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The map label for this gene is argH1 [H]

Identifier: 209551141

GI number: 209551141

Start: 3692691

End: 3694091

Strand: Direct

Name: argH1 [H]

Synonym: Rleg2_3565

Alternate gene names: 209551141

Gene position: 3692691-3694091 (Clockwise)

Preceding gene: 209551139

Following gene: 209551142

Centisome position: 81.37

GC content: 63.74

Gene sequence:

>1401_bases
ATGGCCGACACCACGGATACCAAATCTTCAAACCAGATGTGGGGCGGGCGTTTCGCTTCCGGCCCGGACGCGATCATGGA
GGAGATAAATGCCTCGATCGGTTTCGACAAGAAGCTTTTCGCGCAGGATATCCGCGGTTCGATTGCCCACGCGACCATGC
TCGCCCATCAGGGGATCATATCGGCCGAGGATAAGGACAAGATCGTTCACGGGCTAAACACGATCCTGTCAGAAATCGAA
AGCGGCAATTTCGAATTTTCGCGCCGGCTCGAAGACATCCATATGAATATCGAAGCGCGCCTGGCGACGCTGATTGGACC
GGCCGCCGGCCGGCTGCACACCGCCCGCTCGCGCAACGACCAGGTGGCGCTCGACTTCCGCCTCTGGGTGAAGGAAGAGC
TCGAGAAGACCGAGAAGATGCTGACCGGCCTGATCGCCGCCTTCCTCGACCGAGCCGACGAGCACGCCGAAAGCGTCATG
CCGGGCTTCACCCATCTGCAGACCGCCCAGCCCGTCACCTTCGGCCATCACTGCATGGCCTATGTCGAAATGTTCGGCCG
CGACCGCTCACGCGTGCGCCACGCCATCGAGCATCTGGACGAAAGCCCGATTGGTGCGGCCGCCCTTGCCGGCACCGGCT
ATCCGATCGATCGCCATATGACCGCCAAGGCGCTCGGTTTCCGCGAGCCGACCCGCAACTCCATCGACACCGTCTCCGAC
CGCGATTTCGCCATCGAGTTCCTGTCGATCGCGGCAATAACAGGCATGCACCTGTCGCGCCTGGCCGAAGAGATCGTCAT
CTGGTCGACCCCGCAATTCGGTTTCGTCCGCCTTTCCGACGCCTTCTCCACCGGCTCCTCGATCATGCCGCAGAAGAAGA
ACCCGGATGCCGCCGAACTGGTGCGTGCCAAGACCGGCCGCATCAACGGCTCGCTGGTGGCGCTGCTGACGATCATGAAG
GGCCTGCCGCTCGCTTATTCCAAGGACATGCAGGAAGACAAGGAACAGGTCTTCGACGCGGCCGAGAGCCTGGAACTGGC
AATCGCCGCCATGACCGGCATGGTGCGCGACATGACCGTCAACACCGCGCGCATGAAGGCGGCGGCCGGCTCCGGCTTCT
CGACGGCGACCGACCTTGCCGACTGGCTGGTGCGCGAAGCGGGCCTGCCGTTCCGCGATGCCCATCACGTCACCGGTCGG
GCCGTGGCGCTCGCCGAAAGCAAGGGCTGCGATCTGGCCGAACTGCCGCTCGCCGACCTGCAGGCGATCCATGCCTCGAT
CACCGACAAGGTCTACGACGTGCTGACCGTCGAAGCCTCGGTCGCCAGCCGCAAGAGCTTCGGCGGCACCGCACCCTCCG
AAGTGCGCAGGCAGATCGCTTTCTGGCGCGCCCGCAACTGA

Upstream 100 bases:

>100_bases
GCAACGGCGGCTATCGCGATCCATTTCACGGATGGCAGCCCGAGGGATTTCTTTGTCGTCATTTCATTCTCCAAGACATG
CATTCAAGGCGGGCACCTTC

Downstream 100 bases:

>100_bases
GGGATATCAGGCGGCGCAAGCCGCCGCGGCCTTGCCGCATAGGCGGAAAGACCGTCCAACAATCAGGGTGCACAAGGCGG
ATAAACTTCGCTATGACAAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MADTTDTKSSNQMWGGRFASGPDAIMEEINASIGFDKKLFAQDIRGSIAHATMLAHQGIISAEDKDKIVHGLNTILSEIE
SGNFEFSRRLEDIHMNIEARLATLIGPAAGRLHTARSRNDQVALDFRLWVKEELEKTEKMLTGLIAAFLDRADEHAESVM
PGFTHLQTAQPVTFGHHCMAYVEMFGRDRSRVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSD
RDFAIEFLSIAAITGMHLSRLAEEIVIWSTPQFGFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMK
GLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDMTVNTARMKAAAGSGFSTATDLADWLVREAGLPFRDAHHVTGR
AVALAESKGCDLAELPLADLQAIHASITDKVYDVLTVEASVASRKSFGGTAPSEVRRQIAFWRARN

Sequences:

>Translated_466_residues
MADTTDTKSSNQMWGGRFASGPDAIMEEINASIGFDKKLFAQDIRGSIAHATMLAHQGIISAEDKDKIVHGLNTILSEIE
SGNFEFSRRLEDIHMNIEARLATLIGPAAGRLHTARSRNDQVALDFRLWVKEELEKTEKMLTGLIAAFLDRADEHAESVM
PGFTHLQTAQPVTFGHHCMAYVEMFGRDRSRVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSD
RDFAIEFLSIAAITGMHLSRLAEEIVIWSTPQFGFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMK
GLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDMTVNTARMKAAAGSGFSTATDLADWLVREAGLPFRDAHHVTGR
AVALAESKGCDLAELPLADLQAIHASITDKVYDVLTVEASVASRKSFGGTAPSEVRRQIAFWRARN
>Mature_465_residues
ADTTDTKSSNQMWGGRFASGPDAIMEEINASIGFDKKLFAQDIRGSIAHATMLAHQGIISAEDKDKIVHGLNTILSEIES
GNFEFSRRLEDIHMNIEARLATLIGPAAGRLHTARSRNDQVALDFRLWVKEELEKTEKMLTGLIAAFLDRADEHAESVMP
GFTHLQTAQPVTFGHHCMAYVEMFGRDRSRVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSDR
DFAIEFLSIAAITGMHLSRLAEEIVIWSTPQFGFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMKG
LPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDMTVNTARMKAAAGSGFSTATDLADWLVREAGLPFRDAHHVTGRA
VALAESKGCDLAELPLADLQAIHASITDKVYDVLTVEASVASRKSFGGTAPSEVRRQIAFWRARN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=450, Percent_Identity=42, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=450, Percent_Identity=42, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=450, Percent_Identity=40.8888888888889, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI68303547, Length=450, Percent_Identity=39.7777777777778, Blast_Score=340, Evalue=1e-93,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=45.7142857142857, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321806, Length=453, Percent_Identity=41.280353200883, Blast_Score=355, Evalue=1e-98,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=37.6106194690265, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=37.6106194690265, Blast_Score=330, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50909; Mature: 50778

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTTDTKSSNQMWGGRFASGPDAIMEEINASIGFDKKLFAQDIRGSIAHATMLAHQGII
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SAEDKDKIVHGLNTILSEIESGNFEFSRRLEDIHMNIEARLATLIGPAAGRLHTARSRND
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
QVALDFRLWVKEELEKTEKMLTGLIAAFLDRADEHAESVMPGFTHLQTAQPVTFGHHCMA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
YVEMFGRDRSRVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSD
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
RDFAIEFLSIAAITGMHLSRLAEEIVIWSTPQFGFVRLSDAFSTGSSIMPQKKNPDAAEL
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCCCCCCCCCCCCHHHH
VRAKTGRINGSLVALLTIMKGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDMTV
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTARMKAAAGSGFSTATDLADWLVREAGLPFRDAHHVTGRAVALAESKGCDLAELPLADL
CHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHCCHHHH
QAIHASITDKVYDVLTVEASVASRKSFGGTAPSEVRRQIAFWRARN
HHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADTTDTKSSNQMWGGRFASGPDAIMEEINASIGFDKKLFAQDIRGSIAHATMLAHQGII
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SAEDKDKIVHGLNTILSEIESGNFEFSRRLEDIHMNIEARLATLIGPAAGRLHTARSRND
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
QVALDFRLWVKEELEKTEKMLTGLIAAFLDRADEHAESVMPGFTHLQTAQPVTFGHHCMA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
YVEMFGRDRSRVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSD
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
RDFAIEFLSIAAITGMHLSRLAEEIVIWSTPQFGFVRLSDAFSTGSSIMPQKKNPDAAEL
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCCCCCCCCCCCCHHHH
VRAKTGRINGSLVALLTIMKGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDMTV
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTARMKAAAGSGFSTATDLADWLVREAGLPFRDAHHVTGRAVALAESKGCDLAELPLADL
CHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHCCHHHH
QAIHASITDKVYDVLTVEASVASRKSFGGTAPSEVRRQIAFWRARN
HHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]