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The map label for this gene is hbdA [H]

Identifier: 209551139

GI number: 209551139

Start: 3690931

End: 3691812

Strand: Direct

Name: hbdA [H]

Synonym: Rleg2_3563

Alternate gene names: 209551139

Gene position: 3690931-3691812 (Clockwise)

Preceding gene: 209551138

Following gene: 209551141

Centisome position: 81.33

GC content: 60.66

Gene sequence:

>882_bases
ATGAATGCGGTGTTGAAGAATATTGGTATTATCGGTGCCGGCCAGATGGGCTGCGGCATCGCGCATGTTTCGGCCGCCGC
AGGTTACAGGGTTCACATCTACGATCTCTCACAGGATCGCATCGAGTCCGGCCTTGCCACGATCAACGGCAACCTGGCCC
GCCTGGTGACGAACAGCAAGATGACCGAGGAGGAGCGCAAGTCGACCCTGTCGCTCATCACAGGCTCGTCAGATGTCAAT
GATCTCGCACCCTCCGATCTGGTCATCGAGGCCGCCACCGAGGATGAAACGGTCAAGCGCAAGATCTATGCGCAGGTTTG
TCCGGTCCTGAAGCCGGAAGCGCTGCTTGCCACCAACACCTCTTCCCTTTCCATCACCCGGCTTGCTGCCGCCACCGACC
GCCCCGAACGCTTCATGGGCATTCATTTCATGAACCCGGTGCCGGTGATGAAGCTGGTCGAACTGGTGCGCGGCATTGCG
ACCGATGAGAAGACCTTCTCGGCCGCCAAGGAATTCGTCGGCACGCTGGAAAAGACCATCACCGTCGCCGAGGATTTCCC
GGCCTTCATCGTCAACCGCATCCTTCTGCCGATGATCAACGAGGCGATCTACACGCTCTATGAAGGCGTCGGCACGGTCG
ACGCCATCGACACGGCGATGAAACTCGGCGCCAACCATCCGATGGGACCGCTGCAGCTTGCCGATTTCATCGGCCTCGAC
ACCTGCCTTTCGATCATGCAGGTGCTGCATGACGGCCTGGCGGACTCGAAATACCGCCCCTGCCCGCTGCTGGTGAAGTA
TGTCGAGGCCGGCTGGCTCGGGCGCAAGTCCGGCCGCGGCTTCTACGACTATCGCGGCGAAGTGCCGGTTCCGACGCGGT
AA

Upstream 100 bases:

>100_bases
TCTTTTATCGGGCTACTACTGCTGCCGGGCGATCCTTCGTCCGGCAGCATTGCTAAAAAATGCGGCAGCGCGGGGGCAGA
TGCCGTGCGGGGGTTTGGAG

Downstream 100 bases:

>100_bases
TCAGACATCATCAGAAAGGGCGAATGGACCGAACGCCCGCGAAATGCTTTCCTTGCCGTGAATGGGAGGAAACGCCATGT
CGACTGAAACACCAATGTTC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNAVLKNIGIIGAGQMGCGIAHVSAAAGYRVHIYDLSQDRIESGLATINGNLARLVTNSKMTEEERKSTLSLITGSSDVN
DLAPSDLVIEAATEDETVKRKIYAQVCPVLKPEALLATNTSSLSITRLAAATDRPERFMGIHFMNPVPVMKLVELVRGIA
TDEKTFSAAKEFVGTLEKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLD
TCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPVPTR

Sequences:

>Translated_293_residues
MNAVLKNIGIIGAGQMGCGIAHVSAAAGYRVHIYDLSQDRIESGLATINGNLARLVTNSKMTEEERKSTLSLITGSSDVN
DLAPSDLVIEAATEDETVKRKIYAQVCPVLKPEALLATNTSSLSITRLAAATDRPERFMGIHFMNPVPVMKLVELVRGIA
TDEKTFSAAKEFVGTLEKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLD
TCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPVPTR
>Mature_293_residues
MNAVLKNIGIIGAGQMGCGIAHVSAAAGYRVHIYDLSQDRIESGLATINGNLARLVTNSKMTEEERKSTLSLITGSSDVN
DLAPSDLVIEAATEDETVKRKIYAQVCPVLKPEALLATNTSSLSITRLAAATDRPERFMGIHFMNPVPVMKLVELVRGIA
TDEKTFSAAKEFVGTLEKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLD
TCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=40.4844290657439, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=39.0879478827362, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=34.7368421052632, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=31.1643835616438, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=31.1643835616438, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=27.4678111587983, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=40.4929577464789, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=36.8421052631579, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=30.3370786516854, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=40.4109589041096, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=41.3194444444444, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.9337979094077, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17508953, Length=278, Percent_Identity=33.4532374100719, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=278, Percent_Identity=33.4532374100719, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25144276, Length=278, Percent_Identity=33.4532374100719, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=278, Percent_Identity=32.7338129496403, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=26.0714285714286, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=25.3571428571429, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=33.6842105263158, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=33.6842105263158, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=33.6842105263158, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=25.3393665158371, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549573, Length=245, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31760; Mature: 31760

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVLKNIGIIGAGQMGCGIAHVSAAAGYRVHIYDLSQDRIESGLATINGNLARLVTNSK
CCCHHHHCCEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHCHHHHCCCEEEEHHCCC
MTEEERKSTLSLITGSSDVNDLAPSDLVIEAATEDETVKRKIYAQVCPVLKPEALLATNT
CCHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
SSLSITRLAAATDRPERFMGIHFMNPVPVMKLVELVRGIATDEKTFSAAKEFVGTLEKTI
CCCEEHHHHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPVPTR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAVLKNIGIIGAGQMGCGIAHVSAAAGYRVHIYDLSQDRIESGLATINGNLARLVTNSK
CCCHHHHCCEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHCHHHHCCCEEEEHHCCC
MTEEERKSTLSLITGSSDVNDLAPSDLVIEAATEDETVKRKIYAQVCPVLKPEALLATNT
CCHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
SSLSITRLAAATDRPERFMGIHFMNPVPVMKLVELVRGIATDEKTFSAAKEFVGTLEKTI
CCCEEHHHHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPVPTR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]