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The map label for this gene is ribBA [H]

Identifier: 212223756

GI number: 212223756

Start: 560452

End: 561618

Strand: Reverse

Name: ribBA [H]

Synonym: TON_0608

Alternate gene names: 212223756

Gene position: 561618-560452 (Counterclockwise)

Preceding gene: 212223757

Following gene: 212223755

Centisome position: 30.4

GC content: 49.87

Gene sequence:

>1167_bases
ATGAAACCGGACTGGGAAAGCATCAGGAGGGCAATCATTGATGGAAAACCCGCTGTCCTTGTAGACAATAGGAGGGAGTT
TGAAGCTGATTTAGTTTATCCAGCAGAATTAGCTAATTCAGAGGTTGTGAACTTCATGCTTTCTATGAAAGGTCTTCTCT
GTCTGACGATAGATCTGGAACAGGCCTTAAAAAGGGGCTTCTTTCCACTACCGAGCAAGGGAGGAGAGACGAACTTCCTG
ATTCCAGTTGACTACGAGGAGACGTTCACTGGTATAACAGCCGAGGAGAGGGCTTTAACGGCTAGAAAGATAGCGGAGGG
ACTGGAAGTCGAGCACTTCCGCTATCCCGGCCACCTGCATCTCTTAGGGGGAGTAGGTCTTAACTGGAGAAGAGGCCACA
CGGAGAGCTCATTGGAGCTGATGGAGATACTCGGCTTCAAACGCTATGCCCTAATAGTGGAGATTCTCAACGGAGAAGGA
GACAGTCACGACCATGATTACGTACTGAAGTTCGCTAAGGAGCATGATCTTCCTGTCCTCACGACGGACGACGTCTGGAG
GGAGTTTGTCAGGAGAAAGCAACTGGTGAGTGTTTATGCCAACGCGAGACTGCCGACGCGCTATGGGGAGTTCAGAATAA
TAAGCTTTGAAAACGAGCTAGATTTCAAGGAACACGTGGCAATAGTTAAGGAACCCTATAGTGAAGTGCCACTCGTGAGG
ATACATTCCAAGTGTCTAACCGGCGACACATTGGCGTCGCTCAAATGTGACTGTGGGAGCCAGCTGAGCAACGTCCTGCG
GATGATAGCCCAAGAAGGGGGAATTCTGCTTTACATGGATCAAGAGGGGCGTGGTATAGGGTTAAAGGAGAAAATAAAGG
CCTATGAGCTTCAGGATAAGGGACTCGATACAGTCCAAGCCAACGAAGCTTTGGGGCATAAGGGGGACGAGAGGACTTAC
GAGGCGGCCTTCCAGATGCTTAGAGCATTAGGCGTCTCGAAGGTGAGACTCATAACCAACAACCCTACTAAAGCAAGAGC
GCTGGAGGAGCTCGGAATTGAGGTAGTTGAAATGATTCCCGCCCCGGGTGAGGTTACCGAGCACAACAGACCCTACCTAA
GGATCAAAGCCGAGAAGCTTGGCCACAAGCTTCCTTTTGAAGTTTGA

Upstream 100 bases:

>100_bases
TGAAGAAAACCAATCTCGGCTCGCTGAGGCCAGGTGATGAAGTCAACTATGAGATAGATGTTCTAGCTAGATACGTGAGG
AGAATCCAGGAGGTGAAAGG

Downstream 100 bases:

>100_bases
TTAATTCAGGATCATGTAATCACGTCATTATGCAATTACCGAAGTAACAAACGGAGGTGATGGTATTGGAGGTTAGGGTG
TTTGAGGGCGAATTTAAGGG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKPDWESIRRAIIDGKPAVLVDNRREFEADLVYPAELANSEVVNFMLSMKGLLCLTIDLEQALKRGFFPLPSKGGETNFL
IPVDYEETFTGITAEERALTARKIAEGLEVEHFRYPGHLHLLGGVGLNWRRGHTESSLELMEILGFKRYALIVEILNGEG
DSHDHDYVLKFAKEHDLPVLTTDDVWREFVRRKQLVSVYANARLPTRYGEFRIISFENELDFKEHVAIVKEPYSEVPLVR
IHSKCLTGDTLASLKCDCGSQLSNVLRMIAQEGGILLYMDQEGRGIGLKEKIKAYELQDKGLDTVQANEALGHKGDERTY
EAAFQMLRALGVSKVRLITNNPTKARALEELGIEVVEMIPAPGEVTEHNRPYLRIKAEKLGHKLPFEV

Sequences:

