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The map label for this gene is serA [H]

Identifier: 209550768

GI number: 209550768

Start: 3278354

End: 3279949

Strand: Reverse

Name: serA [H]

Synonym: Rleg2_3192

Alternate gene names: 209550768

Gene position: 3279949-3278354 (Counterclockwise)

Preceding gene: 209550769

Following gene: 209550766

Centisome position: 72.28

GC content: 61.97

Gene sequence:

>1596_bases
ATGGCACCTCGCGTTCTCGTATCCGACGAATTGTCGGAAACCGCCGTCCAGATTTTTCGCGACCGCGGCGTCGAAGTCGA
TTTCGAACCGCAGCTCGGCAAGGACAAGGACCGTCTGCTCGACGTCATCGGCAAGTATGACGGTCTCGCCATCCGCTCCG
CCACCAAGGTGACGGAAAAGATCATCCAGGGAGCGACGAACCTCAAGGTCGTCGGCCGCGCCGGCATCGGCGTCGACAAT
GTCGATATTCCGGCTGCCTCGCGCCGCGGCATCATCGTCATGAACACGCCTTTCGGCAATTCGATCACCACCGCCGAACA
CGCGATCGCGCTGATGTTCGCCGTCGCCCGCCAGCTTCCGGCAGCCGATACCTCGACGCAGGCCGGCAAATGGGAGAAGT
CGAAGTTCATGGGCGTCGAGATCACCGGCAAGACGCTCGGCGTCATCGGCGCCGGCAATATCGGCTCGATCGTCTGCGCC
CGCGCCATCGGCCTCAAGATGCATGTCGTCGCCTACGATCCGTTCCTCTCCAAGGAGCGCGCCGAGGAGATGGGCGTCAC
CAAGGTCGAGCTGGATGAGCTTTTCGCCCGTGCCGACTTCATCACGCTGCATGTGCCGATGACCGACAAGACGCGCGGCA
TCCTCAACAAGGAAGCGCTGGCAAAGACCAAGCCGGGCGTTCGCATCATCAACTGTGCCCGTGGCGGCCTGGTCGATGAG
GCAGCCCTTGCCGAAGCCATCAAGTCCGGCCATGTCGCCGGTGCCGCCTTCGACGTCTTCGAGGTCGAGCCTGCCAAGGA
AAGCCCGCTCTTCGGCCTGCCGAACGTCGTCTGCACGCCGCATCTCGGCGCTTCGACCACCGAGGCGCAGGAAAACGTCG
CCCTGCAGGTGGCTGAACAGATGGCGGATTACCTCGTCAAGGGGGCGGTCTCCAACGCCATCAACATGCCGTCGATCACG
GCTGAGGAAGCGCCGATCCTGAAGCCCTTCATCCGGCTTGCCGATGTTCTCGGCGCCTTCGTCGGCCAGGTCACCGAGGA
GCCGATCAAGGAAATCGAGATCCTCTATGACGGCATCACCGCCAACATGAACACCCGGGCGCTGACGAGCGCGGTGCTTG
CTGGCCTCATCCGCCCGCAGGTCGCCGATGTCAACATGGTTTCGGCGCCGATCATGGTCAAGGAAAAGGGTGTCGTGCTT
TCCGAAGTCAAGCGCGACAAGACAGGTGTCTTCGACGGCTATATCAAGCTGACGGTGACGACCGAGAGCATGACGCGTTC
GGTCGCCGGCACGGTGTTTTCGGATGGCAAGCCGCGCTTCATCCAGATCAAGGGCATCAACCTCGATGCCGATGTCGGCT
CGCACATGATCTATATCACCAATACCGACGTTCCCGGCATGATCGGCTTCATTGGCACGACGCTTGGTACTGCCGGCGTC
AACATCGCCAACTTCCAGCTCGGCCGCGACAAGCAGGGCGGTGACGCCATCGCGCTGCTCTATGTCGACGGCGACGTGGA
CGACACCGTGCTTGCTCAGCTGACGGCGAACCAGGCGATCCGCCAGGCAAAGCTGCTCACCTTCAATATCGACTAA

Upstream 100 bases:

>100_bases
TAAGAGCATGATGTCGTCCGAAAACCGCATACACTTTTCGGCATCATGCTCTGGGATCCCTGATTTCATCCATCGCTGAA
CACTTTTGAAGGAGGCCACA

Downstream 100 bases:

>100_bases
TGCATGTCGCCGGGAAGTGTGCAGCACTTCCCGGATAACGACATGCATAAAACAAAGAGCTAAAGCGCGTCGCATGAATC
AAGTTAACTGCGACGCGCTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAPRVLVSDELSETAVQIFRDRGVEVDFEPQLGKDKDRLLDVIGKYDGLAIRSATKVTEKIIQGATNLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADTSTQAGKWEKSKFMGVEITGKTLGVIGAGNIGSIVCA
RAIGLKMHVVAYDPFLSKERAEEMGVTKVELDELFARADFITLHVPMTDKTRGILNKEALAKTKPGVRIINCARGGLVDE
AALAEAIKSGHVAGAAFDVFEVEPAKESPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMADYLVKGAVSNAINMPSIT
AEEAPILKPFIRLADVLGAFVGQVTEEPIKEIEILYDGITANMNTRALTSAVLAGLIRPQVADVNMVSAPIMVKEKGVVL
SEVKRDKTGVFDGYIKLTVTTESMTRSVAGTVFSDGKPRFIQIKGINLDADVGSHMIYITNTDVPGMIGFIGTTLGTAGV
NIANFQLGRDKQGGDAIALLYVDGDVDDTVLAQLTANQAIRQAKLLTFNID

Sequences:

>Translated_531_residues
MAPRVLVSDELSETAVQIFRDRGVEVDFEPQLGKDKDRLLDVIGKYDGLAIRSATKVTEKIIQGATNLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADTSTQAGKWEKSKFMGVEITGKTLGVIGAGNIGSIVCA
RAIGLKMHVVAYDPFLSKERAEEMGVTKVELDELFARADFITLHVPMTDKTRGILNKEALAKTKPGVRIINCARGGLVDE
AALAEAIKSGHVAGAAFDVFEVEPAKESPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMADYLVKGAVSNAINMPSIT
AEEAPILKPFIRLADVLGAFVGQVTEEPIKEIEILYDGITANMNTRALTSAVLAGLIRPQVADVNMVSAPIMVKEKGVVL
SEVKRDKTGVFDGYIKLTVTTESMTRSVAGTVFSDGKPRFIQIKGINLDADVGSHMIYITNTDVPGMIGFIGTTLGTAGV
NIANFQLGRDKQGGDAIALLYVDGDVDDTVLAQLTANQAIRQAKLLTFNID
>Mature_530_residues
APRVLVSDELSETAVQIFRDRGVEVDFEPQLGKDKDRLLDVIGKYDGLAIRSATKVTEKIIQGATNLKVVGRAGIGVDNV
DIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADTSTQAGKWEKSKFMGVEITGKTLGVIGAGNIGSIVCAR
AIGLKMHVVAYDPFLSKERAEEMGVTKVELDELFARADFITLHVPMTDKTRGILNKEALAKTKPGVRIINCARGGLVDEA
ALAEAIKSGHVAGAAFDVFEVEPAKESPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMADYLVKGAVSNAINMPSITA
EEAPILKPFIRLADVLGAFVGQVTEEPIKEIEILYDGITANMNTRALTSAVLAGLIRPQVADVNMVSAPIMVKEKGVVLS
EVKRDKTGVFDGYIKLTVTTESMTRSVAGTVFSDGKPRFIQIKGINLDADVGSHMIYITNTDVPGMIGFIGTTLGTAGVN
IANFQLGRDKQGGDAIALLYVDGDVDDTVLAQLTANQAIRQAKLLTFNID

