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The map label for this gene is aphA [H]

Identifier: 209551828

GI number: 209551828

Start: 4432516

End: 4433541

Strand: Direct

Name: aphA [H]

Synonym: Rleg2_4260

Alternate gene names: 209551828

Gene position: 4432516-4433541 (Clockwise)

Preceding gene: 209551826

Following gene: 209551829

Centisome position: 97.68

GC content: 64.13

Gene sequence:

>1026_bases
ATGCGCATCATTTATTCCGAAGACCATAAGCTGCGCGATGCCAAAACCGAGCTGCATGCCGGCCAGCTGGTGACGCCTTT
CGAGGCGCCGTTCCGGGCCGAATGGATCCTGGCGGCGGTGAAGGAGGCGGGTTTTGCCGATGTCGTGGCGCCCGGTGCGC
ACGGGCTGGAAACGGCCAAAAAGGTGCACGATCCCGCCTATCTTGATTTTCTCGCCACGGTCTGGGACCGCTGGGTGGCG
GCCGGTTTCACCGGCGAGGCGATCGCCAATTCCTTTCCGGTGCGCCGCACCAGCCAGCGCGTGCCCGACAATATCGTCGG
CGCGATCGGCCATTATGCCAATGCCGCCGACACCTCGATCACCAAGGGGTCCTACGAGGCGGCGATCGCCTCGATGCGCT
GCGCGCTGACGGGCGCCGACTGGCTGGGTGAGGGCAATCGTTTCGCCTTCGCGCTCTGCCGCCCGCCCGGCCATCATGCC
GGCATCGATCTTTTCGGCGGTTATTGCTTCATCAACAATTCGGGTGTGGCAGCGCAGCGGCTGCTCGATCGTGGCGCGAA
AAAGGTCGCCGTGCTTGATGTCGATTTCCACCATGGCAACGGCACGCAGGATCTCTTCTATCACAGAGGCGATGTCTTCA
CCGCCTCGCTGCACGGCGATCCCATGCAGGCCTTTCCCTATTTCCTCGGCCATGCCGACGAGGAGGGCGAGGGGGCGGGC
ACCGGCGCCAACCGCAACTATCCGATGCCGCCGGGCACGCCCTGGGACGTCTGGTCTGCGGCCCTTGCCGATGCACTTGT
CCGCATCAAGGCCTTTGGCGCCGAGGCGATCGTCGTCGCACTCGGCGTCGATACTTTCGAGCGCGACCCGATCTCCTTCT
TCGGGCTCACCTCCGATGATTTCACCCGCATGGGTGCGATGATCACTTCTGCCGACCTGCCGGTGCTCGTCTGCATGGAG
GGCGGCTACGGCGTGCCGGAAATCGGCCTCAACGTCGCCAACGTTCTCAAGGGTCTGGAAGCCTGA

Upstream 100 bases:

>100_bases
GTGGCGTTATTGCTCTGGATGATCAAGAGGTCGCTTCACCGCTTTTTTGTCGCGGCAACCCCGTGTAAATCTCGAGCTTC
AATCAACGGCAGGATCTGAA

Downstream 100 bases:

>100_bases
TCGCTTGATATGACCGACGAGACCATTCCATCCGATATCCCGACACCCCGCATGCTGAGCTGGGCGCGCAACTCCGCCAT
CTATCGCCTGGAGCGGCGGA

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRIIYSEDHKLRDAKTELHAGQLVTPFEAPFRAEWILAAVKEAGFADVVAPGAHGLETAKKVHDPAYLDFLATVWDRWVA
AGFTGEAIANSFPVRRTSQRVPDNIVGAIGHYANAADTSITKGSYEAAIASMRCALTGADWLGEGNRFAFALCRPPGHHA
GIDLFGGYCFINNSGVAAQRLLDRGAKKVAVLDVDFHHGNGTQDLFYHRGDVFTASLHGDPMQAFPYFLGHADEEGEGAG
TGANRNYPMPPGTPWDVWSAALADALVRIKAFGAEAIVVALGVDTFERDPISFFGLTSDDFTRMGAMITSADLPVLVCME
GGYGVPEIGLNVANVLKGLEA

Sequences:

>Translated_341_residues
MRIIYSEDHKLRDAKTELHAGQLVTPFEAPFRAEWILAAVKEAGFADVVAPGAHGLETAKKVHDPAYLDFLATVWDRWVA
AGFTGEAIANSFPVRRTSQRVPDNIVGAIGHYANAADTSITKGSYEAAIASMRCALTGADWLGEGNRFAFALCRPPGHHA
GIDLFGGYCFINNSGVAAQRLLDRGAKKVAVLDVDFHHGNGTQDLFYHRGDVFTASLHGDPMQAFPYFLGHADEEGEGAG
TGANRNYPMPPGTPWDVWSAALADALVRIKAFGAEAIVVALGVDTFERDPISFFGLTSDDFTRMGAMITSADLPVLVCME
GGYGVPEIGLNVANVLKGLEA
>Mature_341_residues
MRIIYSEDHKLRDAKTELHAGQLVTPFEAPFRAEWILAAVKEAGFADVVAPGAHGLETAKKVHDPAYLDFLATVWDRWVA
AGFTGEAIANSFPVRRTSQRVPDNIVGAIGHYANAADTSITKGSYEAAIASMRCALTGADWLGEGNRFAFALCRPPGHHA
GIDLFGGYCFINNSGVAAQRLLDRGAKKVAVLDVDFHHGNGTQDLFYHRGDVFTASLHGDPMQAFPYFLGHADEEGEGAG
TGANRNYPMPPGTPWDVWSAALADALVRIKAFGAEAIVVALGVDTFERDPISFFGLTSDDFTRMGAMITSADLPVLVCME
GGYGVPEIGLNVANVLKGLEA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=216, Percent_Identity=31.4814814814815, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI30795202, Length=216, Percent_Identity=31.4814814814815, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI17158039, Length=213, Percent_Identity=31.4553990610329, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI153085395, Length=190, Percent_Identity=32.1052631578947, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI8923769, Length=285, Percent_Identity=25.9649122807018, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI13128860, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI169234807, Length=188, Percent_Identity=34.5744680851064, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI148539870, Length=187, Percent_Identity=33.6898395721925, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI13128864, Length=194, Percent_Identity=30.4123711340206, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073088, Length=169, Percent_Identity=28.9940828402367, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI62750347, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI62750349, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI20070354, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI293336691, Length=143, Percent_Identity=29.3706293706294, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=231, Percent_Identity=31.1688311688312, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17540332, Length=231, Percent_Identity=31.1688311688312, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193206283, Length=231, Percent_Identity=31.1688311688312, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193209491, Length=301, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537347, Length=205, Percent_Identity=30.7317073170732, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508561, Length=178, Percent_Identity=29.2134831460674, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=197, Percent_Identity=28.4263959390863, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25154020, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561978, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=227, Percent_Identity=33.0396475770925, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321244, Length=169, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323999, Length=216, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325141, Length=105, Percent_Identity=35.2380952380952, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281360899, Length=255, Percent_Identity=30.9803921568627, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24642144, Length=255, Percent_Identity=30.9803921568627, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24642142, Length=255, Percent_Identity=30.9803921568627, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24642146, Length=255, Percent_Identity=30.9803921568627, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360799, Length=193, Percent_Identity=32.6424870466321, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281360801, Length=192, Percent_Identity=31.7708333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641720, Length=192, Percent_Identity=31.7708333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657891, Length=236, Percent_Identity=26.271186440678, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644244, Length=282, Percent_Identity=23.758865248227, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36511; Mature: 36511

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIYSEDHKLRDAKTELHAGQLVTPFEAPFRAEWILAAVKEAGFADVVAPGAHGLETAK
CEEEECCCCCHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHH
KVHDPAYLDFLATVWDRWVAAGFTGEAIANSFPVRRTSQRVPDNIVGAIGHYANAADTSI
HHCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
TKGSYEAAIASMRCALTGADWLGEGNRFAFALCRPPGHHAGIDLFGGYCFINNSGVAAQR
CCCHHHHHHHHHHHEEECHHHCCCCCEEEEEEECCCCCCCCEEEECCEEEECCCCHHHHH
LLDRGAKKVAVLDVDFHHGNGTQDLFYHRGDVFTASLHGDPMQAFPYFLGHADEEGEGAG
HHHCCCCEEEEEEEEEECCCCCCHHEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCCCC
TGANRNYPMPPGTPWDVWSAALADALVRIKAFGAEAIVVALGVDTFERDPISFFGLTSDD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCHH
FTRMGAMITSADLPVLVCMEGGYGVPEIGLNVANVLKGLEA
HHHHHHHHCCCCCCEEEEECCCCCCCHHCCCHHHHHHHCCC
>Mature Secondary Structure
MRIIYSEDHKLRDAKTELHAGQLVTPFEAPFRAEWILAAVKEAGFADVVAPGAHGLETAK
CEEEECCCCCHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHH
KVHDPAYLDFLATVWDRWVAAGFTGEAIANSFPVRRTSQRVPDNIVGAIGHYANAADTSI
HHCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
TKGSYEAAIASMRCALTGADWLGEGNRFAFALCRPPGHHAGIDLFGGYCFINNSGVAAQR
CCCHHHHHHHHHHHEEECHHHCCCCCEEEEEEECCCCCCCCEEEECCEEEECCCCHHHHH
LLDRGAKKVAVLDVDFHHGNGTQDLFYHRGDVFTASLHGDPMQAFPYFLGHADEEGEGAG
HHHCCCCEEEEEEEEEECCCCCCHHEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCCCC
TGANRNYPMPPGTPWDVWSAALADALVRIKAFGAEAIVVALGVDTFERDPISFFGLTSDD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCHH
FTRMGAMITSADLPVLVCMEGGYGVPEIGLNVANVLKGLEA
HHHHHHHHCCCCCCEEEEECCCCCCCHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]