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The map label for this gene is pth [H]

Identifier: 209554113

GI number: 209554113

Start: 101986

End: 102546

Strand: Reverse

Name: pth [H]

Synonym: UUR10_0084

Alternate gene names: 209554113

Gene position: 102546-101986 (Counterclockwise)

Preceding gene: 209554039

Following gene: 209554128

Centisome position: 11.73

GC content: 26.74

Gene sequence:

>561_bases
GTGGAAAAATATTTAATTGTTGGATTAGGCAATCCAGGTTCAAATTATGCAAAAACAAGACATAATGCTGGTTTTATGGT
AATTAATGAAATTTGCAATAAACTTAATCTTTTTTTAGATAATTCAAAATTTAATGGAATGTTCGCTAAAACAATTTATA
ACAATTGTGTTGTATTTTTTTGTCAACCAACAACTTATATGAATCTAAGTGGTGAATTTGTTAGTAAAATGTTAAAGTTT
TATGACATTCCTATTAAGAACTTAATTGTTATTTATGATGATGTTGACACAAAACTAGGTGTAATAAAATTACGAAAAAA
AGGTTCATCTGGTGGGCAAAATGGAATTAAAAATATCATAAATCTTTTAAAAACTGAAGAGATTAAACGAATACGTGTAG
GAATTGGAAAAGATCCACACGCAAAATTAGATCAATACGTCTTATCAAATTTTAAGATCGATGAATTGGTTATAATTAAA
CCAGCTATTATAAAAGGCGCTTTAGCTGCATTAGAAGCGATTGGTGAAGATTTTGACAAAGTTATGAACAAATTTAATTA
A

Upstream 100 bases:

>100_bases
ATTAGGTGTTTAAATGTGCATAACTTAAAATTTATCTATAATATAATATGCTATTGAAGAAAATTATGAACATTAAGTGT
TTATATTGTGGGTATTAAAT

Downstream 100 bases:

>100_bases
TAAAATTACTAATAAAAAATATTTAGCTGCTGTTTCAGGCGGACCTGATTCTATGGCTATGCTAAATATGTATAAAAGAA
ATATTAGTGTTGTTTGTCAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MEKYLIVGLGNPGSNYAKTRHNAGFMVINEICNKLNLFLDNSKFNGMFAKTIYNNCVVFFCQPTTYMNLSGEFVSKMLKF
YDIPIKNLIVIYDDVDTKLGVIKLRKKGSSGGQNGIKNIINLLKTEEIKRIRVGIGKDPHAKLDQYVLSNFKIDELVIIK
PAIIKGALAALEAIGEDFDKVMNKFN

Sequences:

>Translated_186_residues
MEKYLIVGLGNPGSNYAKTRHNAGFMVINEICNKLNLFLDNSKFNGMFAKTIYNNCVVFFCQPTTYMNLSGEFVSKMLKF
YDIPIKNLIVIYDDVDTKLGVIKLRKKGSSGGQNGIKNIINLLKTEEIKRIRVGIGKDPHAKLDQYVLSNFKIDELVIIK
PAIIKGALAALEAIGEDFDKVMNKFN
>Mature_186_residues
MEKYLIVGLGNPGSNYAKTRHNAGFMVINEICNKLNLFLDNSKFNGMFAKTIYNNCVVFFCQPTTYMNLSGEFVSKMLKF
YDIPIKNLIVIYDDVDTKLGVIKLRKKGSSGGQNGIKNIINLLKTEEIKRIRVGIGKDPHAKLDQYVLSNFKIDELVIIK
PAIIKGALAALEAIGEDFDKVMNKFN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=158, Percent_Identity=26.5822784810127, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=185, Percent_Identity=34.5945945945946, Blast_Score=88, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20904; Mature: 20904

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYLIVGLGNPGSNYAKTRHNAGFMVINEICNKLNLFLDNSKFNGMFAKTIYNNCVVFF
CCCEEEEEECCCCCCCHHHCCCCCEEEHHHHHHHHHEEECCCCCCCCHHHHHHCCEEEEE
CQPTTYMNLSGEFVSKMLKFYDIPIKNLIVIYDDVDTKLGVIKLRKKGSSGGQNGIKNII
ECCCEEEECCHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHH
NLLKTEEIKRIRVGIGKDPHAKLDQYVLSNFKIDELVIIKPAIIKGALAALEAIGEDFDK
HHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VMNKFN
HHHHCC
>Mature Secondary Structure
MEKYLIVGLGNPGSNYAKTRHNAGFMVINEICNKLNLFLDNSKFNGMFAKTIYNNCVVFF
CCCEEEEEECCCCCCCHHHCCCCCEEEHHHHHHHHHEEECCCCCCCCHHHHHHCCEEEEE
CQPTTYMNLSGEFVSKMLKFYDIPIKNLIVIYDDVDTKLGVIKLRKKGSSGGQNGIKNII
ECCCEEEECCHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHH
NLLKTEEIKRIRVGIGKDPHAKLDQYVLSNFKIDELVIIKPAIIKGALAALEAIGEDFDK
HHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VMNKFN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA