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The map label for this gene is hpt [H]

Identifier: 209551146

GI number: 209551146

Start: 3699320

End: 3699862

Strand: Reverse

Name: hpt [H]

Synonym: Rleg2_3570

Alternate gene names: 209551146

Gene position: 3699862-3699320 (Counterclockwise)

Preceding gene: 209551147

Following gene: 209551145

Centisome position: 81.53

GC content: 61.88

Gene sequence:

>543_bases
ATGCCTGTCGTGCGCGGAAAAAATATCGAGCCGCTCTTCACTGCCGAGCAGATCGCCGAGCGCAATCATTCGATGGCGCG
GGAGATCGCCAACGGGCCGACCAAGGACCTGCTCGTCATCGCCGTGCTCAAGGGCTCGTTCATCTTCGCCGCCGATCTGA
TCCGCGCCCTGCATGATAGCGGGCTTGCTCCCGAGGTCGAGTTCATCACGCTGTCGAGCTATGGCATCGGCACGGTCTCG
CAGGGCGTGCGCATCGTCAAGGATATCGACAGCGACGTCCATGGCCGCGACGTGCTGCTGATCGACGATATCCTCGAATC
CGGCCGCACCCTGCTCTTTGCCAAGGAATTGCTGTTCGAGCGCGGCGCGCGCAACGTCACCATCGCCGTGCTGCTCGACA
AGCGCGTCAAGCGCAAGGAAAAGCTGGAGGCCGATTATGTCGGCTTCGAATGCCCCGACTATTTCGTCGTCGGCTACGGC
ATGGATGTGGCTTACGCCTTTCGCGAACTGCCCTTCGTCGGTGTGGTCACCGGCGACGCCTGA

Upstream 100 bases:

>100_bases
GTGCGGGTCGCGCCAATCCGTTAATTTCATGGCTAACGAGGCTGTTTCAAGCTCGCATATGTGCTAACGGCTTACCCTTC
TTTTCATGGAGCAAGCCCTT

Downstream 100 bases:

>100_bases
GCTGCTGCACAATTCCTTAAATCGAAAAATTGTGCAGCAAGTGTAACAGCGTCCTTTGTGCGTCTTGTCAGACGCACGGC
GCTGTCATGCTGTCGAGACG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MPVVRGKNIEPLFTAEQIAERNHSMAREIANGPTKDLLVIAVLKGSFIFAADLIRALHDSGLAPEVEFITLSSYGIGTVS
QGVRIVKDIDSDVHGRDVLLIDDILESGRTLLFAKELLFERGARNVTIAVLLDKRVKRKEKLEADYVGFECPDYFVVGYG
MDVAYAFRELPFVGVVTGDA

Sequences:

>Translated_180_residues
MPVVRGKNIEPLFTAEQIAERNHSMAREIANGPTKDLLVIAVLKGSFIFAADLIRALHDSGLAPEVEFITLSSYGIGTVS
QGVRIVKDIDSDVHGRDVLLIDDILESGRTLLFAKELLFERGARNVTIAVLLDKRVKRKEKLEADYVGFECPDYFVVGYG
MDVAYAFRELPFVGVVTGDA
>Mature_179_residues
PVVRGKNIEPLFTAEQIAERNHSMAREIANGPTKDLLVIAVLKGSFIFAADLIRALHDSGLAPEVEFITLSSYGIGTVSQ
GVRIVKDIDSDVHGRDVLLIDDILESGRTLLFAKELLFERGARNVTIAVLLDKRVKRKEKLEADYVGFECPDYFVVGYGM
DVAYAFRELPFVGVVTGDA

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=186, Percent_Identity=32.258064516129, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI9910262, Length=168, Percent_Identity=32.1428571428571, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=38.150289017341, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17510817, Length=156, Percent_Identity=37.1794871794872, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19828; Mature: 19697

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVVRGKNIEPLFTAEQIAERNHSMAREIANGPTKDLLVIAVLKGSFIFAADLIRALHDS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHHHC
GLAPEVEFITLSSYGIGTVSQGVRIVKDIDSDVHGRDVLLIDDILESGRTLLFAKELLFE
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCEEEHHHHHHHH
RGARNVTIAVLLDKRVKRKEKLEADYVGFECPDYFVVGYGMDVAYAFRELPFVGVVTGDA
CCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHCCEEEEEECCC
>Mature Secondary Structure 
PVVRGKNIEPLFTAEQIAERNHSMAREIANGPTKDLLVIAVLKGSFIFAADLIRALHDS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHHHC
GLAPEVEFITLSSYGIGTVSQGVRIVKDIDSDVHGRDVLLIDDILESGRTLLFAKELLFE
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCEEEHHHHHHHH
RGARNVTIAVLLDKRVKRKEKLEADYVGFECPDYFVVGYGMDVAYAFRELPFVGVVTGDA
CCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]