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The map label for this gene is ywrD [H]

Identifier: 209551350

GI number: 209551350

Start: 3903145

End: 3904926

Strand: Direct

Name: ywrD [H]

Synonym: Rleg2_3779

Alternate gene names: 209551350

Gene position: 3903145-3904926 (Clockwise)

Preceding gene: 209551349

Following gene: 209551351

Centisome position: 86.01

GC content: 64.59

Gene sequence:

>1782_bases
ATGACCGAATTCACGACCCGTCCCGAAATCCTCGGCACCTTCGGTGTCGTTACCTCGACGCACTGGATTGGCTCGGCGGT
CGGCATTAGCATTCTCGAAAAGGGCGGCAATGCCTTCGATGCCGCGGTAGCGACGGGATTCGTACTGCAGATCGTCGAGC
CGCATCTCTGCGGCCCGGGCGGCGACCTGCCCGCGGTGATCTATTCGAAGAAAAAGGACAAGGTCGAGGTCATCTCAGCG
CAAGGGCCGGCACCCGCCGGCGCGACGATCGAGCACTATACCAGCGAAGGCCTGACGCTGATCCCCGGTGACGGCCTGCT
TGCGACAGTCATCCCCGGCGCCTTCGACGGCTGGATGCTGATGCTGCGTGACTACGGCACGATGAGCGTGCGCGACGTTC
TGGAACCGGCGATCTATTACGCCGAGCACGGCCATCCCCTGCTGCCGCGCGTCTCCGCGACCATCAAGGGGCTTGCGGCC
TTCTTCGAAAAGGAATGGCCGACCTCCTACGCGACCTGGCTGCCCGGCGGCAGCGTCCCCGCAGCACAGGCGAATTTCAG
GAATCCGGTGCTTGCCGAAACCTGGAAACGGGTCATTGCCGAAGCCGAGGCAAAAAGCGGCCGGGAGGCACAGGTGGAGG
CGGCGCGCGACGCCTTCTACCGCGGCTTCATCGCTGAAAAGATCGATGCCTATCTGAAGATTGCCGAAGTGATGGATGCG
AGCGGCAGCCGCCACAAGGGCGTGCTGACCGCCAACGACATGGCGACCTGGTCGGCAGCGATCGAGGCGCCGCTGACCTA
TGACTATCACGGCTGGACCATCGCCAAGACCGGTCCCTGGGGCCAGGGCCCGGTCTTCCTGCAGGCCCTGTCGATCCTCA
AGGAGTTGGATCTCGCCGCGATGGACCCTGATGGCGCCGATTTCGTCCATACCGTTACCGAGGCGATGAAGCTCGCCTTC
GCCGACCGCGAGGTCTATTACGGCGATCCCGATTTTTCCGACGTCCCCGTCGCGCATCTGCTGTCGGATGCCTATGCGAG
CGAGCGCCGCAAGCTGATCGGCGCCGACGCCTCCTTCGATCTTCGCCCCGGCATCGTTCCAGGCTTCGAGGCGCAGCATG
ATCTGACGATGAAGATGCTCGGCGCCGCTTCCGGGACCGGGACGGTTTACGAGCCGACCATGGCGCATCTGGAAAAACGC
GGCGACACCGTGCATATCGACGTGATCGACCGCGACGGCAACATGGTCTCCGTCACCCCCTCCGGCGGCTGGCTGCAGTC
TTCACCAACCGTTCCCGGCCTCGGCTTCTGCCTCAATTCCCGCGCCCAGATGTTCTGGCTGAAGGCTGGCCTGCCGACCT
CGCTGGCGCCGGGAAAGCGGCCGCGCACGACGCTGACGCCTTCGCTCGGCCTTTACGAGGGCCGCCCGACCCTGGCTTTC
GGCACGCCGGGCGGCGACCAGCAGGAACAATGGCAGCTCTCCTTTTTCTTGCGCCATGTTAATCACAAGCTGAACCTGCA
GGCAGCAATCGATCACCCGCTGTTTCACACCGCCCATTTTCCGAGCTCCTTCTATCCGCGCACCCGCGAACCCGGCAGCC
TGATGGCCGAAGCGAATTTCGGCCCCGATGTGCTCGATGCGCTCACCCGCAAAGGCCACAAGCTGACTGTCACCGATCCC
TGGACCATCGGCCGGCTGACCGCAGCGCGGCGCGATACCGACGGGCTGCTGCGTGCCGCGGCCACCCCGCGCCTCATGCA
GGCCTATGCGGTCGGACGATAG

