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The map label for this gene is atpA [H]

Identifier: 209551226

GI number: 209551226

Start: 3782171

End: 3783700

Strand: Reverse

Name: atpA [H]

Synonym: Rleg2_3654

Alternate gene names: 209551226

Gene position: 3783700-3782171 (Counterclockwise)

Preceding gene: 209551227

Following gene: 209551225

Centisome position: 83.38

GC content: 62.61

Gene sequence:

>1530_bases
ATGGATATCCGCGCCGCGGAAATTTCCGCAATTCTCAAAGACCAGATCAAAAATTTCGGCAAAGAGGCAGAAGTCTCGGA
AGTCGGCCAGGTTCTCTCCGTCGGTGACGGTATCGCCCGCGTCTACGGTCTGGACAATGTCCAGGCCGGTGAAATGGTCG
AGTTCCCCGGCGGCATCCGCGGCATGGCGCTGAACCTTGAATCCGACAATGTCGGCGTCGTTATTTTCGGCTCCGACCGC
GACATCAAGGAAGGCGACACCGTCAAGCGGACAGGCGCCATCGTCGACGTCCCGGTCGGTCCGGAATTGCTCGGCCGCGT
CGTCGACGCGCTCGGCAACCCGATCGACGGCAAGGGCCCGATCAACGCGACGCGCCGCTCGCGCGTCGACGTCAAGGCGC
CTGGCATCATTCCGCGCAAGTCGGTTCATGAGCCGATGTCGACCGGCCTCAAGGCCATCGACGCGCTGATCCCGGTCGGC
CGCGGCCAGCGCGAGCTGGTCATCGGCGACCGCCAGACCGGCAAGACCGCCATTCTTCTCGATGCCTTCCTCAACCAGAA
GGCCATTCACGACAACGGCCCGGAAGGCGAAAAGCTTTACTGCGTCTACGTCGCCGTCGGCCAGAAGCGCTCGACCGTTG
CCCAGTTCGTCAAGGTGCTCGAAGAGCGCGGCGCACTGAAGTATTCGATCATCGTTGCCGCCACCGCTTCCGACCCGGCC
CCGATGCAGTTCCTGGCTCCGTTTGCCGGCTGCGCCATGGGCGAATATTTCCGCGACAACGGCATGCATGCGCTGATCGG
TTATGACGACCTGTCGAAGCAGGCCGTGTCCTACCGCCAGATGTCGCTGCTGCTGCGCCGCCCGCCGGGCCGCGAAGCCT
ATCCGGGCGATGTTTTCTACCTGCACTCGCGTCTGCTCGAGCGCGCTGCGAAGATGAACGACGACAAGGGCGCCGGTTCG
CTGACCGCTCTGCCGGTTATCGAAACGCAGGGCAACGACGTGTCGGCCTTCATTCCGACCAACGTGATCTCGATCACAGA
CGGCCAGATCTTCCTTGAAACCGACCTGTTCTACCAGGGTATCCGCCCGGCCGTGAACGTCGGTCTGTCGGTTTCCCGCG
TCGGCTCGTCGGCACAGATCAAGGCGATGAAGCAGGTTGCCGGCTCGATCAAGGGCGAACTCGCCCAGTATCGCGAAATG
GCCGCCTTCGCCCAGTTCGGTTCGGACCTCGACGCTGCGACGCAGCGGCTGCTGAACCGCGGCGCACGCCTGACCGAACT
CCTGAAGCAGCCGCAGTTCTCGCCGCTGAAGACGGAAGAGCAGGTCGCGGTGATCTTCGCCGGCGTCAACGGCTATCTCG
ACAAGCTGCCGGTTGCTTCGGTCGGCAAGTTCGAGCAGGGCTTCCTCTCCTATTTGCGTTCGGAAGGCTCTGCCATCCTC
GACGCGATCCGCACGGAAAAGGCAATCAGCGACGATACCAAGGGCAAGCTCACCGCTGCTCTCGATAGCTTCGCAAAGTC
TTTCTCGTAA

Upstream 100 bases:

>100_bases
TTCTTGGTGGTCTGATCGTCAAGGTCGGGTCCCGCCAGATTGATACGTCTCTTCGTACCAAACTCTCCACTCTTAAGCTC
GCATTGAAAGAGGTTGGCTG

Downstream 100 bases:

>100_bases
TCAGGCCCTAAGTTAGGACGGATCACGGATGCCTTCACTTAAGGATCTGAAAAACCGGATCGCCTCCGTCAAGGCGACGC
AGAAGATCACCAAGGCGATG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAILLDAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIVAATASDPA
PMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDKGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVASVGKFEQGFLSYLRSEGSAIL
DAIRTEKAISDDTKGKLTAALDSFAKSFS

Sequences:

>Translated_509_residues
MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAILLDAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIVAATASDPA
PMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDKGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVASVGKFEQGFLSYLRSEGSAIL
DAIRTEKAISDDTKGKLTAALDSFAKSFS
>Mature_509_residues
MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAILLDAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIVAATASDPA
PMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDKGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVASVGKFEQGFLSYLRSEGSAIL
DAIRTEKAISDDTKGKLTAALDSFAKSFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=70.9741550695825, Blast_Score=736, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=70.9741550695825, Blast_Score=736, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=350, Percent_Identity=26.8571428571429, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913426, Length=355, Percent_Identity=27.0422535211268, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI32189394, Length=405, Percent_Identity=24.4444444444444, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI19913424, Length=250, Percent_Identity=25.6, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790172, Length=520, Percent_Identity=55.1923076923077, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=25.1173708920188, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788251, Length=302, Percent_Identity=28.1456953642384, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=71.1729622266402, Blast_Score=736, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=71.1729622266402, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=65.6063618290258, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=334, Percent_Identity=26.0479041916168, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17510931, Length=298, Percent_Identity=28.5234899328859, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=401, Percent_Identity=24.1895261845387, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=57.8947368421053, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=52, Percent_Identity=63.4615384615385, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=262, Percent_Identity=25.1908396946565, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=69.7211155378486, Blast_Score=734, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=376, Percent_Identity=29.2553191489362, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=404, Percent_Identity=25, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=70.4950495049505, Blast_Score=734, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=336, Percent_Identity=27.6785714285714, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646341, Length=336, Percent_Identity=27.6785714285714, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17136796, Length=336, Percent_Identity=27.6785714285714, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24638766, Length=402, Percent_Identity=24.3781094527363, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574560, Length=421, Percent_Identity=24.7030878859857, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 54637; Mature: 54637

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLESDNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAILL
CCCCCCCCCEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
DAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIVAATASDPA
HHHHCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKMNDDKGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVASVGKFEQGFLSYLRSEGSAIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHCCCHHHH
DAIRTEKAISDDTKGKLTAALDSFAKSFS
HHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLESDNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAILL
CCCCCCCCCEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
DAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIVAATASDPA
HHHHCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKMNDDKGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVASVGKFEQGFLSYLRSEGSAIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHCCCHHHH
DAIRTEKAISDDTKGKLTAALDSFAKSFS
HHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]