues
MSLARLIQNAWNKQSSWLIVLRPLSCLYRAGFLLNRGFHSSGFKKVYTAPVPVMVIGNITVGGSGKTPLLIELVNYLKQH
NVKVGVISRGYGGAGPFPMLVTSASQAAEAGDEPALIVQSTGVPMAVGPNRQVAIELLLASTKLDLIISDDGLQHWALGR
QIEWIVLDQNRGLGNRKLLPEGYLREPVERLKTSTVIEHTFTPTTTLHMHLDAGQPYLLNPSSATELSFNIQNNYHAVVG
IGFPQRFYQTLKGLGVKQFQEHAFRDHHDYSIDDLLFNDDQPIITTEKDAVKLLPLLEKHPEFKRPIWVVPVKAVLSTEC
YQVLNQQLQKLDIQIS
>Mature_335_residues
SLARLIQNAWNKQSSWLIVLRPLSCLYRAGFLLNRGFHSSGFKKVYTAPVPVMVIGNITVGGSGKTPLLIELVNYLKQHN
VKVGVISRGYGGAGPFPMLVTSASQAAEAGDEPALIVQSTGVPMAVGPNRQVAIELLLASTKLDLIISDDGLQHWALGRQ
IEWIVLDQNRGLGNRKLLPEGYLREPVERLKTSTVIEHTFTPTTTLHMHLDAGQPYLLNPSSATELSFNIQNNYHAVVGI
GFPQRFYQTLKGLGVKQFQEHAFRDHHDYSIDDLLFNDDQPIITTEKDAVKLLPLLEKHPEFKRPIWVVPVKAVLSTECY
QVLNQQLQKLDIQIS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=320, Percent_Identity=37.8125, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37418; Mature: 37287

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLARLIQNAWNKQSSWLIVLRPLSCLYRAGFLLNRGFHSSGFKKVYTAPVPVMVIGNIT
CCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEEE
VGGSGKTPLLIELVNYLKQHNVKVGVISRGYGGAGPFPMLVTSASQAAEAGDEPALIVQS
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHEEECCHHHHHCCCCCEEEEEE
TGVPMAVGPNRQVAIELLLASTKLDLIISDDGLQHWALGRQIEWIVLDQNRGLGNRKLLP
CCCCEEECCCCCEEEEEEEECCEEEEEECCCCCCHHHCCCEEEEEEEECCCCCCCCCCCC
EGYLREPVERLKTSTVIEHTFTPTTTLHMHLDAGQPYLLNPSSATELSFNIQNNYHAVVG
CHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEECCCCCCEEEEEECCCEEEEEE
IGFPQRFYQTLKGLGVKQFQEHAFRDHHDYSIDDLLFNDDQPIITTEKDAVKLLPLLEKH
ECCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHEEECCCCCEEECCCHHHHHHHHHHCC
PEFKRPIWVVPVKAVLSTECYQVLNQQLQKLDIQIS
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEC
>Mature Secondary Structure 
SLARLIQNAWNKQSSWLIVLRPLSCLYRAGFLLNRGFHSSGFKKVYTAPVPVMVIGNIT
CHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEEE
VGGSGKTPLLIELVNYLKQHNVKVGVISRGYGGAGPFPMLVTSASQAAEAGDEPALIVQS
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHEEECCHHHHHCCCCCEEEEEE
TGVPMAVGPNRQVAIELLLASTKLDLIISDDGLQHWALGRQIEWIVLDQNRGLGNRKLLP
CCCCEEECCCCCEEEEEEEECCEEEEEECCCCCCHHHCCCEEEEEEEECCCCCCCCCCCC
EGYLREPVERLKTSTVIEHTFTPTTTLHMHLDAGQPYLLNPSSATELSFNIQNNYHAVVG
CHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEECCCCCCEEEEEECCCEEEEEE
IGFPQRFYQTLKGLGVKQFQEHAFRDHHDYSIDDLLFNDDQPIITTEKDAVKLLPLLEKH
ECCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHEEECCCCCEEECCCHHHHHHHHHHCC
PEFKRPIWVVPVKAVLSTECYQVLNQQLQKLDIQIS
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA