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The map label for this gene is proA [H]

Identifier: 209551447

GI number: 209551447

Start: 4017379

End: 4018662

Strand: Direct

Name: proA [H]

Synonym: Rleg2_3876

Alternate gene names: 209551447

Gene position: 4017379-4018662 (Clockwise)

Preceding gene: 209551446

Following gene: 209551448

Centisome position: 88.53

GC content: 64.64

Gene sequence:

>1284_bases
ATGCTTGATACCGTTGCGCTAAGCCCCGAGATTGACGCGCTGATGAACGACATCGGCCGCAAGGCAAAGGCTGCCGCGCG
ACCACTGAGCTTTGCGTCCACCGAGGTGAAGAACAGGGCGTTGAACGCCATGGCCGATGCGATCCTGGCGAACAAGGCTG
AGATTCTTGCTGAGAATGCCAAGGACCTGAAAGACACCGAAGGCAGCGAGATGCTCGCCTCCTTTGTCGACCGGCTGACA
TTGAACGACAAGCGCGTCGCCGAGATGGCCGAGGGAATCCGCGCCATCGCCGCCCTTGCCGACCCGGTCGGCGAAGTCAT
CGCCGCCTGGGACCGGCCGAACGGCTTGAAGATCGAGCGCGTCCGCACGCCGCTCGGCGTGATCGGCGTCATCTTCGAAA
GCCGGCCGAACGTCACGGCCGATGCCGGCGCCCTCTGCCTCAAGGCGGGCAATGCCGTCATCCTGCGCTGCGGCTCGGAT
TCGCGCCGTTCATCGCAGGCGATCCATGCCTGCCTTGTCGAAGGTCTGAAGGCGGCAGGGCTTCCAGAGCATGCTATCCA
ACTCGTCCCGGTCACCGACCGCGCCGCGGTCGGTGCCATGCTGCGCGGCCTGGATGGGGCGGTCGACGTCATCGTGCCGC
GCGGCGGCAAGAGCCTGGTCGCCCGCGTGCAGAGCGAGGCCCGCGTGCCGGTCTTTGCCCATCTCGAAGGCCTTTGCCAT
ATCTATGTCGATGGCTCGGCCGATATCGAGATGGCGATGCAGATCGTCGTCAATGCCAAGATGCGCCGGACAGGTATCTG
CGGCGCGGCTGAAACCCTGCTCGTCGATGGCGCCGCGATCGGCACGCATCTGACGCCGCTGCTCGAGGTGCTCACCAGTG
CCGGCTGCGAGGTCCGCGCTTCGCCAACGGTGCTGAAGGTCGCGCCCGGCCTGAAGCCCGCGACGGAAGAGGACTGGTCG
ACCGAATATCTCGACGCGATTATTTCGGTCGCCGTCGTCGACGGCATATCGGGCGCGATCGCCCATATCCAGAAATATTC
CTCGAATCATACCGAGGCCGTGATCGCCGAGGATCCCGACGTCGTCGCGCGGTTCTTCACCGAGGTCGATTCAGCGATCC
TGCTGCATAATGCCTCGACGCAGTTTGCCGATGGCGGTGAGTTCGGCATGGGCGCGGAAATCGGCATTGCCACCGGCAAG
ATGCATGCCCGCGGCCCGGTCGGCGTCGAACAGCTCACCTCCTTCAAATATCGGGTGCACGGCGCCGGACAGACGCGGCC
CTGA

Upstream 100 bases:

>100_bases
CTCGGTTATCCCGGCCGCGCCGCCATGGTCCATCGCGACGACATGGTGATGACCGCGCAGATCGGATCGAAATCGGAAAG
GCAGAAGAAGGACGCGGCCC

Downstream 100 bases:

>100_bases
CGTGACGGCGGAGAGTGTGGACCGGCATTATCTCCGCATGCCGCACAGCGAGCGCGGCATGGTCGTCGGCCTGTTCGGCG
GTTCGTTCAATCCGCCGCAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDTVALSPEIDALMNDIGRKAKAAARPLSFASTEVKNRALNAMADAILANKAEILAENAKDLKDTEGSEMLASFVDRLT
LNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSD
SRRSSQAIHACLVEGLKAAGLPEHAIQLVPVTDRAAVGAMLRGLDGAVDVIVPRGGKSLVARVQSEARVPVFAHLEGLCH
IYVDGSADIEMAMQIVVNAKMRRTGICGAAETLLVDGAAIGTHLTPLLEVLTSAGCEVRASPTVLKVAPGLKPATEEDWS
TEYLDAIISVAVVDGISGAIAHIQKYSSNHTEAVIAEDPDVVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVHGAGQTRP

Sequences:

>Translated_427_residues
MLDTVALSPEIDALMNDIGRKAKAAARPLSFASTEVKNRALNAMADAILANKAEILAENAKDLKDTEGSEMLASFVDRLT
LNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSD
SRRSSQAIHACLVEGLKAAGLPEHAIQLVPVTDRAAVGAMLRGLDGAVDVIVPRGGKSLVARVQSEARVPVFAHLEGLCH
IYVDGSADIEMAMQIVVNAKMRRTGICGAAETLLVDGAAIGTHLTPLLEVLTSAGCEVRASPTVLKVAPGLKPATEEDWS
TEYLDAIISVAVVDGISGAIAHIQKYSSNHTEAVIAEDPDVVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVHGAGQTRP
>Mature_427_residues
MLDTVALSPEIDALMNDIGRKAKAAARPLSFASTEVKNRALNAMADAILANKAEILAENAKDLKDTEGSEMLASFVDRLT
LNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSD
SRRSSQAIHACLVEGLKAAGLPEHAIQLVPVTDRAAVGAMLRGLDGAVDVIVPRGGKSLVARVQSEARVPVFAHLEGLCH
IYVDGSADIEMAMQIVVNAKMRRTGICGAAETLLVDGAAIGTHLTPLLEVLTSAGCEVRASPTVLKVAPGLKPATEEDWS
TEYLDAIISVAVVDGISGAIAHIQKYSSNHTEAVIAEDPDVVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVHGAGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=408, Percent_Identity=36.7647058823529, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI62912457, Length=408, Percent_Identity=36.7647058823529, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=40.1960784313725, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17569967, Length=416, Percent_Identity=34.6153846153846, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17569969, Length=416, Percent_Identity=34.6153846153846, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=34.2657342657343, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=33.5766423357664, Blast_Score=232, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44785; Mature: 44785

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTVALSPEIDALMNDIGRKAKAAARPLSFASTEVKNRALNAMADAILANKAEILAENA
CCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KDLKDTEGSEMLASFVDRLTLNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIER
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSDSRRSSQAIHACLVEGLKAAG
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC
LPEHAIQLVPVTDRAAVGAMLRGLDGAVDVIVPRGGKSLVARVQSEARVPVFAHLEGLCH
CCHHHEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHEECCCEEE
IYVDGSADIEMAMQIVVNAKMRRTGICGAAETLLVDGAAIGTHLTPLLEVLTSAGCEVRA
EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHHHHCCCEEEC
SPTVLKVAPGLKPATEEDWSTEYLDAIISVAVVDGISGAIAHIQKYSSNHTEAVIAEDPD
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCHH
VVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVH
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEEE
GAGQTRP
CCCCCCC
>Mature Secondary Structure
MLDTVALSPEIDALMNDIGRKAKAAARPLSFASTEVKNRALNAMADAILANKAEILAENA
CCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KDLKDTEGSEMLASFVDRLTLNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIER
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSDSRRSSQAIHACLVEGLKAAG
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC
LPEHAIQLVPVTDRAAVGAMLRGLDGAVDVIVPRGGKSLVARVQSEARVPVFAHLEGLCH
CCHHHEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHEECCCEEE
IYVDGSADIEMAMQIVVNAKMRRTGICGAAETLLVDGAAIGTHLTPLLEVLTSAGCEVRA
EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHHHHCCCEEEC
SPTVLKVAPGLKPATEEDWSTEYLDAIISVAVVDGISGAIAHIQKYSSNHTEAVIAEDPD
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCHH
VVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVH
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEEE
GAGQTRP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA