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The map label for this gene is glmS [H]

Identifier: 209549322

GI number: 209549322

Start: 1763042

End: 1764868

Strand: Direct

Name: glmS [H]

Synonym: Rleg2_1726

Alternate gene names: 209549322

Gene position: 1763042-1764868 (Clockwise)

Preceding gene: 209549321

Following gene: 209549323

Centisome position: 38.85

GC content: 63.66

Gene sequence:

>1827_bases
ATGTGCGGAATTGTCGGGATCGTCGGAACTCAGCCTGTTGCCGGGCGCCTGGTCGATGCGTTGAAGCGTCTCGAATATCG
CGGTTATGATTCTGCCGGTGTCGCCACCATCCATGAGGGGGTGATGGATCGCCGCCGCGCCGAAGGCAAGCTGTTCAATC
TGGAAAAGCGCCTCGACGCCGAGCCGTTGCCAGGTGTTGTCGGCATTGCCCATACGCGCTGGGCGACCCACGGTGTTCCC
AACGAAACCAATGCCCATCCGCATTTCGTCGAAGGTGTCGCCGTCGTCCACAACGGCATCATCGAGAATTTCTCCGAGCT
GCGCGACGAACTGACCGCGGAGGGTTCGGTCTTCGAAACCCAGACCGACACCGAGGTCGTGGCCCAGCTGATGGCGAAAT
ATCTGCGCGAGGGCCTGGAGCCGCGCGCCGCCATGCTACAGATGCTGAACCGGCTGACCGGCGCCTATGCGCTCGCCGTC
ATGCTCAAGGCCGATCCCGGCACGATCATGGCCGCCCGTTCCGGCCCACCGCTGGCGGTCGGTTACGGGCGCGGCGAGAT
GTTCCTCGGTTCGGATGCGATCGCGCTCTCGCCCTTCACCAACGAGATCACCTACCTGGTCGATGGCGACTGCGCCGTCA
TTACCCGCGACAGCCTCGCCGTCATCGATTTCGCCGGCAAGCCGGTCAAGCGCGCCCGTCAGATCTCGCAGGCGACCGCC
TATGTCGTCGACAAGGGCAACCACCGCCATTTCATGGAGAAGGAAATCTACGAGCAGCCGGAGGTGATCTCCCACGCCCT
CAGCCATTACGTCGATTTTGCCGAGAACACGATCGGCGCCAACGCCGCTGCGATCGACTTCAAGGCGGCGACCGGCCTGG
CGATCTCGGCCTGCGGCACCGCCTATCTCGCCGGCCTCGTCGGCAAATACTGGTTCGAGCGTTATGCCCGCCTGCCGGTC
GAGATCGACGTCGCCTCCGAATTCCGCTATCGCGAAATGCCGCTGTCGCCCTCGCAGGCAGCGCTGTTCATCTCCCAGTC
CGGCGAGACCGCCGATACGCTGGCATCGCTGCGCTATTGCCGCGATAACGGCCTGAAGATCGGCGCCGTCGTCAATGTCC
GCGAATCGACGATCGCCCGCGAGTCCGACGCCGTCTTCCCGATCATGGCCGGCCCCGAAATCGGCGTCGCCTCGACCAAG
GCCTTCACCTGCCAGCTGGCAGTGCTCGCATCGCTGGCGATCGGCGCCGGCAAGGCCCGCGGCACGGTGAGCGCCGATGA
GGAGAGGGCGCTGGTGCGCCATCTCGCCGAAATGCCGCGCATCATGAGCCGGGTGCTGAACCTCATCCAGCCGCAGATGG
AAAGCCTGTCGCGCGAGCTGTCGAAATGCAAGGACGTGCTCTATCTCGGCCGCGGCACCAGCTTCCCGCTCGCCATGGAA
GGCGCGCTGAAGCTCAAGGAAATTTCCTATATCCACGCCGAAGGCTATGCCGCCGGCGAATTGAAGCACGGGCCGATCGC
GCTGATCGACGAGAACATGCCGGTGATCGTCATCGCCCCCTTCGACCGCTTCTTCGAAAAGACCGTCTCGAATATGCAGG
AGGTCGCAGCCCGCGGCGGCCGCATCATCTTCATCACCGATGAGGCCGGGGCTGCCGCCTCGAAACTGCCGACCATGGCG
ACGATCACCCTGCCTGTGGTCGACGAAATCATCGCGCCGATGATCTTCTCGCTGCCGATTCAGCTGCTCGCCTATCACAC
CGCCGTCTTCATGGGCACGGATGTCGATCAGCCGCGCAATCTGGCGAAATCAGTGACCGTGGAATAA

Upstream 100 bases:

>100_bases
AAAGCAATTCCAGCAAAAGTGCGCAGCGGTTTTGCGTCCGGAAATTGCGTGAAGAAAACAGAAGAGCATTTCCGCGGAAA
TGCTCGAGTGGGGATATTGC

Downstream 100 bases:

>100_bases
GCCCGCAACGACCTGATCTTCGCGCCGAAACATATTGTGCGACGCCCCGAATTCTGGCAATTTTGGTCGGCGGACAAGGG
GGAAGGGCCGGCGTTCCGGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGIVGTQPVAGRLVDALKRLEYRGYDSAGVATIHEGVMDRRRAEGKLFNLEKRLDAEPLPGVVGIAHTRWATHGVP
NETNAHPHFVEGVAVVHNGIIENFSELRDELTAEGSVFETQTDTEVVAQLMAKYLREGLEPRAAMLQMLNRLTGAYALAV
MLKADPGTIMAARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAVITRDSLAVIDFAGKPVKRARQISQATA
YVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFAENTIGANAAAIDFKAATGLAISACGTAYLAGLVGKYWFERYARLPV
EIDVASEFRYREMPLSPSQAALFISQSGETADTLASLRYCRDNGLKIGAVVNVRESTIARESDAVFPIMAGPEIGVASTK
AFTCQLAVLASLAIGAGKARGTVSADEERALVRHLAEMPRIMSRVLNLIQPQMESLSRELSKCKDVLYLGRGTSFPLAME
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPFDRFFEKTVSNMQEVAARGGRIIFITDEAGAAASKLPTMA
TITLPVVDEIIAPMIFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGIVGTQPVAGRLVDALKRLEYRGYDSAGVATIHEGVMDRRRAEGKLFNLEKRLDAEPLPGVVGIAHTRWATHGVP
NETNAHPHFVEGVAVVHNGIIENFSELRDELTAEGSVFETQTDTEVVAQLMAKYLREGLEPRAAMLQMLNRLTGAYALAV
MLKADPGTIMAARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAVITRDSLAVIDFAGKPVKRARQISQATA
YVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFAENTIGANAAAIDFKAATGLAISACGTAYLAGLVGKYWFERYARLPV
EIDVASEFRYREMPLSPSQAALFISQSGETADTLASLRYCRDNGLKIGAVVNVRESTIARESDAVFPIMAGPEIGVASTK
AFTCQLAVLASLAIGAGKARGTVSADEERALVRHLAEMPRIMSRVLNLIQPQMESLSRELSKCKDVLYLGRGTSFPLAME
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPFDRFFEKTVSNMQEVAARGGRIIFITDEAGAAASKLPTMA
TITLPVVDEIIAPMIFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIVGIVGTQPVAGRLVDALKRLEYRGYDSAGVATIHEGVMDRRRAEGKLFNLEKRLDAEPLPGVVGIAHTRWATHGVP
NETNAHPHFVEGVAVVHNGIIENFSELRDELTAEGSVFETQTDTEVVAQLMAKYLREGLEPRAAMLQMLNRLTGAYALAV
MLKADPGTIMAARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAVITRDSLAVIDFAGKPVKRARQISQATA
YVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFAENTIGANAAAIDFKAATGLAISACGTAYLAGLVGKYWFERYARLPV
EIDVASEFRYREMPLSPSQAALFISQSGETADTLASLRYCRDNGLKIGAVVNVRESTIARESDAVFPIMAGPEIGVASTK
AFTCQLAVLASLAIGAGKARGTVSADEERALVRHLAEMPRIMSRVLNLIQPQMESLSRELSKCKDVLYLGRGTSFPLAME
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPFDRFFEKTVSNMQEVAARGGRIIFITDEAGAAASKLPTMA
TITLPVVDEIIAPMIFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=36.8267831149927, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI205277386, Length=689, Percent_Identity=36.4296081277213, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=49.3506493506493, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI1788651, Length=218, Percent_Identity=33.9449541284404, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539970, Length=716, Percent_Identity=33.1005586592179, Blast_Score=357, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17532899, Length=716, Percent_Identity=32.9608938547486, Blast_Score=353, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=35.8974358974359, Blast_Score=269, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=39.4919168591224, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=29.6551724137931, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=214, Percent_Identity=34.5794392523364, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=30.5389221556886, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=37.0101596516691, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65754; Mature: 65754

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIVGTQPVAGRLVDALKRLEYRGYDSAGVATIHEGVMDRRRAEGKLFNLEKRLDA
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHCCC
EPLPGVVGIAHTRWATHGVPNETNAHPHFVEGVAVVHNGIIENFSELRDELTAEGSVFET
CCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
QTDTEVVAQLMAKYLREGLEPRAAMLQMLNRLTGAYALAVMLKADPGTIMAARSGPPLAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCCEEE
GYGRGEMFLGSDAIALSPFTNEITYLVDGDCAVITRDSLAVIDFAGKPVKRARQISQATA
ECCCCCEEECCCCEEECCCCCCEEEEECCCEEEEECCCEEEEECCCCCHHHHHHHHHHHE
YVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFAENTIGANAAAIDFKAATGLAISACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHH
AYLAGLVGKYWFERYARLPVEIDVASEFRYREMPLSPSQAALFISQSGETADTLASLRYC
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHH
RDNGLKIGAVVNVRESTIARESDAVFPIMAGPEIGVASTKAFTCQLAVLASLAIGAGKAR
HCCCEEEEEEEEEHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GTVSADEERALVRHLAEMPRIMSRVLNLIQPQMESLSRELSKCKDVLYLGRGTSFPLAME
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPFDRFFEKTVSNMQEVAARGG
CCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
RIIFITDEAGAAASKLPTMATITLPVVDEIIAPMIFSLPIQLLAYHTAVFMGTDVDQPRN
EEEEEECCCCCHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGIVGTQPVAGRLVDALKRLEYRGYDSAGVATIHEGVMDRRRAEGKLFNLEKRLDA
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHCCC
EPLPGVVGIAHTRWATHGVPNETNAHPHFVEGVAVVHNGIIENFSELRDELTAEGSVFET
CCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
QTDTEVVAQLMAKYLREGLEPRAAMLQMLNRLTGAYALAVMLKADPGTIMAARSGPPLAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCCEEE
GYGRGEMFLGSDAIALSPFTNEITYLVDGDCAVITRDSLAVIDFAGKPVKRARQISQATA
ECCCCCEEECCCCEEECCCCCCEEEEECCCEEEEECCCEEEEECCCCCHHHHHHHHHHHE
YVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFAENTIGANAAAIDFKAATGLAISACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHH
AYLAGLVGKYWFERYARLPVEIDVASEFRYREMPLSPSQAALFISQSGETADTLASLRYC
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHH
RDNGLKIGAVVNVRESTIARESDAVFPIMAGPEIGVASTKAFTCQLAVLASLAIGAGKAR
HCCCEEEEEEEEEHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GTVSADEERALVRHLAEMPRIMSRVLNLIQPQMESLSRELSKCKDVLYLGRGTSFPLAME
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPFDRFFEKTVSNMQEVAARGG
CCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
RIIFITDEAGAAASKLPTMATITLPVVDEIIAPMIFSLPIQLLAYHTAVFMGTDVDQPRN
EEEEEECCCCCHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]