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The map label for this gene is pepA [H]

Identifier: 209551767

GI number: 209551767

Start: 4370407

End: 4371798

Strand: Direct

Name: pepA [H]

Synonym: Rleg2_4196

Alternate gene names: 209551767

Gene position: 4370407-4371798 (Clockwise)

Preceding gene: 209551765

Following gene: 209551768

Centisome position: 96.31

GC content: 63.36

Gene sequence:

>1392_bases
ATGGCCCCCTATCAGTTTATCGAGAGATCGACCCCTTTCAACGCGAAGGGCGGTTCGACGCTGCCGATCTTCGCCGTCAC
CCCTGCCCATATCGAGACCGGCACGATCGATCCGATCGCGCTCGATTGGGCGCAGAGGGCGGGCTACAAGGCCGAAAGCG
GGTCGCTGCTCTTGATCCCGACGGCCGACGGCCATCTCGGCGGCGCGCTTTTCGGTCTCGGCACCAATCCATCCGAGCAG
CCCTATATCACCGGCAGGCTCGCGCGGGCGCTGCCCGCCGGCGACTGGCACATCGAGACCGCACCGCTGACGGCAAACCG
CCTGGCTCTTGGTTTTGGTCTCGGCAGCTATCGTTTCGACCGTTACAAGTCTGAAAAATCGCCTGCGGCGACGCTGATGA
TCCCCCGCGATGCCGACAGTGCCGACATCAAGCGCCAGCTCGCCGGCGTCTTTCTCGCCCGCGACCTCATCAATACGCCG
ACGAACGACATGGGGCCGAACCAGCTCGAAACCGTGTTCCGTGGCTTGGCTGCACATTACAAGGCTGATGTATCGGTTAT
CACCGGCGACGAGCTGCTCGAGCAGAATTTCCCCCTCGTCCATACCGTCGGCCGCGCCAGCGCCGATGCACCACGCCTTC
TCGAACTACGCTGGGGCAAGAAGGGCCATCGCAAGGTGACGCTCGTCGGCAAGGGTGTCTGCTTCGATACCGGCGGTCTC
GATATCAAGCCCGCCGCCTCCATGCTGCTGATGAAGAAGGACATGGGCGGCGCGGCGAACGTCATGGGCCTTGCCCTGAT
GATCATGGACGCCAAGCTGAAAGTCGATCTGCGTGTCATCGTCCCGGTCGTCGAAAACGCCATCTCGTCCAATGCCTTCC
GCCCCGGCGACATTTATAAGAGCCGCAAGGGCCTGACCGTCCAGATCGACAATACCGACGCCGAAGGCCGTCTGATCCTT
GCCGATGCGCTTGCCTATGCCGACGAGGAAGAGCCCGATCTCCTGATCGACATGGCGACGCTGACCGGTGCTGCCCGCGT
CGCCCTCGGTCCGGACCTCCCGCCCTTCTTCACCGATGACGCCAATCTGGCGCATGACCTGACCGAAGCGAGCCTGGAAA
CGGACGATCCGATCTGGCGGCTGCCGCTCTATTCCGGTTACGAAAAGGATATCCGCACCAAATTCGCCGATCTCACCAAC
GCGCCGGCCGGCGGCATGGCGGGGGCGATCACCGCGGCGCTCTTCCTCAAGCGTTTCGTCGGCAAGACGAAGAGCTGGGC
GCATTTCGACATTTACGGCTGGGCGCAATCCGAGCGGCCGCATTCGCCGGGCGGCGGTGAAGCGCAGGCCATCCGCGCGC
TCTTCCATCATATCCGCGAGAGCCTGCGCTGA

Upstream 100 bases:

>100_bases
GGAACAGGGAAAGGTTTGACGCAATCTTCGCTCCAGCAATAGTCTGTTAACCCTAACAGACCGTTAAGGAGTGATTCCTT
GCGACCGCCGAAGGACAATC

Downstream 100 bases:

>100_bases
CGGCTGCAAACGAGGGCTGAGGGGCGGTGGCATAGTCAAGCATTGCCCCTCCCTGCTGATCGTTAAAATTTTATTCACCC
TGCCGGGCGGCAATTCCTGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAPYQFIERSTPFNAKGGSTLPIFAVTPAHIETGTIDPIALDWAQRAGYKAESGSLLLIPTADGHLGGALFGLGTNPSEQ
PYITGRLARALPAGDWHIETAPLTANRLALGFGLGSYRFDRYKSEKSPAATLMIPRDADSADIKRQLAGVFLARDLINTP
TNDMGPNQLETVFRGLAAHYKADVSVITGDELLEQNFPLVHTVGRASADAPRLLELRWGKKGHRKVTLVGKGVCFDTGGL
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVIVPVVENAISSNAFRPGDIYKSRKGLTVQIDNTDAEGRLIL
ADALAYADEEEPDLLIDMATLTGAARVALGPDLPPFFTDDANLAHDLTEASLETDDPIWRLPLYSGYEKDIRTKFADLTN
APAGGMAGAITAALFLKRFVGKTKSWAHFDIYGWAQSERPHSPGGGEAQAIRALFHHIRESLR

Sequences:

>Translated_463_residues
MAPYQFIERSTPFNAKGGSTLPIFAVTPAHIETGTIDPIALDWAQRAGYKAESGSLLLIPTADGHLGGALFGLGTNPSEQ
PYITGRLARALPAGDWHIETAPLTANRLALGFGLGSYRFDRYKSEKSPAATLMIPRDADSADIKRQLAGVFLARDLINTP
TNDMGPNQLETVFRGLAAHYKADVSVITGDELLEQNFPLVHTVGRASADAPRLLELRWGKKGHRKVTLVGKGVCFDTGGL
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVIVPVVENAISSNAFRPGDIYKSRKGLTVQIDNTDAEGRLIL
ADALAYADEEEPDLLIDMATLTGAARVALGPDLPPFFTDDANLAHDLTEASLETDDPIWRLPLYSGYEKDIRTKFADLTN
APAGGMAGAITAALFLKRFVGKTKSWAHFDIYGWAQSERPHSPGGGEAQAIRALFHHIRESLR
>Mature_462_residues
APYQFIERSTPFNAKGGSTLPIFAVTPAHIETGTIDPIALDWAQRAGYKAESGSLLLIPTADGHLGGALFGLGTNPSEQP
YITGRLARALPAGDWHIETAPLTANRLALGFGLGSYRFDRYKSEKSPAATLMIPRDADSADIKRQLAGVFLARDLINTPT
NDMGPNQLETVFRGLAAHYKADVSVITGDELLEQNFPLVHTVGRASADAPRLLELRWGKKGHRKVTLVGKGVCFDTGGLD
IKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVIVPVVENAISSNAFRPGDIYKSRKGLTVQIDNTDAEGRLILA
DALAYADEEEPDLLIDMATLTGAARVALGPDLPPFFTDDANLAHDLTEASLETDDPIWRLPLYSGYEKDIRTKFADLTNA
PAGGMAGAITAALFLKRFVGKTKSWAHFDIYGWAQSERPHSPGGGEAQAIRALFHHIRESLR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=375, Percent_Identity=37.0666666666667, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI47155554, Length=295, Percent_Identity=32.5423728813559, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI87082123, Length=323, Percent_Identity=38.0804953560372, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1790710, Length=288, Percent_Identity=39.5833333333333, Blast_Score=189, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=293, Percent_Identity=37.2013651877133, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=32.5581395348837, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355725, Length=339, Percent_Identity=31.5634218289086, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=34.0425531914894, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=292, Percent_Identity=35.2739726027397, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379062, Length=292, Percent_Identity=35.2739726027397, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357381, Length=292, Percent_Identity=35.2739726027397, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24662227, Length=341, Percent_Identity=26.099706744868, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI20129969, Length=342, Percent_Identity=27.4853801169591, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355645, Length=363, Percent_Identity=23.4159779614325, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24662223, Length=363, Percent_Identity=23.4159779614325, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19922386, Length=324, Percent_Identity=26.2345679012346, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161077148, Length=286, Percent_Identity=29.020979020979, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130057, Length=286, Percent_Identity=29.020979020979, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129963, Length=335, Percent_Identity=27.1641791044776, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646701, Length=217, Percent_Identity=35.0230414746544, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646703, Length=217, Percent_Identity=35.0230414746544, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21358201, Length=217, Percent_Identity=35.0230414746544, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49954; Mature: 49822

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPYQFIERSTPFNAKGGSTLPIFAVTPAHIETGTIDPIALDWAQRAGYKAESGSLLLIP
CCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCCCEEEEE
TADGHLGGALFGLGTNPSEQPYITGRLARALPAGDWHIETAPLTANRLALGFGLGSYRFD
CCCCCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCCEEEECCCCCCCEEEEECCCCHHHH
RYKSEKSPAATLMIPRDADSADIKRQLAGVFLARDLINTPTNDMGPNQLETVFRGLAAHY
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KADVSVITGDELLEQNFPLVHTVGRASADAPRLLELRWGKKGHRKVTLVGKGVCFDTGGL
HCCEEEEECHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCCCEEEEEEECCEEEECCCC
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVIVPVVENAISSNAFRPGDIYK
CCCHHHHHHEEHHCCCCHHHHHHHHHHEECCCEEEEEEEEHHHHHHHHHCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLILADALAYADEEEPDLLIDMATLTGAARVALGPDLPPFFTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCCCCCC
ANLAHDLTEASLETDDPIWRLPLYSGYEKDIRTKFADLTNAPAGGMAGAITAALFLKRFV
CHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GKTKSWAHFDIYGWAQSERPHSPGGGEAQAIRALFHHIRESLR
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
APYQFIERSTPFNAKGGSTLPIFAVTPAHIETGTIDPIALDWAQRAGYKAESGSLLLIP
CCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCCCEEEEE
TADGHLGGALFGLGTNPSEQPYITGRLARALPAGDWHIETAPLTANRLALGFGLGSYRFD
CCCCCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCCEEEECCCCCCCEEEEECCCCHHHH
RYKSEKSPAATLMIPRDADSADIKRQLAGVFLARDLINTPTNDMGPNQLETVFRGLAAHY
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KADVSVITGDELLEQNFPLVHTVGRASADAPRLLELRWGKKGHRKVTLVGKGVCFDTGGL
HCCEEEEECHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCCCEEEEEEECCEEEECCCC
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVIVPVVENAISSNAFRPGDIYK
CCCHHHHHHEEHHCCCCHHHHHHHHHHEECCCEEEEEEEEHHHHHHHHHCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLILADALAYADEEEPDLLIDMATLTGAARVALGPDLPPFFTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCCCCCC
ANLAHDLTEASLETDDPIWRLPLYSGYEKDIRTKFADLTNAPAGGMAGAITAALFLKRFV
CHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GKTKSWAHFDIYGWAQSERPHSPGGGEAQAIRALFHHIRESLR
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA