Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 212223181

GI number: 212223181

Start: 31271

End: 32272

Strand: Reverse

Name: hom [H]

Synonym: TON_0036

Alternate gene names: 212223181

Gene position: 32272-31271 (Counterclockwise)

Preceding gene: 212223182

Following gene: 212223180

Centisome position: 1.75

GC content: 54.79

Gene sequence:

>1002_bases
ATGGAGGTAAAGCTCTCTCTTTTCGGCTTCGGAAACGTCGGTAGAGCCGTAGCGAGGGTTCTTCTCGAAAAAGAGACCTT
CTTCAAAGAGCGATACAGCCTGAGCTTTAAGGTGGTTAGCATAGCCGACACGAGCGGAACGGTGTGGCTCCCGGAGAGCA
TCGACCTGAGGGAAGCGCTCACCGTGAAGGAGACCTTCGGAAAGCTCTCGGCATGGACTAACGACTACGAGGTTTACAAC
TTCACACCAAAGGAGGCAGTTCAGGAGATAGACGCAGACATCGTTATCGACGTGACGAACGACAAGAACGCCTACGGGTG
GCATCTAACTGCTTTGAGAGACGGAAAGGCTGTCGTTACGAGCAACAAGCCACCGCTGGCTTTCCACTACGCGGAACTGA
TGGAAGAGGCCAATAAAAGGAGCCTTCCCTATCTCTTCGAGGCGACTGTGATGGCAGGAACCCCGATAATAACGCTCCTC
CGACACGGGCTGAGGGGGGACACCGTGGAGAGAATTGAAGCCGTCCTCAATGCCACAACAACCTTCATCCTGAGCGAGAT
GGAGAAGGGGTTGGACTTTGATGATGCTTTGAAGGAGGCCCAAAAGTTGGGCATAGCGGAGCGCGACCCGAGCGGCGATA
TATTGGGCATCGACGCCGGCTATAAAGCGACCATCCTCCACTGCCTCGCCTTCGAGCCTATAACGTTTGATATGGCGAGT
GTTAAGGGCATCGTCGAGGTAACGCCCGGAGAGATTGAAAGGGCAAAAGCGAAGGGCAAGACAATAAGGCTCGTCGCCAC
GGTTGAAGAGGGGAGGATCGTTGTGGGGCCTAAAGAAATCCCGAAGAACAGTCCGCTCGCAGTTGAAAGCCACGAAAACG
CGGCAGTGATAAAAACCGACCTCCTCGGCGAGCTTGTGATTAAGGGTGCTGGCGCAGGGCTGAAGGAAACCGCCAGCGGG
GTGGTGAGTGATATTGTTATGGCGGCGCTGATGATGCGCTGA

Upstream 100 bases:

>100_bases
TGAAGGCGAGCTTGTCGGCATCGTCAGGGACATGGATATCATAAAGGTCATCCTAAACAAGTGAACTCTTCTTTTTCCCA
ACATTTTAGCGGGTGTTTCT

Downstream 100 bases:

>100_bases
ACTACCCAAACCTTTTTTAGTCCTACCGGAAGCCTAACTCCGGTGAGCTCATGGAGCACGTGATAGCGCTCCACCAGGTC
TACGGCGAGCTGATATTCAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MEVKLSLFGFGNVGRAVARVLLEKETFFKERYSLSFKVVSIADTSGTVWLPESIDLREALTVKETFGKLSAWTNDYEVYN
FTPKEAVQEIDADIVIDVTNDKNAYGWHLTALRDGKAVVTSNKPPLAFHYAELMEEANKRSLPYLFEATVMAGTPIITLL
RHGLRGDTVERIEAVLNATTTFILSEMEKGLDFDDALKEAQKLGIAERDPSGDILGIDAGYKATILHCLAFEPITFDMAS
VKGIVEVTPGEIERAKAKGKTIRLVATVEEGRIVVGPKEIPKNSPLAVESHENAAVIKTDLLGELVIKGAGAGLKETASG
VVSDIVMAALMMR

Sequences:

>Translated_333_residues
MEVKLSLFGFGNVGRAVARVLLEKETFFKERYSLSFKVVSIADTSGTVWLPESIDLREALTVKETFGKLSAWTNDYEVYN
FTPKEAVQEIDADIVIDVTNDKNAYGWHLTALRDGKAVVTSNKPPLAFHYAELMEEANKRSLPYLFEATVMAGTPIITLL
RHGLRGDTVERIEAVLNATTTFILSEMEKGLDFDDALKEAQKLGIAERDPSGDILGIDAGYKATILHCLAFEPITFDMAS
VKGIVEVTPGEIERAKAKGKTIRLVATVEEGRIVVGPKEIPKNSPLAVESHENAAVIKTDLLGELVIKGAGAGLKETASG
VVSDIVMAALMMR
>Mature_333_residues
MEVKLSLFGFGNVGRAVARVLLEKETFFKERYSLSFKVVSIADTSGTVWLPESIDLREALTVKETFGKLSAWTNDYEVYN
FTPKEAVQEIDADIVIDVTNDKNAYGWHLTALRDGKAVVTSNKPPLAFHYAELMEEANKRSLPYLFEATVMAGTPIITLL
RHGLRGDTVERIEAVLNATTTFILSEMEKGLDFDDALKEAQKLGIAERDPSGDILGIDAGYKATILHCLAFEPITFDMAS
VKGIVEVTPGEIERAKAKGKTIRLVATVEEGRIVVGPKEIPKNSPLAVESHENAAVIKTDLLGELVIKGAGAGLKETASG
VVSDIVMAALMMR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=341, Percent_Identity=24.9266862170088, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=23.7430167597765, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=141, Percent_Identity=35.4609929078014, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36302; Mature: 36302

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKLSLFGFGNVGRAVARVLLEKETFFKERYSLSFKVVSIADTSGTVWLPESIDLREAL
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEECCCCCCHHHHH
TVKETFGKLSAWTNDYEVYNFTPKEAVQEIDADIVIDVTNDKNAYGWHLTALRDGKAVVT
HHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCEEEE
SNKPPLAFHYAELMEEANKRSLPYLFEATVMAGTPIITLLRHGLRGDTVERIEAVLNATT
CCCCCEEHHHHHHHHHHCCCCCCEEEEEHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
TFILSEMEKGLDFDDALKEAQKLGIAERDPSGDILGIDAGYKATILHCLAFEPITFDMAS
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEHHH
VKGIVEVTPGEIERAKAKGKTIRLVATVEEGRIVVGPKEIPKNSPLAVESHENAAVIKTD
CCEEEEECCCHHHHHHCCCCEEEEEEEEECCEEEECCHHCCCCCCEEEECCCCCEEEEHH
LLGELVIKGAGAGLKETASGVVSDIVMAALMMR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVKLSLFGFGNVGRAVARVLLEKETFFKERYSLSFKVVSIADTSGTVWLPESIDLREAL
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEECCCCCCHHHHH
TVKETFGKLSAWTNDYEVYNFTPKEAVQEIDADIVIDVTNDKNAYGWHLTALRDGKAVVT
HHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCEEEE
SNKPPLAFHYAELMEEANKRSLPYLFEATVMAGTPIITLLRHGLRGDTVERIEAVLNATT
CCCCCEEHHHHHHHHHHCCCCCCEEEEEHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
TFILSEMEKGLDFDDALKEAQKLGIAERDPSGDILGIDAGYKATILHCLAFEPITFDMAS
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEHHH
VKGIVEVTPGEIERAKAKGKTIRLVATVEEGRIVVGPKEIPKNSPLAVESHENAAVIKTD
CCEEEEECCCHHHHHHCCCCEEEEEEEEECCEEEECCHHCCCCCCEEEECCCCCEEEEHH
LLGELVIKGAGAGLKETASGVVSDIVMAALMMR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]