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The map label for this gene is hisN [H]

Identifier: 209550899

GI number: 209550899

Start: 3421617

End: 3422390

Strand: Reverse

Name: hisN [H]

Synonym: Rleg2_3323

Alternate gene names: 209550899

Gene position: 3422390-3421617 (Counterclockwise)

Preceding gene: 209550900

Following gene: 209550897

Centisome position: 75.42

GC content: 63.95

Gene sequence:

>774_bases
ATGCTTCCTGACCGTTCGTTCTTCAACCGCCTTGCGGAAGCCGCCCGAGCCGAGACGCTGCCGCGCTTCCGCTCCGGCCT
CGATATCACGAACAAGCTTTCCTCCGGTTTCGATCCGGTAACAGAGGGCGACCGGGCGGCCGAACTCGCCATCCGGGCGC
TGATCGAGGAGAACTTCCCCGGCCACGGCATTCTCGGCGAGGAACACGGCAATGTCGGGCTCGACCGCGAATATGTCTGG
GTGATCGATCCGATCGACGGCACGCGTGCGTTCATTTCAGGCGTGCCGGTGTGGGGGACGCTGATCGGCCTGCAGAAAGA
CGGCCGGGCGATCATGGGGATGATCGAACAGCCCTTTACCGGCGAACGTTATTTCGCCGACCAGAACGGCTCGCTCTATA
CCGGGCCGGAGGGGGACCGGCGGCTGGCGACGCGGCAGTGCGATACGCTTTCGAACGCCATCCTGTTCACCACCTCACCA
CATCTCTTTGCCGGCGACGAGATGGAGAAATACCGCGAGATCGAGAGCCAGGTCCGGCTCTTCCGCTACGGCTGCGACTG
CTATGCCTATGCGCTGCTTGCCGCCGGCCATATCGATCTCGTCATCGAAAACAGCCTGAAGCCCTATGACGTTGGCGGCA
TCATTCCCGTCATCGAGGGGGCGGGCGGCATCATCACCACCTGGGACGGCGGGCGGCCTGAGAACGGCGGCTCGATCATC
GCCGCCGGCAGCCGGGCCGTCTATGAGCAGGCGATCGCCGTTCTGCAGCGTTGA

Upstream 100 bases:

>100_bases
GGAGGGTTCGTCGCAACCCTATCGAACTGCCTGCTGTGTTTGCATTCCCGCTGCTTTTCGTTATGAAAAGCGTCACTCCC
GCCAGCCAAACGGATCCCTC

Downstream 100 bases:

>100_bases
TCCCAAGGTCGGCCGTGCCGATCGGGTGTCAGGTTCCTAGGGCGGCGACGTCGTGGTTCTCTTCGGCATCGCTGCCGGGA
ATGAAGGCGTGGAAGGCGGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MLPDRSFFNRLAEAARAETLPRFRSGLDITNKLSSGFDPVTEGDRAAELAIRALIEENFPGHGILGEEHGNVGLDREYVW
VIDPIDGTRAFISGVPVWGTLIGLQKDGRAIMGMIEQPFTGERYFADQNGSLYTGPEGDRRLATRQCDTLSNAILFTTSP
HLFAGDEMEKYREIESQVRLFRYGCDCYAYALLAAGHIDLVIENSLKPYDVGGIIPVIEGAGGIITTWDGGRPENGGSII
AAGSRAVYEQAIAVLQR

Sequences:

>Translated_257_residues
MLPDRSFFNRLAEAARAETLPRFRSGLDITNKLSSGFDPVTEGDRAAELAIRALIEENFPGHGILGEEHGNVGLDREYVW
VIDPIDGTRAFISGVPVWGTLIGLQKDGRAIMGMIEQPFTGERYFADQNGSLYTGPEGDRRLATRQCDTLSNAILFTTSP
HLFAGDEMEKYREIESQVRLFRYGCDCYAYALLAAGHIDLVIENSLKPYDVGGIIPVIEGAGGIITTWDGGRPENGGSII
AAGSRAVYEQAIAVLQR
>Mature_257_residues
MLPDRSFFNRLAEAARAETLPRFRSGLDITNKLSSGFDPVTEGDRAAELAIRALIEENFPGHGILGEEHGNVGLDREYVW
VIDPIDGTRAFISGVPVWGTLIGLQKDGRAIMGMIEQPFTGERYFADQNGSLYTGPEGDRRLATRQCDTLSNAILFTTSP
HLFAGDEMEKYREIESQVRLFRYGCDCYAYALLAAGHIDLVIENSLKPYDVGGIIPVIEGAGGIITTWDGGRPENGGSII
AAGSRAVYEQAIAVLQR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=239, Percent_Identity=27.6150627615063, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI221625487, Length=239, Percent_Identity=27.6150627615063, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788882, Length=217, Percent_Identity=30.8755760368664, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=226, Percent_Identity=28.3185840707965, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664918, Length=207, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357957, Length=239, Percent_Identity=25.1046025104602, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664926, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28085; Mature: 28085

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDRSFFNRLAEAARAETLPRFRSGLDITNKLSSGFDPVTEGDRAAELAIRALIEENFP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GHGILGEEHGNVGLDREYVWVIDPIDGTRAFISGVPVWGTLIGLQKDGRAIMGMIEQPFT
CCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCCHHHHEEECCCCCHHHHHHHCCCCC
GERYFADQNGSLYTGPEGDRRLATRQCDTLSNAILFTTSPHLFAGDEMEKYREIESQVRL
CCEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHHHHHHHH
FRYGCDCYAYALLAAGHIDLVIENSLKPYDVGGIIPVIEGAGGIITTWDGGRPENGGSII
HHHCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCEEE
AAGSRAVYEQAIAVLQR
EECCHHHHHHHHHHHCC
>Mature Secondary Structure
MLPDRSFFNRLAEAARAETLPRFRSGLDITNKLSSGFDPVTEGDRAAELAIRALIEENFP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GHGILGEEHGNVGLDREYVWVIDPIDGTRAFISGVPVWGTLIGLQKDGRAIMGMIEQPFT
CCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCCHHHHEEECCCCCHHHHHHHCCCCC
GERYFADQNGSLYTGPEGDRRLATRQCDTLSNAILFTTSPHLFAGDEMEKYREIESQVRL
CCEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHHHHHHHH
FRYGCDCYAYALLAAGHIDLVIENSLKPYDVGGIIPVIEGAGGIITTWDGGRPENGGSII
HHHCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCEEE
AAGSRAVYEQAIAVLQR
EECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]