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The map label for this gene is mdh [H]

Identifier: 209550211

GI number: 209550211

Start: 2675529

End: 2676680

Strand: Reverse

Name: mdh [H]

Synonym: Rleg2_2631

Alternate gene names: 209550211

Gene position: 2676680-2675529 (Counterclockwise)

Preceding gene: 209550212

Following gene: 209550210

Centisome position: 58.98

GC content: 63.37

Gene sequence:

>1152_bases
ATGAGCAGCAACATCACCGCAAACTGGAGCTATCCGACATCGGTCAAGCTCGGCCGGGGCCGGATCAAGGAACTGGCAGA
CGCCTGCAAGAGCCTCGGCATCAAAAAGCCGCTGCTCGTCACCGACCGCGGCCTCGCCTCGATGGCGATCACCAGCAACG
CGCTCGACATTCTCGAAGATGCAGGCCTCGGCCGGGCGATCTTCGCCGATGTCGATCCGAACCCGAACGAGAAGAACCTC
GAGGCCGGCGTCAAGGCTTTCAAGGATGGCGGTCATGACGGCGTCGTCGCCTTCGGCGGCGGCTCGGGCCTCGATCTCGG
CAAATGCGTCGCCTTCATGGCCGGCCAGACCCGGCCGGTCTGGGATTTCGAGGATATCGGCGACTGGTGGACGCGCGCAA
GCCTCGAGGGCATCGCCCCGATCGTCGCCGTGCCGACGACAGCGGGTACCGGCTCGGAAGTCGGCCGCGCCAGCGTCATC
ACCAATTCTGTCACGCATGTGAAGAAGATCATCTTCCATCCGAAGTTCCTGCCTGGTGTCGTCATCTCCGATCCGGAACT
GACCGTCGGCATGCCGAAGATCATCACGGCCGGCACCGGCATGGATGCCTTTGCCCATTGCCTGGAGGCCTATTCCTCGC
CCTTCTATCACCCGATGTCGGCCGGCATCGCGCTCGAAGGCATGCGGCTCGTCAAGGAATTCCTGCCGCGCGCCTATCGG
GAAGGCACCGATCTCGAAGCCCGCGCCAACATGATGTCCGCCGCCGCCATGGGTGCTGTCGCCTTCCAGAAGGGGCTCGG
CGCCATCCATGCGCTGTCGCACCCGATCGGCGCCGTTTACAACACCCATCACGGCATGACCAACGCGGTTGTCATGCCGG
CGGTGCTGCGCTTCAACCGCAAAGTGATCGAAGAGAAGATCGGCCGGGCGGCCGCCTATCTCGGCATTTCGGGCGGTTTC
GACGGCTTCTACGACTATGTGCTGAAGCTTCGCTCCGACCTCGGCGTGCCGGAGACGCTGACGGCGATGGGGATCGCTGC
CGACCGTATCGATGAATTGTCGGCGATGGCGATCGAAGATCCGAGTGCGGGCGGCAACCCGGTTGCGATGACGCTCGAAA
ACACCAAAGCCCTGTTCAGGGATTGCTTCTGA

Upstream 100 bases:

>100_bases
GGACCGGTGTCAAGGAGACGGGCCGCGGCGGCTCGCTATCGATCATCGGCTTCCAGAATCTGACGCGCCCGAAATCCTTC
CACCTGAAGAAAGTCACAGC

Downstream 100 bases:

>100_bases
GTATTTGGGGGTGGACCTGCAGAGCGGCCCGGAAGGCCTTGCTTTCCGGGCTTCCTTTATTTTAGCGCATCCCCAATTTT
AGGGATGTGAAAAATACCGG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSSNITANWSYPTSVKLGRGRIKELADACKSLGIKKPLLVTDRGLASMAITSNALDILEDAGLGRAIFADVDPNPNEKNL
EAGVKAFKDGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASLEGIAPIVAVPTTAGTGSEVGRASVI
TNSVTHVKKIIFHPKFLPGVVISDPELTVGMPKIITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEFLPRAYR
EGTDLEARANMMSAAAMGAVAFQKGLGAIHALSHPIGAVYNTHHGMTNAVVMPAVLRFNRKVIEEKIGRAAAYLGISGGF
DGFYDYVLKLRSDLGVPETLTAMGIAADRIDELSAMAIEDPSAGGNPVAMTLENTKALFRDCF

Sequences:

>Translated_383_residues
MSSNITANWSYPTSVKLGRGRIKELADACKSLGIKKPLLVTDRGLASMAITSNALDILEDAGLGRAIFADVDPNPNEKNL
EAGVKAFKDGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASLEGIAPIVAVPTTAGTGSEVGRASVI
TNSVTHVKKIIFHPKFLPGVVISDPELTVGMPKIITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEFLPRAYR
EGTDLEARANMMSAAAMGAVAFQKGLGAIHALSHPIGAVYNTHHGMTNAVVMPAVLRFNRKVIEEKIGRAAAYLGISGGF
DGFYDYVLKLRSDLGVPETLTAMGIAADRIDELSAMAIEDPSAGGNPVAMTLENTKALFRDCF
>Mature_382_residues
SSNITANWSYPTSVKLGRGRIKELADACKSLGIKKPLLVTDRGLASMAITSNALDILEDAGLGRAIFADVDPNPNEKNLE
AGVKAFKDGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASLEGIAPIVAVPTTAGTGSEVGRASVIT
NSVTHVKKIIFHPKFLPGVVISDPELTVGMPKIITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEFLPRAYRE
GTDLEARANMMSAAAMGAVAFQKGLGAIHALSHPIGAVYNTHHGMTNAVVMPAVLRFNRKVIEEKIGRAAAYLGISGGFD
GFYDYVLKLRSDLGVPETLTAMGIAADRIDELSAMAIEDPSAGGNPVAMTLENTKALFRDCF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=414, Percent_Identity=27.2946859903382, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI48994951, Length=377, Percent_Identity=30.7692307692308, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789163, Length=382, Percent_Identity=31.151832460733, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082107, Length=374, Percent_Identity=30.7486631016043, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1787493, Length=406, Percent_Identity=28.8177339901478, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789386, Length=366, Percent_Identity=27.3224043715847, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=389, Percent_Identity=25.706940874036, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=385, Percent_Identity=33.2467532467532, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24657991, Length=340, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40517; Mature: 40386

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNITANWSYPTSVKLGRGRIKELADACKSLGIKKPLLVTDRGLASMAITSNALDILED
CCCCEEECCCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AGLGRAIFADVDPNPNEKNLEAGVKAFKDGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPV
CCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCC
WDFEDIGDWWTRASLEGIAPIVAVPTTAGTGSEVGRASVITNSVTHVKKIIFHPKFLPGV
CCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
VISDPELTVGMPKIITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEFLPRAYR
EECCCCCCCCCCHHEECCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHH
EGTDLEARANMMSAAAMGAVAFQKGLGAIHALSHPIGAVYNTHHGMTNAVVMPAVLRFNR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHH
KVIEEKIGRAAAYLGISGGFDGFYDYVLKLRSDLGVPETLTAMGIAADRIDELSAMAIED
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
PSAGGNPVAMTLENTKALFRDCF
CCCCCCCEEEEECHHHHHHHHCC
>Mature Secondary Structure 
SSNITANWSYPTSVKLGRGRIKELADACKSLGIKKPLLVTDRGLASMAITSNALDILED
CCCEEECCCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AGLGRAIFADVDPNPNEKNLEAGVKAFKDGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPV
CCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCC
WDFEDIGDWWTRASLEGIAPIVAVPTTAGTGSEVGRASVITNSVTHVKKIIFHPKFLPGV
CCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
VISDPELTVGMPKIITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEFLPRAYR
EECCCCCCCCCCHHEECCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHH
EGTDLEARANMMSAAAMGAVAFQKGLGAIHALSHPIGAVYNTHHGMTNAVVMPAVLRFNR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHH
KVIEEKIGRAAAYLGISGGFDGFYDYVLKLRSDLGVPETLTAMGIAADRIDELSAMAIED
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
PSAGGNPVAMTLENTKALFRDCF
CCCCCCCEEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]