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The map label for this gene is lysA [H]

Identifier: 209551143

GI number: 209551143

Start: 3694428

End: 3695696

Strand: Direct

Name: lysA [H]

Synonym: Rleg2_3567

Alternate gene names: 209551143

Gene position: 3694428-3695696 (Clockwise)

Preceding gene: 209551142

Following gene: 209551144

Centisome position: 81.41

GC content: 63.36

Gene sequence:

>1269_bases
GTGAACCATTTCGAGTACCGCGACGGCGTCCTGCATGCCGAAAACGTCCCCGTTCCCGAGATCGCCAAGGCGGTCGGCAC
GCCCTTCTACGTCTATTCCACCGCAACGCTGGAGCGCCATTACCGGGTTTTCTCCGAAGCCTTCGCCGATATGGACTCCA
TGGTCTGCTACGCGATGAAGGCGAATTCGAACCAGGCCGTGCTGAAGACGCTCGGCCGTCTCGGCGCCGGCATCGACGTC
GTCTCCGAAGGCGAGCTGCGCCGCGCGCTTGCCGCCGGCATCCCGGCCAGCCGCATCATGTTTTCAGGTGTCGGCAAGAC
GCCGCAGGAAATGGATTTCGCTCTTGAGGCAGGCATCTACTGCTTCAACGTCGAATCCGAGCCCGAGCTCGAAATCCTCA
ACCAGCGCGCCGTCAAGGCCGGGACGAAAGCCCCGGTCTCCTTCCGCATCAACCCCGATGTCGATGCGAAAACCCATTCG
AAGATTTCGACCGGCAAGAAGGAAAACAAGTTCGGCATCTCCTGGGAGCGCGCGCGCGCCATCTATGCCCATGCCGCCAG
GCTGCCGGGCATCGAGGTCACCGGCATCGACATGCATATCGGCAGCCAGATCACCGAATTGCAGCCCTTCGACGACGCCT
TCAAACTGCTGCACGATCTTGTCGCGACGCTGCGCGCCGACGGCCACACGATCGATCACGTCGATATCGGCGGCGGCCTC
GGCATTCCCTATAAGGACGACAACAATCCGCCGCCGCTGCCGGACGCCTATGCGGCGATCGTCAAGAACCAGCTGCGCGG
CCTCAACTGCAAGATCATCACCGAACCCGGCCGCCTGATCGTCGGCAATGCCGGCATCCTGGTGACCGAAGTCCTCTATG
TGAAGGACGGCGGCGAGAAGACCTTCGTCATCGTCGACGGCGCGATGAACGATCTGATCCGCCCGACCCTTTACGAGGCC
TATCACGAGATCCGCCCGGTAACGATTTCGGCGGCGAACGCCCCGCGCATCCGCGCCGACGTGGTCGGGCCGGTCTGCGA
GACCGGCGATTACCTGGCGCTCGACCGCGAGATGGCGATGCCGAAGCCCGGCGACCTGATCGCCGTCAGCACGGCCGGCG
CCTATGGCGCGGTGCAGGCCGGCACCTATAACAGCCGGCTGCTGGTGCCCGAGGTTCTGGTCAAAGGCAGCGATTTCCAT
ACGATTCGCCCGCGCAGAACCTATGCCGAACTGATCGGCCTCGACTCCGTTCCCGCCTGGCTCGATTAA

Upstream 100 bases:

>100_bases
CTGCGGCAACCAAGGAAGGTGACGTTTCCAAGCCGACGAAACAGCCGGGAACCGTCGACAAGCCCTTCCTCCTCGATCCC
CTTCTTTAAGGCATAAGCCC

Downstream 100 bases:

>100_bases
AGTACGTGGCGCAAAACGGTGCGGCCGTTTTGCGATCACGACCTGCGTAAAACAAAAACTTGAAGCGCCGGCAGCAATCT
GAAAGATCGCCACGCGCTTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNHFEYRDGVLHAENVPVPEIAKAVGTPFYVYSTATLERHYRVFSEAFADMDSMVCYAMKANSNQAVLKTLGRLGAGIDV
VSEGELRRALAAGIPASRIMFSGVGKTPQEMDFALEAGIYCFNVESEPELEILNQRAVKAGTKAPVSFRINPDVDAKTHS
KISTGKKENKFGISWERARAIYAHAARLPGIEVTGIDMHIGSQITELQPFDDAFKLLHDLVATLRADGHTIDHVDIGGGL
GIPYKDDNNPPPLPDAYAAIVKNQLRGLNCKIITEPGRLIVGNAGILVTEVLYVKDGGEKTFVIVDGAMNDLIRPTLYEA
YHEIRPVTISAANAPRIRADVVGPVCETGDYLALDREMAMPKPGDLIAVSTAGAYGAVQAGTYNSRLLVPEVLVKGSDFH
TIRPRRTYAELIGLDSVPAWLD

Sequences:

>Translated_422_residues
MNHFEYRDGVLHAENVPVPEIAKAVGTPFYVYSTATLERHYRVFSEAFADMDSMVCYAMKANSNQAVLKTLGRLGAGIDV
VSEGELRRALAAGIPASRIMFSGVGKTPQEMDFALEAGIYCFNVESEPELEILNQRAVKAGTKAPVSFRINPDVDAKTHS
KISTGKKENKFGISWERARAIYAHAARLPGIEVTGIDMHIGSQITELQPFDDAFKLLHDLVATLRADGHTIDHVDIGGGL
GIPYKDDNNPPPLPDAYAAIVKNQLRGLNCKIITEPGRLIVGNAGILVTEVLYVKDGGEKTFVIVDGAMNDLIRPTLYEA
YHEIRPVTISAANAPRIRADVVGPVCETGDYLALDREMAMPKPGDLIAVSTAGAYGAVQAGTYNSRLLVPEVLVKGSDFH
TIRPRRTYAELIGLDSVPAWLD
>Mature_422_residues
MNHFEYRDGVLHAENVPVPEIAKAVGTPFYVYSTATLERHYRVFSEAFADMDSMVCYAMKANSNQAVLKTLGRLGAGIDV
VSEGELRRALAAGIPASRIMFSGVGKTPQEMDFALEAGIYCFNVESEPELEILNQRAVKAGTKAPVSFRINPDVDAKTHS
KISTGKKENKFGISWERARAIYAHAARLPGIEVTGIDMHIGSQITELQPFDDAFKLLHDLVATLRADGHTIDHVDIGGGL
GIPYKDDNNPPPLPDAYAAIVKNQLRGLNCKIITEPGRLIVGNAGILVTEVLYVKDGGEKTFVIVDGAMNDLIRPTLYEA
YHEIRPVTISAANAPRIRADVVGPVCETGDYLALDREMAMPKPGDLIAVSTAGAYGAVQAGTYNSRLLVPEVLVKGSDFH
TIRPRRTYAELIGLDSVPAWLD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=358, Percent_Identity=25.6983240223464, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI16506287, Length=373, Percent_Identity=24.6648793565684, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI22538418, Length=338, Percent_Identity=24.2603550295858, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI21361583, Length=338, Percent_Identity=24.2603550295858, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=31.0588235294118, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562780, Length=346, Percent_Identity=22.8323699421965, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24586472, Length=383, Percent_Identity=25.5874673629243, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24586474, Length=374, Percent_Identity=25.668449197861, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45845; Mature: 45845

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFEYRDGVLHAENVPVPEIAKAVGTPFYVYSTATLERHYRVFSEAFADMDSMVCYAMK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHEEEEEEE
ANSNQAVLKTLGRLGAGIDVVSEGELRRALAAGIPASRIMFSGVGKTPQEMDFALEAGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCHHHHEECCCCCCHHHHHHHHHCCEE
CFNVESEPELEILNQRAVKAGTKAPVSFRINPDVDAKTHSKISTGKKENKFGISWERARA
EEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
IYAHAARLPGIEVTGIDMHIGSQITELQPFDDAFKLLHDLVATLRADGHTIDHVDIGGGL
HHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYKDDNNPPPLPDAYAAIVKNQLRGLNCKIITEPGRLIVGNAGILVTEVLYVKDGGEK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCE
TFVIVDGAMNDLIRPTLYEAYHEIRPVTISAANAPRIRADVVGPVCETGDYLALDREMAM
EEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHCCCCHHCCCCEEEECHHHCC
PKPGDLIAVSTAGAYGAVQAGTYNSRLLVPEVLVKGSDFHTIRPRRTYAELIGLDSVPAW
CCCCCEEEEECCCCCCEEECCCCCCEEEHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCC
LD
CC
>Mature Secondary Structure
MNHFEYRDGVLHAENVPVPEIAKAVGTPFYVYSTATLERHYRVFSEAFADMDSMVCYAMK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHEEEEEEE
ANSNQAVLKTLGRLGAGIDVVSEGELRRALAAGIPASRIMFSGVGKTPQEMDFALEAGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCHHHHEECCCCCCHHHHHHHHHCCEE
CFNVESEPELEILNQRAVKAGTKAPVSFRINPDVDAKTHSKISTGKKENKFGISWERARA
EEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
IYAHAARLPGIEVTGIDMHIGSQITELQPFDDAFKLLHDLVATLRADGHTIDHVDIGGGL
HHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYKDDNNPPPLPDAYAAIVKNQLRGLNCKIITEPGRLIVGNAGILVTEVLYVKDGGEK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCE
TFVIVDGAMNDLIRPTLYEAYHEIRPVTISAANAPRIRADVVGPVCETGDYLALDREMAM
EEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHCCCCHHCCCCEEEECHHHCC
PKPGDLIAVSTAGAYGAVQAGTYNSRLLVPEVLVKGSDFHTIRPRRTYAELIGLDSVPAW
CCCCCEEEEECCCCCCEEECCCCCCEEEHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCC
LD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]