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The map label for this gene is tmk [H]

Identifier: 209554298

GI number: 209554298

Start: 20533

End: 21222

Strand: Reverse

Name: tmk [H]

Synonym: UUR10_0020

Alternate gene names: 209554298

Gene position: 21222-20533 (Counterclockwise)

Preceding gene: 209554221

Following gene: 209554429

Centisome position: 2.43

GC content: 24.93

Gene sequence:

>690_bases
ATGTTAACGAAAAATAGTAATGAACTAAAATCGCCAAAAAAAGGCTTATTTATTGTTTTTGAAGGGATTGATGGAGCTGG
AAAAACATCAATTTTAAAACAATTACTAGATGTTTTAAAAGAACCTAAATTAGTTAATAAAATTTTTTTAACACGTGAAC
CCGGCGGAAAAAACAACACTGCAGCAGAATTAATTCGTGACTTTTTTTTAAAAAATCTAGAAGCATTTGATCCTTTAACA
CTAGCTTATTTATATGCAAGTAGTCGTGCAGAACATGTTAAAAAAACAATTAATCCAAATTTAGAAAAAGGACATATTGT
TATTTCAGATCGTTTTGTTCATTCATCATATATTTATCAAGGGATTGTTCAAAACCAAAGTTTAGAAGTTATTCATCATG
TTAATCAACAAGCGATTGGTAATTTAGAAATTGATTATATTTTTTATTTTGATGTAAGTGTTAATAATGCATTAAATCGT
ATGAAGAATCGTTTTGATAATACAAACGCATTTGATTCACAAAATAAACAATTTTATGAAAAATTATTAAAACAATATCC
AAGTGTTTTTAATGCATACAATCAACCTAAAAAAATTATTTTTATTGATGCTAATAAAAGTGAAAACGAAGTTTTGTGTG
AGGTTAAAGAACGATTATTAGAAATTTTTAAAGAACATAAATATATTTAA

Upstream 100 bases:

>100_bases
GGTCACATCCCTTTTATTGAAGAACCTAAATTATTCACTAATATATTATTAAGTTTTTTAGAAGATAGATTTATAGAACA
AGAAGAAAGTGAAAGCAATG

Downstream 100 bases:

>100_bases
TGAAATATAGTTTTGCCAATTTATTGATTCAATCACCCAAAACCTCATTAACATTAGGTGTTGAACAAATCATGCTAGCG
TTTATTAATGAAAAAAATCA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLTKNSNELKSPKKGLFIVFEGIDGAGKTSILKQLLDVLKEPKLVNKIFLTREPGGKNNTAAELIRDFFLKNLEAFDPLT
LAYLYASSRAEHVKKTINPNLEKGHIVISDRFVHSSYIYQGIVQNQSLEVIHHVNQQAIGNLEIDYIFYFDVSVNNALNR
MKNRFDNTNAFDSQNKQFYEKLLKQYPSVFNAYNQPKKIIFIDANKSENEVLCEVKERLLEIFKEHKYI

Sequences:

>Translated_229_residues
MLTKNSNELKSPKKGLFIVFEGIDGAGKTSILKQLLDVLKEPKLVNKIFLTREPGGKNNTAAELIRDFFLKNLEAFDPLT
LAYLYASSRAEHVKKTINPNLEKGHIVISDRFVHSSYIYQGIVQNQSLEVIHHVNQQAIGNLEIDYIFYFDVSVNNALNR
MKNRFDNTNAFDSQNKQFYEKLLKQYPSVFNAYNQPKKIIFIDANKSENEVLCEVKERLLEIFKEHKYI
>Mature_229_residues
MLTKNSNELKSPKKGLFIVFEGIDGAGKTSILKQLLDVLKEPKLVNKIFLTREPGGKNNTAAELIRDFFLKNLEAFDPLT
LAYLYASSRAEHVKKTINPNLEKGHIVISDRFVHSSYIYQGIVQNQSLEVIHHVNQQAIGNLEIDYIFYFDVSVNNALNR
MKNRFDNTNAFDSQNKQFYEKLLKQYPSVFNAYNQPKKIIFIDANKSENEVLCEVKERLLEIFKEHKYI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=213, Percent_Identity=25.8215962441315, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 26493; Mature: 26493

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKNSNELKSPKKGLFIVFEGIDGAGKTSILKQLLDVLKEPKLVNKIFLTREPGGKNNT
CCCCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCH
AAELIRDFFLKNLEAFDPLTLAYLYASSRAEHVKKTINPNLEKGHIVISDRFVHSSYIYQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHH
GIVQNQSLEVIHHVNQQAIGNLEIDYIFYFDVSVNNALNRMKNRFDNTNAFDSQNKQFYE
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHH
KLLKQYPSVFNAYNQPKKIIFIDANKSENEVLCEVKERLLEIFKEHKYI
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTKNSNELKSPKKGLFIVFEGIDGAGKTSILKQLLDVLKEPKLVNKIFLTREPGGKNNT
CCCCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCH
AAELIRDFFLKNLEAFDPLTLAYLYASSRAEHVKKTINPNLEKGHIVISDRFVHSSYIYQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHH
GIVQNQSLEVIHHVNQQAIGNLEIDYIFYFDVSVNNALNRMKNRFDNTNAFDSQNKQFYE
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHH
KLLKQYPSVFNAYNQPKKIIFIDANKSENEVLCEVKERLLEIFKEHKYI
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA