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The map label for this gene is alkB [H]

Identifier: 209551543

GI number: 209551543

Start: 4127058

End: 4127675

Strand: Direct

Name: alkB [H]

Synonym: Rleg2_3972

Alternate gene names: 209551543

Gene position: 4127058-4127675 (Clockwise)

Preceding gene: 209551542

Following gene: 209551553

Centisome position: 90.95

GC content: 63.59

Gene sequence:

>618_bases
ATGCCGGAGCTCTTGAGCGGCATTCGCCATCTCCCCGGCTATCTCGACCGGGCGCGTCAGGAGGCCCTAGTCGAGGTGAT
CCGCACGATTGTCGCCGAGGCGCCGCTTTATGTGCCCGTCATGCCCGGGACCGGCAAACCGATGTCGGTGCGGATGACCA
ATTGCGGGCCGCTCGGCTGGGTGACCGACAAGGAGCGCGGCTATCGCTACCAGCCGACGCATCCGGCGACCGGCAGGCCT
TGGCCCTATATGCCGCAGGAATTGCTCGAAATCTGGAATGACGTTGCCGGCTACGACAAGCCGCCGGAAGCCTGCCTGAT
CAATTTCTACTCCGACGACGCCCGCATGGGCCTGCATCAGGACAAGGACGAGAGAGATTTGCAGGCGCCTGTCGTCTCGA
TCTCGCTCGGCAACAGCTGCCTCTTCCGCGTCGGCGGCCTCAGCCGCAATGATCGCACGCTATCCTTCAAGCTTTCGAGC
GGCGATCTGGTCGTGCTGGGCGGCGAGGGGAGACTGTGTTTCCACGGCGTCGACCGCATTCATCCGGCGACGTCGACGCT
CTTGAAGAATGGTGGCCGCATCAATCTGACGCTGCGCCGCGTCAATCCTCCAGGCTGA

Upstream 100 bases:

>100_bases
AAGCCGACCAAGGGTTCGGTCGAGCGCCGCCTGAAGGAAAAATCCGGCCGCTCGGAAGTCAAGAAGATGCGGGGCCGCCC
TGGTGGCGGCAGTGAATGAC

Downstream 100 bases:

>100_bases
TGGGCAGCAAGAATCGCCTGCTATAGTTTCCGCAGCGCGACCTGCTCGATCAGATGGTCCTTGCCCTTTTTCAGGATGAG
ATCGGCACGCGGGCGCGTCG

Product: 2OG-Fe(II) oxygenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MPELLSGIRHLPGYLDRARQEALVEVIRTIVAEAPLYVPVMPGTGKPMSVRMTNCGPLGWVTDKERGYRYQPTHPATGRP
WPYMPQELLEIWNDVAGYDKPPEACLINFYSDDARMGLHQDKDERDLQAPVVSISLGNSCLFRVGGLSRNDRTLSFKLSS
GDLVVLGGEGRLCFHGVDRIHPATSTLLKNGGRINLTLRRVNPPG

Sequences:

>Translated_205_residues
MPELLSGIRHLPGYLDRARQEALVEVIRTIVAEAPLYVPVMPGTGKPMSVRMTNCGPLGWVTDKERGYRYQPTHPATGRP
WPYMPQELLEIWNDVAGYDKPPEACLINFYSDDARMGLHQDKDERDLQAPVVSISLGNSCLFRVGGLSRNDRTLSFKLSS
GDLVVLGGEGRLCFHGVDRIHPATSTLLKNGGRINLTLRRVNPPG
>Mature_204_residues
PELLSGIRHLPGYLDRARQEALVEVIRTIVAEAPLYVPVMPGTGKPMSVRMTNCGPLGWVTDKERGYRYQPTHPATGRPW
PYMPQELLEIWNDVAGYDKPPEACLINFYSDDARMGLHQDKDERDLQAPVVSISLGNSCLFRVGGLSRNDRTLSFKLSSG
DLVVLGGEGRLCFHGVDRIHPATSTLLKNGGRINLTLRRVNPPG

Specific function: Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable a

COG id: COG3145

COG function: function code L; Alkylated DNA repair protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe2OG dioxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI87298840, Length=130, Percent_Identity=32.3076923076923, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1788541, Length=185, Percent_Identity=45.945945945946, Blast_Score=151, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45555401, Length=111, Percent_Identity=35.1351351351351, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 22733; Mature: 22602

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELLSGIRHLPGYLDRARQEALVEVIRTIVAEAPLYVPVMPGTGKPMSVRMTNCGPLGW
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCC
VTDKERGYRYQPTHPATGRPWPYMPQELLEIWNDVAGYDKPPEACLINFYSDDARMGLHQ
CCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
DKDERDLQAPVVSISLGNSCLFRVGGLSRNDRTLSFKLSSGDLVVLGGEGRLCFHGVDRI
CCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCEEECCCCCC
HPATSTLLKNGGRINLTLRRVNPPG
CHHHHHHHHCCCEEEEEEEECCCCC
>Mature Secondary Structure 
PELLSGIRHLPGYLDRARQEALVEVIRTIVAEAPLYVPVMPGTGKPMSVRMTNCGPLGW
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCC
VTDKERGYRYQPTHPATGRPWPYMPQELLEIWNDVAGYDKPPEACLINFYSDDARMGLHQ
CCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
DKDERDLQAPVVSISLGNSCLFRVGGLSRNDRTLSFKLSSGDLVVLGGEGRLCFHGVDRI
CCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCEEECCCCCC
HPATSTLLKNGGRINLTLRRVNPPG
CHHHHHHHHCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150207 [H]