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The map label for this gene is ahcY [H]

Identifier: 209551535

GI number: 209551535

Start: 4118999

End: 4120399

Strand: Reverse

Name: ahcY [H]

Synonym: Rleg2_3964

Alternate gene names: 209551535

Gene position: 4120399-4118999 (Counterclockwise)

Preceding gene: 209551536

Following gene: 209551534

Centisome position: 90.8

GC content: 59.96

Gene sequence:

>1401_bases
ATGAGCACTGAAAAAGATTATGTCGTCGCCGATATCGGGCTTGCGGATTTCGGCCGCAAGGAAATTACGATCGCCGAAAC
CGAAATGCCGGGGCTGATGTCCTGCCGCACCGAATTCGGCCAGGCAAAGCCGCTGAAGGGCGCGCGCATTACCGGCTCGC
TGCATATGACCATCCAGACGGCCGTGCTCATCGAAACGCTGGTTGCTCTCGGCGCCGAAGTTCGCTGGGCCTCGTGCAAC
ATCTTCTCGACGCAGGATCACGCCGCTGCCGCGATCGCCGCCGCCGGCGTTCCTGTTTTCGCCATCAAGGGCGAGTCGCT
CGAAGATTACTGGGTCTATACCGACAAGATCTTCCAGTGGGCCGATGGCGGCCTTTCCAACATGATCCTCGATGACGGCG
GCGACGCCACCATGTACATCCTGCTCGGCGCCCGCGCCGAAGCCGGCGAAGACGTGCTGTCGCATCCGCATTCCGAGGAA
GAGGAAATCCTCTTCGCGCAGATCAAGAAGCGCCTCGCCGCTTCGCCTGGCTGGTTCACCAAGCAGCGCGACGCGATCAA
GGGCGTCACCGAGGAAACGACGACCGGCGTCAACCGCCTCTACCAGCTCAGCCAGAAGGGCCTGCTGCCTTTCCCTGCGA
TCAACGTCAACGATTCCGTCACCAAGTCGAAGTTCGACAATAAGTACGGCTGCAAGGAATCGCTGGTCGACGGCATCCGC
CGCGGCACCGATGTGATGATGGCCGGCAAGGTTGCCGTCGTCTGCGGCTACGGCGATGTCGGCAAGGGTTCTGCCGCTTC
GCTCTCCGGCGCCGGCGCCCGCGTCAAGGTAACCGAAGCCGATCCGATCTGCGCCCTGCAGGCCGCCATGGACGGTTATG
AAGTCGTGCTGCTTGAGGACGTCGTTTCCTCGGCAGATATCTTCATCACCACCACCGGCAACAAGGACGTCATCCGCATC
GACCACATGCGTCAGATGAAGGACATGGCGATCGTCGGCAATATCGGCCACTTCGACAATGAAATCGAAGTCGCCGCACT
TCGCAATCTCAAGTGGACCAACGTCAAGCCGCAGGTCGACCTGATCGAATTCCCCAAGGGCAACCGCATTATCCTTCTTT
CCGAAGGCCGCCTGCTCAATCTCGGCAACGCCACCGGCCATCCGTCCTTCGTGATGTCGGCCTCCTTCACCAACCAGACG
CTGGCGCAGATCGAACTCTTCACCAAGCCCGATCAATATTCCAACCAGGTCTATATCCTGCCGAAGCACCTCGATGAAAA
GGTCGCGCGCCTGCATCTCGACAAGCTCGGCGTGAAGCTGACGCAGCTTTCCGAAGAGCAGGCTGCCTATATCGGCGTCT
CGCCGAAGGGCCCTTTCAAGTCAGACCACTACAGATATTGA

Upstream 100 bases:

>100_bases
CACACATCCGGGCGACCTGCATCAGGACGCGGCCCGTCCATCGCGCGGTCATTTTCGCGCCTGCGCCAATTTTGAGACGT
TTTTCAGCCTGGAGGCCTCT

Downstream 100 bases:

>100_bases
TCTGATCGTTAATATCCACAAGATGTAGAAGCCGCGGCATTGACAAATGCCGCGGCTTATTTTTTGGGCGCTCCCTTCCC
GCCGATTCCCATCCGAAGTA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSTEKDYVVADIGLADFGRKEITIAETEMPGLMSCRTEFGQAKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCN
IFSTQDHAAAAIAAAGVPVFAIKGESLEDYWVYTDKIFQWADGGLSNMILDDGGDATMYILLGARAEAGEDVLSHPHSEE
EEILFAQIKKRLAASPGWFTKQRDAIKGVTEETTTGVNRLYQLSQKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEADPICALQAAMDGYEVVLLEDVVSSADIFITTTGNKDVIRI
DHMRQMKDMAIVGNIGHFDNEIEVAALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQT
LAQIELFTKPDQYSNQVYILPKHLDEKVARLHLDKLGVKLTQLSEEQAAYIGVSPKGPFKSDHYRY

Sequences:

>Translated_466_residues
MSTEKDYVVADIGLADFGRKEITIAETEMPGLMSCRTEFGQAKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCN
IFSTQDHAAAAIAAAGVPVFAIKGESLEDYWVYTDKIFQWADGGLSNMILDDGGDATMYILLGARAEAGEDVLSHPHSEE
EEILFAQIKKRLAASPGWFTKQRDAIKGVTEETTTGVNRLYQLSQKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEADPICALQAAMDGYEVVLLEDVVSSADIFITTTGNKDVIRI
DHMRQMKDMAIVGNIGHFDNEIEVAALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQT
LAQIELFTKPDQYSNQVYILPKHLDEKVARLHLDKLGVKLTQLSEEQAAYIGVSPKGPFKSDHYRY
>Mature_465_residues
STEKDYVVADIGLADFGRKEITIAETEMPGLMSCRTEFGQAKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCNI
FSTQDHAAAAIAAAGVPVFAIKGESLEDYWVYTDKIFQWADGGLSNMILDDGGDATMYILLGARAEAGEDVLSHPHSEEE
EILFAQIKKRLAASPGWFTKQRDAIKGVTEETTTGVNRLYQLSQKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRR
GTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEADPICALQAAMDGYEVVLLEDVVSSADIFITTTGNKDVIRID
HMRQMKDMAIVGNIGHFDNEIEVAALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQTL
AQIELFTKPDQYSNQVYILPKHLDEKVARLHLDKLGVKLTQLSEEQAAYIGVSPKGPFKSDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=58.974358974359, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.8636363636364, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=50.4310344827586, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=50.4310344827586, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=50.8620689655172, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=50.8620689655172, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=49.5689655172414, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.7096774193548, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=56.1586638830898, Blast_Score=494, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=60.3004291845494, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=465, Percent_Identity=50.5376344086022, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.1079913606911, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50755; Mature: 50623

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEKDYVVADIGLADFGRKEITIAETEMPGLMSCRTEFGQAKPLKGARITGSLHMTIQT
CCCCCCEEEEECCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEEEEHHH
AVLIETLVALGAEVRWASCNIFSTQDHAAAAIAAAGVPVFAIKGESLEDYWVYTDKIFQW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHH
ADGGLSNMILDDGGDATMYILLGARAEAGEDVLSHPHSEEEEILFAQIKKRLAASPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDAIKGVTEETTTGVNRLYQLSQKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEADPICALQAAMDGYEVVLLED
CCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHCCCEEEEEEEH
VVSSADIFITTTGNKDVIRIDHMRQMKDMAIVGNIGHFDNEIEVAALRNLKWTNVKPQVD
HHCCCCEEEEECCCCCEEEEHHHHHHHHEEEEECCCCCCCCEEEEEECCCEECCCCCCEE
LIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQTLAQIELFTKPDQYSNQVYIL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEEEEE
PKHLDEKVARLHLDKLGVKLTQLSEEQAAYIGVSPKGPFKSDHYRY
CCHHHHHHHHHHHHHHCEEEECCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
STEKDYVVADIGLADFGRKEITIAETEMPGLMSCRTEFGQAKPLKGARITGSLHMTIQT
CCCCCEEEEECCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEEEEHHH
AVLIETLVALGAEVRWASCNIFSTQDHAAAAIAAAGVPVFAIKGESLEDYWVYTDKIFQW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHH
ADGGLSNMILDDGGDATMYILLGARAEAGEDVLSHPHSEEEEILFAQIKKRLAASPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDAIKGVTEETTTGVNRLYQLSQKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEADPICALQAAMDGYEVVLLED
CCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHCCCEEEEEEEH
VVSSADIFITTTGNKDVIRIDHMRQMKDMAIVGNIGHFDNEIEVAALRNLKWTNVKPQVD
HHCCCCEEEEECCCCCEEEEHHHHHHHHEEEEECCCCCCCCEEEEEECCCEECCCCCCEE
LIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQTLAQIELFTKPDQYSNQVYIL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEEEEE
PKHLDEKVARLHLDKLGVKLTQLSEEQAAYIGVSPKGPFKSDHYRY
CCHHHHHHHHHHHHHHCEEEECCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA