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The map label for this gene is phbA [H]

Identifier: 209551393

GI number: 209551393

Start: 3955943

End: 3957124

Strand: Reverse

Name: phbA [H]

Synonym: Rleg2_3822

Alternate gene names: 209551393

Gene position: 3957124-3955943 (Counterclockwise)

Preceding gene: 209551395

Following gene: 209551392

Centisome position: 87.2

GC content: 66.67

Gene sequence:

>1182_bases
ATGAGCAGTTCATCCATCGTCATCGCCAGTGCAGGTCGAACGGCCGTCGGCTCGTTCAACGGCGCTTTCGCAACGGTTCC
CGCGCATGAGCTCGGCGCGGCCGTGATCAAGGGTGCGCTCGCGCGCGCCGGCGTCGATGCCGGCGAAGTGGATGAGGTGA
TCCTCGGTCAGGTGCTCTCTGCCGGCGAGGGCCAGAACCCGGCGCGCCAGGCGGCGATAAAAGCCGGCATTCCGAAGGAG
GCGACGGCCTGGGGCGTCAACCAGCTCTGCGGTTCGGGTCTGCGCGCCGTCGCGCTCGGCATGCAGCAGATCGCCACCGG
CGACGCCAAGATCATCGTTGCCGGCGGCCAGGAATCCATGTCGATGGCGCCGCATGCCATGCACCTGCGCGGCGGCGTCA
AGATGGGCGACGCCAAGATGGTCGACACGATGATCAAGGACGGCCTGACCGATGCCTTCCACGGCTACCACATGGGCATC
ACCGCCGAGAATATCGCCCGTCAGTGGCAGCTTTCGCGCGACGAGCAGGATCAGTTCGCCGTCGCCTCGCAGAACAAGGC
GGAGGCGGCGCAGAAGGCCGGCCGCTTTGCCGACGAGATCATCCCCTACATCATCCAGACGCGTAAGGGCGACGTTACGG
TCGATGCCGACGAATATATCCGCCACGGCGCCACGCTGGAGGCGATGGGCAAGCTGCGCCCGGCCTTCGATAAGGAGGGC
ACGGTGACGGCCGCGAATGCCTCCGGCCTCAACGACGGTGCCGCTGCTGCGGTGCTGATGAGCGAAGCAGAAGCCGTCCG
GCGCGGCATCCAGCCGCTCGCCCGCATCGTTTCCTGGGCAACGGCGGGCGTCGATCCGCAGATCATGGGGACCGGCCCGA
TCCCGGCATCCCGCAAGGCGCTCGAAAGGGCCGGCTGGTCGGTCGGCGATCTCGATCTCGTCGAAGCCAACGAGGCTTTT
GCGGCGCAGGCCTGCGCCGTCACCAAGGATCTCGGATGGGATCCGGCGATCGTCAACGTCAACGGCGGGGCGATCGCGAT
CGGCCATCCGATCGGCGCTTCCGGCGCGCGCGTTCTCAACACGCTGTTGTTCGAAATGAAGCGCCGCGGCGCCAAGCAGG
GCCTTGCTACGCTTTGCATCGGCGGCGGCATGGGTGTCGCCATGTGCTTCGAAGCACTTTAA

Upstream 100 bases:

>100_bases
GTGCCGAAAAATGACCGTGACCGGTCTTCGCGTTTGACTTGCGCTCCAAGCTTTGCCAGTTTCCTCTTATGTAAGTGAGA
CGAAAACGAGGAGCGTCACC

Downstream 100 bases:

>100_bases
ACAGCATACGATCCGTCATTGATTGAAAAATCCCGCCACGGCGGGGCGAAAACAAAAGGGGAGCGGAACATGAGCAGAGT
GGCTGTGGTCACCGGGGGTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSSSSIVIASAGRTAVGSFNGAFATVPAHELGAAVIKGALARAGVDAGEVDEVILGQVLSAGEGQNPARQAAIKAGIPKE
ATAWGVNQLCGSGLRAVALGMQQIATGDAKIIVAGGQESMSMAPHAMHLRGGVKMGDAKMVDTMIKDGLTDAFHGYHMGI
TAENIARQWQLSRDEQDQFAVASQNKAEAAQKAGRFADEIIPYIIQTRKGDVTVDADEYIRHGATLEAMGKLRPAFDKEG
TVTAANASGLNDGAAAAVLMSEAEAVRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALERAGWSVGDLDLVEANEAF
AAQACAVTKDLGWDPAIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRGAKQGLATLCIGGGMGVAMCFEAL

Sequences:

>Translated_393_residues
MSSSSIVIASAGRTAVGSFNGAFATVPAHELGAAVIKGALARAGVDAGEVDEVILGQVLSAGEGQNPARQAAIKAGIPKE
ATAWGVNQLCGSGLRAVALGMQQIATGDAKIIVAGGQESMSMAPHAMHLRGGVKMGDAKMVDTMIKDGLTDAFHGYHMGI
TAENIARQWQLSRDEQDQFAVASQNKAEAAQKAGRFADEIIPYIIQTRKGDVTVDADEYIRHGATLEAMGKLRPAFDKEG
TVTAANASGLNDGAAAAVLMSEAEAVRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALERAGWSVGDLDLVEANEAF
AAQACAVTKDLGWDPAIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRGAKQGLATLCIGGGMGVAMCFEAL
>Mature_392_residues
SSSSIVIASAGRTAVGSFNGAFATVPAHELGAAVIKGALARAGVDAGEVDEVILGQVLSAGEGQNPARQAAIKAGIPKEA
TAWGVNQLCGSGLRAVALGMQQIATGDAKIIVAGGQESMSMAPHAMHLRGGVKMGDAKMVDTMIKDGLTDAFHGYHMGIT
AENIARQWQLSRDEQDQFAVASQNKAEAAQKAGRFADEIIPYIIQTRKGDVTVDADEYIRHGATLEAMGKLRPAFDKEGT
VTAANASGLNDGAAAAVLMSEAEAVRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALERAGWSVGDLDLVEANEAFA
AQACAVTKDLGWDPAIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRGAKQGLATLCIGGGMGVAMCFEAL

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=58.0562659846547, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=43.5897435897436, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=43.0769230769231, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=39.7984886649874, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=32.8638497652582, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=30.7888040712468, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI87082165, Length=387, Percent_Identity=54.5219638242894, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=56.0102301790281, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1787663, Length=389, Percent_Identity=44.2159383033419, Blast_Score=307, Evalue=9e-85,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=43.1818181818182, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=34.2789598108747, Blast_Score=198, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=42.7848101265823, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=39.9491094147583, Blast_Score=287, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=38.3838383838384, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32.4705882352941, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=31, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=43.75, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=38.1074168797954, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=58.4615384615385, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=43.8775510204082, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=40.7594936708861, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.4894613583138, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40409; Mature: 40277

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSSIVIASAGRTAVGSFNGAFATVPAHELGAAVIKGALARAGVDAGEVDEVILGQVLS
CCCCCEEEEECCCCEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEGQNPARQAAIKAGIPKEATAWGVNQLCGSGLRAVALGMQQIATGDAKIIVAGGQESM
CCCCCCHHHHHHHHCCCCCCHHHHCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHH
SMAPHAMHLRGGVKMGDAKMVDTMIKDGLTDAFHGYHMGITAENIARQWQLSRDEQDQFA
HCCCHHHHHCCCCEECCHHHHHHHHHHCCHHHHCCEECCCCHHHHHHHHHCCCCCCHHHH
VASQNKAEAAQKAGRFADEIIPYIIQTRKGDVTVDADEYIRHGATLEAMGKLRPAFDKEG
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAAVLMSEAEAVRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LERAGWSVGDLDLVEANEAFAAQACAVTKDLGWDPAIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCCCHHHHHH
TLLFEMKRRGAKQGLATLCIGGGMGVAMCFEAL
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SSSSIVIASAGRTAVGSFNGAFATVPAHELGAAVIKGALARAGVDAGEVDEVILGQVLS
CCCCEEEEECCCCEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEGQNPARQAAIKAGIPKEATAWGVNQLCGSGLRAVALGMQQIATGDAKIIVAGGQESM
CCCCCCHHHHHHHHCCCCCCHHHHCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHH
SMAPHAMHLRGGVKMGDAKMVDTMIKDGLTDAFHGYHMGITAENIARQWQLSRDEQDQFA
HCCCHHHHHCCCCEECCHHHHHHHHHHCCHHHHCCEECCCCHHHHHHHHHCCCCCCHHHH
VASQNKAEAAQKAGRFADEIIPYIIQTRKGDVTVDADEYIRHGATLEAMGKLRPAFDKEG
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAAVLMSEAEAVRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LERAGWSVGDLDLVEANEAFAAQACAVTKDLGWDPAIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCCCHHHHHH
TLLFEMKRRGAKQGLATLCIGGGMGVAMCFEAL
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]