Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 209551191

GI number: 209551191

Start: 3737696

End: 3738883

Strand: Direct

Name: dxr [H]

Synonym: Rleg2_3617

Alternate gene names: 209551191

Gene position: 3737696-3738883 (Clockwise)

Preceding gene: 209551188

Following gene: 209551199

Centisome position: 82.37

GC content: 65.07

Gene sequence:

>1188_bases
ATGACCGGCAAAACCGCGCCGCGGCGCCTCAGCATCTTCGGCTCGACCGGCTCGATCGGCCAGAACACTCTCAATGTCGT
CGATCACCTGGGCGGACGGGAGAATTTCGAAATTTCCGTGCTGACCGGCAACGGCAATGTCGAATTGCTGGCCCGGCAGG
CGAAGGATTTCGGCGCGCGGATGGCGGTGACGGCAAACGACCGCCATTACGAAGCGCTGAAGAGCGCGCTTTCCGGCAGC
GGCATCGCGGTCGCATCCGGAAAATCCGGCCTGATGGAGGCCGCCGATCGCGGAGCCGACTGGGTGATGGCGGCAATCGT
CGGCACCGCGGGCCTGGCGCCGACACTTGCCGCAGCAAAGCGCGGCGCCGATATCGCCCTTGCCAACAAGGAATGCCTGG
TTTCGGCCGGCGATCTGTTCATCAGCGCCATCCGCAAGGGCGGCGGCAGGCTGCTTCCCGTCGACAGCGAGCACAATGCG
ATTTTCCAGGTGCTGGAGGAAAACCAGCGCCATGCCATCGAGCGCGTCGTGCTGACGGCTTCGGGCGGCCCCTTCCGCAC
CGCCTCGCTGAAGGAGATGGCCGGTGTGACGGCGGAAACCGCGCGCGCCCACCCGAACTGGTCGATGGGCCTGAAGATCT
CGATCGACAGCGCCTCGATGTTCAACAAGGCGCTTGAAATGATCGAAGCCCGGCATCTGTTCGGCCTGACGCCCGAACAG
ATCGAGGTCATCATCCATCCGCAATCGATCATCCATTCGATGGTCGGCTATACCGACGGTTCGGTGCTCGCTCAGCTCGG
CGCCCCCGATATGCGCACCGCCATCGGTTATGCCCTATCCTTTCCGCGCCGGCCGAACCTGCCGATCGAGCGGCTGGATT
TCGCCAAGCTCGCCAGACTCGATTTCGAGGCGCCGGACGAGCTGCGATTTCCCGCCTTGCGGCTGGCGCGCCTGGCGATG
ACGCGCGGCGGTGTTCAGGGCGCGGTGCTGAACGGCGCCAAGGAAGTGGCGCTCGAAGCCTTCATCGAAGGGCGGCTGCC
CTTCCTCGCCATGGCCGAGATCACCGAAAGGGTCATGGACGATCTGGCCGGCCTGCCGCCGGCTGAAGACATGGACGATG
TCTTCGCCGCCGACCGGCAGGCCAGGCAGAGGGCAGCGGATCTGATGAAGCTGGAGATCGCCGGCTGA

Upstream 100 bases:

>100_bases
CCCTTGAGGGATGAAATCTGCTGCACCGCACACTTGCCGCCCCCTGCAAAGCCTAGTAGAGCCTGAGCCTACGAGAGAAA
TTTTCGCGAAATTGCAGATA

Downstream 100 bases:

>100_bases
AGTTTACCGCAGCCGGTTGCCAACCTCGTCGAACAAGCGGCAATCCGACGGTTCGAACAGCAGGCCGACCTGCTCGCCCG
CCGCGAAGATGATCGGTGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTGKTAPRRLSIFGSTGSIGQNTLNVVDHLGGRENFEISVLTGNGNVELLARQAKDFGARMAVTANDRHYEALKSALSGS
GIAVASGKSGLMEAADRGADWVMAAIVGTAGLAPTLAAAKRGADIALANKECLVSAGDLFISAIRKGGGRLLPVDSEHNA
IFQVLEENQRHAIERVVLTASGGPFRTASLKEMAGVTAETARAHPNWSMGLKISIDSASMFNKALEMIEARHLFGLTPEQ
IEVIIHPQSIIHSMVGYTDGSVLAQLGAPDMRTAIGYALSFPRRPNLPIERLDFAKLARLDFEAPDELRFPALRLARLAM
TRGGVQGAVLNGAKEVALEAFIEGRLPFLAMAEITERVMDDLAGLPPAEDMDDVFAADRQARQRAADLMKLEIAG

Sequences:

>Translated_395_residues
MTGKTAPRRLSIFGSTGSIGQNTLNVVDHLGGRENFEISVLTGNGNVELLARQAKDFGARMAVTANDRHYEALKSALSGS
GIAVASGKSGLMEAADRGADWVMAAIVGTAGLAPTLAAAKRGADIALANKECLVSAGDLFISAIRKGGGRLLPVDSEHNA
IFQVLEENQRHAIERVVLTASGGPFRTASLKEMAGVTAETARAHPNWSMGLKISIDSASMFNKALEMIEARHLFGLTPEQ
IEVIIHPQSIIHSMVGYTDGSVLAQLGAPDMRTAIGYALSFPRRPNLPIERLDFAKLARLDFEAPDELRFPALRLARLAM
TRGGVQGAVLNGAKEVALEAFIEGRLPFLAMAEITERVMDDLAGLPPAEDMDDVFAADRQARQRAADLMKLEIAG
>Mature_394_residues
TGKTAPRRLSIFGSTGSIGQNTLNVVDHLGGRENFEISVLTGNGNVELLARQAKDFGARMAVTANDRHYEALKSALSGSG
IAVASGKSGLMEAADRGADWVMAAIVGTAGLAPTLAAAKRGADIALANKECLVSAGDLFISAIRKGGGRLLPVDSEHNAI
FQVLEENQRHAIERVVLTASGGPFRTASLKEMAGVTAETARAHPNWSMGLKISIDSASMFNKALEMIEARHLFGLTPEQI
EVIIHPQSIIHSMVGYTDGSVLAQLGAPDMRTAIGYALSFPRRPNLPIERLDFAKLARLDFEAPDELRFPALRLARLAMT
RGGVQGAVLNGAKEVALEAFIEGRLPFLAMAEITERVMDDLAGLPPAEDMDDVFAADRQARQRAADLMKLEIAG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=45.7286432160804, Blast_Score=318, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42091; Mature: 41960

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKTAPRRLSIFGSTGSIGQNTLNVVDHLGGRENFEISVLTGNGNVELLARQAKDFGAR
CCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCE
MAVTANDRHYEALKSALSGSGIAVASGKSGLMEAADRGADWVMAAIVGTAGLAPTLAAAK
EEEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHH
RGADIALANKECLVSAGDLFISAIRKGGGRLLPVDSEHNAIFQVLEENQRHAIERVVLTA
CCCCEEEECCHHEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEE
SGGPFRTASLKEMAGVTAETARAHPNWSMGLKISIDSASMFNKALEMIEARHLFGLTPEQ
CCCCCCCCHHHHHHCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHH
IEVIIHPQSIIHSMVGYTDGSVLAQLGAPDMRTAIGYALSFPRRPNLPIERLDFAKLARL
EEEEECCHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
DFEAPDELRFPALRLARLAMTRGGVQGAVLNGAKEVALEAFIEGRLPFLAMAEITERVMD
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLAGLPPAEDMDDVFAADRQARQRAADLMKLEIAG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TGKTAPRRLSIFGSTGSIGQNTLNVVDHLGGRENFEISVLTGNGNVELLARQAKDFGAR
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCE
MAVTANDRHYEALKSALSGSGIAVASGKSGLMEAADRGADWVMAAIVGTAGLAPTLAAAK
EEEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHH
RGADIALANKECLVSAGDLFISAIRKGGGRLLPVDSEHNAIFQVLEENQRHAIERVVLTA
CCCCEEEECCHHEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEE
SGGPFRTASLKEMAGVTAETARAHPNWSMGLKISIDSASMFNKALEMIEARHLFGLTPEQ
CCCCCCCCHHHHHHCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHH
IEVIIHPQSIIHSMVGYTDGSVLAQLGAPDMRTAIGYALSFPRRPNLPIERLDFAKLARL
EEEEECCHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
DFEAPDELRFPALRLARLAMTRGGVQGAVLNGAKEVALEAFIEGRLPFLAMAEITERVMD
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLAGLPPAEDMDDVFAADRQARQRAADLMKLEIAG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA