Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 213157081

GI number: 213157081

Start: 1849189

End: 1851177

Strand: Direct

Name: tkt [H]

Synonym: AB57_1762

Alternate gene names: 213157081

Gene position: 1849189-1851177 (Clockwise)

Preceding gene: 213157079

Following gene: 213157083

Centisome position: 45.65

GC content: 41.73

Gene sequence:

>1989_bases
ATGACGACCCCTTTAAACGAACGTCGTATTGCAAACGCAATTCGTGTATTGGCAATGGATGCTGTGCAACAGGCAAACTC
AGGGCATCCGGGTGCTCCAATGGGGATGGCAGATATTGCTGATGTCGTCTGGCGCGAGTTTTTAAATCACAACCCAAATA
ATCCACAATGGGCAAACCGTGACCGTTTTGTTTTATCAAATGGCCATGGTTCAATGTTGCAATATGCTTTGCTTCATTTA
ACAGGTTATGATCTTTCAATTGAAGATTTAAAACAATTCCGTCAATTGCACTCAAAAACTCCTGGTCACCCTGAATATGG
TTATGCTCCAGGAATTGAAACAACGACAGGTCCTTTGGGTCAAGGTATTGCGAACGCCGTTGGTTTTGCATTAGCAGAAA
AAACTTTAGCTGCTCAGTTCAATAAAGATGACTTAAAAGTAGTTGATCACTTTACCTATTGTTTCTTAGGTGATGGCTGT
TTAATGGAAGGTATTTCTCATGAAGTATGTTCTTTAGCAGGTACTTTACAGCTTGGTAAATTGATTGCTTATTATGATGA
CAACGGCATTTCGATTGATGGTGAAGTAGAAGGCTGGTTCAGTGATGACACTGAAGAGCGTTTCAAGTCTTATGGTTGGC
AAGTTCTTCGTGTAGATGGCCACGATGCTGATGCGATTCGTCAAGCAACAGTTGAAGCTAAAGCAGAAACTCAAAAACCA
ACGATTATTATTTGTAAAACAATTATTGGCTTAGGTTCTCCAAACAAGCAAGGTAAAGAAGACTGTCACGGTGCACCGCT
GGGTAAAGATGAAATTACCTTAACTCGTGAAGCTTTAGGCTGGACTGAAGAAGCGTTTGTTATTCCTGCTGATGTATATG
CTGCATGGGATGCTAAAGCAAAAGGTAATGAAGCTGAAGCAGCTTGGAATGAAGTATTTGCTCAATACCAAGCAAAATAT
CCAACGGAAGCGGCTGAGTTACTTCGTCGTATTAGCGGTGACTTACCAGCAGAATTTTCAGCTCAAGCAGATGCATTTAT
TCGTGAAACAAATGCTAAAGCTGAGACTGTAGCAACTCGTAAAGCGAGCCAAAACACATTACAAGCATTTGGTCCTTTAT
TACCTGAATTATTAGGTGGTTCTGCGGACTTGGCAGGTTCTAACTTAACACTTTGGAAAGGTTGCCAAGGCGTTCAAGAA
AACCCGGCTGGTAACTACGTATATTATGGTGTACGTGAGTTCGGTATGACTGCAATCGCTAACGGTGTTGCATTGCATGG
CGGCTTCATTCCTTACGTTGCAACGTTCTTAATGTTTATGGAATATGCACGTAATGCGGTACGTATGTCTGCATTAATGA
AACAGCGCGTGATTCATGTGTATACACATGACTCAATCGGTTTAGGTGAAGATGGTCCAACACACCAACCAATTGAACAA
ATTGCTTCTTTACGTGGCACACCAAACTTAAATACTTGGCGTCCTGCTGATACTGTAGAAACAGCAATTGCGTGGAAATC
TGCTTTAGAGCGTAAAGATGGCCCTACAGCACTTATTTTCTCTCGACAAAACTTACCATTCCAAACGCGTACTGAAGAGC
AAATCCAAAATGCGGCAAAAGGTGGTTATGTTCTTGCTCAAGAGAAAGGTGAGTTGAAAGCAATTATTATTGCTACTGGT
TCAGAAGTTTCTTTAGCAATGGAAGCTTATGCTCAACTTGAAGGTGTTCGTGTTGTTTCTATGCCATGTGCAGAAGAGTT
CATGAAACAAGATGCTGCATATCGTGAAGCAGTATTACCAGCTCACATTCGTGCACGTGTTGCTGTAGAAGCAGCTCACG
TTGACTACTGGTGGAAGTTTGTTGGTCTTGATGGCAAAGTAATTGGTATGACAACTTATGGTGAGTCAGCACCAGCAAAA
GACTTGTTCCAATTCTTCGGTATTACAACTGAGGCTGTAGTTGCTGCGGTGAAAGAGTTAACTGCTTAA

Upstream 100 bases:

>100_bases
TGGGGTTTACCCATAGGCATTTTTTTAAGACAATATAGCGGCATTGAATGGTTATTCATCTTCTTCTTTTCATCAATCTA
TTAAAATTGGATTCTGATCT

Downstream 100 bases:

>100_bases
TCTTTTGAGCAGAATAAAAAGCGTCCCGATTGGGGCGCTTTTTTATGGGCTATTTAAATGTTAAGTTCAGTTTGGATCGT
AATATTAGAAGTTAAAAGCT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPNNPQWANRDRFVLSNGHGSMLQYALLHL
TGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLGQGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGC
LMEGISHEVCSLAGTLQLGKLIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRVDGHDADAIRQATVEAKAETQKP
TIIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDAKAKGNEAEAAWNEVFAQYQAKY
PTEAAELLRRISGDLPAEFSAQADAFIRETNAKAETVATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQE
NPAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAAKGGYVLAQEKGELKAIIIATG
SEVSLAMEAYAQLEGVRVVSMPCAEEFMKQDAAYREAVLPAHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAK
DLFQFFGITTEAVVAAVKELTA

Sequences:

>Translated_662_residues
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPNNPQWANRDRFVLSNGHGSMLQYALLHL
TGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLGQGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGC
LMEGISHEVCSLAGTLQLGKLIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRVDGHDADAIRQATVEAKAETQKP
TIIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDAKAKGNEAEAAWNEVFAQYQAKY
PTEAAELLRRISGDLPAEFSAQADAFIRETNAKAETVATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQE
NPAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAAKGGYVLAQEKGELKAIIIATG
SEVSLAMEAYAQLEGVRVVSMPCAEEFMKQDAAYREAVLPAHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAK
DLFQFFGITTEAVVAAVKELTA
>Mature_661_residues
TTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPNNPQWANRDRFVLSNGHGSMLQYALLHLT
GYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLGQGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGCL
MEGISHEVCSLAGTLQLGKLIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRVDGHDADAIRQATVEAKAETQKPT
IIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDAKAKGNEAEAAWNEVFAQYQAKYP
TEAAELLRRISGDLPAEFSAQADAFIRETNAKAETVATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQEN
PAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQI
ASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAAKGGYVLAQEKGELKAIIIATGS
EVSLAMEAYAQLEGVRVVSMPCAEEFMKQDAAYREAVLPAHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKD
LFQFFGITTEAVVAAVKELTA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=524, Percent_Identity=28.2442748091603, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI4507521, Length=524, Percent_Identity=28.2442748091603, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI133778974, Length=676, Percent_Identity=25, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI225637459, Length=498, Percent_Identity=22.289156626506, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI225637461, Length=421, Percent_Identity=22.8028503562945, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI225637463, Length=421, Percent_Identity=22.8028503562945, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=68.3333333333333, Blast_Score=962, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=63.6913767019667, Blast_Score=911, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=676, Percent_Identity=25, Blast_Score=158, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=663, Percent_Identity=48.4162895927602, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=43.5435435435435, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45551847, Length=676, Percent_Identity=25, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45550715, Length=676, Percent_Identity=25, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24666278, Length=574, Percent_Identity=25.4355400696864, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24645119, Length=642, Percent_Identity=24.7663551401869, Blast_Score=140, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72259; Mature: 72128

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPNNPQWANR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
DRFVLSNGHGSMLQYALLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGCLMEGISHEVCSLAGTLQLGK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCHHHHHHCHHHHHHHHHHHHHCC
LIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRVDGHDADAIRQATVEAKAETQKP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
TIIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDAKA
EEEEEEHHHCCCCCCCCCCHHCCCCCCCCCCEEEEHHHCCCCCCCEEEECHHHEECCCCC
KGNEAEAAWNEVFAQYQAKYPTEAAELLRRISGDLPAEFSAQADAFIRETNAKAETVATR
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
KASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQENPAGNYVYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEHHHHCHHHHH
NGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHH
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAAK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHC
GGYVLAQEKGELKAIIIATGSEVSLAMEAYAQLEGVRVVSMPCAEEFMKQDAAYREAVLP
CCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCC
AHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKDLFQFFGITTEAVVAAVKEL
HHHHHEEEEEEHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHH
TA
CC
>Mature Secondary Structure 
TTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPNNPQWANR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
DRFVLSNGHGSMLQYALLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGCLMEGISHEVCSLAGTLQLGK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCHHHHHHCHHHHHHHHHHHHHCC
LIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRVDGHDADAIRQATVEAKAETQKP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
TIIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDAKA
EEEEEEHHHCCCCCCCCCCHHCCCCCCCCCCEEEEHHHCCCCCCCEEEECHHHEECCCCC
KGNEAEAAWNEVFAQYQAKYPTEAAELLRRISGDLPAEFSAQADAFIRETNAKAETVATR
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
KASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQENPAGNYVYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEHHHHCHHHHH
NGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHH
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAAK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHC
GGYVLAQEKGELKAIIIATGSEVSLAMEAYAQLEGVRVVSMPCAEEFMKQDAAYREAVLP
CCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCC
AHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKDLFQFFGITTEAVVAAVKEL
HHHHHEEEEEEHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHH
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]