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The map label for this gene is folP [H]

Identifier: 212223532

GI number: 212223532

Start: 357534

End: 358352

Strand: Reverse

Name: folP [H]

Synonym: TON_0386

Alternate gene names: 212223532

Gene position: 358352-357534 (Counterclockwise)

Preceding gene: 212223533

Following gene: 212223528

Centisome position: 19.4

GC content: 52.14

Gene sequence:

>819_bases
ATGAAGTTTGCAAGGGTTGATTTGGACGAGCCGAGGATAATGGGGGTCATCAACGTCTCACCCGAAAGCTTCTACAAAGG
AAGCGTCAAAAATGACGAAGAAAAGCTGATAGAAACTGCGGTGAAGATGGTGGAGGAGGGAGCCGCTTTTATTGACATCG
GGGCGAAATCGACTGCCCCCTACCTTGAGACCCAGATTCCGCTTGAGGAAGAGATAAGAAGGGCAGTGTGGGCGATAAAG
ACCATCAGAGAGCATGTTGACGTTCCGATAAGTATAGACACCACCAGTGCGAAGGTCGCGGAGGAAGCCCTCAAAGCCGG
TGCTGACATTATAAACGACGTTACCGGCCTCAAAGGCGATGAGAAAATGGCAGAAGTGGCTAGAGAATACGGCGCCCCAG
TGATAGTCTGCGCCCACGGGGAAGTACGGAACCTCAGCGACCCGGTTCACACCGTCATAGATTTCCTCGAGGAGAGCATA
ACCATAGCCGAAAAGTACGGCATCGAGGAGATTGCTGTTGATCCAGCCATCGGATTTCTCCGCCCGGAGTGGCCGCCTTG
GTACGAGTGGGACTCCAAGGTCATAGCAAACCTCAACGCCCTCAAGATATTTGGTAGACCGATACTTATTGGCGTTTCGA
GAAAGTCGTTCATCGGAGCAATAACCGGCAGAAAAGACCCCTCGGAAAGGCTTCCGGGAAGTTTGGCGGCCACAGCAATA
GCCGTCCTCAAGGGTGCTAACATAGTGAGAACACACGATGTGAAAGAAACGCTCGATGCGGTTAAGATAGCAGACTTCAT
AAGGCGGTTCGGGCCTTAG

Upstream 100 bases:

>100_bases
TATGGAGCGACATGAGCTGGGAAATACGGCACGTGCTCACAGCCCTCGCGACCCTAACATTTATACTCTGGGGCATCAAG
CTCAGTACCGAGGTGAAACC

Downstream 100 bases:

>100_bases
CTTTCACTTCTTTCCACTCCTCCACGAGGGTGGCCAGGAGGGACAGCGCGAGGGGGCCGATTATGATGCCGACGAATCCG
AAGGCCAGAAAACCTCCAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKFARVDLDEPRIMGVINVSPESFYKGSVKNDEEKLIETAVKMVEEGAAFIDIGAKSTAPYLETQIPLEEEIRRAVWAIK
TIREHVDVPISIDTTSAKVAEEALKAGADIINDVTGLKGDEKMAEVAREYGAPVIVCAHGEVRNLSDPVHTVIDFLEESI
TIAEKYGIEEIAVDPAIGFLRPEWPPWYEWDSKVIANLNALKIFGRPILIGVSRKSFIGAITGRKDPSERLPGSLAATAI
AVLKGANIVRTHDVKETLDAVKIADFIRRFGP

Sequences:

>Translated_272_residues
MKFARVDLDEPRIMGVINVSPESFYKGSVKNDEEKLIETAVKMVEEGAAFIDIGAKSTAPYLETQIPLEEEIRRAVWAIK
TIREHVDVPISIDTTSAKVAEEALKAGADIINDVTGLKGDEKMAEVAREYGAPVIVCAHGEVRNLSDPVHTVIDFLEESI
TIAEKYGIEEIAVDPAIGFLRPEWPPWYEWDSKVIANLNALKIFGRPILIGVSRKSFIGAITGRKDPSERLPGSLAATAI
AVLKGANIVRTHDVKETLDAVKIADFIRRFGP
>Mature_272_residues
MKFARVDLDEPRIMGVINVSPESFYKGSVKNDEEKLIETAVKMVEEGAAFIDIGAKSTAPYLETQIPLEEEIRRAVWAIK
TIREHVDVPISIDTTSAKVAEEALKAGADIINDVTGLKGDEKMAEVAREYGAPVIVCAHGEVRNLSDPVHTVIDFLEESI
TIAEKYGIEEIAVDPAIGFLRPEWPPWYEWDSKVIANLNALKIFGRPILIGVSRKSFIGAITGRKDPSERLPGSLAATAI
AVLKGANIVRTHDVKETLDAVKIADFIRRFGP

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=269, Percent_Identity=35.3159851301115, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=332, Percent_Identity=29.5180722891566, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29875; Mature: 29875

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFARVDLDEPRIMGVINVSPESFYKGSVKNDEEKLIETAVKMVEEGAAFIDIGAKSTAP
CCCCCCCCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YLETQIPLEEEIRRAVWAIKTIREHVDVPISIDTTSAKVAEEALKAGADIINDVTGLKGD
CHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
EKMAEVAREYGAPVIVCAHGEVRNLSDPVHTVIDFLEESITIAEKYGIEEIAVDPAIGFL
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHCC
RPEWPPWYEWDSKVIANLNALKIFGRPILIGVSRKSFIGAITGRKDPSERLPGSLAATAI
CCCCCCCCCCCHHHHHCCHHHEEECCEEEEEECCHHHHHHHCCCCCCHHHCCCHHHHHHH
AVLKGANIVRTHDVKETLDAVKIADFIRRFGP
HHHHCCCEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFARVDLDEPRIMGVINVSPESFYKGSVKNDEEKLIETAVKMVEEGAAFIDIGAKSTAP
CCCCCCCCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YLETQIPLEEEIRRAVWAIKTIREHVDVPISIDTTSAKVAEEALKAGADIINDVTGLKGD
CHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
EKMAEVAREYGAPVIVCAHGEVRNLSDPVHTVIDFLEESITIAEKYGIEEIAVDPAIGFL
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHCC
RPEWPPWYEWDSKVIANLNALKIFGRPILIGVSRKSFIGAITGRKDPSERLPGSLAATAI
CCCCCCCCCCCHHHHHCCHHHEEECCEEEEEECCHHHHHHHCCCCCCHHHCCCHHHHHHH
AVLKGANIVRTHDVKETLDAVKIADFIRRFGP
HHHHCCCEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]