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The map label for this gene is purL [H]

Identifier: 209549528

GI number: 209549528

Start: 1978066

End: 1980297

Strand: Direct

Name: purL [H]

Synonym: Rleg2_1934

Alternate gene names: 209549528

Gene position: 1978066-1980297 (Clockwise)

Preceding gene: 209549527

Following gene: 209549529

Centisome position: 43.59

GC content: 64.11

Gene sequence:

>2232_bases
ATGACCATTCCAAACACCATCCCGATCACGCCAGAACTCATTGCGGGCCATGGCCTGAAGCCGGACGAGTATCAGCGCAT
TCTGGATCTGATCGGCCGCGAACCGACTTTCACCGAGCTCGGCATCTTCTCGGCCATGTGGAACGAGCACTGCTCCTATA
AATCCTCGAAGAAATGGCTACGCACGCTGCCGACCAAGGGGCCGCGCGTCATCCAGGGCCCCGGCGAAAATGCCGGCGTG
GTCGATATCGATGACGGCGATTGCGTCGTCTTCAAGATGGAGAGCCACAACCACCCCTCCTATATCGAGCCTTACCAGGG
GGCTGCGACCGGCGTCGGCGGCATCCTGCGTGACGTCTTCACCATGGGCGCGCGCCCGATCGCCGCGATGAACGCCTTGC
GCTTCGGCGAGCCGGATCATCCGAAGACCCGCCACCTCGTCTCCGGCGTCGTCTCCGGCGTCGGCGGTTACGGCAATTCC
TTCGGCGTGCCGACGGTCGGCGGCGAAGTCGAGTTCGATGCGCGCTATAACGGCAACATCCTCGTCAACGCCTTTGCCGC
CGGCATCGCCAAATCCAATGCCATCTTCCTCTCCGAGGCCAAGGGCGTCGGCCTTCCGGTCGTTTATCTCGGCGCCAAGA
CCGGCCGCGACGGCGTCGGCGGCGCGACCATGGCCTCGGCCGAATTCGACGAATCGATCGAGGAAAAGCGCCCGACCGTT
CAGGTCGGCGACCCCTTCACCGAAAAATGCCTGCTCGAAGCCTGCCTCGAGCTGATGCAGACCGGCGCCGTTATCGCCAT
CCAGGATATGGGTGCGGCCGGCCTCACCTGCTCGGCGGTCGAAATGGGCGCCAAGGGCGACCTGGGCATCCTGCTCGAAC
TCGACAAGGTGCCTGTGCGTGAAGAGCGCATGACCGCCTATGAAATGATGCTGTCGGAAAGCCAGGAGCGCATGCTCATG
GTGCTGCAGCCGGAGAAGGAACAGGAAGCCAAGGCGATCTTCGTCAAATGGGGCCTCGACTTCGCCATCGTCGGTAAGAC
CACGGATGACCTGCGCTTCCGCGTGATGCATCAGGGCGAGGAAGTCGCCAACCTGCCTATCAAGGATCTCGGCGACCAGG
CGCCGGAATATGATCGCCCCTGGCGCGAGTCGGGCAAACAGGCTCCGCTGCCCGCCAATCTCGTCGCTGCCCCCAAGGAT
TATGGTCAGGCGCTGCTGCAACTCGTCGGCTCCGCCAACCAGTCGAGCCGCCGCTGGGTCTATGAGCAATATGACACGCT
GATCCAGGGCAATTCGCTGCAACTTCCGGGCGGCGATGCCGGCGTCGTGCGCGTCGACGGCCATCCGAGCAAGGCGCTCG
CCTTCTCCTCCGACGTGACGCCGCGTTATGTCGAGGCCGATCCGTTCGAAGGCGGCAAGCAGGCGGTCGCCGAATGCTGG
CGCAACATCACCGCAACCGGCGCCGAGCCGCTCGCCGCCACCGACAATCTGAACTTCGGCAATCCCGAAAAGCCCGAGAT
CATGGGCCAGTTCGTCCAGGCGGTGAAGGGCATCGGCGAGGCCTGCCGGGCGCTCGACTTCCCGATCGTCTCAGGCAACG
TCTCGCTCTACAATGAGACCAACGGCGTCGCCATCCTGCCGACCCCGACGATTGCAGGCGTCGGCCTGCTGCCGGATTGG
CGCAAGATGGCCCGCATCGGCAGCGCCAATGACGGCGACAAGGTGATCATGATCGGCGTCGACGGCAGCCATCTCGGCCA
GTCGGTCTATCTGCGCGATGTGCTCGACAGCCGCGAAGGTCCCGCCCCCGAGGTGGATCTGTTTGCCGAGCGCCGCAACG
GCGATTTCGTCCGCTCCGTCATCCGCAACGGCCAGGCGACCGCCTGCCACGATATTTCCTCGGGCGGCCTTGCGGTCGCG
CTTGCCGAAATGGTCATGGCATCGGACAAGGGTCTGGCGATTGATCTCGGCGAAGGCAAGGGTGCGCCGCATGCGCTGCT
CTTCGGTGAGGATCAGGCGCGCTACGTGCTGACGGTCCCGGCTGATGTCGCCGATTTCCTCTGCGCCAATGCCGAAGGTG
CGGGCGTTCCCTTCCGGCGTCTCGGCACGGTCGGGGGGACGGCGCTTACCGTTGGCGATCTCATCTCGCTGCCGATTCAG
CAATTGCGCGATGCCCATGAATCGTGGTTCCCTGATTTCATGGAAGGCCGCGGCGAACTGGCTGCGGAATGA

Upstream 100 bases:

>100_bases
TCGGGGGTCAGTTCACTGTGTTGATGGCTGGCTTTTTTCTGTCGCGCGCCGCCGCGACATAAGCTAAAGACAGCGCAAAC
GCGCCAGGGACTTTCCGCTC

Downstream 100 bases:

>100_bases
TGCGCAAGGAGTAAAGATCATGGCCATGAAACCCGGCGATATCGAAGACATGATCAAGGCTGGGATTCCCGGTGCCAAGG
TGACGATCCGCGATCTGGCG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGV
VDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNS
FGVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLM
VLQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGEEVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKD
YGQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECW
RNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDW
RKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREGPAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVA
LAEMVMASDKGLAIDLGEGKGAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQ
QLRDAHESWFPDFMEGRGELAAE

Sequences:

>Translated_743_residues
MTIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGV
VDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNS
FGVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLM
VLQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGEEVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKD
YGQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECW
RNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDW
RKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREGPAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVA
LAEMVMASDKGLAIDLGEGKGAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQ
QLRDAHESWFPDFMEGRGELAAE
>Mature_742_residues
TIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVV
DIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSF
GVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQ
VGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLMV
LQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGEEVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKDY
GQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECWR
NITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDWR
KMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREGPAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVAL
AEMVMASDKGLAIDLGEGKGAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQQ
LRDAHESWFPDFMEGRGELAAE

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=684, Percent_Identity=22.953216374269, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI48994899, Length=770, Percent_Identity=24.025974025974, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17553022, Length=677, Percent_Identity=22.5997045790251, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=737, Percent_Identity=24.2876526458616, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79439; Mature: 79308

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSFGVPTVGGEVEFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEECCCE
LVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCEEEEEEECCCCCC
EERMTAYEMMLSESQERMLMVLQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGE
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECCCC
EVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKDYGQALLQLVGSANQSSRRWV
HHHCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHH
RNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGVAILPTPTIAGVGLLPDWRKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREG
CCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHCCHHHHHHHHHCCCC
PAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVALAEMVMASDKGLAIDLGEGK
CCCCHHHEEECCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCC
GAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQ
CCCEEEEECCCCCCEEEEECHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHH
QLRDAHESWFPDFMEGRGELAAE
HHHHHHHHCCCHHHCCCCCCCCC
>Mature Secondary Structure 
TIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSFGVPTVGGEVEFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEECCCE
LVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCEEEEEEECCCCCC
EERMTAYEMMLSESQERMLMVLQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGE
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECCCC
EVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKDYGQALLQLVGSANQSSRRWV
HHHCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHH
RNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGVAILPTPTIAGVGLLPDWRKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREG
CCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHCCHHHHHHHHHCCCC
PAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVALAEMVMASDKGLAIDLGEGK
CCCCHHHEEECCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCC
GAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQ
CCCEEEEECCCCCCEEEEECHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHH
QLRDAHESWFPDFMEGRGELAAE
HHHHHHHHCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA