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The map label for this gene is manB [H]

Identifier: 209554256

GI number: 209554256

Start: 741951

End: 743609

Strand: Reverse

Name: manB [H]

Synonym: UUR10_0621

Alternate gene names: 209554256

Gene position: 743609-741951 (Counterclockwise)

Preceding gene: 209554522

Following gene: 209554623

Centisome position: 85.03

GC content: 26.64

Gene sequence:

>1659_bases
ATGGAAAATACAAACAAACTTTTTAATTGTTGATTAAATTCACCAAAAATTTCTCAAACAATTAAAGAAGAGTATAAAAA
TAAAACACAAGAAGAAATTGATCATATTTTTGATGAGAATTATCGTTTTAAATTTGGGACTTCGGGGGTACGCTGTATCT
ATCAAGAAGGAGCTCGTTATTTAAATGTGATAACTTACACTCAATTAGCATTAGGATTTATTAAATATTTAGAAACAAAA
AAAAGTCCTAATAAAATTATTGTTATTGGTCGTGATAACCGCTTTGGATCACGTGAAAATTTAAAGTTAATTGCTGAAAT
TTTTAGTAGTTTTGATTATACTGTTTATGTAAATGAAGACTATGGCATGTTATCAACGCCAATCACTTCGTTTTTAGTAA
ATGAACTACAAGCGAGTGCTGGAATCATGATTACAGCTTCACATAATCCTAAAAACTATAATGGTTTTAAAGTTTATAAT
GCGAATGGTGCTCAACCATTAGTTGATGATACTAATACTATTGAGTCATTAATGCCATCATATATTGAAGCACTAAATTT
TAGTTTTGAACCAAAGCAAGATAGTATTAAATTTTTAACACAACAACATCTTCAAACTTATTTTGATGCAGTTAAAGCTC
AATTAATTCATACTAACCTAAATACTAAAAAACCATTTAAAGTTGTTTTTAGTGGTCATCATGGAACAACAACAAATGAC
ATGATTCCTTTTTTAGAATCACTTGGTTATGACATGGTTAGTGTTAAAGAACAAAACTTTGAAGATCCTAATTTTAGTGA
TGATCCAAGTTCTAACCCAGAAGAACAACGTTCATTTGATTTAAGTATTGAATACGCTGATAATGCCAATGCTGATGTTA
TGATTGCATCAGATCCAGATGGTGATCGAATGGCTATTGCTGTGCGTCATCAAAATTATTGAAAATTTTTAACTGGCAAT
CAAACAGGTGTATTAATTGCTCATTATTTATTACATCATAAAAAATTCACTAAACCACCATATATTATTTCAACATTTAT
TTCAACACGTTATCCAGAATTATTTGCCAAAGATTTTAATTGTGATGTTTTATATGTTGATGTTGGTTTTAAAAATCATG
GTAATTTAGTTGCTAATCGTAAAAAAACACACGACTTAGTTGTAGGTTTTGAAGAAGCAATTGGTTCATTGTCATCTGAT
ATTAATAATGATAAAGACTCATATCAAGCAGCGTCTATTTTATTAGAAATGGTTAATTACTATCATGAACAAAATCTTGA
TTTATTCACTGTTCTAAAAAAAGAAATTTTTGCAAAATATGGCAATTGATATAGTAAAACTGCACAATTTGTAATTGATG
GTGAAAATTGAAAACAAAAAGCACTTGCTATTTTAAATAATTTAAAAAATTTTGAGTTTAAAACAATTACACAATATACT
ATTCAAAACATTATTTTTCATGAACAAGGTTCTTATCTTGAATGAAAATTAGATGAATATTCAACAATTAAATTTAGATT
ATCAGGAACAGAACCTAAATTTAAAGTTTATATTGATTTATATGATTTTACTAAAGATCAAAATCGTGATTTTTATCAAG
AATTAAAAGTTAAAGTCGAAGATATTTTAGATTTTTTAAAAAATTATTTAGATCTTTAA

Upstream 100 bases:

