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The map label for this gene is hslU [H]

Identifier: 209551554

GI number: 209551554

Start: 4133924

End: 4135231

Strand: Direct

Name: hslU [H]

Synonym: Rleg2_3983

Alternate gene names: 209551554

Gene position: 4133924-4135231 (Clockwise)

Preceding gene: 209551553

Following gene: 209551555

Centisome position: 91.1

GC content: 61.93

Gene sequence:

>1308_bases
ATGACGACCTTTTCCCCTCGCGAGATCGTTTCCGAACTCGATCGCTACATTATCGGCCAGCATGATGCCAAACGCGCCGT
CGCCATCGCGCTGCGCAACCGCTGGCGCCGGCAGCAGCTCGACCCGAGCCTGCGCGACGAAGTCATGCCGAAGAACATCC
TGATGATCGGCCCGACCGGCGTCGGCAAGACCGAAATCTCCCGCCGCCTGGCAAAACTCGCCGGCGCGCCCTTCATCAAG
GTTGAGGCCACCAAATTCACCGAAGTCGGTTATGTTGGCCGCGATGTCGAGCAGATCATCCGCGATCTGGTCGAGGTCGG
CATCGGTCTCGTGCGTGAGAAGAAGCGGACCGAGGTCCAGGCCAAGGCGCATGTCAGCGCCGAGGAGCGTGTTCTCGATG
CGCTGGTCGGCACCACCGCATCGCCCGCCACCCGCGAAAGCTTCCGCAAGAAGCTGCGGGACGGCGAGCTCGACGACAAG
GAAATCGATATCGAGGTGGCCGATGCCGGTTCCGGCATGGGAGGATTCGAAATACCCGGCATGCCGGGCGCCAATATCGG
CGTGCTCAATCTGTCTGAGATGTTCGGCAAGGCGATGGGCGGACGCACCAAGAAGGTCCGCACGACCGTCAAGGCCTCCT
ATACCGACCTGATCCGTGATGAATCCGACAAGCTTATCGACAATGAGGTGATCCAGCGCGAGGCCGTTCGCTCCACCGAG
AATGACGGGATCGTCTTCCTCGATGAAATCGACAAGATCGCCGCCCGCGACGGCGGCATGGGCGCCGGCGTTTCGCGCGA
AGGCGTCCAGCGTGACCTTCTGCCGCTCGTCGAAGGCACGACGGTTTCGACCAAATACGGGCCGGTGAAGACGGATCATA
TCCTCTTCATCGCCTCAGGCGCCTTCCATGTCTCCAAACCCTCCGATCTTCTGCCGGAGCTGCAGGGCCGATTGCCGATC
CGCGTCGAATTGCGCCCGCTGAACAAGGAGGATTTCCGCCGGATCCTGACCGAGACGGAAGCAAGCCTCATCCGCCAGTA
TCGCGCGCTGATGGAGACCGAAAGCCTGAACCTCGAATTCACCGACGACGCGATCGATGCGCTCGCCGATGTCGCCGTCC
ATCTGAACTCCTCCGTCGAGAATATCGGCGCCCGCAGGCTGCAGACGGTAATGGAGCGGGTCCTGGACGACATTTCCTAT
AACGCCCCCGATCGGGGCGGGACGGCCGTCACCATCGATGCCGCCTATGTGCGCGAACATGTCGGCGATCTCGCGCAGAA
TACCGATCTCTCGCGCTTCATTTTGTGA

Upstream 100 bases:

>100_bases
CGAAGGCTGAATCTCAGGCCTTCCGGCCGCTGCCGCGGCGAACAAAGACGAATTGCGGCCGGGCGCTGATGGCCCTGGAC
CGCCAGGAGAATGACACGCA

Downstream 100 bases:

>100_bases
TATCGGCGCACCGGTCCATGTCTTTCCCGATGTGAATGCCGGATTGTGACGAACTCTCTCTCGACAGCGGGCCTTTTACT
TTTTAGTGAAGGCCCGTTTT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIK
VEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQAKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDK
EIDIEVADAGSGMGGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTE
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASGAFHVSKPSDLLPELQGRLPI
RVELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISY
NAPDRGGTAVTIDAAYVREHVGDLAQNTDLSRFIL

Sequences:

>Translated_435_residues
MTTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIK
VEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQAKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDK
EIDIEVADAGSGMGGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTE
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASGAFHVSKPSDLLPELQGRLPI
RVELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISY
NAPDRGGTAVTIDAAYVREHVGDLAQNTDLSRFIL
>Mature_434_residues
TTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIKV
EATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQAKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDKE
IDIEVADAGSGMGGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTEN
DGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASGAFHVSKPSDLLPELQGRLPIR
VELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISYN
APDRGGTAVTIDAAYVREHVGDLAQNTDLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=57.9418344519016, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=47.0588235294118, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648291, Length=242, Percent_Identity=30.1652892561983, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24648289, Length=242, Percent_Identity=30.1652892561983, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 48017; Mature: 47886

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQ
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDKEIDIEVADAGSGMGGFEIPG
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTE
CCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASG
CCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECC
AFHVSKPSDLLPELQGRLPIRVELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEF
CEECCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISYNAPDRGGTAVTIDAAYVREH
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHH
VGDLAQNTDLSRFIL
HHHHHHCCCHHHHCC
>Mature Secondary Structure 
TTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQ
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDKEIDIEVADAGSGMGGFEIPG
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTE
CCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASG
CCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECC
AFHVSKPSDLLPELQGRLPIRVELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEF
CEECCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISYNAPDRGGTAVTIDAAYVREH
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHH
VGDLAQNTDLSRFIL
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA