Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 209550568

GI number: 209550568

Start: 3056094

End: 3056801

Strand: Reverse

Name: ung [H]

Synonym: Rleg2_2992

Alternate gene names: 209550568

Gene position: 3056801-3056094 (Counterclockwise)

Preceding gene: 209550572

Following gene: 209550567

Centisome position: 67.36

GC content: 61.16

Gene sequence:

>708_bases
ATGAGCGATACATCAGTCAGTCTCGAAGAGAGCTGGAAAGCCGCCTTGGCGGGGGAGTTCTCAAGCCCCTATATGCAGCA
GCTCAAATCCTTTCTTGTCGCGCAGAAGCAGGGCGGTAAGCGCATTTTCCCCCGGGGCAGTGAATATTTCCGCGCCCTCG
ACCTGACACCGATCTCCAGCGTCAAGGTCGTCATTCTCGGGCAGGACCCCTATCACGGGCTGGGGCAGGCCCATGGGCTG
TGTTTCAGCGTGCGGCCGGGCGTGCGCATTCCGCCCTCGCTCGTCAATATCTATAAGGAGATGCAGACCGATCTTGGCAT
AGCGCCGGCGCGTCACGGTTTTCTCGAACATTGGGCAAGGCAGGGCGTGCTGCTGCTGAACAGCGTGCTGACTGTCGAGG
AAGGGCAGGCGGCGGCCCATCAGGGCAAGGGGTGGGAGCGCTTTACCGACGCCGTCATCCGCAAAGTCAACGACGAGTGC
GAATCCGTCGTCTTCATGCTCTGGGGCTCCTATGCCCAGCGCAAGGCCGCCTTTGTTGATGCGACGCGGCATCTGGTGCT
CAGGGCGCCGCATCCCTCGCCGCTTTCGGCCCATAACGGATTTTTCGGCTGCGGGCATTTCTCGAAGGCGAACGATTTCC
TGCAGTCGCGCGGGCGGTCGCCGATCGATTGGCAGTTGCCGACCGATCCCCAAGATATCGAGATGTGA

Upstream 100 bases:

>100_bases
TCTCCCTGGACCCATTGCCGAGCCGACAGGCATTGCAGCGTAGATCGATTTTGTTAGAACCGTGTGTCCGTTGTTTCGTG
ATATGCGAAGGGTTTGCTGG

Downstream 100 bases:

>100_bases
ACGCAAGCCGGTGTTCGTTCACTAAAAGAAGACAATGCGTTTTGGTCTGGGGGTCTGTTCCCACGGAGTTGCAGCGCGCA
TCTTAGCCCCATCGAAAGCC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSDTSVSLEESWKAALAGEFSSPYMQQLKSFLVAQKQGGKRIFPRGSEYFRALDLTPISSVKVVILGQDPYHGLGQAHGL
CFSVRPGVRIPPSLVNIYKEMQTDLGIAPARHGFLEHWARQGVLLLNSVLTVEEGQAAAHQGKGWERFTDAVIRKVNDEC
ESVVFMLWGSYAQRKAAFVDATRHLVLRAPHPSPLSAHNGFFGCGHFSKANDFLQSRGRSPIDWQLPTDPQDIEM

Sequences:

>Translated_235_residues
MSDTSVSLEESWKAALAGEFSSPYMQQLKSFLVAQKQGGKRIFPRGSEYFRALDLTPISSVKVVILGQDPYHGLGQAHGL
CFSVRPGVRIPPSLVNIYKEMQTDLGIAPARHGFLEHWARQGVLLLNSVLTVEEGQAAAHQGKGWERFTDAVIRKVNDEC
ESVVFMLWGSYAQRKAAFVDATRHLVLRAPHPSPLSAHNGFFGCGHFSKANDFLQSRGRSPIDWQLPTDPQDIEM
>Mature_234_residues
SDTSVSLEESWKAALAGEFSSPYMQQLKSFLVAQKQGGKRIFPRGSEYFRALDLTPISSVKVVILGQDPYHGLGQAHGLC
FSVRPGVRIPPSLVNIYKEMQTDLGIAPARHGFLEHWARQGVLLLNSVLTVEEGQAAAHQGKGWERFTDAVIRKVNDECE
SVVFMLWGSYAQRKAAFVDATRHLVLRAPHPSPLSAHNGFFGCGHFSKANDFLQSRGRSPIDWQLPTDPQDIEM

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=225, Percent_Identity=52.8888888888889, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI6224979, Length=225, Percent_Identity=52.8888888888889, Blast_Score=236, Evalue=1e-62,
Organism=Escherichia coli, GI1788934, Length=227, Percent_Identity=55.5066079295154, Blast_Score=260, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=45.6221198156682, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=41.7721518987342, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26091; Mature: 25960

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSVSLEESWKAALAGEFSSPYMQQLKSFLVAQKQGGKRIFPRGSEYFRALDLTPISS
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCC
VKVVILGQDPYHGLGQAHGLCFSVRPGVRIPPSLVNIYKEMQTDLGIAPARHGFLEHWAR
EEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QGVLLLNSVLTVEEGQAAAHQGKGWERFTDAVIRKVNDECESVVFMLWGSYAQRKAAFVD
CCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRHLVLRAPHPSPLSAHNGFFGCGHFSKANDFLQSRGRSPIDWQLPTDPQDIEM
HHHEEEEECCCCCCCCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDTSVSLEESWKAALAGEFSSPYMQQLKSFLVAQKQGGKRIFPRGSEYFRALDLTPISS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCC
VKVVILGQDPYHGLGQAHGLCFSVRPGVRIPPSLVNIYKEMQTDLGIAPARHGFLEHWAR
EEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QGVLLLNSVLTVEEGQAAAHQGKGWERFTDAVIRKVNDECESVVFMLWGSYAQRKAAFVD
CCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRHLVLRAPHPSPLSAHNGFFGCGHFSKANDFLQSRGRSPIDWQLPTDPQDIEM
HHHEEEEECCCCCCCCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]