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The map label for this gene is fhuB [H]

Identifier: 209554091

GI number: 209554091

Start: 25694

End: 26797

Strand: Reverse

Name: fhuB [H]

Synonym: UUR10_0025

Alternate gene names: 209554091

Gene position: 26797-25694 (Counterclockwise)

Preceding gene: 209553993

Following gene: 209554619

Centisome position: 3.06

GC content: 26.72

Gene sequence:

>1104_bases
ATGCACAATTATACTTTTCGTTTTAAATTATTTAAACAAATTCAAAATCAAACAACTAAAAAGTTAAAACCATTAATTTT
ATTAGTAGCTGCAATTATTTTAATTGCTACTATTTTTAGTATTTGAATATGAAACATTTCATATGCTAATTTTTATGATC
AAACATTAAATAAATATGTTTACTTTTCTTTAAATGAATCACTAAAACTAATTTTTAGTGGCCAATTTTTAGATTCATCA
AATATTAAATATTTAAACTTACAAGCCACATTTTGAGCAAGCATTGCTTCAATTTTATCTGGGATTAGTTTAGCTATAGC
TGGTTGTGTAACACAAGCATTAACAAGAAATCCATTAGCGGATTCAAGTACATTAGGAATTGTACAATCAAGTGTTTTTA
TGATTGTAATTGCTTTTTCACATAATATTATTTCTTTTGGTGGCCTTTTTGGATTTGCGATTGTTGGGGGAATTGTTGCA
AGCATTATTTTATTAATTCTAGTTTTTGCTACAAGAAATAAATTATCATATGTCAAAATTACTTTAGCAGGATTAGCAAT
AGGCGTTTTTTTTAATACAATTGCTTATTTTGTTCGTATTCAAAGTGCTAAGGGTTCAAGTATTAACTTTAAATATGTAT
TAGGGGGAAGTGAAAACATTTATCCAACCCATATTGATCCTTTTTTAACATTATGAGTTAGTGCAGTTTTAATTTTAATT
GGTGTGATTATTGCTTGCGTTTTATCCCATAAATTAACCTTATTAGAAATTGGTGATGAAAAAGCTAAAAATTTAGGATC
ATCAATTATTATTGTTAAAATACTAGCTATTGTATCTACAATTTTTTTAATTTCGCCAACTATTTTATTAGTTGGTAATA
TTGCTTTTGTTGGTTTATTTGCACCTCATATTGTTCGTAAAGTTTTTGGAATTAGAGATTATCGTTATGTTATGCCCTTA
TCAGGATTGTTTGGAGCAATGATTACTTCTTTGGGTTTGATATTATATCGCGAAACAATTTATATTAATTCATCAATATG
AATGAGTTTTATTGGGGCTCCTGTTTTAGCTTATTTAGGATGAAAACATTGAAACAGAGCCTAA

Upstream 100 bases:

>100_bases
TAAATAATTTATATTAAAAAATAAACAAAGACCATTTTTAAAAAATGTTTAATTTGTTATATTTATTAGATTAAAAACTA
GAGAATTAACTATTAAATTA

Downstream 100 bases:

>100_bases
TTTTTTATTATTATTATTATTATTATTTAGATAAATATTAATTATGGTTTAAAAATGAAGATTAGTTTCAAATGTAAATT
GATTAGTGTAATTTCAATAA

Product: ferrichrome ABC transporter

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MHNYTFRFKLFKQIQNQTTKKLKPLILLVAAIILIATIFSIWIWNISYANFYDQTLNKYVYFSLNESLKLIFSGQFLDSS
NIKYLNLQATFWASIASILSGISLAIAGCVTQALTRNPLADSSTLGIVQSSVFMIVIAFSHNIISFGGLFGFAIVGGIVA
SIILLILVFATRNKLSYVKITLAGLAIGVFFNTIAYFVRIQSAKGSSINFKYVLGGSENIYPTHIDPFLTLWVSAVLILI
GVIIACVLSHKLTLLEIGDEKAKNLGSSIIIVKILAIVSTIFLISPTILLVGNIAFVGLFAPHIVRKVFGIRDYRYVMPL
SGLFGAMITSLGLILYRETIYINSSIWMSFIGAPVLAYLGWKHWNRA

