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The map label for this gene is icd [H]

Identifier: 209549547

GI number: 209549547

Start: 1997668

End: 1998879

Strand: Direct

Name: icd [H]

Synonym: Rleg2_1953

Alternate gene names: 209549547

Gene position: 1997668-1998879 (Clockwise)

Preceding gene: 209549536

Following gene: 209549548

Centisome position: 44.02

GC content: 59.82

Gene sequence:

>1212_bases
ATGAACAAGATCAAGGTCGCCAATCCCGTCGCCGATCTCGACGGCGATGAAATGACGCGCATCATTTGGCAGCTCATCAA
GGATAAGCTGATCCATCCGTATCTCGACCTCGATATCGACTATTTCGACCTCTCCGTCGAAAACCGCGACGCCACCAACG
ACCAGGTAACGGTCGATGCCGCCAACGCCATCAAGAAATACGGCGTCGGCATCAAGTGCGCGACGATCACGCCGGACGAA
GCCCGCGTCAAGGAATTCAACCTCAAGGAAATGTGGAAGAGCCCGAACGGTACGATCCGCAACATTCTGGGCGGCGTCAT
CTTCCGCGAGCCGATCATTTGCAAAAACGTGCCGCGCCTGGTTCCCGGCTGGACGCAGCCGATCGTCGTCGGCCGTCACG
CCTTCGGCGACCAGTATCGCGCAACGGATTTCAAATTCCCCGGCAAGGGCAAGCTGACGATCAAGTTCGTCGGTGAAGAC
GGCACCGTGATCGAAAAGGAAGTCTTCAACGCGCCGGGCGCCGGCGTCGCCATGGCCATGTACAACCTCGACGAATCGAT
CCGCGAATTCGCCCGCGCCTCGATGATGTACGGCCTGATGCGCAAGTGGCCGGTCTACCTGTCGACCAAGAACACCATCC
TCAAGGCCTATGACGGACGCTTCAAGGATATCTTCGAAGAAGTCTTCGAGGCCGAATTCAAGGATCAGTTCAAGGACGCC
GGCATCACTTACGAACATCGTCTGATCGACGACATGGTCGCCTCGGCGCTCAAGTGGTCGGGCGGCTACGTCTGGGCCTG
CAAGAACTATGACGGCGACGTCCAGTCCGACACTGTTGCCCAGGGCTTCGGCTCGCTCGGTCTGATGACCTCGGTTCTGC
TCACGCCGGATGGCAAGACGGTCGAAGCCGAAGCCGCTCACGGCACCGTCACCCGCCACTACCGCCAGCACCAGAAGGGC
CAGGAAACCTCGACGAACTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTCGCTCACCGCGCCAAGCTCGACGACAA
TGCCGAACTGGCCCGCTTCGCCTCGACGCTCGAAAAGGTCTGCGTCGATACCGTCGAATCCGGATTCATGACCAAGGACT
TGGCGCTCTTGATCGGCCCGGATCAGCCGTGGCTCTCCACCACCGCCTTCCTCGACAAGATCGACCAGAACCTGCAGAAG
GCGATGGCGTAA

Upstream 100 bases:

>100_bases
CGTTGCAGCTTTGCGTTCCCAGTTCACAATGCTATAGCGCTCCTCATCACGTCACCCACCCGGGACGCTTGTCCCCTTCA
AGCTCGAACGAGGCAGATAC

Downstream 100 bases:

>100_bases
GCCTGCCCTTTCGCGATAGCATTGAAACGGCGGGGATTTCCCCGCCGTTTTTATTTGGGAACGAACCGATGACCGCCATC
CTGCGACCGCTTGAACCCTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDAANAIKKYGVGIKCATITPDE
ARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGED
GTVIEKEVFNAPGAGVAMAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVFEAEFKDQFKDA
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGKTVEAEAAHGTVTRHYRQHQKG
QETSTNSIASIFAWTRGLAHRAKLDDNAELARFASTLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDQNLQK
AMA

Sequences:

>Translated_403_residues
MNKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDAANAIKKYGVGIKCATITPDE
ARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGED
GTVIEKEVFNAPGAGVAMAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVFEAEFKDQFKDA
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGKTVEAEAAHGTVTRHYRQHQKG
QETSTNSIASIFAWTRGLAHRAKLDDNAELARFASTLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDQNLQK
AMA
>Mature_403_residues
MNKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDAANAIKKYGVGIKCATITPDE
ARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGED
GTVIEKEVFNAPGAGVAMAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVFEAEFKDQFKDA
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGKTVEAEAAHGTVTRHYRQHQKG
QETSTNSIASIFAWTRGLAHRAKLDDNAELARFASTLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDQNLQK
AMA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=67.156862745098, Blast_Score=573, Evalue=1e-164,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=66.0975609756098, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=67.910447761194, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=66.0933660933661, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6320137, Length=407, Percent_Identity=63.8820638820639, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=62.7160493827161, Blast_Score=535, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=61.4250614250614, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=407, Percent_Identity=65.6019656019656, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330987, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330985, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI28574947, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660849, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660856, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330983, Length=407, Percent_Identity=65.6019656019656, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660868, Length=407, Percent_Identity=65.6019656019656, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660860, Length=407, Percent_Identity=65.6019656019656, Blast_Score=557, Evalue=1e-159,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45061; Mature: 45061

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEEEEEECCCCCCCCEEEEEH
ANAIKKYGVGIKCATITPDEARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGEDGTVIEKEVFNAPGAGVAMAM
CCCCCCCEEEECHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCHHHHH
YNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVFEAEFKDQFKDA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCE
VEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELARFASTLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDQNLQKAMA
HHHHHHCCCCEECEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEEEEEECCCCCCCCEEEEEH
ANAIKKYGVGIKCATITPDEARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGEDGTVIEKEVFNAPGAGVAMAM
CCCCCCCEEEECHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCHHHHH
YNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVFEAEFKDQFKDA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCE
VEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELARFASTLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDQNLQKAMA
HHHHHHCCCCEECEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]