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The map label for this gene is sir2 [H]

Identifier: 209549237

GI number: 209549237

Start: 1668161

End: 1669831

Strand: Direct

Name: sir2 [H]

Synonym: Rleg2_1638

Alternate gene names: 209549237

Gene position: 1668161-1669831 (Clockwise)

Preceding gene: 209549236

Following gene: 209549238

Centisome position: 36.76

GC content: 62.72

Gene sequence:

>1671_bases
ATGTACCGTTACGACGAATTTGACCATGCCTTTGTCAGCGAGCGCGTCGAGCAGTTCCGCGACCAGGTCCAGCGCCGCCT
TGCCGGCGAGCTTGCCGAGGATGCGTTCAAGCCGCTGCGCCTGATGAACGGCGTCTACCTGCAGCTCCATGCCTATATGC
TGCGCATCGCCATTCCCTATGGCACGCTGAGCGCGCGCCAGATGCGCATGCTCGCCCATATCGCCCGCACCTATGACCGC
GGTTATGGCCATTTCACCACACGCCAGAACCTGCAGTTCAACTGGCCGAAGCTCTCGGAAATCCCCGATGCGCTCGCCGA
TCTCGCCAGCGTCGAGATGCATGCCCTGCAGACCTCGGGCAACTGCATCAGAAACGTCACCGCCGATCACTTTGCCGGTG
CTGCCGCCGACGAGATCGCCGATCCACGGCCCTATGCCGAAATCCTGCGTCAGTGGTCGTCGGTCCATCCGGAATTCTCC
TTTCTGCCGCGCAAGTTCAAGATCGCCGTCACCGGCGCCGAGCGCGACCGCGCTGCCATTCAGGTCCATGATATCGGCCT
GCACCTGAAGAAGAACGACAAGGGCGAGATCGGTTTTGCCGTCTATGTCGGCGGTGGCCAGGGCCGTACGCCGATGATCG
CCAAGCTGATCCGCGACTTCCTGCCCGAGGAGGATCTGCTCTCCTACACCACGGCTATCGTGCGCGTGTACAATCTGCAC
GGCCGCCGCGACAACAAGTACAAGGCCCGCATCAAGATCCTCGTGCATGAAACCGGCACCGAGGAACTGACGCGCCAGGT
CGAGGCCGAATTCGCCTCGCTGAGGGATAGTGAGCTCAAGCTGCCGGAACAGGACGTCGAGGCGATCGCCGCCTATTTCG
CGCCGCCGGCTCTGCCTCAGCGCGCCGAAGGCTGGGAAAACCTTGCCCGCTGGAAGAAGGCCGATCCAGATTTCGCCCGC
TGGGTGCAGCAGAATGTGCAGCCGCACAAGAATCCCGACTACGGCATGGTGACGATCTCGCTGAAGCCGATCGGCGGCAT
TCCGGGCGATGCCACCGACGCGCAGATGGATGCGATCGCCGATCTCGCCGAAGAATATGCCTTCGACGAAATCCGCGTCA
GCCATGAGCAGAACCTGATCCTGCCACATGTGGCGCTGGCCGATCTCGAAGCCGTCTATCGCGGTCTCGTCGCCATCGAT
CTGGCCGAAGCCAATGCCGGCCTGATCACCGATATTATTGCCTGTCCCGGGCTCGACTATTGCGCGCTCGCCAATGCGCG
CTCCATCCCGCTGGCGCAGGAAATCTCCCGTCGCTTCGGCAGCGCCGAACGCCAGGCCGAGATCGGCGAGCTGAAGATCA
AGATCTCCGGCTGCATCAATGCCTGCGGCCACCACCATGTCGGCCATATCGGTCTGCTCGGTGTGGAGAAGAAGGGCGCC
GAACTCTATCAGATCACGCTCGGCGGCTCCGGCGACGAACATACCTCGATCGGCGAAATCATCGGCCGCGGCTTCGAGCC
GGACCGGGTGACGGACGCGATCGAGACGATCGTCGACACCTATCTCGGCCTCCGCCTCGATCCGTCGGAGATCTTCCTTG
CTGCCTATCGCCGCGTCGGGCCGCAGCCTTTCAAGACTGCGCTCTATGGCGCTGCCGCGGAAGCGGCATAA

Upstream 100 bases:

>100_bases
TTCGCCTTCGCGAGCGCATCCGCGCGCAAGGGCCGACCATGGAATATGCACCGGGCTACGCTCCGGCCGATCCCGAATTC
ATTGCAGTCTGAGGAAGACG

Downstream 100 bases:

>100_bases
GGAGGCGATGATGACGAAGATCTGGAGAGAAACCGGTTTTGTCGACAACGATCCCTGGGTGATCGAGACCGACGAGGTGA
AGGCGACCGGGGAACAGAAG

Product: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MYRYDEFDHAFVSERVEQFRDQVQRRLAGELAEDAFKPLRLMNGVYLQLHAYMLRIAIPYGTLSARQMRMLAHIARTYDR
GYGHFTTRQNLQFNWPKLSEIPDALADLASVEMHALQTSGNCIRNVTADHFAGAAADEIADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKLIRDFLPEEDLLSYTTAIVRVYNLH
GRRDNKYKARIKILVHETGTEELTRQVEAEFASLRDSELKLPEQDVEAIAAYFAPPALPQRAEGWENLARWKKADPDFAR
WVQQNVQPHKNPDYGMVTISLKPIGGIPGDATDAQMDAIADLAEEYAFDEIRVSHEQNLILPHVALADLEAVYRGLVAID
LAEANAGLITDIIACPGLDYCALANARSIPLAQEISRRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
ELYQITLGGSGDEHTSIGEIIGRGFEPDRVTDAIETIVDTYLGLRLDPSEIFLAAYRRVGPQPFKTALYGAAAEAA

Sequences:

>Translated_556_residues
MYRYDEFDHAFVSERVEQFRDQVQRRLAGELAEDAFKPLRLMNGVYLQLHAYMLRIAIPYGTLSARQMRMLAHIARTYDR
GYGHFTTRQNLQFNWPKLSEIPDALADLASVEMHALQTSGNCIRNVTADHFAGAAADEIADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKLIRDFLPEEDLLSYTTAIVRVYNLH
GRRDNKYKARIKILVHETGTEELTRQVEAEFASLRDSELKLPEQDVEAIAAYFAPPALPQRAEGWENLARWKKADPDFAR
WVQQNVQPHKNPDYGMVTISLKPIGGIPGDATDAQMDAIADLAEEYAFDEIRVSHEQNLILPHVALADLEAVYRGLVAID
LAEANAGLITDIIACPGLDYCALANARSIPLAQEISRRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
ELYQITLGGSGDEHTSIGEIIGRGFEPDRVTDAIETIVDTYLGLRLDPSEIFLAAYRRVGPQPFKTALYGAAAEAA
>Mature_556_residues
MYRYDEFDHAFVSERVEQFRDQVQRRLAGELAEDAFKPLRLMNGVYLQLHAYMLRIAIPYGTLSARQMRMLAHIARTYDR
GYGHFTTRQNLQFNWPKLSEIPDALADLASVEMHALQTSGNCIRNVTADHFAGAAADEIADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKLIRDFLPEEDLLSYTTAIVRVYNLH
GRRDNKYKARIKILVHETGTEELTRQVEAEFASLRDSELKLPEQDVEAIAAYFAPPALPQRAEGWENLARWKKADPDFAR
WVQQNVQPHKNPDYGMVTISLKPIGGIPGDATDAQMDAIADLAEEYAFDEIRVSHEQNLILPHVALADLEAVYRGLVAID
LAEANAGLITDIIACPGLDYCALANARSIPLAQEISRRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
ELYQITLGGSGDEHTSIGEIIGRGFEPDRVTDAIETIVDTYLGLRLDPSEIFLAAYRRVGPQPFKTALYGAAAEAA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

None

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 61833; Mature: 61833

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRYDEFDHAFVSERVEQFRDQVQRRLAGELAEDAFKPLRLMNGVYLQLHAYMLRIAIPY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLSARQMRMLAHIARTYDRGYGHFTTRQNLQFNWPKLSEIPDALADLASVEMHALQTSG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEIADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCCEE
QVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKLIRDFLPEEDLLSYTTAIVRVYNLH
EEEEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRRDNKYKARIKILVHETGTEELTRQVEAEFASLRDSELKLPEQDVEAIAAYFAPPALPQ
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
RAEGWENLARWKKADPDFARWVQQNVQPHKNPDYGMVTISLKPIGGIPGDATDAQMDAIA
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHH
DLAEEYAFDEIRVSHEQNLILPHVALADLEAVYRGLVAIDLAEANAGLITDIIACPGLDY
HHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCH
CALANARSIPLAQEISRRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
HHHCCCCCCCHHHHHHHHHCCHHHCCCCCEEEEEEHHHHHHCCCCCCCCEEEEEECCCCC
ELYQITLGGSGDEHTSIGEIIGRGFEPDRVTDAIETIVDTYLGLRLDPSEIFLAAYRRVG
EEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHCC
PQPFKTALYGAAAEAA
CCHHHHHHHHHHHCCC
>Mature Secondary Structure
MYRYDEFDHAFVSERVEQFRDQVQRRLAGELAEDAFKPLRLMNGVYLQLHAYMLRIAIPY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLSARQMRMLAHIARTYDRGYGHFTTRQNLQFNWPKLSEIPDALADLASVEMHALQTSG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEIADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCCEE
QVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKLIRDFLPEEDLLSYTTAIVRVYNLH
EEEEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRRDNKYKARIKILVHETGTEELTRQVEAEFASLRDSELKLPEQDVEAIAAYFAPPALPQ
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
RAEGWENLARWKKADPDFARWVQQNVQPHKNPDYGMVTISLKPIGGIPGDATDAQMDAIA
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHH
DLAEEYAFDEIRVSHEQNLILPHVALADLEAVYRGLVAIDLAEANAGLITDIIACPGLDY
HHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCH
CALANARSIPLAQEISRRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
HHHCCCCCCCHHHHHHHHHCCHHHCCCCCEEEEEEHHHHHHCCCCCCCCEEEEEECCCCC
ELYQITLGGSGDEHTSIGEIIGRGFEPDRVTDAIETIVDTYLGLRLDPSEIFLAAYRRVG
EEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHCC
PQPFKTALYGAAAEAA
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA