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The map label for this gene is mdmC [H]

Identifier: 209549763

GI number: 209549763

Start: 2228066

End: 2228683

Strand: Reverse

Name: mdmC [H]

Synonym: Rleg2_2172

Alternate gene names: 209549763

Gene position: 2228683-2228066 (Counterclockwise)

Preceding gene: 209549767

Following gene: 209549762

Centisome position: 49.11

GC content: 64.08

Gene sequence:

>618_bases
ATGGACAACCGGATCGAGGAAGTGCTCGACATCTATCACGGGATGATCGAGACGGAGCGCAACAGCCCGCGCGAGCAGCC
TCCCGGCGGCCGCGACGGAGGGCAGGATCAGCGGCTGCGCGCGGTCGGGCCGGAGACCGGGCAGTTCATCAATATTCTCA
CCAGGAGCCTCAAGGCGCCGACCATTCTCGAACTCGGCACCTCCTTCGGCTATTCCGGGATATGGCTGGCGGAAGCCGCC
CGCGCTACCGGCGGTCGGCTGATCACCATAGAAATGCGCGATTACAAGTCGGCCTATGCGCGCGACATGGCCGTCAAGGC
GGGCCTTGCCGACCATGTCGAGTTCAAGGTCGGCGACGCCGTCCAGGTGATCGGCGCGCTTTCTGAGGGCATCGACTTCG
TGCTCGTGGATCTCTGGAAGGACCTTTACCTTCCCTGCCTCGAGGCCTTCTATCCCAAGCTCAATCCGGGCGCGATCATC
GTGGCCGACAATATGATCCGACCCGGGGGCGAGGATGTGAGACGCTACGGCGAAGCCATCCGCGCCAAGCCGGGGATCTC
AAGCGTGCTGCTGCCGGTCGGCAGCGGACTTGAGGTGAGCCGGTTCGACCGAGGTTGA

Upstream 100 bases:

>100_bases
CATCGAGGCCGCAAAACCCGATGATTGCCGAAGTTTAACTTTTCCGAGCCAGTTCGGTCGGGCAATGTCGGCCATCAATC
GAGACAGAAGGGCAGGGCCG

Downstream 100 bases:

>100_bases
CGGCGGGCGATCACAAGAATCCGGTGCGTCCAACTCCTTAGGCGAGAGCGTATCGTGGGATTACAGCGTGTCTTGTCGAC
CTCGTAACTTCACACAAATT

Product: O-methyltransferase family 3

Products: S-adenosyl-L-homocysteine; guaiacol

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MDNRIEEVLDIYHGMIETERNSPREQPPGGRDGGQDQRLRAVGPETGQFINILTRSLKAPTILELGTSFGYSGIWLAEAA
RATGGRLITIEMRDYKSAYARDMAVKAGLADHVEFKVGDAVQVIGALSEGIDFVLVDLWKDLYLPCLEAFYPKLNPGAII
VADNMIRPGGEDVRRYGEAIRAKPGISSVLLPVGSGLEVSRFDRG

Sequences:

>Translated_205_residues
MDNRIEEVLDIYHGMIETERNSPREQPPGGRDGGQDQRLRAVGPETGQFINILTRSLKAPTILELGTSFGYSGIWLAEAA
RATGGRLITIEMRDYKSAYARDMAVKAGLADHVEFKVGDAVQVIGALSEGIDFVLVDLWKDLYLPCLEAFYPKLNPGAII
VADNMIRPGGEDVRRYGEAIRAKPGISSVLLPVGSGLEVSRFDRG
>Mature_205_residues
MDNRIEEVLDIYHGMIETERNSPREQPPGGRDGGQDQRLRAVGPETGQFINILTRSLKAPTILELGTSFGYSGIWLAEAA
RATGGRLITIEMRDYKSAYARDMAVKAGLADHVEFKVGDAVQVIGALSEGIDFVLVDLWKDLYLPCLEAFYPKLNPGAII
VADNMIRPGGEDVRRYGEAIRAKPGISSVLLPVGSGLEVSRFDRG

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI6466450, Length=138, Percent_Identity=34.0579710144928, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI205830453, Length=145, Percent_Identity=33.1034482758621, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI205830451, Length=145, Percent_Identity=33.1034482758621, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4502969, Length=145, Percent_Identity=33.1034482758621, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: 2.1.1.6

Molecular weight: Translated: 22405; Mature: 22405

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRIEEVLDIYHGMIETERNSPREQPPGGRDGGQDQRLRAVGPETGQFINILTRSLKAP
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
TILELGTSFGYSGIWLAEAARATGGRLITIEMRDYKSAYARDMAVKAGLADHVEFKVGDA
HHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCHHHHEECCCHH
VQVIGALSEGIDFVLVDLWKDLYLPCLEAFYPKLNPGAIIVADNMIRPGGEDVRRYGEAI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
RAKPGISSVLLPVGSGLEVSRFDRG
HCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MDNRIEEVLDIYHGMIETERNSPREQPPGGRDGGQDQRLRAVGPETGQFINILTRSLKAP
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
TILELGTSFGYSGIWLAEAARATGGRLITIEMRDYKSAYARDMAVKAGLADHVEFKVGDA
HHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCHHHHEECCCHH
VQVIGALSEGIDFVLVDLWKDLYLPCLEAFYPKLNPGAIIVADNMIRPGGEDVRRYGEAI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
RAKPGISSVLLPVGSGLEVSRFDRG
HCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; catechol

Specific reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]