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The map label for this gene is fba [H]

Identifier: 213157106

GI number: 213157106

Start: 1876120

End: 1877157

Strand: Direct

Name: fba [H]

Synonym: AB57_1789

Alternate gene names: 213157106

Gene position: 1876120-1877157 (Clockwise)

Preceding gene: 213157105

Following gene: 213157109

Centisome position: 46.32

GC content: 42.0

Gene sequence:

>1038_bases
ATGGCACTCATTTCAATGCGCCAGCTCTTGGATCACGCTGCGGAACATAACTACGGCGTACCAGCATTTAACGTAAATAA
CTTAGAACAAATGCGTGCAATTATGCTTGCCGCAGATGCTACCAATTCACCTGTAATTGTTCAGGCATCTGCTGGAGCTC
GCAAATATGCAGGCGCTCCATTCTTACGCCATCTTATTTTGGCTGCAATTGAAGAATGGCCACACATTCCAGTGGTAATG
CACCAAGACCATGGTACAAGCCCTGATGTATGCCAACGTTCTATTCAACTTGGTTTTAGCTCAGTGATGATGGACGGTTC
ATTAGGCGCTGATGGTAAAACTCCTACAACTTACGATTACAACGTAGATGTAACTCGTCAAGTGGTAGCAATGGCTCATG
CTTGTGGTGTATCTGTTGAAGGTGAGATCGGTTGCTTAGGTAGCCTTGAAACAGGTATGGCTGGAGAAGAAGACGGTGTG
GGTGCAGAAGGTGTACTTGACCATTCTCAGCTTTTAACCTCTGTTGAAGAAGCAAAACAATTCGTTGCTGATACAAATGT
TGATGCTTTAGCAATTGCTGTAGGTACTTCACACGGTGCTTATAAATTTACACGTCCACCTACAGGGGATATTTTAGCAA
TTGACCGTATTAAAGAAATTCATGCGGCATTGCCAAATACTCACCTTGTAATGCACGGTTCAAGCTCTGTACCACAAGAA
TGGTTAAAAGTAATTAACGAGTTTGGTGGTAATATTGGTGAGACTTATGGTGTACCAGTTGAACAGCTTGTAGAAGCGAT
TAAACATGGTGTACGTAAAATCAATATCGATACTGACTTGCGTTTAGCTTCAACAGGTGCAATTCGTCGTTTCATGGCGG
AAAACCCAGCTGAATTTGACCCACGTAAGTATTTCGCTAAAACTGTCGATTCAATGAAACAAATTTGTATCGATCGTTAT
GAAGCTTTCGGTACAGCTGGTAATGCTGACAAGATTCGTCCAATTTCTTTAGAGAAAATGGTTGATCGTTATAAATAA

Upstream 100 bases:

>100_bases
TTCCCTGCAAATGCAGGGATTTTTTTTGAAATACTGTGATTTGTTGCTGAATTGAAATAAATGACAAGGTAGAATAAGCC
GCACTACCTGGGAGGATATT

Downstream 100 bases:

>100_bases
TTCCCGTTAGGGTTTGATTTATAGAAACCGGTTATTCATATAACCGGTTTTTTAATGGCTGGGTTTTGTTTATAAAAAAA
CCTGTGATCAACACAGGTTT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAPFLRHLILAAIEEWPHIPVVM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDYNVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGV
GAEGVLDHSQLLTSVEEAKQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQE
WLKVINEFGGNIGETYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFDPRKYFAKTVDSMKQICIDRY
EAFGTAGNADKIRPISLEKMVDRYK

Sequences:

>Translated_345_residues
MALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAPFLRHLILAAIEEWPHIPVVM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDYNVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGV
GAEGVLDHSQLLTSVEEAKQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQE
WLKVINEFGGNIGETYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFDPRKYFAKTVDSMKQICIDRY
EAFGTAGNADKIRPISLEKMVDRYK
>Mature_344_residues
ALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAPFLRHLILAAIEEWPHIPVVMH
QDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDYNVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGVG
AEGVLDHSQLLTSVEEAKQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQEW
LKVINEFGGNIGETYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFDPRKYFAKTVDSMKQICIDRYE
AFGTAGNADKIRPISLEKMVDRYK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=326, Percent_Identity=32.8220858895706, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=30.0911854103343, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788072, Length=332, Percent_Identity=25.6024096385542, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789293, Length=323, Percent_Identity=23.2198142414861, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37355; Mature: 37224

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAP
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHCCCH
FLRHLILAAIEEWPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEC
NVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGVGAEGVLDHSQLLTSVEEAKQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQE
HHHCCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLKVINEFGGNIGETYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKYFAKTVDSMKQICIDRYEAFGTAGNADKIRPISLEKMVDRYK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAP
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHCCCH
FLRHLILAAIEEWPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEC
NVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGVGAEGVLDHSQLLTSVEEAKQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQE
HHHCCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLKVINEFGGNIGETYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKYFAKTVDSMKQICIDRYEAFGTAGNADKIRPISLEKMVDRYK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]