>Translated_388_residues
MKPDWESIRRAIIDGKPAVLVDNRREFEADLVYPAELANSEVVNFMLSMKGLLCLTIDLEQALKRGFFPLPSKGGETNFL
IPVDYEETFTGITAEERALTARKIAEGLEVEHFRYPGHLHLLGGVGLNWRRGHTESSLELMEILGFKRYALIVEILNGEG
DSHDHDYVLKFAKEHDLPVLTTDDVWREFVRRKQLVSVYANARLPTRYGEFRIISFENELDFKEHVAIVKEPYSEVPLVR
IHSKCLTGDTLASLKCDCGSQLSNVLRMIAQEGGILLYMDQEGRGIGLKEKIKAYELQDKGLDTVQANEALGHKGDERTY
EAAFQMLRALGVSKVRLITNNPTKARALEELGIEVVEMIPAPGEVTEHNRPYLRIKAEKLGHKLPFEV
>Mature_388_residues
MKPDWESIRRAIIDGKPAVLVDNRREFEADLVYPAELANSEVVNFMLSMKGLLCLTIDLEQALKRGFFPLPSKGGETNFL
IPVDYEETFTGITAEERALTARKIAEGLEVEHFRYPGHLHLLGGVGLNWRRGHTESSLELMEILGFKRYALIVEILNGEG
DSHDHDYVLKFAKEHDLPVLTTDDVWREFVRRKQLVSVYANARLPTRYGEFRIISFENELDFKEHVAIVKEPYSEVPLVR
IHSKCLTGDTLASLKCDCGSQLSNVLRMIAQEGGILLYMDQEGRGIGLKEKIKAYELQDKGLDTVQANEALGHKGDERTY
EAAFQMLRALGVSKVRLITNNPTKARALEELGIEVVEMIPAPGEVTEHNRPYLRIKAEKLGHKLPFEV

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=188, Percent_Identity=51.5957446808511, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789420, Length=188, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=42.0118343195266, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320695, Length=185, Percent_Identity=28.6486486486486, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43913; Mature: 43913

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDWESIRRAIIDGKPAVLVDNRREFEADLVYPAELANSEVVNFMLSMKGLLCLTIDLE
CCCCHHHHHHHHHCCCCEEEECCCCCCCCCEECHHHHCCHHHHHHHHHHCCEEEEEEEHH
QALKRGFFPLPSKGGETNFLIPVDYEETFTGITAEERALTARKIAEGLEVEHFRYPGHLH
HHHHCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCEEE
LLGGVGLNWRRGHTESSLELMEILGFKRYALIVEILNGEGDSHDHDYVLKFAKEHDLPVL
EEECCCCCCCCCCCCHHHHHHHHHCCHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCEE
TTDDVWREFVRRKQLVSVYANARLPTRYGEFRIISFENELDFKEHVAIVKEPYSEVPLVR
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCEEE
IHSKCLTGDTLASLKCDCGSQLSNVLRMIAQEGGILLYMDQEGRGIGLKEKIKAYELQDK
EHHHHCCCCCHHHEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCC
GLDTVQANEALGHKGDERTYEAAFQMLRALGVSKVRLITNNPTKARALEELGIEVVEMIP
CCCCEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCHHHHHHCC
APGEVTEHNRPYLRIKAEKLGHKLPFEV
CCCCCCCCCCCEEEEEHHHCCCCCCCCC
>Mature Secondary Structure
MKPDWESIRRAIIDGKPAVLVDNRREFEADLVYPAELANSEVVNFMLSMKGLLCLTIDLE
CCCCHHHHHHHHHCCCCEEEECCCCCCCCCEECHHHHCCHHHHHHHHHHCCEEEEEEEHH
QALKRGFFPLPSKGGETNFLIPVDYEETFTGITAEERALTARKIAEGLEVEHFRYPGHLH
HHHHCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCEEE
LLGGVGLNWRRGHTESSLELMEILGFKRYALIVEILNGEGDSHDHDYVLKFAKEHDLPVL
EEECCCCCCCCCCCCHHHHHHHHHCCHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCEE
TTDDVWREFVRRKQLVSVYANARLPTRYGEFRIISFENELDFKEHVAIVKEPYSEVPLVR
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCEEE
IHSKCLTGDTLASLKCDCGSQLSNVLRMIAQEGGILLYMDQEGRGIGLKEKIKAYELQDK
EHHHHCCCCCHHHEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCC
GLDTVQANEALGHKGDERTYEAAFQMLRALGVSKVRLITNNPTKARALEELGIEVVEMIP
CCCCEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCHHHHHHCC
APGEVTEHNRPYLRIKAEKLGHKLPFEV
CCCCCCCCCCCEEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]