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The map label for this gene is pepP [H]

Identifier: 209554182

GI number: 209554182

Start: 744255

End: 745328

Strand: Reverse

Name: pepP [H]

Synonym: UUR10_0624

Alternate gene names: 209554182

Gene position: 745328-744255 (Counterclockwise)

Preceding gene: 209554057

Following gene: 209554522

Centisome position: 85.23

GC content: 32.22

Gene sequence:

>1074_bases
ATGAGTGATTTTAAGTTACAACAAGTTTTAAAAACAATTAAAGAACATGAAGCACAAGGCGTAGATGGCATGATTTTATT
TTGCCCTTATAACCGTTATTGATTTTTAGAGTTTGCTTCAAGTGATGGTTTTGTATTTATTAACAAAGATGGTAAAGCAA
TTTATCTAGTTGATGCTCGTTATTATACAGCAGCATCTGAAGCTGTAAAAAATGCTAAGGTAATTTTATTAGCTCGTACA
CCACAAAAATCAACTTTTGATCTTTTAAAAGATGCAATGGTTGAATTAAATATTACTAATGCACTAGTAGAAGCAGATTA
TGTAACATTAAACGTACATGAAATGTTACAAAAATTAGTTAGAAAAACTACTCTTTTTACATCGGCTGCATTACGTGCTA
TTAAAACAGAAAAAGAACTTGAATATTTACAAAAAGCCGCTGATATTGCTGCTTTAACATGTAATTGAATTCGAGAACAA
GATATTATTGGTCGAACAGAACTTGAAGTTGCAATGCTAGTTTCAAAACACATGTTAGAATTAGGTGGCGAACTAAATTC
ATTTGATCCGATTATTGCCTCAGGACCAAATGGAGGTTCACCACACCACCATCCAGGCAATCGTGTAATTGAAGATGGTG
ATATGGTAACAGTTGACATTGGTTGCACTTACAAAGGTTATTGTTCTGATATTACAAGATCTTTCATTGTTGGTAATAAA
GCAAATCCCCAAATGCAAGAAATTTATGATAAAGTACTTGAATCGCAAACAGCTGGAATTGATTTAGTAAGCACAAAAGT
AACTGGTCAAGAAGTTGATAAGTTATGTCGTGATATTATTGATAATTCTAAATTTAACGGCTATTTCACACATGGAACAG
GACATGGTGTTGGATTAGAAGTTCATGAATTACCAAATACTAATGCTGGTAACCCTAATAAATTACCATTAAATGCTGTT
GTTACTGTTGAACCAGGGATTTACATTCCAAATGTTGGTGGCGTAAGAATTGAAGATACAGTTGTAGTAAAAGATGGTCA
AGCTTTAGTTTTAACAAGATTAGCTTATAAATAA

Upstream 100 bases:

>100_bases
GCAAAAAATAATCCAGACAAACTTTCTTTAAACAAATTTTGTCCTAAATGTCGTAAAGTAACAACTCACGTTGAAATTAA
GAAGAAATAGGTATTAGATT

Downstream 100 bases:

>100_bases
AATTTAATAAAAAAGGGTATAGTTCAATTGGTAGAACAGCAGACTCCAAATCTGCGTGTTGCGGGTTCGAGTCCTGTTAC
CCTTGCCATTAAAAATAAAA

Product: peptidase/creatianse family protein

Products: NA

Alternate protein names: X-Pro aminopeptidase; Aminoacylproline aminopeptidase; Aminopeptidase P; APP [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSDFKLQQVLKTIKEHEAQGVDGMILFCPYNRYWFLEFASSDGFVFINKDGKAIYLVDARYYTAASEAVKNAKVILLART
PQKSTFDLLKDAMVELNITNALVEADYVTLNVHEMLQKLVRKTTLFTSAALRAIKTEKELEYLQKAADIAALTCNWIREQ
DIIGRTELEVAMLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNK
ANPQMQEIYDKVLESQTAGIDLVSTKVTGQEVDKLCRDIIDNSKFNGYFTHGTGHGVGLEVHELPNTNAGNPNKLPLNAV
VTVEPGIYIPNVGGVRIEDTVVVKDGQALVLTRLAYK

Sequences:

>Translated_357_residues
MSDFKLQQVLKTIKEHEAQGVDGMILFCPYNRY*FLEFASSDGFVFINKDGKAIYLVDARYYTAASEAVKNAKVILLART
PQKSTFDLLKDAMVELNITNALVEADYVTLNVHEMLQKLVRKTTLFTSAALRAIKTEKELEYLQKAADIAALTCN*IREQ
DIIGRTELEVAMLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNK
ANPQMQEIYDKVLESQTAGIDLVSTKVTGQEVDKLCRDIIDNSKFNGYFTHGTGHGVGLEVHELPNTNAGNPNKLPLNAV
VTVEPGIYIPNVGGVRIEDTVVVKDGQALVLTRLAYK
>Mature_356_residues
SDFKLQQVLKTIKEHEAQGVDGMILFCPYNRY*FLEFASSDGFVFINKDGKAIYLVDARYYTAASEAVKNAKVILLARTP
QKSTFDLLKDAMVELNITNALVEADYVTLNVHEMLQKLVRKTTLFTSAALRAIKTEKELEYLQKAADIAALTCN*IREQD
IIGRTELEVAMLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKA
NPQMQEIYDKVLESQTAGIDLVSTKVTGQEVDKLCRDIIDNSKFNGYFTHGTGHGVGLEVHELPNTNAGNPNKLPLNAVV
TVEPGIYIPNVGGVRIEDTVVVKDGQALVLTRLAYK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=300, Percent_Identity=30, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI264681563, Length=279, Percent_Identity=29.3906810035842, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI93141226, Length=263, Percent_Identity=28.5171102661597, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI149589008, Length=283, Percent_Identity=26.1484098939929, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI260593665, Length=283, Percent_Identity=26.1484098939929, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788728, Length=340, Percent_Identity=34.1176470588235, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789275, Length=242, Percent_Identity=30.5785123966942, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17509539, Length=239, Percent_Identity=30.1255230125523, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=279, Percent_Identity=25.8064516129032, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=251, Percent_Identity=27.4900398406374, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321118, Length=278, Percent_Identity=26.978417266187, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322999, Length=233, Percent_Identity=27.0386266094421, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357079, Length=391, Percent_Identity=25.0639386189258, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=26.0536398467433, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137632, Length=170, Percent_Identity=34.7058823529412, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 39034; Mature: 38903

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFKLQQVLKTIKEHEAQGVDGMILFCPYNRYFLEFASSDGFVFINKDGKAIYLVDARY
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCH
YTAASEAVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLNVHEMLQKLVR
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEEHHHEEEEEEEEEEHHHHHHHHHH
KTTLFTSAALRAIKTEKELEYLQKAADIAALTCNIREQDIIGRTELEVAMLVSKHMLELG
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHC
GELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKAN
CCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCC
PQMQEIYDKVLESQTAGIDLVSTKVTGQEVDKLCRDIIDNSKFNGYFTHGTGHGVGLEVH
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
ELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTVVVKDGQALVLTRLAYK
ECCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEEEEEEEECCCEEEEEEECCC
>Mature Secondary Structure 
SDFKLQQVLKTIKEHEAQGVDGMILFCPYNRYFLEFASSDGFVFINKDGKAIYLVDARY
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCH
YTAASEAVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLNVHEMLQKLVR
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEEHHHEEEEEEEEEEHHHHHHHHHH
KTTLFTSAALRAIKTEKELEYLQKAADIAALTCNIREQDIIGRTELEVAMLVSKHMLELG
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHC
GELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKAN
CCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCC
PQMQEIYDKVLESQTAGIDLVSTKVTGQEVDKLCRDIIDNSKFNGYFTHGTGHGVGLEVH
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
ELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTVVVKDGQALVLTRLAYK
ECCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEEEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993; 8253680 [H]