Sequences:

>Translated_367_residues
MHNYTFRFKLFKQIQNQTTKKLKPLILLVAAIILIATIFSI*I*NISYANFYDQTLNKYVYFSLNESLKLIFSGQFLDSS
NIKYLNLQATF*ASIASILSGISLAIAGCVTQALTRNPLADSSTLGIVQSSVFMIVIAFSHNIISFGGLFGFAIVGGIVA
SIILLILVFATRNKLSYVKITLAGLAIGVFFNTIAYFVRIQSAKGSSINFKYVLGGSENIYPTHIDPFLTL*VSAVLILI
GVIIACVLSHKLTLLEIGDEKAKNLGSSIIIVKILAIVSTIFLISPTILLVGNIAFVGLFAPHIVRKVFGIRDYRYVMPL
SGLFGAMITSLGLILYRETIYINSSI*MSFIGAPVLAYLG*KH*NRA
>Mature_367_residues
MHNYTFRFKLFKQIQNQTTKKLKPLILLVAAIILIATIFSI*I*NISYANFYDQTLNKYVYFSLNESLKLIFSGQFLDSS
NIKYLNLQATF*ASIASILSGISLAIAGCVTQALTRNPLADSSTLGIVQSSVFMIVIAFSHNIISFGGLFGFAIVGGIVA
SIILLILVFATRNKLSYVKITLAGLAIGVFFNTIAYFVRIQSAKGSSINFKYVLGGSENIYPTHIDPFLTL*VSAVLILI
GVIIACVLSHKLTLLEIGDEKAKNLGSSIIIVKILAIVSTIFLISPTILLVGNIAFVGLFAPHIVRKVFGIRDYRYVMPL
SGLFGAMITSLGLILYRETIYINSSI*MSFIGAPVLAYLG*KH*NRA

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=278, Percent_Identity=25.8992805755396, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786805, Length=263, Percent_Identity=29.277566539924, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788004, Length=233, Percent_Identity=27.8969957081545, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786804, Length=224, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790740, Length=231, Percent_Identity=26.4069264069264, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790741, Length=270, Percent_Identity=25.1851851851852, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 39161; Mature: 39161

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNYTFRFKLFKQIQNQTTKKLKPLILLVAAIILIATIFSIINISYANFYDQTLNKYVYF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SLNESLKLIFSGQFLDSSNIKYLNLQATFASIASILSGISLAIAGCVTQALTRNPLADSS
EECCCEEEEEECCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLGIVQSSVFMIVIAFSHNIISFGGLFGFAIVGGIVASIILLILVFATRNKLSYVKITLA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
GLAIGVFFNTIAYFVRIQSAKGSSINFKYVLGGSENIYPTHIDPFLTLVSAVLILIGVII
HHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ACVLSHKLTLLEIGDEKAKNLGSSIIIVKILAIVSTIFLISPTILLVGNIAFVGLFAPHI
HHHHHCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKVFGIRDYRYVMPLSGLFGAMITSLGLILYRETIYINSSIMSFIGAPVLAYLGKHNRA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHNYTFRFKLFKQIQNQTTKKLKPLILLVAAIILIATIFSIINISYANFYDQTLNKYVYF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SLNESLKLIFSGQFLDSSNIKYLNLQATFASIASILSGISLAIAGCVTQALTRNPLADSS
EECCCEEEEEECCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLGIVQSSVFMIVIAFSHNIISFGGLFGFAIVGGIVASIILLILVFATRNKLSYVKITLA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
GLAIGVFFNTIAYFVRIQSAKGSSINFKYVLGGSENIYPTHIDPFLTLVSAVLILIGVII
HHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ACVLSHKLTLLEIGDEKAKNLGSSIIIVKILAIVSTIFLISPTILLVGNIAFVGLFAPHI
HHHHHCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKVFGIRDYRYVMPLSGLFGAMITSLGLILYRETIYINSSIMSFIGAPVLAYLGKHNRA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]