>100_bases
TGGAACTTATAAGGAGTATAGTGTCGAACAATTATTACCATTTGGATGAGATCCAAATGTATCTCTATAATTATTTACAA
TAAGAAGGGAGATAAAAATT

Downstream 100 bases:

>100_bases
AATACTAATATAAACAAAACGACCCTTTTTTTGGGTCGTTTTTTATTATATTTATATATTTTTATATAAATAACATTTGT
ATATAATCATGTCAGTATGA

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MENTNKLFNCWLNSPKISQTIKEEYKNKTQEEIDHIFDENYRFKFGTSGVRCIYQEGARYLNVITYTQLALGFIKYLETK
KSPNKIIVIGRDNRFGSRENLKLIAEIFSSFDYTVYVNEDYGMLSTPITSFLVNELQASAGIMITASHNPKNYNGFKVYN
ANGAQPLVDDTNTIESLMPSYIEALNFSFEPKQDSIKFLTQQHLQTYFDAVKAQLIHTNLNTKKPFKVVFSGHHGTTTND
MIPFLESLGYDMVSVKEQNFEDPNFSDDPSSNPEEQRSFDLSIEYADNANADVMIASDPDGDRMAIAVRHQNYWKFLTGN
QTGVLIAHYLLHHKKFTKPPYIISTFISTRYPELFAKDFNCDVLYVDVGFKNHGNLVANRKKTHDLVVGFEEAIGSLSSD
INNDKDSYQAASILLEMVNYYHEQNLDLFTVLKKEIFAKYGNWYSKTAQFVIDGENWKQKALAILNNLKNFEFKTITQYT
IQNIIFHEQGSYLEWKLDEYSTIKFRLSGTEPKFKVYIDLYDFTKDQNRDFYQELKVKVEDILDFLKNYLDL

Sequences:

>Translated_552_residues
MENTNKLFNC*LNSPKISQTIKEEYKNKTQEEIDHIFDENYRFKFGTSGVRCIYQEGARYLNVITYTQLALGFIKYLETK
KSPNKIIVIGRDNRFGSRENLKLIAEIFSSFDYTVYVNEDYGMLSTPITSFLVNELQASAGIMITASHNPKNYNGFKVYN
ANGAQPLVDDTNTIESLMPSYIEALNFSFEPKQDSIKFLTQQHLQTYFDAVKAQLIHTNLNTKKPFKVVFSGHHGTTTND
MIPFLESLGYDMVSVKEQNFEDPNFSDDPSSNPEEQRSFDLSIEYADNANADVMIASDPDGDRMAIAVRHQNY*KFLTGN
QTGVLIAHYLLHHKKFTKPPYIISTFISTRYPELFAKDFNCDVLYVDVGFKNHGNLVANRKKTHDLVVGFEEAIGSLSSD
INNDKDSYQAASILLEMVNYYHEQNLDLFTVLKKEIFAKYGN*YSKTAQFVIDGEN*KQKALAILNNLKNFEFKTITQYT
IQNIIFHEQGSYLE*KLDEYSTIKFRLSGTEPKFKVYIDLYDFTKDQNRDFYQELKVKVEDILDFLKNYLDL
>Mature_552_residues
MENTNKLFNC*LNSPKISQTIKEEYKNKTQEEIDHIFDENYRFKFGTSGVRCIYQEGARYLNVITYTQLALGFIKYLETK
KSPNKIIVIGRDNRFGSRENLKLIAEIFSSFDYTVYVNEDYGMLSTPITSFLVNELQASAGIMITASHNPKNYNGFKVYN
ANGAQPLVDDTNTIESLMPSYIEALNFSFEPKQDSIKFLTQQHLQTYFDAVKAQLIHTNLNTKKPFKVVFSGHHGTTTND
MIPFLESLGYDMVSVKEQNFEDPNFSDDPSSNPEEQRSFDLSIEYADNANADVMIASDPDGDRMAIAVRHQNY*KFLTGN
QTGVLIAHYLLHHKKFTKPPYIISTFISTRYPELFAKDFNCDVLYVDVGFKNHGNLVANRKKTHDLVVGFEEAIGSLSSD
INNDKDSYQAASILLEMVNYYHEQNLDLFTVLKKEIFAKYGN*YSKTAQFVIDGEN*KQKALAILNNLKNFEFKTITQYT
IQNIIFHEQGSYLE*KLDEYSTIKFRLSGTEPKFKVYIDLYDFTKDQNRDFYQELKVKVEDILDFLKNYLDL

Specific function: Involved In The Biosynthesis Of The Capsular Polysaccharide Colanic Acid. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=592, Percent_Identity=29.0540540540541, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI63055049, Length=554, Percent_Identity=29.4223826714801, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71993870, Length=551, Percent_Identity=26.8602540834846, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71993878, Length=314, Percent_Identity=29.9363057324841, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323934, Length=565, Percent_Identity=27.787610619469, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20129809, Length=552, Percent_Identity=28.4420289855072, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24651977, Length=450, Percent_Identity=30.2222222222222, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653722, Length=459, Percent_Identity=27.6688453159041, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17864244, Length=430, Percent_Identity=24.8837209302326, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR016066 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 62984; Mature: 62984

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTNKLFNCLNSPKISQTIKEEYKNKTQEEIDHIFDENYRFKFGTSGVRCIYQEGARYL
CCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCHHH
NVITYTQLALGFIKYLETKKSPNKIIVIGRDNRFGSRENLKLIAEIFSSFDYTVYVNEDY
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCC
GMLSTPITSFLVNELQASAGIMITASHNPKNYNGFKVYNANGAQPLVDDTNTIESLMPSY
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
IEALNFSFEPKQDSIKFLTQQHLQTYFDAVKAQLIHTNLNTKKPFKVVFSGHHGTTTNDM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
IPFLESLGYDMVSVKEQNFEDPNFSDDPSSNPEEQRSFDLSIEYADNANADVMIASDPDG
HHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCHHHCCEEEEEEECCCCCCEEEEEECCCC
DRMAIAVRHQNYKFLTGNQTGVLIAHYLLHHKKFTKPPYIISTFISTRYPELFAKDFNCD
CEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCE
VLYVDVGFKNHGNLVANRKKTHDLVVGFEEAIGSLSSDINNDKDSYQAASILLEMVNYYH
EEEEEECCCCCCCEEECCCCCHHHEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EQNLDLFTVLKKEIFAKYGNYSKTAQFVIDGENKQKALAILNNLKNFEFKTITQYTIQNI
HCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
IFHEQGSYLEKLDEYSTIKFRLSGTEPKFKVYIDLYDFTKDQNRDFYQELKVKVEDILDF
HEECCCCHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LKNYLDL
HHHHHCC
>Mature Secondary Structure
MENTNKLFNCLNSPKISQTIKEEYKNKTQEEIDHIFDENYRFKFGTSGVRCIYQEGARYL
CCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCHHH
NVITYTQLALGFIKYLETKKSPNKIIVIGRDNRFGSRENLKLIAEIFSSFDYTVYVNEDY
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCC
GMLSTPITSFLVNELQASAGIMITASHNPKNYNGFKVYNANGAQPLVDDTNTIESLMPSY
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
IEALNFSFEPKQDSIKFLTQQHLQTYFDAVKAQLIHTNLNTKKPFKVVFSGHHGTTTNDM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
IPFLESLGYDMVSVKEQNFEDPNFSDDPSSNPEEQRSFDLSIEYADNANADVMIASDPDG
HHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCHHHCCEEEEEEECCCCCCEEEEEECCCC
DRMAIAVRHQNYKFLTGNQTGVLIAHYLLHHKKFTKPPYIISTFISTRYPELFAKDFNCD
CEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCE
VLYVDVGFKNHGNLVANRKKTHDLVVGFEEAIGSLSSDINNDKDSYQAASILLEMVNYYH
EEEEEECCCCCCCEEECCCCCHHHEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EQNLDLFTVLKKEIFAKYGNYSKTAQFVIDGENKQKALAILNNLKNFEFKTITQYTIQNI
HCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
IFHEQGSYLEKLDEYSTIKFRLSGTEPKFKVYIDLYDFTKDQNRDFYQELKVKVEDILDF
HEECCCCHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LKNYLDL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8349569 [H]