Upstream 100 bases:

>100_bases
TCCTCTCCGCGCGCTCGGCACACGCCGGAGCTTCGAGCCATCCGACTTCCTAGAAAAGACATTCGGCCAGAAAAGACATC
CGGCCAGAAGGGCATCCCGA

Downstream 100 bases:

>100_bases
CGCCTGAGCGCGCGTCGTCGACCGCTTCCAAGAGGGGTGGAGGCAACAAGTATTACGGGAAAATAACCCGGGCCGGTGGT
GCGCGACCGGCTCTTTTTGC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTEFTTRPEILGTFGVVTSTHWIGSAVGISILEKGGNAFDAAVATGFVLQIVEPHLCGPGGDLPAVIYSKKKDKVEVISA
QGPAPAGATIEHYTSEGLTLIPGDGLLATVIPGAFDGWMLMLRDYGTMSVRDVLEPAIYYAEHGHPLLPRVSATIKGLAA
FFEKEWPTSYATWLPGGSVPAAQANFRNPVLAETWKRVIAEAEAKSGREAQVEAARDAFYRGFIAEKIDAYLKIAEVMDA
SGSRHKGVLTANDMATWSAAIEAPLTYDYHGWTIAKTGPWGQGPVFLQALSILKELDLAAMDPDGADFVHTVTEAMKLAF
ADREVYYGDPDFSDVPVAHLLSDAYASERRKLIGADASFDLRPGIVPGFEAQHDLTMKMLGAASGTGTVYEPTMAHLEKR
GDTVHIDVIDRDGNMVSVTPSGGWLQSSPTVPGLGFCLNSRAQMFWLKAGLPTSLAPGKRPRTTLTPSLGLYEGRPTLAF
GTPGGDQQEQWQLSFFLRHVNHKLNLQAAIDHPLFHTAHFPSSFYPRTREPGSLMAEANFGPDVLDALTRKGHKLTVTDP
WTIGRLTAARRDTDGLLRAAATPRLMQAYAVGR

Sequences:

>Translated_593_residues
MTEFTTRPEILGTFGVVTSTHWIGSAVGISILEKGGNAFDAAVATGFVLQIVEPHLCGPGGDLPAVIYSKKKDKVEVISA
QGPAPAGATIEHYTSEGLTLIPGDGLLATVIPGAFDGWMLMLRDYGTMSVRDVLEPAIYYAEHGHPLLPRVSATIKGLAA
FFEKEWPTSYATWLPGGSVPAAQANFRNPVLAETWKRVIAEAEAKSGREAQVEAARDAFYRGFIAEKIDAYLKIAEVMDA
SGSRHKGVLTANDMATWSAAIEAPLTYDYHGWTIAKTGPWGQGPVFLQALSILKELDLAAMDPDGADFVHTVTEAMKLAF
ADREVYYGDPDFSDVPVAHLLSDAYASERRKLIGADASFDLRPGIVPGFEAQHDLTMKMLGAASGTGTVYEPTMAHLEKR
GDTVHIDVIDRDGNMVSVTPSGGWLQSSPTVPGLGFCLNSRAQMFWLKAGLPTSLAPGKRPRTTLTPSLGLYEGRPTLAF
GTPGGDQQEQWQLSFFLRHVNHKLNLQAAIDHPLFHTAHFPSSFYPRTREPGSLMAEANFGPDVLDALTRKGHKLTVTDP
WTIGRLTAARRDTDGLLRAAATPRLMQAYAVGR
>Mature_592_residues
TEFTTRPEILGTFGVVTSTHWIGSAVGISILEKGGNAFDAAVATGFVLQIVEPHLCGPGGDLPAVIYSKKKDKVEVISAQ
GPAPAGATIEHYTSEGLTLIPGDGLLATVIPGAFDGWMLMLRDYGTMSVRDVLEPAIYYAEHGHPLLPRVSATIKGLAAF
FEKEWPTSYATWLPGGSVPAAQANFRNPVLAETWKRVIAEAEAKSGREAQVEAARDAFYRGFIAEKIDAYLKIAEVMDAS
GSRHKGVLTANDMATWSAAIEAPLTYDYHGWTIAKTGPWGQGPVFLQALSILKELDLAAMDPDGADFVHTVTEAMKLAFA
DREVYYGDPDFSDVPVAHLLSDAYASERRKLIGADASFDLRPGIVPGFEAQHDLTMKMLGAASGTGTVYEPTMAHLEKRG
DTVHIDVIDRDGNMVSVTPSGGWLQSSPTVPGLGFCLNSRAQMFWLKAGLPTSLAPGKRPRTTLTPSLGLYEGRPTLAFG
TPGGDQQEQWQLSFFLRHVNHKLNLQAAIDHPLFHTAHFPSSFYPRTREPGSLMAEANFGPDVLDALTRKGHKLTVTDPW
TIGRLTAARRDTDGLLRAAATPRLMQAYAVGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=526, Percent_Identity=24.5247148288973, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915090, Length=526, Percent_Identity=24.5247148288973, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915096, Length=526, Percent_Identity=24.5247148288973, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915094, Length=526, Percent_Identity=24.5247148288973, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI113429324, Length=518, Percent_Identity=22.5868725868726, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=23.062381852552, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI153266885, Length=568, Percent_Identity=22.3591549295775, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI153266901, Length=569, Percent_Identity=22.3198594024605, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=588, Percent_Identity=27.891156462585, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI72000294, Length=537, Percent_Identity=23.463687150838, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI212646519, Length=537, Percent_Identity=23.463687150838, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859893, Length=562, Percent_Identity=24.7330960854093, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077496, Length=513, Percent_Identity=25.9259259259259, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64071; Mature: 63940

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFTTRPEILGTFGVVTSTHWIGSAVGISILEKGGNAFDAAVATGFVLQIVEPHLCGPG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
GDLPAVIYSKKKDKVEVISAQGPAPAGATIEHYTSEGLTLIPGDGLLATVIPGAFDGWML
CCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCHHHHH
MLRDYGTMSVRDVLEPAIYYAEHGHPLLPRVSATIKGLAAFFEKEWPTSYATWLPGGSVP
HHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCC
AAQANFRNPVLAETWKRVIAEAEAKSGREAQVEAARDAFYRGFIAEKIDAYLKIAEVMDA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGSRHKGVLTANDMATWSAAIEAPLTYDYHGWTIAKTGPWGQGPVFLQALSILKELDLAA
CCCCCCCEEEECCCHHHHHHHCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCEE
MDPDGADFVHTVTEAMKLAFADREVYYGDPDFSDVPVAHLLSDAYASERRKLIGADASFD
ECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
LRPGIVPGFEAQHDLTMKMLGAASGTGTVYEPTMAHLEKRGDTVHIDVIDRDGNMVSVTP
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEECHHHHHHHHCCCEEEEEEEECCCCEEEECC
SGGWLQSSPTVPGLGFCLNSRAQMFWLKAGLPTSLAPGKRPRTTLTPSLGLYEGRPTLAF
CCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCEEEE
GTPGGDQQEQWQLSFFLRHVNHKLNLQAAIDHPLFHTAHFPSSFYPRTREPGSLMAEANF
CCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEECCC
GPDVLDALTRKGHKLTVTDPWTIGRLTAARRDTDGLLRAAATPRLMQAYAVGR
CHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
TEFTTRPEILGTFGVVTSTHWIGSAVGISILEKGGNAFDAAVATGFVLQIVEPHLCGPG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
GDLPAVIYSKKKDKVEVISAQGPAPAGATIEHYTSEGLTLIPGDGLLATVIPGAFDGWML
CCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCHHHHH
MLRDYGTMSVRDVLEPAIYYAEHGHPLLPRVSATIKGLAAFFEKEWPTSYATWLPGGSVP
HHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCC
AAQANFRNPVLAETWKRVIAEAEAKSGREAQVEAARDAFYRGFIAEKIDAYLKIAEVMDA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGSRHKGVLTANDMATWSAAIEAPLTYDYHGWTIAKTGPWGQGPVFLQALSILKELDLAA
CCCCCCCEEEECCCHHHHHHHCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCEE
MDPDGADFVHTVTEAMKLAFADREVYYGDPDFSDVPVAHLLSDAYASERRKLIGADASFD
ECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
LRPGIVPGFEAQHDLTMKMLGAASGTGTVYEPTMAHLEKRGDTVHIDVIDRDGNMVSVTP
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEECHHHHHHHHCCCEEEEEEEECCCCEEEECC
SGGWLQSSPTVPGLGFCLNSRAQMFWLKAGLPTSLAPGKRPRTTLTPSLGLYEGRPTLAF
CCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCEEEE
GTPGGDQQEQWQLSFFLRHVNHKLNLQAAIDHPLFHTAHFPSSFYPRTREPGSLMAEANF
CCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEECCC
GPDVLDALTRKGHKLTVTDPWTIGRLTAARRDTDGLLRAAATPRLMQAYAVGR
CHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]