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The map label for this gene is fdhA [H]

Identifier: 212223427

GI number: 212223427

Start: 248322

End: 250391

Strand: Reverse

Name: fdhA [H]

Synonym: TON_0281

Alternate gene names: 212223427

Gene position: 250391-248322 (Counterclockwise)

Preceding gene: 212223428

Following gene: 212223426

Centisome position: 13.55

GC content: 54.11

Gene sequence:

>2070_bases
ATGGGTATGGCAGAAAAGCGCATATCAGTGGTGTGTCCGTGGTGTTCCGTTGGTTGTAGATTTTACATAGTAAACGTCAA
TGGCTACCCAAAGAAGATCGAGTTCGACTACGACCACGACATCAGGAACCACGGCAAGCTCTGTCCAAAGGGTGTCGCAG
CCTTCCAGCATCTCAGGCATCCAGACAGGCTTAAAAAGCCCCTTAAGAGGGTTGGCGAGAGGGGTGAAGGCAAGTTCAAG
GAAATAAGCTGGGAAGAGGCTATTAAGGAAATCGCACAGAAGCTCAGTGAAATCAAGGAGAAGTATGGTTCGGAGGCTCT
TGCTTTTCTCGGAAGTGAAAGGTGCTCCATAGAGGAGAACTACGTTCTTCAGAAGCTGGCAAGGGCTTTGGGAACCAACA
ACATTGAATATGTGTGTAGGATGTGTCAGTCAACGGCTGTTGCAGGTAAGGGGATGGTTCTTGGACACCCCGGTCTGACG
AACCCCTTCGAGGACATTCTTAAGGCCAAAGTTATCGTCCTTTGGGGATACAATCCAGCCGCAACTAATCCGGTCTTCTT
CGGCCAGTACATTGAGAAGGCAATTCTCGACAACAACGCCACCCTCATTGTCGTTGACCCAAGAAAAACGAAGACTGCCA
AGTACGCAGACATACACCTGCAGCCATATCCCGGAACCGACCTTGCCATTGCGTTGGCTATGCTCAACGTCATAATCACC
GAGGAGCTCTACGATAAGGACTTCGTGGCGGAGCGCGCGGAGGGCCTTGAGGAGCTCGCCAAGACCGTCGAAAAGTACAC
TCCAGAATGGGCTGAGAAGGTCAGCGGCGTTCCTGCCGAGCTCATAAGGAAGGCCGCAATCACCTTTGCAACGGCTGGAA
CTGCCGCCCTGCTGACGAACGAGGGAGTGAACCAGCACGCCAACGGAACGAGGACTGTTATGGCTATCACTGAGATGATG
GTTCTCTGCGGCTACTTCGGAAAGGAGGGCGTCATGTCTGGAGCTATACCCGGTGCCCACAACGGTATGGGCGCTGGTCT
AATGGGTATTGGACCACACGAACTGCCAGGAAGATTCCCGCTCCACGCCGAGGAGCACAAGAGGAGAATTGAGGAGGCAT
GGGGCTTCAAGATCCCAGAGAAGCCTGGAATCACTTACGTTGAAATGATTGATGCAATCCTTGAGGGCAAGCTCAAGGCC
CTCTACGTCATGGGAACCAACCCTGCCAAGGCCCTTCCGAACCTCAAGAAGGCTGAGGAGGCCTTTAAGAACATCGAGTT
CCTCGTCGTCCAGGATATCTTCCTTACTGAGACCGCGAAATACGCCGACATAGTCCTTCCAGCGGCTGCATGGTTTGAGA
AGGACGGAACCGCCATAAGCTTCGAGAGAAGGGTTCAGAGGAGCTTTAAGGCTGCTGACGCACCGGGAGAGGCCAAGCCT
GACTGGGAAATCCTTGTTATGCTCGCTAAGGAGCTCGGCTTTGGAGAGTACTTCAACTACTCTGATGCAGACGACATCCT
GAGAGAAATAAACAGAATCATTCCGCCCCTTGCTGGCGCGACACCCGAGAGGCTCAAGAAGAACCTCAAAGGCTGTATGA
TACCCTGCCCAGACGAGAACACTGAGGTTCCGAGGCTCTTTGTCCAGGGCTTCCTCACGCCAAACGGAAAGGCCCAGCTT
ATTCCTGTGGAGTATAAAGAGCCTGGAGAAGTCCCCGATGAGGAGTACCCGTTCTGGCTCACCAACTACAGGTTCGTTGG
CCACTTCCACACCGGAACCATGAGCCACAGGAGCAAGAGCCTGAGCAAGAGGTGGCCAGAGGAGTACATTGAGATCAACG
AGAACGACGCGAAGAGGCTCGGCATAAAGGACGGCGACCTCGTGAGAGTCGAGACCAGGAGGGCAGCGCTGGTTCTCAGG
GCCAAGGTTACACCGCACATCAGGGAGGGCGTCGTTGCCGCGCCGTGGCACTGGGACTTCAACTACCTGACCACGGACGT
CCTCGACGAATACGCCAAGATGCCGGAGTTGAAGACGGCCGCGTGTAGGATCTCCAAGGTTGAGGGGTGA

Upstream 100 bases:

>100_bases
ATCAATTATGTGTACAACATAATGTTAGAGAAAATTATTTAAATGGTTCATTACTCACACCATCTGAATAAACTGACTAG
TCAGTCATCACGGGTTGGTG

Downstream 100 bases:

>100_bases
TTTAAATGAGCAAAAAGATATTTATCGATTTTAAGCGCTGCATTGCCTGTAAGGCCTGTGAAGTCGCCTGTGAAATGGAG
CACGGGGAAGCGAGGATTAG

Product: fdhA formate dehydrogenase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MGMAEKRISVVCPWCSVGCRFYIVNVNGYPKKIEFDYDHDIRNHGKLCPKGVAAFQHLRHPDRLKKPLKRVGERGEGKFK
EISWEEAIKEIAQKLSEIKEKYGSEALAFLGSERCSIEENYVLQKLARALGTNNIEYVCRMCQSTAVAGKGMVLGHPGLT
NPFEDILKAKVIVLWGYNPAATNPVFFGQYIEKAILDNNATLIVVDPRKTKTAKYADIHLQPYPGTDLAIALAMLNVIIT
EELYDKDFVAERAEGLEELAKTVEKYTPEWAEKVSGVPAELIRKAAITFATAGTAALLTNEGVNQHANGTRTVMAITEMM
VLCGYFGKEGVMSGAIPGAHNGMGAGLMGIGPHELPGRFPLHAEEHKRRIEEAWGFKIPEKPGITYVEMIDAILEGKLKA
LYVMGTNPAKALPNLKKAEEAFKNIEFLVVQDIFLTETAKYADIVLPAAAWFEKDGTAISFERRVQRSFKAADAPGEAKP
DWEILVMLAKELGFGEYFNYSDADDILREINRIIPPLAGATPERLKKNLKGCMIPCPDENTEVPRLFVQGFLTPNGKAQL
IPVEYKEPGEVPDEEYPFWLTNYRFVGHFHTGTMSHRSKSLSKRWPEEYIEINENDAKRLGIKDGDLVRVETRRAALVLR
AKVTPHIREGVVAAPWHWDFNYLTTDVLDEYAKMPELKTAACRISKVEG

Sequences:

>Translated_689_residues
MGMAEKRISVVCPWCSVGCRFYIVNVNGYPKKIEFDYDHDIRNHGKLCPKGVAAFQHLRHPDRLKKPLKRVGERGEGKFK
EISWEEAIKEIAQKLSEIKEKYGSEALAFLGSERCSIEENYVLQKLARALGTNNIEYVCRMCQSTAVAGKGMVLGHPGLT
NPFEDILKAKVIVLWGYNPAATNPVFFGQYIEKAILDNNATLIVVDPRKTKTAKYADIHLQPYPGTDLAIALAMLNVIIT
EELYDKDFVAERAEGLEELAKTVEKYTPEWAEKVSGVPAELIRKAAITFATAGTAALLTNEGVNQHANGTRTVMAITEMM
VLCGYFGKEGVMSGAIPGAHNGMGAGLMGIGPHELPGRFPLHAEEHKRRIEEAWGFKIPEKPGITYVEMIDAILEGKLKA
LYVMGTNPAKALPNLKKAEEAFKNIEFLVVQDIFLTETAKYADIVLPAAAWFEKDGTAISFERRVQRSFKAADAPGEAKP
DWEILVMLAKELGFGEYFNYSDADDILREINRIIPPLAGATPERLKKNLKGCMIPCPDENTEVPRLFVQGFLTPNGKAQL
IPVEYKEPGEVPDEEYPFWLTNYRFVGHFHTGTMSHRSKSLSKRWPEEYIEINENDAKRLGIKDGDLVRVETRRAALVLR
AKVTPHIREGVVAAPWHWDFNYLTTDVLDEYAKMPELKTAACRISKVEG
>Mature_688_residues
GMAEKRISVVCPWCSVGCRFYIVNVNGYPKKIEFDYDHDIRNHGKLCPKGVAAFQHLRHPDRLKKPLKRVGERGEGKFKE
ISWEEAIKEIAQKLSEIKEKYGSEALAFLGSERCSIEENYVLQKLARALGTNNIEYVCRMCQSTAVAGKGMVLGHPGLTN
PFEDILKAKVIVLWGYNPAATNPVFFGQYIEKAILDNNATLIVVDPRKTKTAKYADIHLQPYPGTDLAIALAMLNVIITE
ELYDKDFVAERAEGLEELAKTVEKYTPEWAEKVSGVPAELIRKAAITFATAGTAALLTNEGVNQHANGTRTVMAITEMMV
LCGYFGKEGVMSGAIPGAHNGMGAGLMGIGPHELPGRFPLHAEEHKRRIEEAWGFKIPEKPGITYVEMIDAILEGKLKAL
YVMGTNPAKALPNLKKAEEAFKNIEFLVVQDIFLTETAKYADIVLPAAAWFEKDGTAISFERRVQRSFKAADAPGEAKPD
WEILVMLAKELGFGEYFNYSDADDILREINRIIPPLAGATPERLKKNLKGCMIPCPDENTEVPRLFVQGFLTPNGKAQLI
PVEYKEPGEVPDEEYPFWLTNYRFVGHFHTGTMSHRSKSLSKRWPEEYIEINENDAKRLGIKDGDLVRVETRRAALVLRA
KVTPHIREGVVAAPWHWDFNYLTTDVLDEYAKMPELKTAACRISKVEG

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=696, Percent_Identity=35.7758620689655, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI171474008, Length=726, Percent_Identity=28.5123966942149, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1788534, Length=527, Percent_Identity=27.3244781783681, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI3868720, Length=609, Percent_Identity=25.944170771757, Blast_Score=176, Evalue=7e-45,
Organism=Escherichia coli, GI87081797, Length=724, Percent_Identity=27.0718232044199, Blast_Score=173, Evalue=4e-44,
Organism=Escherichia coli, GI3868719, Length=621, Percent_Identity=25.1207729468599, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787870, Length=747, Percent_Identity=26.9076305220884, Blast_Score=172, Evalue=7e-44,
Organism=Escherichia coli, GI87081994, Length=665, Percent_Identity=24.6616541353383, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1787778, Length=397, Percent_Identity=24.9370277078086, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI145693196, Length=665, Percent_Identity=22.8571428571429, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1787231, Length=702, Percent_Identity=23.0769230769231, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17565758, Length=121, Percent_Identity=34.7107438016529, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 77046; Mature: 76914

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMAEKRISVVCPWCSVGCRFYIVNVNGYPKKIEFDYDHDIRNHGKLCPKGVAAFQHLRH
CCCCCCCCEEEECHHCCCCEEEEEEECCCCCEEECCCCCCHHHCCCCCHHHHHHHHHCCC
PDRLKKPLKRVGERGEGKFKEISWEEAIKEIAQKLSEIKEKYGSEALAFLGSERCSIEEN
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHH
YVLQKLARALGTNNIEYVCRMCQSTAVAGKGMVLGHPGLTNPFEDILKAKVIVLWGYNPA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCEEEEEECCCCC
ATNPVFFGQYIEKAILDNNATLIVVDPRKTKTAKYADIHLQPYPGTDLAIALAMLNVIIT
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
EELYDKDFVAERAEGLEELAKTVEKYTPEWAEKVSGVPAELIRKAAITFATAGTAALLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC
EGVNQHANGTRTVMAITEMMVLCGYFGKEGVMSGAIPGAHNGMGAGLMGIGPHELPGRFP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LHAEEHKRRIEEAWGFKIPEKPGITYVEMIDAILEGKLKALYVMGTNPAKALPNLKKAEE
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHCCCHHHHHH
AFKNIEFLVVQDIFLTETAKYADIVLPAAAWFEKDGTAISFERRVQRSFKAADAPGEAKP
HHCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCC
DWEILVMLAKELGFGEYFNYSDADDILREINRIIPPLAGATPERLKKNLKGCMIPCPDEN
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCC
TEVPRLFVQGFLTPNGKAQLIPVEYKEPGEVPDEEYPFWLTNYRFVGHFHTGTMSHRSKS
CCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECEEEEEEEECCCHHHHHHH
LSKRWPEEYIEINENDAKRLGIKDGDLVRVETRRAALVLRAKVTPHIREGVVAAPWHWDF
HHHHCCHHHEECCCCCHHCCCCCCCCEEEEECCCEEEEEEECCCCHHHCCCEECCCCCCC
NYLTTDVLDEYAKMPELKTAACRISKVEG
HHHHHHHHHHHHHCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
GMAEKRISVVCPWCSVGCRFYIVNVNGYPKKIEFDYDHDIRNHGKLCPKGVAAFQHLRH
CCCCCCCEEEECHHCCCCEEEEEEECCCCCEEECCCCCCHHHCCCCCHHHHHHHHHCCC
PDRLKKPLKRVGERGEGKFKEISWEEAIKEIAQKLSEIKEKYGSEALAFLGSERCSIEEN
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHH
YVLQKLARALGTNNIEYVCRMCQSTAVAGKGMVLGHPGLTNPFEDILKAKVIVLWGYNPA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCEEEEEECCCCC
ATNPVFFGQYIEKAILDNNATLIVVDPRKTKTAKYADIHLQPYPGTDLAIALAMLNVIIT
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
EELYDKDFVAERAEGLEELAKTVEKYTPEWAEKVSGVPAELIRKAAITFATAGTAALLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC
EGVNQHANGTRTVMAITEMMVLCGYFGKEGVMSGAIPGAHNGMGAGLMGIGPHELPGRFP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LHAEEHKRRIEEAWGFKIPEKPGITYVEMIDAILEGKLKALYVMGTNPAKALPNLKKAEE
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHCCCHHHHHH
AFKNIEFLVVQDIFLTETAKYADIVLPAAAWFEKDGTAISFERRVQRSFKAADAPGEAKP
HHCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCC
DWEILVMLAKELGFGEYFNYSDADDILREINRIIPPLAGATPERLKKNLKGCMIPCPDEN
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCC
TEVPRLFVQGFLTPNGKAQLIPVEYKEPGEVPDEEYPFWLTNYRFVGHFHTGTMSHRSKS
CCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECEEEEEEEECCCHHHHHHH
LSKRWPEEYIEINENDAKRLGIKDGDLVRVETRRAALVLRAKVTPHIREGVVAAPWHWDF
HHHHCCHHHEECCCCCHHCCCCCCCCEEEEECCCEEEEEEECCCCHHHCCCEECCCCCCC
NYLTTDVLDEYAKMPELKTAACRISKVEG
HHHHHHHHHHHHHCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]