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The map label for this gene is map [H]

Identifier: 212223508

GI number: 212223508

Start: 337129

End: 338016

Strand: Reverse

Name: map [H]

Synonym: TON_0362

Alternate gene names: 212223508

Gene position: 338016-337129 (Counterclockwise)

Preceding gene: 212223511

Following gene: 212223507

Centisome position: 18.29

GC content: 52.36

Gene sequence:

>888_bases
GTGGATGAAAGGGAGGCCCTCATAAAAGCTGGGGAGATAGCCAGACAGGTTAAGAAAGAAGTAATTAGCCTAATAAAGCC
AGGGACAAAGCTTTATGATATAGCCGAGTTCGTGGAGAGAAGAATAATCGAGCTCGGCGGAAAGCCTGCCTTTCCGTGCA
ACCTTTCGATAAACGAGATAGCGGCACACTACACGCCCTACAAGGGCGACGAGACCGTTCTAAAGGAGGGCGACTACCTA
AAGGTTGACATTGGGGTTCACGTTGATGGTTATATAGCCGACACCGCCCTGACCTTCCGGGTCGGAATGGAAGAGGACGA
CCTAGTGACGGCTGCGAGAGAGGCTCTCGAGAACGCTATAAAAGTCATCCGCGCCGGAATCAAGATAAACGAGATTGGAA
AGGCCATAGAAGAAACCATTAGAGGATACGGCTTCAACCCGATAGTGAACCTCAGCGGTCACAAGATAGAGAGGTATAAA
CTCCACGCCGGCATCTCAATCCCCAACATCTACCGTCCAGCGGACAGCTACGTGCTGAAGGAGGGTGACGTGATAGCAAT
AGAACCCTTCGCCACAACTGGGGCAGGACAGGTCATTGAGGTTCCACCGGCACTGATTTTTATGTATCTCAGAGACAGGC
CAGTGAGGATGGCCCAGGCAAGAAGAGTGCTTATGCACATAAAGAGGGAGTACAACGGCCTTCCCTTCGCATACCGGTGG
CTCCAGGGGTTTATGCCCGAAGGCCAGCTTAAGCTAGCCCTAGCCCAGCTCGATAGAGTGGGGGCGATATACAGCTACCC
GATACTGAGGGAAGTCCGCGGCGGTCTCGTTGCTCAGTTCGAGCACACTGTTATAGTCGAGAAGGAGGGGGCTTACATAA
CCACCTAA

Upstream 100 bases:

>100_bases
ATGGGCCCACCGTAGAGGTAGGGTCTGCACCAAATAAAAGGTTTTTCCTGGGTGGAAAGGTTTAAGGGCGGGGACTGCTT
TCTTATCCTGGTGATAGAAC

Downstream 100 bases:

>100_bases
CTGAAAGCCGCTTTTCTACCCTTTAATTTCCCCAAGAATAGCTTTGGAAGGAAGTGTAAGGAAGGAAAGGACTCCCAACG
GGCTCGGCAGATGGCGCCGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDEREALIKAGEIARQVKKEVISLIKPGTKLYDIAEFVERRIIELGGKPAFPCNLSINEIAAHYTPYKGDETVLKEGDYL
KVDIGVHVDGYIADTALTFRVGMEEDDLVTAAREALENAIKVIRAGIKINEIGKAIEETIRGYGFNPIVNLSGHKIERYK
LHAGISIPNIYRPADSYVLKEGDVIAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMAQARRVLMHIKREYNGLPFAYRW
LQGFMPEGQLKLALAQLDRVGAIYSYPILREVRGGLVAQFEHTVIVEKEGAYITT

Sequences:

>Translated_295_residues
MDEREALIKAGEIARQVKKEVISLIKPGTKLYDIAEFVERRIIELGGKPAFPCNLSINEIAAHYTPYKGDETVLKEGDYL
KVDIGVHVDGYIADTALTFRVGMEEDDLVTAAREALENAIKVIRAGIKINEIGKAIEETIRGYGFNPIVNLSGHKIERYK
LHAGISIPNIYRPADSYVLKEGDVIAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMAQARRVLMHIKREYNGLPFAYRW
LQGFMPEGQLKLALAQLDRVGAIYSYPILREVRGGLVAQFEHTVIVEKEGAYITT
>Mature_295_residues
MDEREALIKAGEIARQVKKEVISLIKPGTKLYDIAEFVERRIIELGGKPAFPCNLSINEIAAHYTPYKGDETVLKEGDYL
KVDIGVHVDGYIADTALTFRVGMEEDDLVTAAREALENAIKVIRAGIKINEIGKAIEETIRGYGFNPIVNLSGHKIERYK
LHAGISIPNIYRPADSYVLKEGDVIAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMAQARRVLMHIKREYNGLPFAYRW
LQGFMPEGQLKLALAQLDRVGAIYSYPILREVRGGLVAQFEHTVIVEKEGAYITT

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=296, Percent_Identity=35.472972972973, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI124494254, Length=261, Percent_Identity=25.6704980842912, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI164420681, Length=196, Percent_Identity=31.1224489795918, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI40385867, Length=242, Percent_Identity=28.9256198347107, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=28.9855072463768, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17544396, Length=298, Percent_Identity=35.5704697986577, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17542840, Length=309, Percent_Identity=30.0970873786408, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71996291, Length=236, Percent_Identity=28.8135593220339, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319380, Length=305, Percent_Identity=35.4098360655738, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323273, Length=213, Percent_Identity=29.1079812206573, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137568, Length=300, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24658585, Length=316, Percent_Identity=26.5822784810127, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355531, Length=212, Percent_Identity=27.8301886792453, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583427, Length=205, Percent_Identity=29.7560975609756, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 33014; Mature: 33014

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEREALIKAGEIARQVKKEVISLIKPGTKLYDIAEFVERRIIELGGKPAFPCNLSINEI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
AAHYTPYKGDETVLKEGDYLKVDIGVHVDGYIADTALTFRVGMEEDDLVTAAREALENAI
HHHCCCCCCCHHHCCCCCEEEEEEEEEECCEEECEEEEEEECCCCHHHHHHHHHHHHHHH
KVIRAGIKINEIGKAIEETIRGYGFNPIVNLSGHKIERYKLHAGISIPNIYRPADSYVLK
HHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEE
EGDVIAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMAQARRVLMHIKREYNGLPFAYRW
CCCEEEEECCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
LQGFMPEGQLKLALAQLDRVGAIYSYPILREVRGGLVAQFEHTVIVEKEGAYITT
HHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEECC
>Mature Secondary Structure
MDEREALIKAGEIARQVKKEVISLIKPGTKLYDIAEFVERRIIELGGKPAFPCNLSINEI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
AAHYTPYKGDETVLKEGDYLKVDIGVHVDGYIADTALTFRVGMEEDDLVTAAREALENAI
HHHCCCCCCCHHHCCCCCEEEEEEEEEECCEEECEEEEEEECCCCHHHHHHHHHHHHHHH
KVIRAGIKINEIGKAIEETIRGYGFNPIVNLSGHKIERYKLHAGISIPNIYRPADSYVLK
HHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEE
EGDVIAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMAQARRVLMHIKREYNGLPFAYRW
CCCEEEEECCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
LQGFMPEGQLKLALAQLDRVGAIYSYPILREVRGGLVAQFEHTVIVEKEGAYITT
HHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA