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The map label for this gene is clpA [C]

Identifier: 209549171

GI number: 209549171

Start: 1595713

End: 1598205

Strand: Direct

Name: clpA [C]

Synonym: Rleg2_1572

Alternate gene names: 209549171

Gene position: 1595713-1598205 (Clockwise)

Preceding gene: 209549170

Following gene: 209549172

Centisome position: 35.16

GC content: 62.9

Gene sequence:

>2493_bases
GTGCCAACATTTTCGCCTAGTTTAGAGAAGGCGCTCCATCAGGCACTGACTTTTGCCAACGAGCGGCACCACGAATATGC
GACGCTCGAGCATCTGCTGCTCGCCCTGATCGACGATGCCGATGCGGCCGCGGTCATGGGTGCCTGCAATGTCGATCTCG
ACGCGCTGCGCAAGACGCTCGTCGAATATGTCGATAACGAACTCTCCAACCTGATCACCGGATATGACGAGGATTCGAAG
CCGACCTCCGGCTTCCAGCGCGTCATCCAGCGTGCCGTCATCCACGTGCAATCGTCCGGCCGCGAAGAGGTGACCGGCGC
CAACGTGCTCGTCGCGATCTTTGCCGAGCGCGAGAGCCATGCCGCCTATTTCCTGCAAGAGCAGGAGATGACCCGCTACG
ACGCCGTCAACTATATCTCCCACGGCATCGGTAAGCGCCCGGGTGCTTCCGAAGCGCGCCCCCCGCGCGGCGCCGAGGAG
GAAGCCGAGAGCAGCAAGCCGACGGCGCGCGGCGGCGAGGAAGAGGGCGGCCCGAAGAAGCAGCAGGATGCGCTCAAGGC
CTATTGCGTCAATCTCAACGAGAAGGCCAAGGGCGGCAAGATCGACCCGCTGATCGGCCGTCACGCCGAGGTAAGCCGCA
CCATCCAGATCCTGTGCCGCCGTTCGAAGAACAATCCGCTCTATGTCGGCGATCCCGGCGTCGGCAAGACGGCGATCGCC
GAAGGCCTTGCCAAGCGCATCGTCGAAGGCAAGGTTCCCGAAGCGCTCGCCGATGCGACGATCTTCTCCCTCGACATGGG
CACGCTGCTGGCCGGCACGCGCTACCGCGGCGATTTCGAGGAGCGTCTGAAGCAGGTCGTCAAGGAACTCGAGGAATATC
CGGGCGCCGTGCTGTTCATCGACGAGATCCACACGGTGATCGGTGCCGGTGCCACCTCGGGCGGTGCGATGGATGCATCG
AACCTCTTGAAGCCGGCCCTGTCGTCGGGCGCGATCCGCTGCATCGGGTCGACCACCTACAAGGAATATCGCCAGTTCTT
CGAAAAGGACCGGGCGCTGGTTCGCCGATTCCAGAAGATCGACGTCAGCGAGCCGTCGATCGACGACGCGATCGAGATCA
TGAAGGGCCTGAAGCCCTATTTCGAGGAATATCACCACCTGCGTTATTCCAACGATGCCATCAAGTCGGCCGTCGAACTC
TCGGCCCGCTACATCTCCGACCGCAAGCTGCCGGACAAGGCGATCGACGTGATCGACGAGACCGGTGCGGCCCAGATGCT
GCTGCCGCCGTCGAAGCGCCGCAAGCTGATCACCGAAAAGGAGATCGAGGCAACGGTCGCCACGATGGCGCGCATTCCGC
CGAAGACTGTCTCCAAGGATGACGAAGCGGTGCTTGCCAATCTCGAGCAGGAACTGCGCTCGGTCGTCTACGGCCAGGAT
ATCGCCATCGAAGCCCTTTCGACCTCGATCAAGCTGGCGCGCGCCGGCCTTCGCGAGCCGAACAAGCCGATCGGCGCCTA
TGTCTTCTCCGGTCCGACCGGCGTCGGGAAGACCGAGGTGGCAAAGCAGCTGGCATCGTCACTCGGCGTCGAGCTTCTGC
GCTTCGACATGTCGGAATATATGGAGCGGCACACGGTGTCGCGCCTGCTCGGTGCACCTCCCGGCTATGTCGGTTTCGAC
CAGGGCGGTCTTCTCACCGATGGCGTCGACCAGCACCCGCATTGCGTGGTCCTGCTCGACGAAATCGAGAAGGCGCATCC
CGACATCTACAATATCCTGCTGCAGGTCATGGACCATGGCACGCTGACCGACCATAACGGCAAGAAGATCGACTTCCGCA
ACGTCATCCTGATCATGACAACGAATGCGGGCGCGTCCGAAATGGCCAAGGCGGCGATCGGCTTCGGCTCGTCCAAGCGC
ACCGGTGAGGACGAGGAGGCGCTGACCCGCCTGTTCACGCCGGAGTTCCGCAACCGTCTCGACGCGATCATTCCTTTCGC
GGCACTGCCGACGGCTGTGATCCACAAGGTCGTGCAGAAGTTTATCATGCAGCTGGAGGCCCAGCTTTCCGAAAGGAACG
TCACCTTCGACCTGCATGAGGACGCGATCGCCTGGCTGTCGGAAAAGGGTTACGACGAGAAGATGGGCGCCCGCCCGCTT
GCCCGCGTGATCCAGGACACCATTAAGAAGCCGCTTGCCAACGAAATCCTCTTCGGCAAGCTGAAGAAGGGCGGCGTCGT
CAACGTCACCGTCGGCCCGAAGGAAGACGGCAAGCCCGGCATCGTGCTGGAGGCCATCCCGGATACGGCGCCGATCAAGC
CGAAGCCGGAAGCCGAAGTCGTCCATCCCGACGCCGACGACCAGGGCGACGGCGAGCTGAAGACCAAGGCGGCGCCCAAG
ACCCGCGCCAAGACGGTCCCGCAGGCCGAGCCCGAGGTCCGCGACGCCCCGAAGAAGGGCAGCACGGTTCCGAAGGTTCC
GCGCAAGAAGTAA

Upstream 100 bases:

>100_bases
TACGAGGTGGCGGAAACGAAGGTCAGCCAGGTGATGGACTTCGCCCGGCAGCACCAGCATCCGCTGCAATGCGTCATGGA
AAAGAAGTGAGGATCTGAAC

Downstream 100 bases:

>100_bases
GATCCACCAATTGAAAAAGGCCGCGTCATGCGGCCTTTTTCGTCTTGGGACTTTTTCTCCCGTTGAACCGGCCGCATCTC
ATCGAGGCGGTATTAGTCAG

Product: ATP-dependent Clp protease ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 829

Protein sequence:

>830_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVDLDALRKTLVEYVDNELSNLITGYDEDSK
PTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGASEARPPRGAEE
EAESSKPTARGGEEEGGPKKQQDALKAYCVNLNEKAKGGKIDPLIGRHAEVSRTIQILCRRSKNNPLYVGDPGVGKTAIA
EGLAKRIVEGKVPEALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEYPGAVLFIDEIHTVIGAGATSGGAMDAS
NLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVSEPSIDDAIEIMKGLKPYFEEYHHLRYSNDAIKSAVEL
SARYISDRKLPDKAIDVIDETGAAQMLLPPSKRRKLITEKEIEATVATMARIPPKTVSKDDEAVLANLEQELRSVVYGQD
IAIEALSTSIKLARAGLREPNKPIGAYVFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLLGAPPGYVGFD
QGGLLTDGVDQHPHCVVLLDEIEKAHPDIYNILLQVMDHGTLTDHNGKKIDFRNVILIMTTNAGASEMAKAAIGFGSSKR
TGEDEEALTRLFTPEFRNRLDAIIPFAALPTAVIHKVVQKFIMQLEAQLSERNVTFDLHEDAIAWLSEKGYDEKMGARPL
ARVIQDTIKKPLANEILFGKLKKGGVVNVTVGPKEDGKPGIVLEAIPDTAPIKPKPEAEVVHPDADDQGDGELKTKAAPK
TRAKTVPQAEPEVRDAPKKGSTVPKVPRKK

Sequences:

>Translated_830_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVDLDALRKTLVEYVDNELSNLITGYDEDSK
PTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGASEARPPRGAEE
EAESSKPTARGGEEEGGPKKQQDALKAYCVNLNEKAKGGKIDPLIGRHAEVSRTIQILCRRSKNNPLYVGDPGVGKTAIA
EGLAKRIVEGKVPEALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEYPGAVLFIDEIHTVIGAGATSGGAMDAS
NLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVSEPSIDDAIEIMKGLKPYFEEYHHLRYSNDAIKSAVEL
SARYISDRKLPDKAIDVIDETGAAQMLLPPSKRRKLITEKEIEATVATMARIPPKTVSKDDEAVLANLEQELRSVVYGQD
IAIEALSTSIKLARAGLREPNKPIGAYVFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLLGAPPGYVGFD
QGGLLTDGVDQHPHCVVLLDEIEKAHPDIYNILLQVMDHGTLTDHNGKKIDFRNVILIMTTNAGASEMAKAAIGFGSSKR
TGEDEEALTRLFTPEFRNRLDAIIPFAALPTAVIHKVVQKFIMQLEAQLSERNVTFDLHEDAIAWLSEKGYDEKMGARPL
ARVIQDTIKKPLANEILFGKLKKGGVVNVTVGPKEDGKPGIVLEAIPDTAPIKPKPEAEVVHPDADDQGDGELKTKAAPK
TRAKTVPQAEPEVRDAPKKGSTVPKVPRKK
>Mature_829_residues
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVDLDALRKTLVEYVDNELSNLITGYDEDSKP
TSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGASEARPPRGAEEE
AESSKPTARGGEEEGGPKKQQDALKAYCVNLNEKAKGGKIDPLIGRHAEVSRTIQILCRRSKNNPLYVGDPGVGKTAIAE
GLAKRIVEGKVPEALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEYPGAVLFIDEIHTVIGAGATSGGAMDASN
LLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVSEPSIDDAIEIMKGLKPYFEEYHHLRYSNDAIKSAVELS
ARYISDRKLPDKAIDVIDETGAAQMLLPPSKRRKLITEKEIEATVATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDI
AIEALSTSIKLARAGLREPNKPIGAYVFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLLGAPPGYVGFDQ
GGLLTDGVDQHPHCVVLLDEIEKAHPDIYNILLQVMDHGTLTDHNGKKIDFRNVILIMTTNAGASEMAKAAIGFGSSKRT
GEDEEALTRLFTPEFRNRLDAIIPFAALPTAVIHKVVQKFIMQLEAQLSERNVTFDLHEDAIAWLSEKGYDEKMGARPLA
RVIQDTIKKPLANEILFGKLKKGGVVNVTVGPKEDGKPGIVLEAIPDTAPIKPKPEAEVVHPDADDQGDGELKTKAAPKT
RAKTVPQAEPEVRDAPKKGSTVPKVPRKK

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=344, Percent_Identity=31.1046511627907, Blast_Score=160, Evalue=7e-39,
Organism=Escherichia coli, GI1787109, Length=751, Percent_Identity=58.3222370173103, Blast_Score=902, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=266, Percent_Identity=54.8872180451128, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6320464, Length=322, Percent_Identity=43.7888198757764, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323002, Length=281, Percent_Identity=44.4839857651246, Blast_Score=247, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 90792; Mature: 90660

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVDLDALRKTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHH
VEYVDNELSNLITGYDEDSKPTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNYISHGIGKRPGASEARPPRGAEEEAESSKPTARGGEEEGGPKK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCH
QQDALKAYCVNLNEKAKGGKIDPLIGRHAEVSRTIQILCRRSKNNPLYVGDPGVGKTAIA
HHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHH
EGLAKRIVEGKVPEALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEYPGAVLFI
HHHHHHHHCCCCCHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEH
DEIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKI
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHC
DVSEPSIDDAIEIMKGLKPYFEEYHHLRYSNDAIKSAVELSARYISDRKLPDKAIDVIDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
TGAAQMLLPPSKRRKLITEKEIEATVATMARIPPKTVSKDDEAVLANLEQELRSVVYGQD
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCC
IAIEALSTSIKLARAGLREPNKPIGAYVFSGPTGVGKTEVAKQLASSLGVELLRFDMSEY
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MERHTVSRLLGAPPGYVGFDQGGLLTDGVDQHPHCVVLLDEIEKAHPDIYNILLQVMDHG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCC
TLTDHNGKKIDFRNVILIMTTNAGASEMAKAAIGFGSSKRTGEDEEALTRLFTPEFRNRL
CEECCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHH
DAIIPFAALPTAVIHKVVQKFIMQLEAQLSERNVTFDLHEDAIAWLSEKGYDEKMGARPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHCCHHH
ARVIQDTIKKPLANEILFGKLKKGGVVNVTVGPKEDGKPGIVLEAIPDTAPIKPKPEAEV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCE
VHPDADDQGDGELKTKAAPKTRAKTVPQAEPEVRDAPKKGSTVPKVPRKK
ECCCCCCCCCCCEECCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVDLDALRKTL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHH
VEYVDNELSNLITGYDEDSKPTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNYISHGIGKRPGASEARPPRGAEEEAESSKPTARGGEEEGGPKK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCH
QQDALKAYCVNLNEKAKGGKIDPLIGRHAEVSRTIQILCRRSKNNPLYVGDPGVGKTAIA
HHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHH
EGLAKRIVEGKVPEALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEYPGAVLFI
HHHHHHHHCCCCCHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEH
DEIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKI
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHC
DVSEPSIDDAIEIMKGLKPYFEEYHHLRYSNDAIKSAVELSARYISDRKLPDKAIDVIDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
TGAAQMLLPPSKRRKLITEKEIEATVATMARIPPKTVSKDDEAVLANLEQELRSVVYGQD
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCC
IAIEALSTSIKLARAGLREPNKPIGAYVFSGPTGVGKTEVAKQLASSLGVELLRFDMSEY
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MERHTVSRLLGAPPGYVGFDQGGLLTDGVDQHPHCVVLLDEIEKAHPDIYNILLQVMDHG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCC
TLTDHNGKKIDFRNVILIMTTNAGASEMAKAAIGFGSSKRTGEDEEALTRLFTPEFRNRL
CEECCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHH
DAIIPFAALPTAVIHKVVQKFIMQLEAQLSERNVTFDLHEDAIAWLSEKGYDEKMGARPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHCCHHH
ARVIQDTIKKPLANEILFGKLKKGGVVNVTVGPKEDGKPGIVLEAIPDTAPIKPKPEAEV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCE
VHPDADDQGDGELKTKAAPKTRAKTVPQAEPEVRDAPKKGSTVPKVPRKK
ECCCCCCCCCCCEECCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]