Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 209554312

GI number: 209554312

Start: 508759

End: 509592

Strand: Reverse

Name: mutM [H]

Synonym: UUR10_0458

Alternate gene names: 209554312

Gene position: 509592-508759 (Counterclockwise)

Preceding gene: 209554047

Following gene: 209554567

Centisome position: 58.27

GC content: 26.02

Gene sequence:

>834_bases
ATGCCAGAACTACCAGAAGTCCAAACCATTGTTGATTATTTAAATCTTAATGTTTTAAATTTATTAATTAAAAAAGTAAT
TGTCCATTTACCAAAAATTTTAAAAAATAAAACACCTGCTGAATTTGAGAATTTATTAGTTAATCATAAAATTACTAATA
TTAAACGCCTTGGCAAATACTTATTATTCTTTTTAGATAATAATTTAGTATTAAGTGTGCATTTGCGAATGGAAGGAAAA
TTTTATTACCAACCAAAAGATGAGTGATTTAATTTAGCGCATACTCATATTATTATTGAATTTGAGAATGGAATGCAACT
ACGTTATAATGACACACGTCAGTTTGGTACTTTTCATATTTATGAACAAGAATCTTTTTTAGATTCTAAAGAATTAAAAA
AGATTGCTTTAGATCCTCTTGATGCTAATTTTACGCCCCAATACTTGTATGAAAAACTTAAAAAAAGTAATAAAGCTATT
AAAACTGCTTTATTAGACCAATCTAATGTTTCTGGAATTGGTAATATTTATGCTGATGAAATTTTGTTTGCTACTAAGAT
TTTTCCCACTACTTTAGCTAAAGATCTTACAATAAAAGATTATGAAAATATTGCAAAAGAAGCTAAAAGAATTTTATTAT
TATCAATCCAAAATAAAGGAACAACAATTCATACTTATAAATTTGGCAATGATGAAACAGGGATGTTTCAAAAAATGTTA
TTAGTACACACTCACGCTAAAAAACCATGTCAAACTTGTGGCACAATTATTCAAAAAACAAAAGTTAATGGACGTGGAAC
TTATTATTGCTCAAATTGCCAAAATCAAAAATAA

Upstream 100 bases:

>100_bases
TCAAGAATTAGATACTTTATTTGAATCTTTAAAAATAAATAATATGCACAATTATTATAAATAGTGTATATTTAAAATGC
TATTTAAGGAGGATTTTAAA

Downstream 100 bases:

>100_bases
TATTATTGTTAATTACTAATATTTTTAAACTCAAAATTGCTATAATAATTAGAGTTTAATTTGCTCAAGTGGCGAAATGG
CAGACGCAGTTGACTCAAAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPELPEVQTIVDYLNLNVLNLLIKKVIVHLPKILKNKTPAEFENLLVNHKITNIKRLGKYLLFFLDNNLVLSVHLRMEGK
FYYQPKDEWFNLAHTHIIIEFENGMQLRYNDTRQFGTFHIYEQESFLDSKELKKIALDPLDANFTPQYLYEKLKKSNKAI
KTALLDQSNVSGIGNIYADEILFATKIFPTTLAKDLTIKDYENIAKEAKRILLLSIQNKGTTIHTYKFGNDETGMFQKML
LVHTHAKKPCQTCGTIIQKTKVNGRGTYYCSNCQNQK

Sequences:

>Translated_277_residues
MPELPEVQTIVDYLNLNVLNLLIKKVIVHLPKILKNKTPAEFENLLVNHKITNIKRLGKYLLFFLDNNLVLSVHLRMEGK
FYYQPKDE*FNLAHTHIIIEFENGMQLRYNDTRQFGTFHIYEQESFLDSKELKKIALDPLDANFTPQYLYEKLKKSNKAI
KTALLDQSNVSGIGNIYADEILFATKIFPTTLAKDLTIKDYENIAKEAKRILLLSIQNKGTTIHTYKFGNDETGMFQKML
LVHTHAKKPCQTCGTIIQKTKVNGRGTYYCSNCQNQK
>Mature_276_residues
PELPEVQTIVDYLNLNVLNLLIKKVIVHLPKILKNKTPAEFENLLVNHKITNIKRLGKYLLFFLDNNLVLSVHLRMEGKF
YYQPKDE*FNLAHTHIIIEFENGMQLRYNDTRQFGTFHIYEQESFLDSKELKKIALDPLDANFTPQYLYEKLKKSNKAIK
TALLDQSNVSGIGNIYADEILFATKIFPTTLAKDLTIKDYENIAKEAKRILLLSIQNKGTTIHTYKFGNDETGMFQKMLL
VHTHAKKPCQTCGTIIQKTKVNGRGTYYCSNCQNQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=280, Percent_Identity=33.9285714285714, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786932, Length=279, Percent_Identity=24.3727598566308, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31904; Mature: 31772

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVQTIVDYLNLNVLNLLIKKVIVHLPKILKNKTPAEFENLLVNHKITNIKRLGKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLFFLDNNLVLSVHLRMEGKFYYQPKDEFNLAHTHIIIEFENGMQLRYNDTRQFGTFHIY
EEEEECCCEEEEEEEEECCEEEECCCCCCCEEEEEEEEEECCCCEEEECCCCCCCEEEEE
EQESFLDSKELKKIALDPLDANFTPQYLYEKLKKSNKAIKTALLDQSNVSGIGNIYADEI
ECHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LFATKIFPTTLAKDLTIKDYENIAKEAKRILLLSIQNKGTTIHTYKFGNDETGMFQKMLL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCCHHHHHHHHH
VHTHAKKPCQTCGTIIQKTKVNGRGTYYCSNCQNQK
HHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
PELPEVQTIVDYLNLNVLNLLIKKVIVHLPKILKNKTPAEFENLLVNHKITNIKRLGKY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLFFLDNNLVLSVHLRMEGKFYYQPKDEFNLAHTHIIIEFENGMQLRYNDTRQFGTFHIY
EEEEECCCEEEEEEEEECCEEEECCCCCCCEEEEEEEEEECCCCEEEECCCCCCCEEEEE
EQESFLDSKELKKIALDPLDANFTPQYLYEKLKKSNKAIKTALLDQSNVSGIGNIYADEI
ECHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LFATKIFPTTLAKDLTIKDYENIAKEAKRILLLSIQNKGTTIHTYKFGNDETGMFQKMLL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCCHHHHHHHHH
VHTHAKKPCQTCGTIIQKTKVNGRGTYYCSNCQNQK
HHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]