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=397, Percent_Identity=42.5692695214106, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI61743967, Length=282, Percent_Identity=30.8510638297872, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI4557497, Length=282, Percent_Identity=30.8510638297872, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=34.2307692307692, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=32.258064516129, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=35.6923076923077, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=31.8996415770609, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.7142857142857, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081824, Length=260, Percent_Identity=28.4615384615385, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=28.5171102661597, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.364238410596, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI25147481, Length=278, Percent_Identity=32.0143884892086, Blast_Score=149, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=36.8580060422961, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=35.9516616314199, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324055, Length=260, Percent_Identity=28.8461538461538, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=28.5198555956679, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=28.2828282828283, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=180, Percent_Identity=31.6666666666667, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=42.0529801324503, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=33.2046332046332, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=33.2046332046332, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=33.2046332046332, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=33.2046332046332, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=33.2046332046332, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=28.1045751633987, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=29.9625468164794, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=29.9625468164794, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=29.9625468164794, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=29.9625468164794, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552429, Length=233, Percent_Identity=31.7596566523605, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574286, Length=233, Percent_Identity=31.3304721030043, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=32.0754716981132, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56502; Mature: 56371

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLVSDELSETAVQIFRDRGVEVDFEPQLGKDKDRLLDVIGKYDGLAIRSATKVTEK
CCCCEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHH
IIQGATNLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADTSTQAGKWEKSKFMGVEITGKTLGVIGAGNIGSIVCARAIGLKMHVVAYDPFLSKER
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHH
AEEMGVTKVELDELFARADFITLHVPMTDKTRGILNKEALAKTKPGVRIINCARGGLVDE
HHHCCCEEEEHHHHHHCCCEEEEEECCCCCHHCCCCHHHHHHCCCCCEEEEECCCCCCHH
AALAEAIKSGHVAGAAFDVFEVEPAKESPLFGLPNVVCTPHLGASTTEAQENVALQVAEQ
HHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
MADYLVKGAVSNAINMPSITAEEAPILKPFIRLADVLGAFVGQVTEEPIKEIEILYDGIT
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ANMNTRALTSAVLAGLIRPQVADVNMVSAPIMVKEKGVVLSEVKRDKTGVFDGYIKLTVT
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEEEEE
TESMTRSVAGTVFSDGKPRFIQIKGINLDADVGSHMIYITNTDVPGMIGFIGTTLGTAGV
HHHHHHHHHHHHCCCCCCCEEEEEECEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
NIANFQLGRDKQGGDAIALLYVDGDVDDTVLAQLTANQAIRQAKLLTFNID
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure 
APRVLVSDELSETAVQIFRDRGVEVDFEPQLGKDKDRLLDVIGKYDGLAIRSATKVTEK
CCCEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHH
IIQGATNLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADTSTQAGKWEKSKFMGVEITGKTLGVIGAGNIGSIVCARAIGLKMHVVAYDPFLSKER
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHH
AEEMGVTKVELDELFARADFITLHVPMTDKTRGILNKEALAKTKPGVRIINCARGGLVDE
HHHCCCEEEEHHHHHHCCCEEEEEECCCCCHHCCCCHHHHHHCCCCCEEEEECCCCCCHH
AALAEAIKSGHVAGAAFDVFEVEPAKESPLFGLPNVVCTPHLGASTTEAQENVALQVAEQ
HHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
MADYLVKGAVSNAINMPSITAEEAPILKPFIRLADVLGAFVGQVTEEPIKEIEILYDGIT
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ANMNTRALTSAVLAGLIRPQVADVNMVSAPIMVKEKGVVLSEVKRDKTGVFDGYIKLTVT
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEEEEE
TESMTRSVAGTVFSDGKPRFIQIKGINLDADVGSHMIYITNTDVPGMIGFIGTTLGTAGV
HHHHHHHHHHHHCCCCCCCEEEEEECEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
NIANFQLGRDKQGGDAIALLYVDGDVDDTVLAQLTANQAIRQAKLLTFNID
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]